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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1084-1088

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

(19) Ray, Peter a Wright, Jane a Adam, Julia a Boucharens, Sylviane a Black, Darcey a Brown, Angus R a Epemolu, Ola a Fletcher, Dan a Huggett, Margaret a Jones, Phil a Laats, Steven a Lyons, Amanda a Man, Jos De a Morphy, Richard a Sherborne, Brad a Sherry, Lorcan a Straten, Nicole Van a Westwood, Paul a York, Mark a

a MSD (United Kingdom)

Author keywords

Inhibitor; Optimisation; Rho kinase; ROCK I; ROCK II; Serine threonine kinase

Indexed keywords

AMINE; FASUDIL; ISOQUINOLIN 1 AMINE; ISOQUINOLINE; RHO KINASE; RHO KINASE 2; RHO KINASE I; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL MIGRATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HYPERTENSION; IN VIVO STUDY; NONHUMAN; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMINES; ANIMALS; DISEASE MODELS, ANIMAL; HYPERTENSION; ISOQUINOLINES; MODELS, CHEMICAL; MODELS, MOLECULAR; PIPERIDINES; PROTEIN KINASE INHIBITORS; QUINOLONES; RATS; RHO-ASSOCIATED KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 79851510276 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.12.104 Document Type: Article

Times cited : (21)

References (26)

1
- 0034715885
- M. Amano, Y. Fukata, and K. Kaibuchi Exp. Cell Res. 261 2000 44
- (2000) Exp. Cell Res. , vol.261 , pp. 44
- Amano, M.¹ Fukata, Y.² Kaibuchi, K.³

2
- 0035003738
- H. Shimokawa, K. Morishige, K. Miyata, T. Kandabashi, Y. Eto, I. Ikegaki, T. Asano, K. Kaibuchi, and A. Takeshita Cardiovasc. Res. 51 2001 169
- (2001) Cardiovasc. Res. , vol.51 , pp. 169
- Shimokawa, H.¹ Morishige, K.² Miyata, K.³ Kandabashi, T.⁴ Eto, Y.⁵ Ikegaki, I.⁶ Asano, T.⁷ Kaibuchi, K.⁸ Takeshita, A.⁹

3
- 0035049575
- K. Morishige, H. Shimokawa, Y. Eto, T. Kandabashi, K. Miyata, Y. Matsumoto, M. Hoshijima, K. Kaibuchi, and A. Takeshita Arterioscler. Thromb. Vasc. Biol. 21 2001 548
- (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 548
- Morishige, K.¹ Shimokawa, H.² Eto, Y.³ Kandabashi, T.⁴ Miyata, K.⁵ Matsumoto, Y.⁶ Hoshijima, M.⁷ Kaibuchi, K.⁸ Takeshita, A.⁹

4
- 0036826835
- H. Saito, Y. Minamiya, S. Saito, and J. Ogawa J. Leukocyte Biol. 72 2002 829
- (2002) J. Leukocyte Biol. , vol.72 , pp. 829
- Saito, H.¹ Minamiya, Y.² Saito, S.³ Ogawa, J.⁴

5
- 0036561103
- Y. Kawano, T. Yoshimura, and K. Kaibuchi J. Med. Sci. 65 2002 1
- (2002) J. Med. Sci. , vol.65 , pp. 1
- Kawano, Y.¹ Yoshimura, T.² Kaibuchi, K.³

6
- 0037370706
- T.M. Seasholtz Am J Physiol Cell Physiol. 284 2003 C596
- (2003) Am J Physiol Cell Physiol. , vol.284 , pp. 596
- Seasholtz, T.M.¹

7
- 9644280885
- D.L. Lee, R.C. Webb, and L. Jin Hypertension 44 2004 796
- (2004) Hypertension , vol.44 , pp. 796
- Lee, D.L.¹ Webb, R.C.² Jin, L.³

8
- 10944244704
- M. Schwartz J. Cell Sci. 117 2004 5457
- (2004) J. Cell Sci. , vol.117 , pp. 5457
- Schwartz, M.¹

9
- 79851511050
- K. Budzyn, P.D. Marley, C.G. Sobey, Y. Irooka, H. Shimokawa, and A. Takeshita Drug News Perspect. 17 2004 523 527
- (2004) Drug News Perspect. , vol.17 , pp. 523-527
- Budzyn, K.¹ Marley, P.D.² Sobey, C.G.³ Irooka, Y.⁴ Shimokawa, H.⁵ Takeshita, A.⁶

10
- 12344329603
- T.M. Seasholtz, and J.H. Brown Mol. Interv. 4 2004 348
- (2004) Mol. Interv. , vol.4 , pp. 348
- Seasholtz, T.M.¹ Brown, J.H.²

11
- 27644489210
- A. Lai, and W.H. Frishman Cardiol. Rev. 13 2005 285
- (2005) Cardiol. Rev. , vol.13 , pp. 285
- Lai, A.¹ Frishman, W.H.²

12
- 31844450444
- K. Budzyn, P.D. Marley, and C.G. Sobey Trends Pharmacol. Sci. 27 2006 97
- (2006) Trends Pharmacol. Sci. , vol.27 , pp. 97
- Budzyn, K.¹ Marley, P.D.² Sobey, C.G.³

13
- 34147093748
- J. Shi, and L. Wei Arch. Immunol. Ther Exp. 55 2007 61
- (2007) Arch. Immunol. Ther Exp. , vol.55 , pp. 61
- Shi, J.¹ Wei, L.²

14
- 18944372230
- B.K. Mueller, H. Mack, and N. Teusch Nat. Rev. Drug Disc. 4 2005 387
- (2005) Nat. Rev. Drug Disc. , vol.4 , pp. 387
- Mueller, B.K.¹ MacK, H.² Teusch, N.³

15
- 71749104528
- E. Hu, and D. Lee Expert Opin. Ther. Targets 9 2005 4
- (2005) Expert Opin. Ther. Targets , vol.9 , pp. 4
- Hu, E.¹ Lee, D.²

16
- 33846246321
- R.A. Stavenger, H. Cui, S.E. Dowdell, R.G. Franz, D.E. Gaitanopoulos, K.B. Goodman, M.A. Hilfiker, R.L. Ivy, J.D. Leber, J.P. Marino Jr., H.-J. Oh, A.Q. Viet, W. Xu, G. Ye, D. Zhang, Y. Zhao, L.J. Jolivette, M.S. Head, S.F. Semus, P.A. Elkins, R.B. Kirkpatrick, E. Dul, S.S. Khandekar, T. Yi, D.K. Jung, L.L. Wright, G.K. Smith, D.J. Behm, C.P. Doe, R. Bentley, Z.X. Chen, E. Hu, and D. Lee J. Med. Chem. 50 2007 2
- (2007) J. Med. Chem. , vol.50 , pp. 2
- Stavenger, R.A.¹ Cui, H.² Dowdell, S.E.³ Franz, R.G.⁴ Gaitanopoulos, D.E.⁵ Goodman, K.B.⁶ Hilfiker, M.A.⁷ Ivy, R.L.⁸ Leber, J.D.⁹ Marino Jr., J.P.¹⁰ Oh, H.-J.¹¹ Viet, A.Q.¹² Xu, W.¹³ Ye, G.¹⁴ Zhang, D.¹⁵ Zhao, Y.¹⁶ Jolivette, L.J.¹⁷ Head, M.S.¹⁸ Semus, S.F.¹⁹ Elkins, P.A.²⁰ more..

17
- 33846192375
- K.B. Goodman, H. Cui, S.E. Dowdell, D.E. Gaitanopoulos, R.L. Ivy, C.A. Sehon, R.A. Stavenger, G.Z. Wang, A.Q. Viet, W. Xu, G. Ye, S.F. Semus, C. Evans, H.E. Fries, L.J. Jolivette, R.B. Kirkpatrick, E. Dul, S.S. Khandekar, T. Yi, D.K. Jung, L.L. Wright, G.K. Smith, D.J. Behm, R. Bentley, C.P. Doe, E. Hu, and D. Lee J. Med. Chem 50 2007 6
- (2007) J. Med. Chem , vol.50 , pp. 6
- Goodman, K.B.¹ Cui, H.² Dowdell, S.E.³ Gaitanopoulos, D.E.⁴ Ivy, R.L.⁵ Sehon, C.A.⁶ Stavenger, R.A.⁷ Wang, G.Z.⁸ Viet, A.Q.⁹ Xu, W.¹⁰ Ye, G.¹¹ Semus, S.F.¹² Evans, C.¹³ Fries, H.E.¹⁴ Jolivette, L.J.¹⁵ Kirkpatrick, R.B.¹⁶ Dul, E.¹⁷ Khandekar, S.S.¹⁸ Yi, T.¹⁹ Jung, D.K.²⁰ more..

18
- 78650513427
- P. Ray, J. Wright, J. Adam, S. Boucharens, D. Black, A.R. Brown, O. Epemolu, D. Fletcher, M. Huggett, S. Laats, A. Lyons, J.de Man, R. Morphy, B. Sherborne, L. Sherry, N.v. Straten, and P. Westwood Bioorg. Med. Chem. Lett. 21 2011 97
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 97
- Ray, P.¹ Wright, J.² Adam, J.³ Boucharens, S.⁴ Black, D.⁵ Brown, A.R.⁶ Epemolu, O.⁷ Fletcher, D.⁸ Huggett, M.⁹ Laats, S.¹⁰ Lyons, A.¹¹ De Man, J.¹² Morphy, R.¹³ Sherborne, B.¹⁴ Sherry, L.¹⁵ N, V.S.¹⁶ Westwood, P.¹⁷

19
- 75749129008
- F. Denonne, F. Atienzar, S. Célanire, B. Christophe, F. Delannois, F. Delaunoy, M.-L. Delporte, V. Durieu, M. Gillard, B. Lallemand, Y. Lamberty, G. Lorent, A. Vanbellinghen, N. Houtvin, V. Verbois, and L. Provins ChemMedChem 5 2010 206
- (2010) ChemMedChem , vol.5 , pp. 206
- Denonne, F.¹ Atienzar, F.² Célanire, S.³ Christophe, B.⁴ Delannois, F.⁵ Delaunoy, F.⁶ Delporte, M.-L.⁷ Durieu, V.⁸ Gillard, M.⁹ Lallemand, B.¹⁰ Lamberty, Y.¹¹ Lorent, G.¹² Vanbellinghen, A.¹³ Houtvin, N.¹⁴ Verbois, V.¹⁵ Provins, L.¹⁶

20
- 34447313653
- J.I. Trujillo, H.-C. Huang, W.L. Neumann, M.W. Mahoney, S. Long, W. Huang, D.J. Garland, C. Kusturin, Z. Abbas, M.S. South, and D.B. Reitz Bioorg. Med. Chem. Lett. 17 2007 4568
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 4568
- Trujillo, J.I.¹ Huang, H.-C.² Neumann, W.L.³ Mahoney, M.W.⁴ Long, S.⁵ Huang, W.⁶ Garland, D.J.⁷ Kusturin, C.⁸ Abbas, Z.⁹ South, M.S.¹⁰ Reitz, D.B.¹¹

21
- 11144355930
- A. Takami, M. Iwakubo, Y. Okada, T. Kawata, H. Odai, N. Takahashi, K. Shindo, K. Kimura, Y. Tagami, M. Miyake, K. Fukushima, M. Inagaki, M. Amano, K. Kaibuchi, and H. Iijima Bioorg. Med. Chem. 12 2004 2115
- (2004) Bioorg. Med. Chem. , vol.12 , pp. 2115
- Takami, A.¹ Iwakubo, M.² Okada, Y.³ Kawata, T.⁴ Odai, H.⁵ Takahashi, N.⁶ Shindo, K.⁷ Kimura, K.⁸ Tagami, Y.⁹ Miyake, M.¹⁰ Fukushima, K.¹¹ Inagaki, M.¹² Amano, M.¹³ Kaibuchi, K.¹⁴ Iijima, H.¹⁵

22
- 0030656619
- M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Maekawa, and S. Narumiya Nature 389 1997 990
- (1997) Nature , vol.389 , pp. 990
- Uehata, M.¹ Ishizaki, T.² Satoh, H.³ Ono, T.⁴ Kawahara, T.⁵ Morishita, T.⁶ Tamakawa, H.⁷ Yamagami, K.⁸ Inui, J.⁹ Maekawa, M.¹⁰ Narumiya, S.¹¹

23
- 27644449718
- R.M. Vicari, B. Chaitman, D. Keefe, W.B. Smith, S.G. Chrysant, M.J. Tonkon, N. Bittar, R.J. Weiss, H. Morales-Ballejo, and U. Thadani J. Am. Coll. Cardiol. 46 2005 1803
- (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 1803
- Vicari, R.M.¹ Chaitman, B.² Keefe, D.³ Smith, W.B.⁴ Chrysant, S.G.⁵ Tonkon, M.J.⁶ Bittar, N.⁷ Weiss, R.J.⁸ Morales-Ballejo, H.⁹ Thadani, U.¹⁰

24
- 11144355930
- A. Takami, M. Iwakubo, Y. Okada, T. Kawata, H. Odai, N. Takahashi, K. Shindo, K. Kimura, Y. Tagami, M. Miyake, K. Fukushima, M. Inagaki, M. Amano, K. Kaibuchi, and H. Iijima Bioorg. Med. Chem. 12 2004 2115 The study was conducted in 2004. A ROCK crystal structure was published in 2006.
- (2004) Bioorg. Med. Chem. , vol.12 , pp. 2115
- Takami, A.¹ Iwakubo, M.² Okada, Y.³ Kawata, T.⁴ Odai, H.⁵ Takahashi, N.⁶ Shindo, K.⁷ Kimura, K.⁸ Tagami, Y.⁹ Miyake, M.¹⁰ Fukushima, K.¹¹ Inagaki, M.¹² Amano, M.¹³ Kaibuchi, K.¹⁴ Iijima, H.¹⁵

25
- 33644857442
- M. Jacobs, K. Hayakawa, L. Swenson, S. Bellon, M. Fleming, P. Taslimi, and J. Doran J. Biol. Chem. 281 2006 260
- (2006) J. Biol. Chem. , vol.281 , pp. 260
- Jacobs, M.¹ Hayakawa, K.² Swenson, L.³ Bellon, S.⁴ Fleming, M.⁵ Taslimi, P.⁶ Doran, J.⁷

26
- 0344234281
- Furthermore, ROCK inhibitors bound to PKA were also reported. C. Breitenlechner, M. Gassel, H. Hidaka, V. Kinzel, R. Huber, and R.A. Engh Bossemeyer. Structure. 11 2003 1595
- (2003) Bossemeyer. Structure. , vol.11 , pp. 1595
- Breitenlechner, C.¹ Gassel, M.² Hidaka, H.³ Kinzel, V.⁴ Huber, R.⁵ Engh, R.A.⁶

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