메뉴 건너뛰기




Volumn 79, Issue 2, 2011, Pages 83-91

The significance of a B cell-dependent immunopathology in multiple sclerosis;Die Relevanz einer B-Zell-abhängigen Immunpathologie für die Multiple Sklerose

Author keywords

antibodies; autoimmunity; B cells; EAE; MS

Indexed keywords

AUTOANTIBODY;

EID: 79751524893     PISSN: 07204299     EISSN: 14393522     Source Type: Journal    
DOI: 10.1055/s-0029-1245937     Document Type: Article
Times cited : (8)

References (96)
  • 1
    • 77955844059 scopus 로고    scopus 로고
    • Emerging concepts in autoimmune encephalomyelitis beyond the CD 4 /T(H)1 paradigm
    • Batoulis H, Addicks K, Kuerten S. Emerging concepts in autoimmune encephalomyelitis beyond the CD 4 /T(H)1 paradigm. Ann Anat 2010 192 179-193
    • (2010) Ann Anat , vol.192 , pp. 179-193
    • Batoulis, H.1    Addicks, K.2    Kuerten, S.3
  • 2
    • 1342345214 scopus 로고    scopus 로고
    • The CD4-Th1 model for multiple sclerosis: A crucial re-appraisal
    • DOI 10.1016/j.it.2004.01.007
    • Lassmann H, Ransohoff R M. The CD 4-Th1 model for multiple sclerosis: a (Pubitemid 38249486)
    • (2004) Trends in Immunology , vol.25 , Issue.3 , pp. 132-137
    • Lassmann, H.1    Ransohoff, R.M.2
  • 3
    • 77249098682 scopus 로고    scopus 로고
    • Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis
    • Awad A, Hemmer B, Hartung H P. et al. Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. J Neuroimmunol 2010 219 1-7
    • (2010) J Neuroimmunol , vol.219 , pp. 1-7
    • Awad, A.1    Hemmer, B.2    Hartung, H.P.3
  • 4
    • 34248660806 scopus 로고    scopus 로고
    • Cerebrospinal fluid analysis in multiple sclerosis
    • Luque F A., Jaffe S L. Cerebrospinal fluid analysis in multiple sclerosis. Int Rev Neurobiol 2007 79 341-56
    • (2007) Int Rev Neurobiol , vol.79 , pp. 341-56
    • Luque, F.A.1    Jaffe, S.L.2
  • 5
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005 23 683-747 (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 7
    • 74249097818 scopus 로고    scopus 로고
    • Monoclonal antibodies in MS - Mechanisms of action
    • Bielekova B, Becker B. Monoclonal antibodies in MS - Mechanisms of action. Neurology 2010 74 (Suppl 1) S31-S40
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Bielekova, B.1    Becker, B.2
  • 8
    • 67650082863 scopus 로고    scopus 로고
    • Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid
    • Owens G P., Bennett J L., Lassmann H et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol 2009 65 639-649
    • (2009) Ann Neurol , vol.65 , pp. 639-649
    • Owens, G.P.1    Bennett, J.L.2    Lassmann, H.3
  • 9
    • 0032723691 scopus 로고    scopus 로고
    • Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: A comparative study
    • Reindl M, Linington C, Brehm U et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 1999 122 2047-2056
    • (1999) Brain , vol.122 , pp. 2047-2056
    • Reindl, M.1    Linington, C.2    Brehm, U.3
  • 10
    • 33750633465 scopus 로고    scopus 로고
    • Antibodies as biological markers for pathophysiological processes in MS
    • DOI 10.1016/j.jneuroim.2006.06.028, PII S0165572806002694
    • Reindl M, Khalil M, Berger T. Antibodies as biological markers for pathophysiological processes in MS. J Neuroimmunol 2006 180 50-62 (Pubitemid 44692320)
    • (2006) Journal of Neuroimmunology , vol.180 , Issue.1-2 , pp. 50-62
    • Reindl, M.1    Khalil, M.2    Berger, T.3
  • 11
    • 50549098924 scopus 로고    scopus 로고
    • Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies
    • Büdingen H C., Harrer M D., Kuenzle S von et al. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur J Immunol 2008 38 2014-2023
    • (2008) Eur J Immunol , vol.38 , pp. 2014-2023
    • Büdingen, H.C.1    Harrer, M.D.2    Von, K.S.3
  • 12
    • 73149096240 scopus 로고    scopus 로고
    • Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce oligoclonal bands
    • Büdingen H C., Gulati M von, Kuenzle S et al. Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce oligoclonal bands. J Neuroimmunol 2010 218 134-139
    • (2010) J Neuroimmunol , vol.218 , pp. 134-139
    • Büdingen, H.C.1    Von, G.M.2    Kuenzle, S.3
  • 13
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • DOI 10.1093/brain/awm038
    • Magliozzi R, Howell O, Vora A et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007 130 1089-1104 (Pubitemid 47355604)
    • (2007) Brain , vol.130 , Issue.4 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopolo, M.6    Reynolds, R.7    Aloisi, F.8
  • 16
    • 60349108876 scopus 로고    scopus 로고
    • Einsatz von Rituximab in der Behandlung neuroimmunologischer Erkrankungen
    • Schröder A, Ellrichmann G, Chehab G et al. Einsatz von Rituximab in der Behandlung neuroimmunologischer Erkrankungen. Nervenarzt 2009 80 155-165
    • (2009) Nervenarzt , vol.80 , pp. 155-165
    • Schröder, A.1    Ellrichmann, G.2    Chehab, G.3
  • 17
    • 77951843688 scopus 로고    scopus 로고
    • Treating multiple sclerosis with monoclonal antibodies: A 2010 update
    • Buttmann M. Treating multiple sclerosis with monoclonal antibodies: a 2010 update. Expert Rev Neurother 2010 10 791-809
    • (2010) Expert Rev Neurother , vol.10 , pp. 791-809
    • Buttmann, M.1
  • 18
    • 84959827843 scopus 로고
    • Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys
    • Rivers T M., Schwentker F F. Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 1935 61 689-702
    • (1935) J Exp Med , vol.61 , pp. 689-702
    • Rivers, T.M.1    Schwentker, F.F.2
  • 19
    • 0001435965 scopus 로고
    • An electrophoretic study of the protein components in cerebrospinal fluid and the relationship to the serum proteins
    • Kabat E A., Moore D H., Landow H. An electrophoretic study of the protein components in cerebrospinal fluid and the relationship to the serum proteins. J Clin Invest 1942 21 571-577
    • (1942) J Clin Invest , vol.21 , pp. 571-577
    • Kabat, E.A.1    Moore, D.H.2    Landow, H.3
  • 21
    • 0026147769 scopus 로고
    • Immunopathological recognition of autoantigens in multiple sclerosis
    • Bernard C C., Rosbo N K. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol 1991 13 171-178
    • (1991) Acta Neurol , vol.13 , pp. 171-178
    • Bernard, C.C.1    Rosbo, N.K.2
  • 22
    • 0031008342 scopus 로고    scopus 로고
    • Demyelinating antibodies to myelin oligodendrocyte glycoprotein and galactocerebroside induce degradation of myelin basic protein in isolated human myelin
    • Menon K de, Piddlesden S J., Bernard C C. Demyelinating antibodies to myelin oligodendrocyte glycoprotein and galactocerebroside induce degradation of myelin basic protein in isolated human myelin. J Neurochem 1997 69 214-222 (Pubitemid 27274175)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.1 , pp. 214-222
    • Menon, K.K.1    Piddlesden, S.J.2    Bernard, C.C.A.3
  • 23
    • 0032727128 scopus 로고    scopus 로고
    • The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages
    • DOI 10.1016/S0165-5728(99)00133-2, PII S0165572899001332
    • Van der Goes A, Kortekaas M, Hoekstra K et al. The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages. J Neuroimmunol 1999 101 61-67 (Pubitemid 29505174)
    • (1999) Journal of Neuroimmunology , vol.101 , Issue.1 , pp. 61-67
    • Van Der Goes, A.1    Kortekaas, M.2    Hoekstra, K.3    Dijkstra, C.D.4    Amor, S.5
  • 25
    • 0029879141 scopus 로고    scopus 로고
    • Immunolocalization of 17 and 21.5 kDa MBP isoforms in compact myelin and radial component
    • Karthigasan J, Garvey J S., Ramamurthy G V. et al. Immunolocalization of 17 and 21.5 kDa MBP isoforms in compact myelin and radial component. J Neurocytol 1996 25 1-7
    • (1996) J Neurocytol , vol.25 , pp. 1-7
    • Karthigasan, J.1    Garvey, J.S.2    Ramamurthy, G.V.3
  • 26
    • 0028000423 scopus 로고
    • Autoimmunity in the central nervous system: Mechanisms of antigen presentation and recognition
    • DOI 10.1006/clin.1994.1145
    • Wucherpfennig K W. Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition. Clin Immunol Immunopathol 1994 72 293-306 (Pubitemid 24275207)
    • (1994) Clinical Immunology and Immunopathology , vol.72 , Issue.3 , pp. 293-306
    • Wucherpfennig, K.W.1
  • 27
    • 0033006444 scopus 로고    scopus 로고
    • Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin
    • DOI 10.1046/j.1460-9568.1999.00490.x
    • Yamamoto Y, Yoshikawa H, Nagano S et al. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Eur J Neurosci 1998 11 847-855 (Pubitemid 29106045)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.3 , pp. 847-855
    • Yamamoto, Y.1
  • 28
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann P V., Forsthuber T, Miller A et al. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992 358 155-157
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3
  • 29
    • 0026132370 scopus 로고
    • Major Myelin proteolipid: The 4-alpha-helix topology
    • Popot J L., Pham Dinh D, Dautigny A. Major Myelin proteolipid: the 4-alpha-helix topology. J Membr Biol 1991 120 233-246
    • (1991) J Membr Biol , vol.120 , pp. 233-246
    • Popot, J.L.1    Pham Dinh, D.2    Dautigny, A.3
  • 30
    • 0026216052 scopus 로고
    • Evolution of the myelin integral membrane proteins of the central nervous system
    • Schliess F, Stoffel W. Evolution of the myelin integral membrane proteins of the central nervous system. Biol Chem Hoppe Seyler 1991 372 865-874
    • (1991) Biol Chem Hoppe Seyler , vol.372 , pp. 865-874
    • Schliess, F.1    Stoffel, W.2
  • 31
    • 67649472442 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers in multiple sclerosis
    • Tumani H, Hartung H P., Hemmer B et al. Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiol Dis 2009 35 117-127
    • (2009) Neurobiol Dis , vol.35 , pp. 117-127
    • Tumani, H.1    Hartung, H.P.2    Hemmer, B.3
  • 32
  • 33
    • 0037076504 scopus 로고    scopus 로고
    • Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit
    • Silber E, Semra Y K., Gregson N A. et al. Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit. Neurology 2002 58 1372-1381 (Pubitemid 34507164)
    • (2002) Neurology , vol.58 , Issue.9 , pp. 1372-1381
    • Silber, E.1    Semra, Y.K.2    Gregson, N.A.3    Sharief, M.K.4
  • 34
    • 0031789948 scopus 로고    scopus 로고
    • Increased circulating antiganglioside antibodies in primary and secondary progressive multiple sclerosis
    • Sadatipour B T., Greer J M., Pender M P. Increased circulating antiganglioside antibodies in primary and secondary progressive multiple sclerosis. Ann Neurol 1998 44 980-983 (Pubitemid 28558264)
    • (1998) Annals of Neurology , vol.44 , Issue.6 , pp. 980-983
    • Sadatipour, B.T.1    Greer, J.M.2    Pender, M.P.3
  • 39
    • 0037076504 scopus 로고    scopus 로고
    • Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit
    • Silber E, Semra Y K., Gregson N A. et al. Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit. Neurology 2002 58 1372-1381 (Pubitemid 34507164)
    • (2002) Neurology , vol.58 , Issue.9 , pp. 1372-1381
    • Silber, E.1    Semra, Y.K.2    Gregson, N.A.3    Sharief, M.K.4
  • 41
    • 0018324814 scopus 로고
    • Isoelectric focusing and crossed immunoelectrofocusing of CSF immunoglobulins in MS
    • DOI 10.1007/BF00313168
    • Sidén A. Isoelectric focusing and crossed immunoelectrofocusing of CSF immunoglobulins in MS. J Neurol 1979 221 39-51 (Pubitemid 9245037)
    • (1979) Journal of Neurology , vol.221 , Issue.1 , pp. 39-51
    • Siden, A.1
  • 42
    • 33750604563 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness
    • Link H, Huang Y M. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol 2007 180 17-28
    • (2007) J Neuroimmunol , vol.180 , pp. 17-28
    • Link, H.1    Huang, Y.M.2
  • 43
    • 0020368055 scopus 로고
    • Cerebrospinal fluid IgG bands and virus-specific IgG, IgM, and IgA antibodies in herpes simplex virus encephalitis
    • DOI 10.1016/0165-5728(82)90029-7
    • Vaheri A, Keski-Oja J, Salonen E M. et al. Cerebrospinal fluid IgG bands and virus-specific IgG, IgM, and IgA antibodies in herpes simplex virus encephalitis. J Neuroimmunol 1982 3 247-261 (Pubitemid 13151359)
    • (1982) Journal of Neuroimmunology , vol.3 , Issue.4 , pp. 247-261
    • Vaheri, A.1    Keski-Oja, J.2    Salonen, E.M.3    Koskiniemi, M.L.4
  • 44
    • 0025768827 scopus 로고
    • Laboratory diagnosis and seroepidemiology of Lyme borreliosis
    • Stanek G. Laboratory diagnosis and seroepidemiology of Lyme borreliosis. Infection 1991 19 263-267
    • (1991) Infection , vol.19 , pp. 263-267
    • Stanek, G.1
  • 45
    • 0025622344 scopus 로고
    • Specific activation of B-cell clones within the central nervous system in course of herpes simplex encephalitis
    • Ceroni M, Camana C, Franciotta D M. et al. Specific activation of B-cell clones within the central nervous system in course of herpes simplex encephalitis. Boll Soc Ital Biol Sper 1990 66 1223-1230
    • (1990) Boll Soc Ital Biol Sper , vol.66 , pp. 1223-1230
    • Ceroni, M.1    Camana, C.2    Franciotta, D.M.3
  • 46
    • 0035668029 scopus 로고    scopus 로고
    • Detection of oligoclonal immunoglobulins in the cerebrospinal fluid by immunofixation electrophoresis
    • DOI 10.1515/CCLM.2001.192
    • Shen X, Tan Y. Detection of oligoclonal immunoglobulins in the cerebrospinal fluid by immunofixation electrophoresis. Clin Chem Lab Med 2001 39 1209-1210 (Pubitemid 34026560)
    • (2001) Clinical Chemistry and Laboratory Medicine , vol.39 , Issue.12 , pp. 1209-1210
    • Shen, X.1    Tan, Y.2
  • 47
    • 73449105725 scopus 로고    scopus 로고
    • Novel approaches for identifying target antigens of autoreactive human B and T cells
    • Dornmair K, Meinl E, Hohlfeld R. Novel approaches for identifying target antigens of autoreactive human B and T cells. Semin Immunopathol 2009 31 467-477
    • (2009) Semin Immunopathol , vol.31 , pp. 467-477
    • Dornmair, K.1    Meinl, E.2    Hohlfeld, R.3
  • 48
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • DOI 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q
    • Lucchinetti C, Brück W, Parisi J et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000 47 707-717 (Pubitemid 30390191)
    • (2000) Annals of Neurology , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 50
    • 0021209335 scopus 로고
    • Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
    • Rock K L., Benacerraf B, Abbas A K. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med 1984 160 1102-1113 (Pubitemid 14020970)
    • (1984) Journal of Experimental Medicine , vol.160 , Issue.4 , pp. 1102-1113
    • Rock, K.L.1    Benacerraf, B.2    Abbas, A.K.3
  • 51
    • 0033563084 scopus 로고    scopus 로고
    • + T cell priming in vivo
    • Constant S L. B lymphocytes as antigen-presenting cells for CD 4 T cell priming in vivo. J Immunol 1999 162 5695-5703 (Pubitemid 29314919)
    • (1999) Journal of Immunology , vol.162 , Issue.10 , pp. 5695-5703
    • Constant, S.L.1
  • 53
    • 41649112738 scopus 로고    scopus 로고
    • The role of B cells in multiple sclerosis: Rationale for B-cell-targeted therapies
    • DOI 10.1097/01.wco.0000313359.61176.15, PII 0001905220080400100003
    • Racke M. The role of B cells in multiple sclerosis: rationale for B-cell-targeted therapies. Curr Opin Neurol 2008 21 (Suppl 1) S9-S18 (Pubitemid 351483538)
    • (2008) Current Opinion in Neurology , vol.21 , Issue.SUPPL. 1
    • Racke, M.K.1
  • 54
    • 49149111862 scopus 로고    scopus 로고
    • Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis
    • Harp C T., Lovett-Racke A E., Racke M K. et al. Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis. Clin Immunol 2008 128 382-391
    • (2008) Clin Immunol , vol.128 , pp. 382-391
    • Harp, C.T.1    Lovett-Racke, A.E.2    Racke, M.K.3
  • 55
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini B, Rosicarelli B, Magliozzi R et al. Detection of ectopic B-cell follicles with germinal centers in meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004 14 164-174 (Pubitemid 38656388)
    • (2004) Brain Pathology , vol.14 , Issue.2 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 56
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • DOI 10.1038/nri1786
    • Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006 6 205-217 (Pubitemid 43290990)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.3 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 57
    • 67349169962 scopus 로고    scopus 로고
    • A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis
    • Kaiser C C., Shukla D K., Stebbins G T. et al. A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis. J Neuroimmunol 2009 211 124-130
    • (2009) J Neuroimmunol , vol.211 , pp. 124-130
    • Kaiser, C.C.1    Shukla, D.K.2    Stebbins, G.T.3
  • 58
    • 77954725231 scopus 로고    scopus 로고
    • Epstein-Barr virus latent i nfection and BAFF expression in B cells in the multiple sclerosis brain: Implications for viral persistence and intrathecal B-cell activation
    • Serafini B, Severa M, Columba-Cabezas S et al. Epstein-Barr virus latent i nfection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J Neuropathol Exp Neurol 2010 69 677-693
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 677-693
    • Serafini, B.1    Severa, M.2    Columba-Cabezas, S.3
  • 59
    • 0042123685 scopus 로고    scopus 로고
    • Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
    • DOI 10.1191/1352458503ms917oa
    • Bø L, Vedeler C A., Nyland H et al. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 2003 9 323-331 (Pubitemid 36958014)
    • (2003) Multiple Sclerosis , vol.9 , Issue.4 , pp. 323-331
    • Bo, L.1    Vedeler, C.A.2    Nyland, H.3    Trapp, B.D.4    Mork, S.J.5
  • 60
    • 72649104099 scopus 로고    scopus 로고
    • Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain
    • Willis S N., Stadelmann C, Rodig S J. et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009 132 3318-3328
    • (2009) Brain , vol.132 , pp. 3318-3328
    • Willis, S.N.1    Stadelmann, C.2    Rodig, S.J.3
  • 61
    • 77951021143 scopus 로고    scopus 로고
    • Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis
    • Sargsyan S A., Shearer A J., Ritchie A M. et al. Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 2010 74 1127-1135
    • (2010) Neurology , vol.74 , pp. 1127-1135
    • Sargsyan, S.A.1    Shearer, A.J.2    Ritchie, A.M.3
  • 63
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • Matsushita T, Yanaba K, Bouaziz J D. et al. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008 118 3420-3430
    • (2008) J Clin Invest , vol.118 , pp. 3420-3430
    • Matsushita, T.1    Yanaba, K.2    Bouaziz, J.D.3
  • 65
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 Years of merits and culprits in experimental autoimmune encephalomyelitis research
    • DOI 10.1093/brain/awl075
    • Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006 129 1953-1971 (Pubitemid 44289062)
    • (2006) Brain , vol.129 , Issue.8 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 66
    • 0029851099 scopus 로고    scopus 로고
    • Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis
    • Goverman J, Brabb T. Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis. Lab Anim Sci 1996 46 482-492
    • (1996) Lab Anim Sci , vol.46 , pp. 482-492
    • Goverman, J.1    Brabb, T.2
  • 67
    • 38649124013 scopus 로고    scopus 로고
    • Comparing the CNS morphology and immunobiology of different EAE models in C 57BL/ 6 mice - A step towards understanding the complexity of multiple sclerosis
    • Kuerten S, Angelov D N. Comparing the CNS morphology and immunobiology of different EAE models in C 57BL/ 6 mice - a step towards understanding the complexity of multiple sclerosis. Ann Anat 2008 190 1-15
    • (2008) Ann Anat , vol.190 , pp. 1-15
    • Kuerten, S.1    Angelov, D.N.2
  • 68
    • 28444499085 scopus 로고    scopus 로고
    • Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis
    • DOI 10.1016/j.it.2005.08.014, PII S1471490605002334, Autoimmunity Special Issue
    • Steinmann L, Zamvil S. Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends in Immunol 2005 26 565-571 (Pubitemid 41726443)
    • (2005) Trends in Immunology , vol.26 , Issue.11 , pp. 565-571
    • Steinman, L.1    Zamvil, S.S.2
  • 69
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L, Zamvil S S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 2006 60 12-21
    • (2006) Ann Neurol , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 71
    • 28544450761 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis
    • DOI 10.1002/ana.20743
    • Sriram S, Steiner I. Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Ann Neurol 2005 58 939-945 (Pubitemid 41746884)
    • (2005) Annals of Neurology , vol.58 , Issue.6 , pp. 939-945
    • Sriram, S.1    Steiner, I.2
  • 72
    • 0034920606 scopus 로고    scopus 로고
    • Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone
    • Stefferl A, Storch M K., Linington C et al. Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone. Endocrinology 2001 142 3616-3612
    • (2001) Endocrinology , vol.142 , pp. 3616-3612
    • Stefferl, A.1    Storch, M.K.2    Linington, C.3
  • 73
    • 0028849855 scopus 로고
    • Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate
    • Genain C P., Nguyen M H., Letvin N L. et al. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. J Clin Invest 1995 96 2966-2974
    • (1995) J Clin Invest , vol.96 , pp. 2966-2974
    • Genain, C.P.1    Nguyen, M.H.2    Letvin, N.L.3
  • 74
    • 65349158206 scopus 로고    scopus 로고
    • Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus)
    • 't Hart B A., Massacesi L. Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J Neuropathol Exp Neurol 2009 68 341-355
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 341-355
    • 'T Hart, B.A.1    Massacesi, L.2
  • 75
    • 0032209673 scopus 로고    scopus 로고
    • Cutting edge: B cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • Hjelmstrom P, Juedes A E., Fjell J et al. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 1998 161 4480-4483 (Pubitemid 28492015)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4480-4483
    • Hjelmstrom, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 76
    • 0038643518 scopus 로고    scopus 로고
    • Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice
    • Oliver A R., Lyon G M., Ruddle N H. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C 57BL/ 6 mice. J Immunol 2003 171 462-468 (Pubitemid 36745321)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 462-468
    • Oliver, A.R.1    Lyon, G.M.2    Ruddle, N.H.3
  • 78
    • 53749106546 scopus 로고    scopus 로고
    • Fundamental differences in the CNS lesion development and composition in MP 4- and MOG:35 - 55-induced EAE
    • Kuerten S, Javeri S, Tary-Lehmann M et al. Fundamental differences in the CNS lesion development and composition in MP 4- and MOG:35 - 55-induced EAE. Clin Immunol 2008 129 256-267
    • (2008) Clin Immunol , vol.129 , pp. 256-267
    • Kuerten, S.1    Javeri, S.2    Tary-Lehmann, M.3
  • 80
    • 67449116625 scopus 로고    scopus 로고
    • Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    • Pöllinger B, Krishnamoorthy G, Berer K et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med 2009 206 1303-1316
    • (2009) J Exp Med , vol.206 , pp. 1303-1316
    • Pöllinger, B.1    Krishnamoorthy, G.2    Berer, K.3
  • 81
    • 0030973198 scopus 로고    scopus 로고
    • + B cells in active multiple sclerosis and reversal by interferon -1b therapy
    • Genc K, Dona D L., Reder A T. Increased CD 80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J Clin Invest 1997 99 2664-2671 (Pubitemid 27259813)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.11 , pp. 2664-2671
    • Genc, K.1    Dona, D.L.2    Reder, A.T.3
  • 83
    • 72749096461 scopus 로고    scopus 로고
    • B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis
    • Kala M, Rhodes S N., Piao W H. et al. B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis. Exp Neurol 2010 221 136-145
    • (2010) Exp Neurol , vol.221 , pp. 136-145
    • Kala, M.1    Rhodes, S.N.2    Piao, W.H.3
  • 84
    • 77249142775 scopus 로고    scopus 로고
    • Increased expression of B-cell associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis
    • Begum-Haque S, Sharma A, Christy M et al. Increased expression of B-cell associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol 2010 219 47-53
    • (2010) J Neuroimmunol , vol.219 , pp. 47-53
    • Begum-Haque, S.1    Sharma, A.2    Christy, M.3
  • 86
    • 20844454381 scopus 로고    scopus 로고
    • Blocking adhesion molecules as therapy for multiple sclerosis: Natalizumab
    • DOI 10.1038/nrd1752
    • Steinman L. Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab. Nat Rev Drug Discov 2005 4 510-518 (Pubitemid 40861993)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.6 , pp. 510-518
    • Steinman, L.1
  • 87
    • 3042739652 scopus 로고    scopus 로고
    • 4-integrin antagonist selective adhesion molecule inhibitors for MS
    • DOI 10.1586/14737175.4.4.571
    • Rudick R A., Sandrock A. Natalizumab. alpha 4-integrin antagonist selective adhesion molecule inhibitors for MS. Expert Rev Neurother 2004 4 571-580 (Pubitemid 38890585)
    • (2004) Expert Review of Neurotherapeutics , vol.4 , Issue.4 , pp. 571-580
    • Rudick, R.A.1    Sandrock, A.2
  • 88
    • 55449137632 scopus 로고    scopus 로고
    • Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis
    • Krumbholz M, Meinl I, Kümpfel T et al. Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 2008 71 1350-1354
    • (2008) Neurology , vol.71 , pp. 1350-1354
    • Krumbholz, M.1    Meinl, I.2    Kümpfel, T.3
  • 89
    • 79751536487 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy
    • 9 Oct [Epub ahead of print]
    • Weissert R. Progressive multifocal leukoencephalopathy. J Neuroimmunol 9 Oct 2010 [Epub ahead of print]
    • (2010) J Neuroimmunol
    • Weissert, R.1
  • 90
    • 33744802197 scopus 로고    scopus 로고
    • B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production, and therapeutic modulation
    • DOI 10.1002/ana.20890
    • Meinl E, Krumbholz M, Hohlfeld R. B linage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production and therapeutic modulation. Ann Neurol 2006 59 880-892 (Pubitemid 43830920)
    • (2006) Annals of Neurology , vol.59 , Issue.6 , pp. 880-892
    • Meinl, E.1    Krumbholz, M.2    Hohlfeld, R.3
  • 91
    • 60349098419 scopus 로고    scopus 로고
    • B-Zell-gerichtete Multiple-Sklerose-Therapie: Aktueller Stand
    • Menge T, Büdingen H C., Dalakas M C. et al. B-Zell-gerichtete Multiple-Sklerose-Therapie: Aktueller Stand. Nervenarzt 2009 80 190-198
    • (2009) Nervenarzt , vol.80 , pp. 190-198
    • Menge, T.1    Büdingen, H.C.2    Dalakas, M.C.3
  • 92
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • DOI 10.1016/j.jneuroim.2006.06.029, PII S0165572806002700
    • Cross A H., Stark J L., Lauber J et al. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 2006 180 63-70 (Pubitemid 44767709)
    • (2006) Journal of Neuroimmunology , vol.180 , Issue.1-2 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.-A.5
  • 93
    • 19444377855 scopus 로고    scopus 로고
    • Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    • DOI 10.1016/j.ejphar.2005.03.024, PII S0014299905003225
    • Nückel H, Frey U H., Röth A et al. Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity. Eur J Pharmacol 2005 514 217-224 (Pubitemid 40723643)
    • (2005) European Journal of Pharmacology , vol.514 , Issue.2-3 , pp. 217-224
    • Nuckel, H.1    Frey, U.H.2    Roth, A.3    Duhrsen, U.4    Siffert, W.5
  • 94
    • 41649114547 scopus 로고    scopus 로고
    • B-cell-targeted treatment for multiple sclerosis: Mechanism of action and clinical data
    • DOI 10.1097/01.wco.0000313360.38306.ab, PII 0001905220080400100004
    • Hawker K. B-cell-targeted treatment for multiple sclerosis: mechanism of action and clinical data. Curr Opin Neurol 2008 21 (Suppl 1) S19-S25 (Pubitemid 351483539)
    • (2008) Current Opinion in Neurology , vol.21 , Issue.SUPPL. 1
    • Hawker, K.1
  • 95
    • 41649096096 scopus 로고    scopus 로고
    • The natural history of B cells
    • DOI 10.1097/01.wco.0000313358.53553.c7, PII 0001905220080400100002
    • Monson N. The natural history of B cells. Curr Opin Neurol 2008 21 (Suppl 1) S3-S8 (Pubitemid 351483537)
    • (2008) Current Opinion in Neurology , vol.21 , Issue.SUPPL. 1
    • Monson, N.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.