Homonojirimycin isomers and N-alkylated homonojirimycins: Structural and conformational basis of inhibition of glycosidases

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2565-2571

  Asano, Naoki ^a   Nishida, Makoto ^a   Kato, Atsushi ^a   Kizu, Haruhisa ^a   Matsui, Katsuhiko ^a   Shimada, Yutaka ^b   Itoh, Takashi ^b   Baba, Masanori ^c   Watson, Alison A ^d   Nash, Robert J ^d   De Lilley, Paul M Q ^e   Watkin, David J ^e   Fleet, George W J ^e  

^a HOKURIKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d ABERYSTWYTH UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 3,4 DI EPIHOMONOJIRIMYCIN; ALPHA GLUCOSIDASE; ALPHA HOMOMANNOJIRIMYCIN; ALPHA HOMONOJIRIMYCIN; ALPHA MANNOSIDASE; BETA 4,5 DI EPIHOMONOJIRIMYCIN; BETA GLUCOSIDASE; BETA HOMOMANNOJIRIMYCIN; BETA HOMONOJIRIMYCIN; BETA MANNOSIDASE; FUCOSE; GLYCOSIDASE INHIBITOR; N BUTYL ALPHA HOMONOJIRIMYCIN; N METHYL ALPHA HOMONOJIRIMYCIN; NOJIRIMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOMER; MOUSE; NONHUMAN; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

1-DEOXYNOJIRIMYCIN; ALPHA-GLUCOSIDASES; ANIMALS; ANTI-HIV AGENTS; CATTLE; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; HIV-1; HUMANS; IMINO PYRANOSES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PIPERIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 15444356550     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970836l     Document Type: Article

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