Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition

Brain

Volumn 133, Issue 11, 2010, Pages 3166-3180

  Geis, Christian ^a   Weishaupt, Andreas ^a   Hallermann, Stefan ^a,b   Grünewald, Benedikt ^a   Wessig, Carsten ^a   Wultsch, Thomas ^a   Reif, Andreas ^a   Byts, Nadiya ^a   Beck, Marcus ^a   Jablonka, Sibylle ^a   Boettger, Michael K ^a,c   Üeyler, Nurcan ^a   Fouquet, Wernher ^a,d   Gerlach, Manfred ^a   Meinck, Hans Michael ^e   Sirén, Anna Leena ^a   Sigrist, Stephan J ^a,d   Toyka, Klaus V ^a   Heckmann, Manfred ^a,b,d   Sommer, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d Deutsche Forschungsgemeinschaft   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

amphiphysin; GABA; patch clamp; STED microscopy; stiff person syndrome

Indexed keywords

4 AMINOBUTYRIC ACID; AMPHIPHYSIN; AUTOANTIBODY; DYE; EPITOPE; GLUTAMIC ACID; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANXIETY; ARTICLE; BRAIN SLICE; CASE REPORT; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; DORSAL ROOT; DORSAL ROOT POTENTIAL; ENDOCYTOSIS; FEMALE; GABAERGIC TRANSMISSION; GRANULE CELL; HIPPOCAMPUS; HOFFMANN REFLEX; HUMAN; IN VIVO STUDY; MICROSCOPY; MUSCLE SPASM; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PATCH CLAMP; PATHOPHYSIOLOGY; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; RIGIDITY; STIFF MAN SYNDROME; SYNAPTIC INHIBITION; WHOLE CELL;

EID: 78049485287     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq253     Document Type: Article

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