Tumour xenograft detection through quantitative analysis of the metabolic profile of urine in mice

Physics in Medicine and Biology

Volumn 56, Issue 3, 2011, Pages 535-556

  Moroz, Jennifer ^a   Turner, Joan ^a   Slupsky, Carolyn ^b   Fallone, Gino ^a   Syme, Alasdair ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AREA UNDER THE CURVES; BEFORE AND AFTER; CANCER CELLS; CELL INJECTION; COLD PROBE; GLIOBLASTOMA MULTIFORME; INTER-RELATIONSHIPS; METABOLIC PROFILES; METABOLITE CONCENTRATIONS; NMR SPECTROMETER; NUDE MICE; PARTIAL LEAST SQUARES; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC CURVES; ROC ANALYSIS; TIME POINTS; URINE SAMPLE; WILCOXON RANK SUM TEST;

ANIMALS; BIOMOLECULES; BODY FLUIDS; CONCENTRATION (PROCESS); DISCRIMINANT ANALYSIS; METABOLITES; NUCLEAR MAGNETIC RESONANCE; POPULATION STATISTICS; RESONANCE; SPECTROMETERS; TUMORS;

METABOLISM;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CELL TRANSFORMATION; GLIOBLASTOMA; HUMAN; INJECTION; METABOLISM; METABOLOME; METHODOLOGY; MOUSE; MULTIVARIATE ANALYSIS; PATHOLOGY; RECEIVER OPERATING CHARACTERISTIC; TUMOR CELL LINE; URINALYSIS; URINE; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; INJECTIONS; METABOLOME; MICE; MULTIVARIATE ANALYSIS; NEOPLASM TRANSPLANTATION; ROC CURVE; TRANSPLANTATION, HETEROLOGOUS; URINALYSIS;

EID: 79551718675     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/3/002     Document Type: Article

References (44)

1. Altman D and Bland M 1994 Diagnostic (Pubitemid 24216486)
2. Barba I, Fernandez-Montesinos R, Garcia-Dorado D and Pozo D 2008 Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopy-based metabolomics J. Cell Mol. Med. 12 1477-85
3. Beckonert O, Keun H C, Ebbels T M D, Bundy J, Holmes E, Lindon J C and Nicholson J K 2007 Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts Nat. Protoc. 2 692-2703
4. Benjamini Y and Hochberg Y 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing J. R. Static. Soc. B 57 289-300
5. 1H NMR spectroscopy of urine and pattern recognition Anal. Biochem. 295 194-202 (Pubitemid 32756974)
6. Broadhurst D I and Kell D B 2006 Statistical strategies for avoiding false discoveries in metabolomics and related experiments Metabolomics 2 171-96 (Pubitemid 46099798)
7. 1H NMR metabonomics Anal. Chem. 78 4281-90
8. Erb G, Elbayed K, Piotto M, Raya J, Neuville A, Mohr M, Maitrot D, Kehrli P and Namer I J 2008 Towards improved grading of malignancy in oligodendrogliomas using metabolomics Magn. Reson. Med. 59 959-65 (Pubitemid 351590507)
9. Franko A, Parliament M, Allalunis-Turner J and Wolokoff B 1998 Variable presence of hypoxia in M006 human glioma spheroids and in spheroids and xenografts of clonally derived sublines Br. J. Cancer 78 1261-8 (Pubitemid 28495235)
10. Griffin J L and Shockcor J P 2004 Metabolic profiles of cancer cells Nat. Rev. Cancer 4 551-61 (Pubitemid 38868624)
11. 1H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue Anal. Biochem. 293 16-21 (Pubitemid 32500500)
12. Holmes E and Antti H 2002 Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterizing and interpreting complex biological NMR spectra Analyst 127 1549-57 (Pubitemid 36020854)
13. Issaq H, Nativ O, Waybright T, Luke B, Veenstra T D, Issaq E J, Kravstov A and Mullerad M 2008 Detection of bladder cancer in human urine by metabolomic profiling using high performance liquid chromatography/mass spectroscopy J. Urol. 179 2422-6
14. 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis Metabolomics 4 150-60
15. Keun H C, Ebbels T M, Bollard M E, Beckonert O, Antti H, Holmes E, Lindon J C and Nicholson J K 2004 Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles Chem. Res. Toxicol. 17 579-87 (Pubitemid 38669514)
16. Kim K B, Chung M W, Um S Y, Oh J S, Kim S H, Na M A, Oh H Y, Cho W S and Choi K H 2008 Metabolomics and biomarker discovery: NMR spectral data of urine and hepatotoxicity by carbon tetrachloride, acetaminophen and D-galactosamine in rats Metabolomics 4 377-92
17. Larocque M, Syme A, Yahya A, Wachowicz K, Allalunis-Turner J and Fallone G 2009 Temporal and dose dependence of T2 and ADC at 9.4T in a mouse model following single fraction radiation therapy Med. Phys. 36 2948-54
18. 1H NMR spectroscopy, HPLC-TOFÉMS and chemometrics J. Pharm. Biomed. Anal. 35 599-608 (Pubitemid 38609380)
19. Lenz E M and Wilson I D 2007 Analytical strategies in metabonomics J Proteome Res. 6 443-58 (Pubitemid 46340149)
20. Lindon J C, Holmes E and Nicholson J K 2001 Pattern recognition methods and applications in biomedical magnetic resonance Prog. Nucl. Magn. Reson. Spectrosc. 39 1-40 (Pubitemid 32529183)
21. Lokhov P, Dashtiev M, Moshkovskii S and Archakov A 2010 Metabolite profiling of blood plasma of patients with prostate cancer Metabolomics 6 156-63
22. Murdoch T B, Fu H, MacFarlane S, Sydora B C, Fedorak R N and Slupsky C M 2008 Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice Anal. Chem. 80 5524-31
23. 1H-NMR-based metabonomics Int. J. Cancer 113 782-7888
24. Park S H, Goo J M and Jo C H 2004 Receiver operating characteristic (ROC) curve: practical review for radiologists Korean J. Radiol. 5 11-8 (Pubitemid 38569451)
25. Pohjanen E, Thysell E, Lindberg J, Schuppe-Koistinen I, Moritz T, Jonsson P and Antti H 2006 Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics Metabolomics 2 257-68 (Pubitemid 46099802)
26. Sabatine M, Liu E, Morrow D, Heller E, McCarroll R, Wiegand R, Berriz G, Roth F and Gerszten R 2005 Metabolomic identification of novel biomarkers of myocardial ischemia Circulation 112 3868-75 (Pubitemid 43739484)
27. Salek R M et al 2007 A metabolic comparison of urinary changes in type 2 diabetes in mouse, rat, and human Physiol. Genomics 29 99-108 (Pubitemid 46701991)
28. Saude E and Sykes B 2007 Urine stability for metabolomic studies: effects of preparation and storage Metabolomics 3 19-27 (Pubitemid 46453528)
29. Serkova N J, Reisdorph N A and Tissot van Patot M C 2008 Metabolic markers of hypoxia: systems biology application in biomedicine Toxicol. Mech. Methods 18 81-95 (Pubitemid 351157012)
30. Slupsky C M et al 2009 Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile J. Proteome Res. 8 5550-8
31. Spratlin J L, Serkova N J and Eckhardt S G 2009 Clinical applications of metabolomics in oncology: a review Clin. Cancer Res. 15 431-40
32. Storey J D 2002 A direct approach to false discovery rates J. R. Stat. Soc. B 64 479-98
33. Storey J D, Taylor J E and Siegmund D 2004 Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: a unified approach J. R. Stat. Soc. B 66 187-205 (Pubitemid 38210666)
34. Storey J D and Tibshirani R 2003 Statistical significance for genome-wide experiments Proc. Natl Acad. Sci. 100 9440-5
35. 1H NMR-based metabolomics Neoplasia 11 269-76
36. Trygg J, Holmes E and Lundstedt T 2007 Chemometrics in metabolomics J. Proteome Res. 6 469-79
37. Tyburski J, Patterson A, Krausz K, Slavik J, Fornace A, Gonzalez F and Idle J 2009 Radiation metabolomics: 2. Dose-and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice Radiat. Res. 172 42-57
38. 1H NMR-based metabolomics in rats Anal. Chem. 81 4734-41
39. Verpoorte R, Choi Y H, Mustafa N R and Kim H K 2008 Metabolomics: back to basics Phytochem. Rev. 7 525-37
40. Vion-Dury J, Favre R, Sciaky M, Kriat M, Confort-Gouny S, Harle J R, Grazziani N, Viout P, Grisoli F and Cozzone P J 1993 Graphic-aided study of metabolic modifications of plasma in cancer using proton magnetic resonance spectroscopy NMR Biomed. 6 58-65
41. Weinstein S, Obuchowski N A and Lieber M L 2005 Fundamentals of clinical research for radiologists: clinical evaluation of diagnostic tests AJR 184 14-9
42. 1H NMR metabolomics data Anal. Chem. 78 4430-42
43. Westerhuis J A, Hoefslott H C J, Smit S, Vis D J, Smilde A K, van Velzen E J J, van Dujjnhoven J P M and van Dorsten F A 2008 Assessment of PLSDA cross validation Metabolomics 4 81-9 (Pubitemid 351217591)
44. 1H-NMR metabonomics analysis of sera differentiates between mammary tumour-bearing mice and healthy controls Metabolomics 1 269-78