Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1

Apoptosis

Volumn 16, Issue 1, 2011, Pages 35-44

  Ray, Ramesh M ^a   Bhattacharya, Sujoy ^a   Johnson, Leonard R ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Caspase 3; Caspase 9; E2F1; Mdm2; Nutlin 3; p73; PUMA; Siva 1

Indexed keywords

CAMPTOTHECIN; CASPASE 3; CASPASE 9; CELL PROTEIN; CYCLOHEXIMIDE; NUTLIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN NOXA; PROTEIN P53; PROTEIN P73; PROTEIN SIVA 1; PUMA PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN CACO 2; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVATION; GENE DISRUPTION; GENE INDUCTION; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CACO-2 CELLS; CAMPTOTHECIN; CASPASES; CELL LINE, TRANSFORMED; COLONIC NEOPLASMS; DNA FRAGMENTATION; DNA-BINDING PROTEINS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION; HUMANS; IMIDAZOLES; NUCLEAR PROTEINS; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 79951552276     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0538-0     Document Type: Article

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