Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

Tetrahedron Asymmetry

Volumn 21, Issue 3, 2010, Pages 311-319

  Best, Daniel ^a   Wang, Chen ^a   Weymouth Wilson, Alexander C ^b   Clarkson, Robert A ^b   Wilson, Francis X ^e   Nash, Robert J ^d   Miyauchi, Saori ^c   Kato, Atsushi ^c   Fleet, George W J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Dextra Laboratories Ltd   (United Kingdom)

^c UNIVERSITY OF TOYAMA   (Japan)

^d Phytoquest Limited   (United Kingdom)

^e SUMMIT PLC   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYNOJIROMYCIN; 2,5 BIS(HYDROXYMETHYL)PYRROLIDINE 3,4 DIOL; 3 HYDROXY DEXTRO BULGECININE; 3 HYDROXY LEVO BULGECININE; 5 AZIDO 5 DEOXY 1,2 O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE; ALPHA GLUCOSIDASE INHIBITOR; AZIDE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; DEXTRO GLUCURONOLACTONE; GLUCURONOLACTONE; GLYCOGEN PHOSPHORYLASE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; PRIORITY JOURNAL; QUANTUM YIELD; X RAY CRYSTALLOGRAPHY;

EID: 77949334636     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2010.01.017     Document Type: Article

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