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1042276934
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Love, K. R., and Seeberger, P. H. (2004) Automated solid-phase synthesis of protected tumor-associated antigen and blood group determinant oligosaccharides, Angew. Chem., Int. Ed. 43, 602-605.
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Werz D. B., Castaner, B., and Seeberger, P. H. (2007) Automated synthesis of tumor-associated carbohydrate antigens Gb-3 and Globo-H: incorporation of α-galactosidic linkages, J. Am. Chem. Soc. 129, 2770-2771.
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Less complex oligosaccharides may dominate as a result of experimental difficulties in sequencing larger structures. This problem is common to all the glycan databanks.
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14
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About 47% of the 3299 structures are derived from N-linked glycoproteins, 19% of them from O-linked glycoproteins and 17% from glycolipids. The rest are not assigned.
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About 47% of the 3299 structures are derived from N-linked glycoproteins, 19% of them from O-linked glycoproteins and 17% from glycolipids. The rest are not assigned.
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Building blocks 1 and 16: Love, K. R., and Seeberger, P. H. (2005) Solution syntheses of protected type II Lewis blood group oligosaccharides: study for automated synthesis, J. Org. Chem. 70, 3168-3177.
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Building block 2: Tanaka, K., Goi, T., and Fukase, K. (2005) Highly efficient sialylation towards alpha(2-3)- and α(2-6)-Neu5Ac-Gal synthesis: significant 'fixed dipole effect' of N-phthalyl group on alpha-selectivity, Synlett 19, 2958 -2962.
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Building blocks 3, 6,11,13, and 14: Love, K. R., and Seeberger, P. H. (2004) Automated solid-phase synthesis of protected tumor-associated antigen and blood group determinant oligosaccharides, Angew. Chem., Inl. Ed. 43, 602-605.
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25
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Building blocks 4, 8, and 12: Hewitt, M. C., and Seeberger, P. H, (2001) Automated solid-phase synthesis of a branched Leishmania cap tetrasaccharide, Org. Lett. 3, 3699-3702.
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Building block 5: Wu, X., Grathwohl, M., and Schmidt, R. R. (2002) Efficient solid-phase synthesis of a complex, branched N-glycan hexasaccharide: Use of a novel linker and temporary-protecting-group pattern, Angew. Chem., Int. Ed. 41, 4489-4493.
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Building blocks 7,10,15,17, and 18: Kröck, L, Oberli, M., Werz, D. B., Seeberger, P. H. Unpublished results.
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Building blocks 9: Blatter, G., Beau, J. M., and Jacquinet, J. C. (1994) The use of 2-deoxy-2-trichloroacetamido-D-glucopyranose derivatives in syntheses of oligosaccharides, Carbohydr. Res. 260, 189-202.
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Building block 19: Wang, C. C., Lee, J. C., Luo, S. Y., Fan, H. F., Pai, C. L., Yang, W. C., Lu, L. D., and Hung, S. C. (2002) Synthesis of biologically potent α1 → 2-linked disaccharide derivatives via regio-selective one-pot protection-glycosylation, Angew. Chem., Int. Ed. 41, 2360-2362.
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Building block 19: Wang, C. C., Lee, J. C., Luo, S. Y., Fan, H. F., Pai, C. L., Yang, W. C., Lu, L. D., and Hung, S. C. (2002) Synthesis of biologically potent α1 → 2-linked disaccharide derivatives via regio-selective one-pot protection-glycosylation, Angew. Chem., Int. Ed. 41, 2360-2362.
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Building block 20: Belén Cid, M., Bonilla, J. B., Alfonso, F., and Martín-Lomas, M. (2003) Synthesis of new hexosaminyl D- and L-chiro-inositols related to putative insulin mediators, Eur. J. Org. Chem. 3505-3515.
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