Fluorine - A current literature review. An NRC and ATSDR based review of safety standards for exposure to fluorine and fluorides

Toxicology Mechanisms and Methods

Volumn 21, Issue 2, 2011, Pages 103-170

  Prystupa, Jeff ^a  

^a Independent Research Foundation   (United States)

Author keywords

Alzheimer's; arthritis; bone; calcium; cancer; chemical; corrosion; depression; disease vector; fluoride; Fluorine; health; heart attack; hip fractures; hypertension; immune; IQ deficits; kidney; mitochondrial poisoning; non fever illness; osteoporosis; poison; pollution; stroke; teeth; thyroid; water

Indexed keywords

BROMINE; CALCITONIN; CALCIUM; CHLORINE; COBALT; DRINKING WATER; FLUORIDE; FLUORIDE SODIUM; FLUORINE; HYDROFLUORIC ACID; IODINE; LIOTHYRONINE; ORGANIC COMPOUND; PARATHYROID HORMONE; PESTICIDE; THYROTROPIN; THYROXINE; TOOTHPASTE; TOSYLCHLORAMIDE SODIUM; WATER;

ABDOMINAL PAIN; ACNE CONGLOBATA; AIR; ANOREXIA; ARTHRALGIA; ARTIFICIAL MILK; BLADDER CANCER; BLEEDING; BLOOD; BONE; BREAST MILK; BREATHING DISORDER; CARCINOGENICITY; CELL FUNCTION; CELLULAR IMMUNITY; CHEMISTRY; COGNITION; CONVULSION; DEMENTIA; DENTAL CARIES; DIABETES INSIPIDUS; DIARRHEA; DISEASE ASSOCIATION; DROWSINESS; DRUG EXCRETION; EMBRYOLOGY; ENDOCRINE SYSTEM; ENVIRONMENTAL EXPOSURE; FAINTNESS; FLUORIDATION; FLUOROSIS; FOOD; GASTROINTESTINAL TRACT; GENOTOXICITY; GOITER; HAIR; HEART ARRHYTHMIA; HEART FAILURE; HISTORY; HUMAN; HYPERKALEMIA; HYPERREFLEXIA; HYPOCALCEMIA; HYPOMAGNESEMIA; IMMUNE SYSTEM; INDUSTRIAL PRODUCTION; KIDNEY; KIDNEY CANCER; LITERATURE; MILK; MINERALIZATION; MUSCULOSKELETAL SYSTEM; NAIL; NAIL DISEASE; NAUSEA; NEUROTOXICITY; NONHUMAN; PARATHYROID GLAND; PH; PLASMA; POLYDIPSIA; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; RENAL SYSTEM PARAMETERS; REPRODUCTION; RESPIRATORY ARREST; REVIEW; SAFETY; SALIVA; SHOCK; TETANY; THYROID GLAND; TOOTH; TOOTH DISEASE; TREMOR; URINE; VOMITING; WATER SUPPLY; WEAKNESS;

AIR POLLUTANTS; ANIMALS; CALCIUM; CHEMICAL INDUSTRY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; FLUORIDES; FLUORINE; GOVERNMENT AGENCIES; HUMANS; MALE; NATIONAL ACADEMY OF SCIENCES (U.S.); PUBLIC HEALTH; REGISTRIES; RISK ASSESSMENT; TOXICITY TESTS; UNITED STATES; UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES;

EID: 79551714784     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.542931     Document Type: Review

References (437)

1. Adair SM. 1999. Overview of the history and current status of fluoride supplementation schedules. J Public Health Dent 59:252-258.
2. Adair SM, Piscitelli WP, McKnight-Hanes C. 1997. Comparison of the use of a child and an adult dentifrice by a sample of pr (Pubitemid 127735274)
3. Agency for Toxic Substances & Disease Registry (ATSDR). 2003. Toxicological profile for fluorides, hydrogen fluoride, and fluorine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
4. Ahn HW, Fulton B, Moxon D, Jeffery EH. 1995. Interactive effects of fluoride and aluminum uptake and accumulation in bones of rabbits administered both agents in their drinking water. J Toxicol Environ Health 44:337-350.
5. Alhava EM, Olkkonen H, Kauranen P, Kari T. 1980. The effect of drinking water fluoridation on the fluoride content, strength and mineral density of human bone. Acta Orthop Scand 51:413-420. (Pubitemid 10066754)
6. Allegood J. 2005. Water treatment process called potential risk. Chemicals' mix with plumbing could put lead in tap water. The News & Observer. May 18.
7. American Dental Association (ADA). 2005. Fluoridation Facts. Chicago, IL: American Dental Association.
8. American Dental Association (ADA). 2006. Interim guidance on reconstituted infant formula. ADA,eGRAM.
9. American Diabetes Association. 2004. Basic Diabetes Information. American Diabetes Association. American Diabetes Association 1701 North Beauregard Street Alexandria, VA 22311.
10. Anbar M, Guttmann S, Lewitus Z. 1959. Effect of monofluorosulphonate, difluorophosphate and fluoroborate ions on the iodine uptake of the thyroid gland. Nature 183:1517-1518.
11. Antich PP, Pak CY, Gonzales J, Anderson J, Sakhaee K, Rubin C. 1993. Measurement of intrinsic bone quality in vivo by reflection ultrasound: correction of impaired quality with slow-release sodium fluoride and calcium citrate. J Bone Miner Res 8:301-311. (Pubitemid 23095895)
12. Antonny B, and Chabre M. 1992. Characterization of the aluminum and beryllium fluoride species which activate transducin. Analysis of the binding and dissociation kinetics. J Biol Chem 267(10):6710-6718.
13. Aoba T, Fejerskov O. 2002. Dental fluorosis: chemistry and biology. Crit Rev Oral Biol Med 13:155-170. (Pubitemid 34791216)
14. Arnala I, Alhava EM, Kivivouri R, Kauranen P. 1986. Hip fracture incidence not affected by fluoridation. Osteofluorosis studied in Finland. Acta Orthop Scand 57:344-348. (Pubitemid 17202387)
15. Arnow PM, Bland LA, Garcia-Houchins S, Fridkin S, Fellner SK. 1994. An outbreak of fatal fluoride intoxication in a long-term hemodialysis unit. Ann Intern Med 121:339-344.
16. Arola D, Reprogel RK. 2005. Effects of aging on the mechanical behavior of human dentin. Biomaterials 26:4051-4061. (Pubitemid 40038794)
17. Assem ES, Wan BY. 1982. Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride. Experientia 38:369-370. (Pubitemid 12075711)
18. ATSDR (Agency for Toxic Substances and Disease Registry). 1999. Toxicological Profile for Aluminum. U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA.
19. ATSDR (Agency for Toxic Substances and Disease Registry). 2003. Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine. U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA. September 2003.
20. Austen KF, Dworetzky M, Farr RS, Logan GB, Malkiel S, Middleton E, Jr, Miller MM, Patterson R, Reed CE, Siegel SC, Van Arsdel PP, Jr. 1971. A statement on the question of allergy to fluoride as used in the fluoridation of community water supplies. J Allergy 47:347-348.
21. Bachinskii, P.P., O.A. Gutsalenko, N.D. Naryzhniuk, V.D. Sidora, and A.I. Shliakhta. 1985. Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system [translated from Russian by Ralph McElroy. Translation Company, Austin, TX] Probl Endokrinol 31(6):25-29. (Pubitemid 16254546)
22. Baelum V, Fejerskov O, Manji F, Larsen MJ. 1987. Daily dose of fluoride and dental fluorosis. Tandlaegebladet 91:452-456.
23. Baker MT, Ronnenberg WC, Jr. 1992. Acute stimulation of trifluoroethene defluorination and cytochrome P450 inactivation in the rat by exposure to isoflurane. Toxicol Appl Pharmacol 114:25-30.
24. Barnhart WE, Hiller LK, Leonard GJ, Michaels SE. 1974. Dentifrice usage and ingestion among four age groups. J Dent Res 53:1317-1322.
25. Baud CA, Lagier R, Boivin G, Boilla MA. 1978. Value of the bone biopsy in the diagnosis of industrial fluorosis. Virchows Archiv A Pathol Anat Histol 380:283-297.
26. Bayley TA, Harrison JE, Murray TM, Josse RG, Sturtridge W, Pritzker KP, Strauss A, Vieth R, Goodwin S. 1990. Fluoride-induced fractures: relation to osteogenic effect. J Bone Min Res 5(Suppl 1):S217-S222. (Pubitemid 20284911)
27. Baylis P, Cheetham T. 1998. Diabetes insipidus. Arch Dis Child 79:84-89. (Pubitemid 28331261)
28. Becaria A, Bondy SC, Campbell A. 2003. Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's disease. J Alzheimers Dis 5:31-38. (Pubitemid 36422849)
29. Beers MH, Berkow R, editors. 1999. The Merck manual of diagnosis and therapy. 17th ed. Whitehouse Station, NJ: Merck Research Laboratories.
30. Behrendt A, Oberste V, Wetzel WE. 2002. Fluoride concentration and pH of iced tea products. Caries Res 36:405-410. [Abstract]
31. Belchetz PE, Hammond PJ. 2003. Mosby's color atlas and text of diabetes and endocrinology. Edinburgh: Mosby.
32. Bentley EM, Ellwood RP, Davies RM. 1999. Fluoride ingestion from toothpaste by young children. Br Dent J 186:460-462.
33. Bergan T. 1989. Pharmacokinetics of ciprofloxacin with reference to other fluorinated quinolones. J Chemother 1:10-17. (Pubitemid 19128455)
34. Berry WT. 1958. A study of the incidence of mongolism in relation to the fluoride content of water. Am J Ment Defic 62:634-636.
35. Bobek S, Kahl S, Ewy Z. 1976. Effect of long-term fluoride administration on thyroid hormones level blood in rats. Endocrinol Exp 10(4):289-295.
36. Bronckers AL, Lyaruu DM, Bervoets TJ, Woltgens JH. 2002. Fluoride enhances intracellular degradation of amelogenins during secretory phase of amelogenesis of hamster teeth in organ culture. Connect Tissue Res 43:456-465. (Pubitemid 34777963)
37. Brownlee M, Aiello LP, Friedman E, Vinik AI, Nesto RW, Boulton AJM. 2002. Complications of diabetes mellitus. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Williams textbook of endocrinology. 10th ed. Philadelphia, PA: Saunders. pp 1509-1583.
38. Bryson C. 2004. The fluoride deception. New York: Seven Stories Press.
39. Bucher JR, Hejtmancik MR, Toft JD, 2nd, Persing RL, Eustis SL, Haseman JK. 1991. Results and conclusions of the National Toxicology Program's rodent carcinogenicity studies with sodium fluoride. Int J Cancer 48:733-737.
40. Burgstahler AW, Robinson MA. 1997. Fluoride in California wines and raisins. Fluoride 30:142-146. (Pubitemid 27348919)
41. Burt BA. 1992. The changing patterns of systemic fluoride intake. J Dent Res 71:1228-1237.
42. Burt BA. 1994. Letter. Fluoride 27:180-181.
43. Burt BA, Eklund SA. 1999. Dentistry, dental practice, and the community. 5th ed. Philadelphia, PA: WB Saunders Co.
44. Butler JE, Satam M, Ekstrand J. 1990. Fluoride: an adjuvant for mucosal and systemic immunity. Immunol Lett 26:217-220.
45. Buzalaf M, Damante CA, Trevizani LM, Granjeiro JM. 2004. Risk of fluorosis associated with infant formulas prepared with bottled water. Journal of Dentistry for Children 71:110-113. May-August. (Pubitemid 39614229)
46. Calderon J, Machado B, Navarro M, Carrizales L, Ortiz MD, Diaz-Barriga F. 2000. Influence of fluoride exposure on reaction time and visuospatial organization in children. Epidemiology 11:S153.
47. Call RA, Greenwood DA, Lecheminant WH, Shupe JL, Nielsen HM, Olson LE, Lamborn RE, Mangelson FL, Davis RV. 1965. Histological and chemical studies in man on effects of fluoride. Public Health Rep 80:529-538.
48. Caverzasio J, Palmer G, Bonjour JP. 1998. Fluoride: Mode of action. Bone 22(6):585-589. (Pubitemid 28284606)
49. Centers for Disease Control and Prevention (CDC). 1993. Fluoridation Census 1992. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Prevention Services, Division of Oral Health.
50. Centers for Disease Control and Prevention (CDC). 2001. Recommendations for using fluoride to prevent and control dental caries in the United States. MMWR 50:1-42.
51. Centers for Disease Control and Prevention (CDC). 2002. Prevalence of selfreported arthritis and chronic joint symptoms among adults. MMWR 51:948-950.
52. Centers for Disease Control and Prevention (CDC). 2005. Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis- United States, 1988-1994 and 1999-2002. MMWR Surveill Summ 54:1-43.
53. CEPA (Canadian Environmental Protection Act). 1996. National Ambient Air Quality Objectives for Hydrogen Fluoride (HF): Science Assessment Document. Ontario: CEPA/FPAC Working Group on Air Quality Objectives and Guidelines, Canadian Environmental Protection Act (as cited in ATSDR 2003).
54. Chabre, M. 1990. Aluminofluoride and beryllofluoride complexes: A new phosphate analogs in enzymology. Trends Biochem Sci 15(1):6-10.
55. Challacombe SJ. 1996. Does fluoridation harm immune function? Community Dent Health 13(Suppl 2):69-71. (Pubitemid 126474649)
56. Chan JT, Koh SH. 1996. Fluoride content in caffeinated, decaffeinated and herbal teas. Caries Res 30:88-92. (Pubitemid 126460827)
57. Chang, C.Y., P.H. Phillips, E.B. Hart, and G. Bonstedt. 1934. The effect of feeding raw rock phosphate on the fluorine content of the organs and tissues of dairy cows. J Dairy Sci 17:695-700 (as cited in Galletti and Joyet 1958).
58. Charen J, Taves DR, Stamm JW, Parkins FM. 1979. Bone fluoride concentrations associated with fluoridated drinking water. Calcif Tissue Int 27:95-99. (Pubitemid 10220021)
59. Cheng KK, Chalmers I, Sheldon TA. 2007. Adding fluoride to water supplies. Brit Med J 335:699-702. (Pubitemid 47582978)
60. Cohn PD. 1992. A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. New Jersey Department of Health Environ. Health Service: 17pp.
61. Clabby C. 2005. Water tests to plumb extent of lead problem. Durham among cities where chemical could cause toxic taint in tap water. Raleigh, NC: The News and Observer.
62. Clarkson J, McLoughlin J. 2000. Role of fluoride in oral health promotion. Int Dent J 50:119-128.
63. Clovis J, Hargreaves JA. 1988. Fluoride intake from beverage consumption. Community Dent Oral Epidemiol 16:11-15.
64. Cohen-Solal ME, Augry F, Mauras Y, Morieux C, Allain P, de Vernejoul MC. 2002. Fluoride and strontium accumulation in bone does not correlate with osteoid tissue in dialysis patients. Nephrol Dial Transplant 17:449-454. (Pubitemid 34211142)
65. Cohn PD. 1992. A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. New Jersey Department of Health Environ. Health Service: 1-17.
66. Colquhoun J. 1997. Why I changed my mind about fluoridation. Perspect Biol Med 41:29-44.
67. Convertino VA, Armstrong LE, Coyle EF, Mack GW, Sawka MN, Senay LC, Jr, Sherman WM. 1996. American College of Sports Medicine position stand: exercise and fluid replacement. Med Sci Sports Exerc 28:1-7.
68. Coplan MJ, Masters RD. 2001. Silicofluorides and fluoridation. Guest Editorial Fluoride 34:161-220.
69. Coris EE, Ramirez AM, Van Durme DJ. 2004. Heat illness in athletes: the dangerous combination of heat, humidity and exercise. Sports Med 34:9-16. (Pubitemid 38186941)
70. Correa Rodrigues MA, de Magalhaes Bastos JR, Buzalaf MAR. 2004. Fingernails and toenails as biomarkers of subchronic exposure to fluoride from dentifrice in 2- to 3-year-old children. Caries Res 38:109-114. (Pubitemid 38223721)
71. Cousins MJ, Mazze RI. 1973. Methoxyflurane nephrotoxicity: a study of the dose response in man. JAMA 225:1611-1616.
72. Cox GR, Broad EM, Riley MD, Burke LM. 2002. Body mass changes and voluntary fluid intakes of elite level water polo players and swimmers. J Sci Med Sport 5:183-193. (Pubitemid 35190779)
73. Coyle EF. 2004. Fluid and fuel intake during exercise. J Sports Sci 22:39-55. (Pubitemid 38173089)
74. Cross DW, Carton RC. 2003. Fluoridation: a violation of medical ethics and human rights. Int J Occup Environ Health 9:24-29. (Pubitemid 36519705)
75. Crossman M. 2003. Inside a diet plan. Sporting News 1:26-27.
76. Cutress TW, Suckling GW, Coote GE, Gao J. 1996. Fluoride uptake into the developing enamel and dentine in sheep incisors following daily ingestion of fluoridated milk or water. N Z Dent J 92:68-72.
77. Czarnowski W, Krechniak J. 1990. Fluoride in the urine, hair, and nails of phosphate fertiliser workers. Br J Ind Med 47:349-351. (Pubitemid 20170619)
78. Czarnowski W, Krechniak J, Urbanska B, Stolarska K, Taraszewska- Czarnowska M, Muraszko-Klaudel A. 1999. The impact of water-borne fluoride on bone density. Fluoride 32:91-95. (Pubitemid 29394840)
79. Dabeka RW, Karpinski KF, McKenzie AD, Bajdik CD. 1986. Survey of lead, cadmium and fluoride in human milk and correlation of levels with environmental and food factors. Food Chem Toxicol 24:913-921. (Pubitemid 17191350)
80. Dabeka RW, McKenzie AD. 1987. Lead, cadmium, and fluoride levels in market milk and infant formulas in Canada. J Assoc Off Anal Chem 70:754-757.
81. Dabeka RW, McKenzie AD. 1995. Survey of lead, cadmium, fluoride, nickel, and cobalt in food composites and estimation on dietary intakes of these elements by Canadians in 1986-1988. J AOAC Int 78:897-909.
82. Daniels TC, Jorgensen EC. 1977. Physicochemical properties in relation to biological action. In: Wilson CO, Gisvold O, Doerge RF, editors. Textbook of organic medicinal and pharmaceutical chemistry. 7th ed. Philadelphia: Lippincott; pp 5-62.
83. Dean HT. 1942. The investigation of physiological effects by the epidemiological method. In: Mouton FR, editor. Fluorine and Dental Health. AAAS No. 19. Washington, DC: American Association for the Advancement of Science; pp 23-31.
84. DeLucia MC, Mitnick ME, Carpenter TO. 2003. Nutritional rickets with normal circulating 25-hydroxyvitamin D: a call for reexamining the role of dietary calcium intake in North American infants. J Clin Endocrinol Metab 88:3539-3545. (Pubitemid 37034492)
85. DenBesten P. 1999. Biological mechanism of dental fluorosis relevant to the use of fluoride supplements. Community Dent Oral Epidemiol 27:41-47.
86. DenBesten PK. 1994. Dental fluorosis: its use as a biomarker. Adv Dent Res 8:105-110.
87. DenBesten PK, Thariani H. 1992. Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis. J Dent Res 71:1238-1243.
88. DenBesten PK, Yan Y, Featherstone JD, Hilton JF, Smith CE, Li W. 2002. Effects of fluoride on rat dental enamel matrix proteinases. Arch Oral Biol 47:763-770. (Pubitemid 35442109)
89. Denver Post. 2009. Mercury mystery in state's waters. (pg1) Jaffe, Mark. 5 April.
90. Dillenberg JS, Levy SM, Schroeder DC, Gerston EN, Andersen CJ. 1992. Arizona providers' use and knowledge of fluoride supplements. Clin Prev Dent 14:15-26.
91. Dreisbach RH. 1966. Dreisbach's Handbook of Poisoning. 5th ed. Lang Medical Publications. Los Altos, CA. Library of Congress Catalog Card Number 66-16732
92. DrugDex Evaluations. 2006. Sodium fluoride. Vol. 126. Englewood, CO: Micromedex, Inc.
93. Dunipace AJ, Brizendine EJ, Zhang W, Wilson ME, Miller LL, Katz BP, Warrick JM, Stookey GK. 1995. Effect of aging on animal response to chronic fluoride exposure. J Dent Res 74:358-368.
94. Duperon DF, Jedrychowski JR, Kong J. 1995. Fluoride content of Los Angeles County water. J Calif Dent Assoc 23:45-46, 48.
95. Durand M, Grattan J. 2001. Effects of volcanic air pollution on health. Lancet 357:164. (Pubitemid 32108085)
96. Easmann RP, Steflik DE, Pashley DH, McKinney RV, Whitford GM. 1984. Surface changes in rat gastric mucosa induced by sodium fluoride: a scanning electron microscopic study. J Oral Pathol 13:255-264. (Pubitemid 14079477)
97. Eble DM, Deaton TG, Wilson FC, Jr, Bawden JW. 1992. Fluoride concentrations in human and rat bone. J Public Health Dent 52:288-291.
98. Edwards SL, Poulos TL, Kraut J. 1984. The crystal structure of fluoride-inhibited cytochrome c peroxidase. J Biol Chem 259:12984-12988. (Pubitemid 15223810)
99. Eisenbarth GS, Polonsky KS, Buse JB. 2002. Type 1 diabetes mellitus. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Williams textbook of endocrinology. 10th ed. Philadelphia, PA: Saunders; pp 1485-1508.
100. Ekstrand J, Fomon SJ, Ziegler EE, Nelson SE. 1994. Fluoride pharmacokinetics in infancy. Pediatr Res 35:157-163. (Pubitemid 24039141)
101. Ekstrand J, Spak CJ. 1990. Fluoride pharmacokinetics: Its implications in the fluoride treatment of osteoporosis. J Bone Miner Res 5(Suppl 1):S53-S61. (Pubitemid 20284886)
102. Ekstrand, J., M. Ehrnebo, and L.O. Boreus. 1978. Fluoride bioavailability after intravenous and oral administration: Importance of renal clearance and urine flow. Clin Pharmacol Ther 23(3):329-337. (Pubitemid 8302190)
103. Emsley J, Jones DJ, Miller JM, Overill RE, Waddilove RA. 1981. An unexpectedly strong hydrogen bond: ab initio calculations and spectroscopic studies of amide-fluoride systems. J Am Chem Soc 103:24-28.
104. Environmental Protection Agency (EPA). 1985. National primary drinking water regulations; fluoride. Federal Register 50:20164-20175.
105. EPA (U.S. Environmental Protection Agency). 1988. Summary review of health effects associated with hydrogen fluoride and related compounds. Health Issue Assessment. EPA/600/8-89/002F. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC.
106. EPA (U.S. Environmental Protection Agency). 1992. Sulfuryl Fluoride. R.E.D. (Registration Eligibility Decision) Facts. EPA-738-R-93-012. Office of Prevention, Pesticide and Toxic Substances, U.S. Environmental Protection Agency.
107. EPA (U.S. Environmental Protection Agency). 1996a. Cryolite. R.E.D. (Registration Eligibility Decision) Facts. EPA-738-R-96-016. Office of Prevention, Pesticide and Toxic Substances, U.S. Environmental Protection Agency.
108. EPA (U.S. Environmental Protection Agency). 1997. Exposure Factors Handbook,Vol. I, II, III. EPA/600/P-95/002Fa-c. National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency.
109. EPA (U.S. Environmental Protection Agency). 2000c. Food Commodity Intake Database (FCID). Computer data file. NTIS PB2000-500101. Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC.
110. EPA (U.S. Environmental Protection Agency). 2003a. Occurrence estimation methodology and occurrence findings report for the six-year review of existing National primary drinking water regulations. EPA-815-R-03-006. Office of Water, U.S. Environmental Protection Agency.
111. EPA (U.S. Environmental Protection Agency). 2003b. Preliminary risk assessment of the developmental toxicity associated with exposure to perfluorooctanoic acid and its salts. Risk Assessment Division, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency.
112. EPA (U.S. Environmental Protection Agency). 2004. Human health risk assessment for sulfuryl fluoride and fluoride anion addressing the section 3 registration of sulfuryl fluoride post-harvest fumigation of stored cereal grains, dried fruits and tree nutsand pest control in grain processing facilities. PP# 1F6312. Memorandum to DennisMcNeilly/Richard Keigwin, Fungicide Branch, Registration Division, from Michael Doherty, Edwin Budd, Registration Action Branch 2, and Becky Daiss, Registration Action Branch 4, Health Effects Division, Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency, Washington, DC.
113. Erben J, Hajakova B, Pantucek M, Kubes L. 1984. Fluoride metabolism and renal osteodystrophy in regular dialysis treatment. Proc Eur Dial Transplant Assoc Eur Ren Assoc 21:421-425.
114. Erdal S, Buchanan SN. 2005. A quantitative look at fluorosis, fluoride exposure, and intake in children using a health risk assessment approach. Environ Health Perspect 113:111-117.
115. Erickson JD. 1980. Down syndrome, water fluoridation, and maternal age. Teratology 21:177-180. (Pubitemid 10124057)
116. Erickson JD, Oakley GP, Jr, Flynt JW, Jr, Hay S. 1976. Water fluoridation and congenital malformations: no association. J Am Dent Assoc 93:981-984.
117. Ernst P, Thomas D, Becklake MR. 1986. Respiratory survey of North American Indian children living in proximity to an aluminum smelter. Am Rev Respir Dis 133:307-312. (Pubitemid 16123929)
118. Eto B, Boisset M, Desjeux JF. 1996. Sodium fluoride inhibits the antisecretory effect of peptide YY and its analog in rabbit jejunum. Arch Physiol Biochem 104(2):180-184. (Pubitemid 26229313)
119. Evans, R.W., and J.W. Stamm. 1991. An epidemiologic estimate of the critical period during which human maxillary central incisors are most susceptible to fluorosis. J Public Health Dent 51(4):251-259.
120. Facanha AR, Okorokova-Facanha AL. 2002. Inhibition of phosphate uptake in corn roots by aluminum-fluoride complexes. Plant Physiol 129(4):1763-1772. (Pubitemid 34923240)
121. Featherstone JDB. 1999. Prevention and reversal of dental caries: role of low level fluoride. Community Dent Oral Epidemiol 27:31-40.
122. Fein NJ, Cerklewski FL. 2001. Fluoride content of foods made with mechanically separated chicken. J Agric Food Chem 49:4284-4286. (Pubitemid 32896423)
123. Fejerskov O. 2004. Changing paradigms in concepts on dental caries: consequences for oral health care. Caries Res 38:182-191. (Pubitemid 38716208)
124. Fejerskov, O., M.J. Larsen, A. Richards, and V. Baelum. 1994. Dental tissue effects of fluoride. Adv Dent Res 8(1):15-31.
125. Fejerskov O, Manji F, Baelum V. 1990. The nature and mechanisms of dental fluorosis in man. J Dent Res 69:692-700. (Pubitemid 20167516)
126. Fejerskov O, Stephen KW, Richards A, Speirs R. 1987. Combined effect of systemic and topical fluoride treatments on human deciduous teeth-case studies. Caries Res 21:452-459. (Pubitemid 17136541)
127. Felsenfeld AJ, Roberts MA. 1991. A report of fluorosis in the United States secondary to drinking well water. J Am Med Assoc 265:486-488.
128. Feskanich D, Owusu W, Hunter DJ, Willett W, Ascherio A, Spiegelman D, Morris S, Spate VL, Colditz G. 1998. Use of toenail fluoride levels as an indicator for the risk of hip and forearm fractures in women. Epidemiology 9:412-416. (Pubitemid 28298363)
129. Fomon SJ, Ekstrand J. 1999. Fluoride intake by infants. J Public Health Dent 59:229-234.
130. Fomon SJ, Ekstrand J, Ziegler EE. 2000. Fluoride intake and prevalence of dental fluorosis: trends in fluoride intake with special attention to infants. J Public Health Dent 60:131-139. [Abstract]
131. Foster, N.L., T.N. Chase, P. Fedio, N.J. Patronas, R.A. Brooks, and G. Di Chiro. 1983. Alzheimer's disease: Focal cortical changes shown by positron emission tomography. Neurology 33(8):961-965. (Pubitemid 13030175)
132. Franke J, Rath F, Runge H, Fengler F, Auermann E, Saale GDR. 1975. Industrial fluorosis. Fluoride 8:61-83.
133. Freni SC. 1994. Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates. J Toxicol Environ Health 42:109-121. (Pubitemid 24162562)
134. Fujii, A., and T. Tamura. 1989. Deleterious effect of sodium fluoride on gastrointestinal tract. Gen Pharmacol 20(5):705-710. (Pubitemid 19232613)
135. Gabler, W.L., and P.A. Leong. 1979. Fluoride inhibition of polymorphonuclear leukocytes. J Dent Res 58(9):1933-1939. (Pubitemid 10188727)
136. Gedalia, I., J. Gross, S. Guttmann, J.E. Steiner, F.G. Sulman, and M.M. Weinreb. 1960. The effects of water fluorination on thyroid function, bones and teeth of rats on a low iodine diet. Arch Int Pharmacodyn Ther 129(Dec.1):116-124.
137. Gedalia I, Brzezinski A, Bercovici B, et al. 1961. Placental transfer of fluorine in the human fetus. Proc Soc Exper Biol Med 106:147-149.
138. Gibson, S.L. 1992. Effects of fluoride on immune system function. Complement Med Res 6:111-113. (Pubitemid 23099668)
139. Goldman, R., Y. Granot, and U. Zor. 1995. A pleiotropic effect of fluoride on signal trans-duction in macrophages: Is it mediated by GPT-binding proteins? J Basic Clin Physiol Pharmacol 6(1):79-94.
140. Gomez-Ubric, J.L., J. Liebana, J. Gutierrez, and A. Castillo A. 1992. In vitro immune modulation of polymorphonuclear leukocyte adhesiveness by sodium fluoride. Eur J Clin Invest 22(10):659-661.
141. Goyer, R.A. 1995. Nutrition and metal toxicity. Am J Clin Nutr 61(3 Suppl.):646S- 650S.
142. Greenberg LW, Nelsen CE, Kramer N. 1974. Nephrogenic diabetes insipidus with fluorosis. Pediatrics 54:320-322.
143. Grimbergen GW. 1974. A double blind test for determination of intolerance to fluoridated water (Preliminary Report). Fluoride 7:146-152.
144. Gruebbel, A.O. 1952. Summarization of the subject. J Am Dent Assoc 44(2):151-155.
145. Guan, Z.Z., Z.J. Zhuang, P.S. Yang, and S. Pan. 1988. Synergistic action of iodine-deficiency and fluorine-intoxication on rat thyroid. Chin Med J 101(9):679-684. (Pubitemid 19026173)
146. Guan, Z.Z., Y.N. Wang, K.Q. Xiao, D.Y. Dai, Y.H, Chen, J.L. Liu, P. Sindelar, and G. Dallner. 1998. Influence of chronic fluorosis on membrane lipids in rat brain. Neurotoxicol Teratol 20(5):537-542 (Pubitemid 28511116)
147. Guan, Z.Z., X. Zhang, K. Blennow, and A. Nordberg. 1999. Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain. NeuroReport 10(8):1779-1782 (Pubitemid 29354310)
148. Gupta, S.K., T.I. Khan, R.C. Gupta, A.B. Gupta, K.C. Gupta, P. Jain, and A. Gupta. 2001. Compensatory hyperparathyroidism following high fluoride ingestion-a clinico-biochemical correlation. Indian Pediatr 38(2):139-146. (Pubitemid 32183513)
149. Gutteridge DH, Price RI, Kent GN, Prince RL, Michell PA. 1990. Spontaneous hip fractures in fluoride-treated patients: potential causative factors. J Bone Miner Res 5(Suppl 1):S205-S215. (Pubitemid 20284910)
150. Hac, E., W. Czarnowski, T. Gos, and J. Krechniak. 1997. Lead and fluoride content in human bone and hair in the Gdansk region. Sci Total Environ 206(2-3):249-254. (Pubitemid 27486385)
151. Haftenberger, M., G. Viergutz, V. Neumeister, and G. Hetzer. 2001. Total fluoride intake and urinary excretion in German children aged 3-6 years. Caries Res 35(6):451-457. (Pubitemid 33636865)
152. Hanhijarvi, H. 1974. The effect of renal diseases on the free ionized plasma fluoride concentrations in patients from anb artificially fluoridated and non-fluoridated drinking water community. Proc Finn Dent Soc 70(Suppl. 1-3):35-43.
153. Hanhijarvi H. 1975. Inorganic plasma fluoride concentrations and its renal excretion in certain physiological and pathological conditions in man. Fluoride 8(4):198-207.
154. Hanhijarvi, H. 1982. The effect of renal impairment of fluoride retention of patients hospitalized in a low-fluoride community. Proc Finn Dent Soc 78(1):13-19.
155. Hanhijärvi H, Penttilä I. 1981. The relationship between human ionic plasma fluoride and serum creatinine concentrations in cases of renal and cardiac insufficiency in a fluoridated community. Proc Finn Dent Soc 77(6):330-335.
156. Hanhijarvi, H., V.M. Anttonen, A. Pekkarinen, and A. Penttila. 1972. The effects of artificially fluoridated drinking water on the plasma of ionized fluoride content in certain clinical disease and in normal individuals. Acta Pharmacol Toxicol 31(1):104-110.
157. Hanhijarvi, H., I. Penttila, and A. Pekkarinen. 1981. Human ionic plasma fluoride concentrations and age in a fluoridated community. Proc Finn Dent Soc 77(4):211-221
158. Hara K. 1980. Studies on fluorosis, especially effects of fluoride on thyroid metabolism [in Japanese]. Koku Eisei Gakkai Zasshi 30(1):42-57.
159. Harris NO, Hayes RL. 1955. A tracer study of the effect of acute and chronic exposure to sodium fluoride on the thyroid iodine metabolism of rats. J Dent Res 34:470-477.
160. Hartfield, P.J., and J.M. Robinson. 1990. Fluoride-mediated activation of the respiratory burst in electropermeabilized neutrophils. Biochim Biophys Acta 1054(2):176-180. (Pubitemid 20257638)
161. Heath K, Singh V, Logan R, McIntyre J. 2001. Analysis of fluoride levels retained intraorally or ingested following routine clinical applications of topical fluoride products. Aust Dent J 46:24-31. (Pubitemid 33637044)
162. Hefti A, Marthaler TM. 1981. Bone fluoride concentrations after 16 years of drinking water fluoridation. Caries Res 15:85-89. (Pubitemid 11214409)
163. Heilman JR, Kiritsy MC, Levy SM, Wefel JS. 1997. Fluoride concentrations of infant foods. J Am Dent Assoc 128:857-863. (Pubitemid 127457016)
164. Heilman JR, Kiritsy MC, Levy SM, Wefel JS. 1999. Assessing fluoride levels of carbonated soft drinks. J Am Dent Assoc 130:1593-1599.
165. Hein, J.W., F.A. Smith, and F. Brudevold. 1954. Distribution of 1 ppm fluoride as radioactively tagged NaF in soft tissues of adult female albino rats. J Dent Res 33(Oct.):709-710.
166. Hein JW, Bonner JF, Brudevold F, et al. 1956. Distribution in the soft tissue of the rat of radioactive fluoride administered as sodium fluoride. Nature 178 (4545):1295-1296.
167. Heller KE, Eklund SA, Burt BA. 1997. Dental caries and dental fluorosis at varying water fluoride concentrations. J Pub Health Dent 57:136-143. (Pubitemid 127688906)
168. Heller KE, Sohn W, Burt BA, Eklund SA. 1999. Water consumption in the United States in 1994-96 and implications for water fluoridation policy. J Public Health Dent 59:3-11.
169. Heller KE, Sohn W, Burt BA, Feigal RJ. 2000. Water consumption and nursing characteristics of infants by race and ethnicity. J Public Health Dent 60:140-146.
170. Hileman B. 1988. Fluoridation of water: questions about health risks and benefits remain after more than 40 years. Chem Engin News 1:26-42.
171. Hirano, S., M. Ando, and S. Kanno. 1999. Inflammatory responses of rat alveolar macrophages following exposure to fluoride. Arch Toxicol 73(6):310-315. (Pubitemid 29409036)
172. Hodge HC, Smith FA. 1965. Fluorine Chemistry Vol. IV. New York: Academic Press.
173. Hoover RN, Devesa SS, Cantor KP, Lubin JH, Fraumeni JF. 1991. Time trends for bone and joint cancers and osteosarcomas in the Surveillance, Epidemiology and End Results (SEER) Program. National Cancer Institute. In: Review of Fluoride: Benefits and Risks Report of the Ad Hoc Committee on Fluoride of the Committee to Coordinate Environmental Health and Related Programs US Public Health Service. Appendix E & F.
174. Horswill CA. 1998. Effective fluid replacement. Int J Sport Nutr 8:175-195.
175. Hossny E, Reda S, Marzouk S, Diab D, Fahmy H. 2003. Serum fluoride levels in a group of Egyptian infants and children from Cairo City. Arch Environ Health 58:306-315. (Pubitemid 38049555)
176. Hrudey SE, Soskolne CJ, Berkel J, Fincham S. 1990. Drinking water fluoridation and osteosarcoma. Can J Pub Health 81:415-416.
177. HSDB (Hazardous Substances Data Bank). 2005. Sodium Fluoride, HSDB number 1766. National Library of Medicine, National Institutes of Health. Bethesda, MD.
178. Hull WE, Port RE, Herrmann R, Britsch B, Kunz W. 1988. Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment. Cancer Res 48:1680-1688. (Pubitemid 18091227)
179. Huraib S, Souqqiyeh MZ, Aswad S, al-Swailem AR. 1993. Pattern of renal osteodystrophy in haemodialysis patients in Saudi Arabia. Nephrol Dial Transplant 8:603-608. (Pubitemid 23231142)
180. Husdan H, Vogl R, Oreopoulos D, Gryfe C, Rapoport A. 1976. Serum ionic fluoride: normal range and relationship to age and sex. Clin Chem 22:1884-1888.
181. Imbeni V, Kruzic JJ, Marshall GW, Marshall SJ, Ritchie RO. 2005. The dentin enamel junction and the fracture of human teeth. Nat Mater 4:229-232. (Pubitemid 40330274)
182. Inkielewicz I, Krechniak J. 2004. Fluoride effects on glutathione peroxidase and lipid peroxidation in rats. Fluoride 37:7-12. (Pubitemid 38899364)
183. Institute of Medicine. 1997. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board. National Academy Press.
184. Ishii T, Suckling G. 1991. The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. J Dent Res 70:952-956.
185. Jackson D, Weidman SM. 1958. Fluorine in human bone related to age and the water supply of different regions. J Pathol Bacteriol 76:451-459.
186. Jackson R, Kelly S, Noblitt T, Zhang W, Dunipace A, Li Y, Stookey G, Katz B, Brizendine E, Farley S, Baylink D. 1994. The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. Bone Miner 27:13-23.
187. Jackson RD, Brizendine EJ, Kelly SA, Hinesley R, Stookey GK, Dunipace AJ. 2002. The fluoride content of foods and beverages from negligibly and optimally fluoridated communities. Community Dent Oral Epidemiol 30:382-391.
188. Jacqmin-Gadda H, Commenges D, Dartigues JF. 1995. Fluorine concentration in drinking water and fractures in the elderly. (Letter). JAMA (10) 273:775-776.
189. Jain SK, Susheela AK. 1987. Effect of sodium fluoride on antibody formation in rabbits. Environ Res 44:117-125.
190. Johnson, W.J., D.R. Taves, and J. Jowsey. 1979. Fluoridation and bone disease. Pp. 275-293 in Continuing Evaluation of the Use of Fluorides. E. Johansen, D.R. Taves, and T.O. Olsen, eds. AAAS Selected Symposium. Boulder, CO: Westview Press.
191. Johnson KA, Holman BL, Mueller SP, Rosen TJ, English R, Nagel JS, Growdon JH. 1988. Single photon emission computed tomography in Alzheimer's disease. Abnormal iofetamine I 123 uptake reflects dementia severity. Arch Neurol 45:392-396. (Pubitemid 18098278)
192. Jonderko G, Kita K, Pietrzak J, Primus-Slowinska B, Ruranska B, Zylka-Wloszczyk M, Straszecka J. 1983. Effect of subchronic poisoning with sodium fluoride on the thyroid gland of rabbits with normal and increased supply of iodine [In Polish]. Endokrynol Pol 34:195-203. (Pubitemid 14246939)
193. Jones KF, Berg JH. 1992. Fluoride supplementation. A survey of pediatricians and pediatric dentists. Am J Dis Child 146:1488-1491.
194. Jope RS. 1988. Modulation of phosphoinositide hydrolysis by NaF and aluminum in rat cortical slices. J Neurochem 51:1731-1736. (Pubitemid 19010958)
195. Juncos LI, Donadio JV. 1972. Renal failure and fluorosis. J Am Med Assoc 222(7):783-785.
196. Juuti M, Heinonen OP. 1980. Incidence of urolithiasis and composition of household water in southern Finland. Scand J Urol Nephrol 14:181-187. (Pubitemid 11167810)
197. Kato S, Nakagaki H, Toyama Y, Kanayama T, Arai M, Togari A, Matsumoto S, Strong M, Robinson C. 1997. Fluoride profiles in the cementum and root dentine of human permanent anterior teeth extracted from adult residents in a naturally fluoridated and a non-fluoridated area. Gerodontology 14:1-8.
198. Kawase T, Oguro A, Orikasa M, Burns DM. 1996. Characteristics of NaF-induced differentiation of HL-60 cells. J Bone Miner Res 11:1676-1687. (Pubitemid 26367678)
199. Kekki M, Lampainen E, Kauranen P, Hoikka F, Alhava M, Pasternack A. 1982. The nonlinear tissue binding characteristics of fluoride kinetics in normal and anephric subjects. Nephron 31:129-134.
200. Kertesz P, Kerenyi T, Kulka J, Banoczy J. 1989. Comparison of the effects of NaF and CaF2 on rat gastric mucosa. A light-, scanning- and transmission electron microscopic study. Acta Morphol Hung 37:21-28. (Pubitemid 20255746)
201. Kharasch ED, Hankins DC. 1996. P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1 -(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product. Drug Metab Dispos 24:649-654. (Pubitemid 26171687)
202. Kinney JH, Nalla RK, Pople JA, Breunig TM, Ritchie RO. 2005. Age-related transparent root dentin: mineral concentration, crystallite size, and mechanical properties. Biomaterials 26:3363-3376. (Pubitemid 39647269)
203. Kiritsy MC, Levy SM, Warren JJ, Guha-Chowdhury N, Heilman JR, Marshall T. 1996. Assessing fluoride concentrations of juices and juice-flavored drinks. J Am Dent Assoc 127:895-902. (Pubitemid 126433031)
204. Klein RZ, Sargent JD, Larsen PR, Waisbren SE, Haddow JE, Mitchell ML. 2001. Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen 8:18-20. (Pubitemid 32467570)
205. Knappwost A, Westendorf J. 1974. Inhibition of cholinesterases caused by fluorinecomplex of silicon and of iron [In German]. Naturwissenschaften 61:275.
206. Kolka MA, Latzka WA, Montain SJ, Corr WP, O'Brien KK, Sawka MN. 2003. Effectiveness of revised fluid replacement guidelines for military training in hot weather. Aviat Space Environ Med 74:242-246. (Pubitemid 36307450)
207. Kudo N, Kawashima Y. 2003. Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals. J Toxicol Sci 28:49-57. (Pubitemid 36764755)
208. Kunzel VW. 1976. [Cross-sectional comparison of the median eruption time for permanent teeth in children from fluoride poor and optimally fluoridated areas] [Article in German]. Stomatol DDR 5:310-321.
209. Kuo HC, Stamm JW. 1974. Fluoride levels in human rib bone: a preliminary study. Can J Public Health 65:359-361.
210. Lafage MH, Balena R, Battle MA, Shea M, Seedor JG, Klein H, Hayes WC, Rodan GA. 1995. Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study. J Clin Invest 95:2127-2133.
211. Lalumandier JA, Ayers LW. 2000. Fluoride and bacterial content of bottled water vs. tap water. Arch Fam Med 9:246-250.
212. Lantz O, Jouvin MH, De Vernejoul MC, Druet P. 1987. Fluoride-induced chronic renal failure. Am J Kidney Dis 10:136-139. (Pubitemid 17135633)
213. Larsen PR, Davies TF. 2002. Hypothyroidism and thyroiditis. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Williams textbook of endocrinology. 10th ed. Philadelphia, PA: Saunders; pp 423-455.
214. Larsen PR, Davies TF, Schlumberger MJ, Hay ID. 2002. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Williams textbook of endocrinology. 10th ed. Philadelphia, PA: Saunders; pp 331-373.
215. Lee R. 1953. Systemic cause of dental caries. Loveland, CO: Selene River Press.
216. Lees S, Hanson DB. 1992. Effect of fluoride dosage on bone density, sonic velocity, and longitudinal modulus of rabbit femurs. Calcif Tissue Int 50:88-92.
217. Leroy R, Bogaerts K, Lesaffre E, Declerck D. 2003. The effect of fluorides and caries in primary teeth on permanent tooth emergence. Community Dent Oral Epidemiol 31:463-470. (Pubitemid 37465425)
218. Levi JE, Silberstein HE. 1955. Lack of effect of fluorine ingestion on uptake of iodine 131 by the thyroid gland. J Lab Clin Med 45:348-351.
219. Levy FM, de Magalhães Bastos JR, Buzalaf MAR. 2004. Nails as biomarkers of fluoride in children of fluoridated communities. J Dent Child 71:121-125. (Pubitemid 39611953)
220. Levy S, Furst K, Chern W. 2001a. A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. Clin Ther 23:908-920. (Pubitemid 32554572)
221. Levy SM. 1993. A review of fluoride intake from fluoride dentifrice. J Dent Child 60:115-124.
222. Levy SM. 1994. Review of fluoride exposures and ingestion. Community Dent Oral Epidemiol 22:173-180.
223. Levy SM. 2003. An update on fluorides and fluorosis. J Can Dent Assoc 69:286-291.
224. Levy SM, Broffitt B, Slayton R, Warren JJ, Kanellis MJ. 2003a. Dental visits and professional fluoride applications for children ages 3 to 6 in Iowa. Pediatr Dent 25:565-571.
225. Levy SM, Guha-Chowdhury N. 1999. Total fluoride intake and implications for dietary fluoride supplementation. J Public Health Dent 59:211-223.
226. Levy SM, Hillis SL, Warren JJ, Broffitt BA, Mahbubul Islam AK, Wefel JS, Kanellis MJ. 2002a. Primary tooth fluorosis and fluoride intake during the first year of life. Community Dent Oral Epidemiol 30:286-295.
227. Levy SM, Kiritsy MC, Slager SL, Warren JJ, Kohout FJ. 1997. Patterns of fluoride dentifrice use among infants. Pediatr Dent 19:50-55. (Pubitemid 127735289)
228. Levy SM, Kiritsy MC, Warren JJ. 1995a. Sources of fluoride intake in children. J Public Health Dent 55(1):39-52.
229. Levy SM, Kohout FJ, Guha-Chowdhury N, Kiritsy MC, Heilman JR, Wefel JS. 1995b. Infants' fluoride intake from drinking water alone and from water added to formula, beverages, and food. J Dent Res 74(7):1399-1407.
230. Levy SM, Kohout FJ, Kiritsy MC, Heilman JR, Wefel JS. 1995c. Infants' fluoride ingestion from water, supplements and dentifrice. J Am Dent Assoc 126(12):1625-1632.
231. Levy SM, Maurice TJ, Jakobsen JR. 1992. A pilot study of preschoolers' use of regular flavored dentifrices and those flavored for children. Pediatr Dent 14:388-391.
232. Levy SM, Maurice TJ, Jakobsen JR. 1993. Dentifrice use among preschool children. J Am Dent Assoc 124:57-60.
233. Levy SM, McGrady JA, Bhuridej P, Warren JJ, Heilman JR, Wefel JS. 2000. Factors affecting dentifrice use and ingestion among a sample of U.S. preschoolers. Pediatr Dent 22:389-394.
234. Levy SM, Muchow G. 1992. Provider compliance with recommended dietary fluoride supplement protocol. Am J Public Health 82:281-283.
235. Levy SM, Shavlik DA. 1991. The status of water fluoride assay programs and implications for prescribing of dietary fluoride supplements. J Dent Child 58:23-26.
236. Levy SM, Warren JJ, Davis CS, Kirchner HL, Kanellis MJ, Wefel JS. 2001b. Patterns of fluoride intake from birth to 36 months. J Public Health Dent 61:70-77. (Pubitemid 33721631)
237. Levy SM, Zarei-M Z. 1991. Evaluation of fluoride exposures in children. J Dent Child 58:467-473.
238. Lewis, D.W., and H. Limeback. 1996. Comparison of recommended and actual mean intakes of fluoride by Canadians. J Can Dent Assoc 62(9):708-715.
239. Li L. 2003. The biochemistry and physiology of metallic fluoride: action, mechanism, and implications. Crit Rev Oral Biol Med 14(2):100-114.
240. Li LC, Zhang YS, Hu RZ, Zhou XC. 1992. Inhibitory effect of fluoride on renal stone formation in rats. Urol Int 48:336-341.
241. Li XS, Zhi JL, Gao RO. 1995. Effect of fluoride exposure on intelligence in children. Fluoride 28:189-192.
242. Limeback H. 1999. A re-examination of the pre-eruptive and post-eruptive mechanism of the anti-caries effects of fluoride: is there any caries benefit from swallowing fluoride? Community Dent Oral Epidemiol 27:62-71. [Abstract]
243. Limeback H, Ismail A, Banting D, DenBesten P, Featherstone J, Riordan PJ. 1998. Canadian Consensus Conference on the appropriate use of fluoride supplements for the prevention of dental caries in children. J Can Dent Assoc 64:636-639.
244. Lindstrom J. 1997. Nicotinic acetylcholine receptors in health and disease. Mol Neurobiol 15:193-222. (Pubitemid 127719578)
245. Liptrot GF. 1974. Modern inorganic chemistry. London: Mills and Boon, Ltd.
246. Locker D. 1999. Benefits and risks of water fluoridation. An update of the 1996 Federal-Provincial Sub-committee report. Prepared for Ontario Ministry of Health and Long Term Care.
247. Loftenius A, Andersson B, Butler J, Ekstrand J. 1999. Fluoride augments the mitogenic and antigenic response of human blood lymphocytes in vitro. Caries Res 33:148-155.
248. Long YG, Wang YN, Chen J, Jiang SF, Nordberg A, Guan ZZ. 2002. Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain. Neurotoxicol Teratol 24:751-757. (Pubitemid 35375779)
249. Lu Y, Sun ZR, Wu LN, Wang X, Lu W, Liu SS. 2000. Effect of high-fluoride water on intelligence of children. Fluoride 33:74-78.
250. Luke J. 2001. Fluoride deposition in the aged human pineal gland. Caries Res 35:125-128. [Abstract] (Pubitemid 33639789)
251. Lundy MW, Stauffer M, Wergedal JE, Baylink DJ, Featherstone JD, Hodgson SF, Riggs BL. 1995. Histomorphometric analysis of iliac crest bone biopsies in placebo-treated versus fluoride-treated subjects. Osteoporos Int 5:115-129. [Abstract]
252. Maas RP, Patch SC, Christian AM, Coplan MJ. 2007. Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts. Neurotoxicology 28:1023-1031. (Pubitemid 47519800)
253. Macek M, Matte TD, Sinks T, Malvitz DM. 2006. Blood lead concentrations in children and method of water fluoridation in the United States, 1988-1994. Environ Health Perspect 114:130-134. (Pubitemid 43056880)
254. Machalínski, B., M. Zejmo, I. Stecewicz, A. Machalinska, Z. Machoy, and M.Z. Ratajczak. 2000. The influence of sodium fluoride on the clonogenecity of human hematopoietic progenitor cells: Preliminary report. Fluoride 33(4):168-173. (Pubitemid 32246466)
255. Machalinski B, Baskiewicz-Masiuk M, Sadowska B, Machalinska A, Marchlewicz M, Wiszniewska B, Stecewicz I. 2003. The influence of sodium fluoride and sodium hexafluorosilicate on human leukemic cell lines: preliminary report. Fluoride 36:231-240. (Pubitemid 38325350)
256. Maguire A, Moynihan PJ, Zohouri V. 2004. Bioavailability of fluoride in drinking water-A human experimental study, June 2004. Prepared for the UK Department of Health, by School of Dental Sciences, University of Newcastle.
257. Mahoney MC, Nasca PC, Burnett WS, Melius JM. 1991. Bone cancer rates in New York State: time trends and fluoridated drinking water. Am J Pub Health 81:475-479.
258. Marier JR. 1977. Some current aspects of environmental fluoride. Sci Total Environ 8:253-265. (Pubitemid 8187668)
259. Marshall TA, Levy SM, Warren JJ, Broffitt B, Eichenberger-Gilmore JM, Stumbo PJ. 2004. Associations between intakes of fluoride from beverages during infancy and dental fluorosis of primary teeth. Journal of the American College of Nutrition 23(2):108-16. April.
260. Martin RB. 1988. Ternary hydroxide complexes in neutral solutions of Al3+ and F-. Biochem Biophys Res Commun 155:1194-1200.
261. Martindale. 2006. The Complete Drug Reference Monographs. Sodium fluoride. United Kingdom: The Royal Pharmaceutical Press.
262. Martínez OB, Díaz C, Borges TM, Díaz E, Pérez JP. 1998. Concentrations of fluoride in wines from the Canary Islands. Food Addit Contam 15:893-897. (Pubitemid 28561460)
263. Masters RD, Coplan M. 1999. Water treatment with silicofluorides and lead toxicity. Int J Environ Stud 56:435-449. (Pubitemid 29395813)
264. Masters RD, Coplan MJ, Hone BT, Dykes JE. 2000. Association of silicofluoride treated water with elevated blood lead. Neurotoxicology 21:1091-1099. (Pubitemid 32172159)
265. Matsuo S, Kiyomiya K, Kurebe M. 1998. Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride. Arch Toxicol 72:798-806. (Pubitemid 29048924)
266. Maurer JK, Cheng MC, Boysen BG, Anderson RL. 1990. Two-year carcinogenicity study of sodium fluoride in rats. J Natl Cancer Inst 82:1118-1126. (Pubitemid 20213252)
267. Maurer JK, Cheng MC, Boysen BG, Squire RA, Strandberg JD, Weisbrode SE, Seymour JL, Anderson RL. 1993. Confounded carcinogenicity study of sodium fluoride in CD-1 mice. Reg Toxicol Pharmacol 18:154-168.
268. Mazze RI, Calverley RK, Smith NT. 1977. Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology 46:265-271. (Pubitemid 8071857)
269. McDonnell ST, O'Mullane D, Cronin M, MacCormac C, Kirk J. 2004. Relevant factors when considering fingernail clippings as a fluoride biomarker. Community Dent Health 21:19-24. (Pubitemid 38918269)
270. McClure FJ. 1970. Water fluoridation, the search and the victory. Bethesda, MD: U.S. Department of Health, Education, and Welfare, National Institutes of Health, National Institute of Dental Research.
271. McClure FJ, Mitchell HH, Hamilton TS, Kinser CA. 1945. Balances of fluorine ingested from various sources in food and water by five young men. Excretion of fluorine through the skin. J Ind Hyg Toxicol 27:159-170.
272. McDonagh M, Whiting PF, Wilson PM, Sutton AJ, Chestnutt I, Cooper J, Misso K, Bradley M, Treasure E, Kleijnen J. 2000. A systematic review of public water fluoridation. NHS Center for Reviews and Dissemination. University of York.
273. McNall PE, Schlegel JC. 1968. Practical thermal environmental limits for young adult males working in hot, humid environments. ASHRAE Trans 74:225-235.
274. Mehta MN, Raghavan K, Gharpure VP, Shenoy R. 1998. Fluorosis: a rare complication of diabetes insipidus. Indian Pediatr 35:463-467. (Pubitemid 128518611)
275. Millan-Plano S, Garcia JJ, Martinez-Ballarin E, Reiter RJ, Ortega-Gutierrez S, Lazaro RM, Escanero JF. 2003. Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes. J Trace Elem Med Biol 17:39-44. (Pubitemid 36538170)
276. Miller AH. 1952. Fluoridation of water. Congressional Record United States Congress Report. 3/24/1952.
277. Miu AC, Andreescu CE, Vasiu R, Olteanu AL. 2003. A behavioral and histological study of the effects of long-term exposure of adult rats to aluminum. Int J Neurosci 113:1197-1211. (Pubitemid 37247872)
278. Morris MD. 2004. The chemistry of fluorosilicate hydrolysis in municipal water supplies. A review of the literature and a summary of University of Michigan Studies. Report to the National Academy of Science, by M.D. Morris, University of Michigan, Ann Arbor, MI.
279. Moss SJ. 1999. The case for retaining the current supplementation schedule. J Public Health Dent 59:259-262.
280. Mukhopadhyay D, GokulkrishnanL, Mohanaruban K. 2001. Lithium-induced nephrogenic diabetes insipidus in older people. Age Ageing 30:347-350. (Pubitemid 32798968)
281. Mukai M, Ikeda M, Yanagihara T, Hara G, Kato K, Ishiguro K, Nakagaki H, Robinson C. 1994. Fluoride distribution in dentine and cementum in human permanent teeth with vital and non-vital pulps. Arch Oral Biol 39:191-196. (Pubitemid 124034480)
282. Mullenix P, Denbesten PK, Schunior A, Kernan WJ. 1995. Neurotoxicity of sodium fluoride in rats. Neurotoxicol Teratol 17:169-177.
283. Myers BS, Martin JS, Dempsey DT, Parkman HP, Thomas RM, Ryan JP. 1997. Acute experimental colitis decreases colonic circular smooth muscle contractility in rats. Am J Physiol 273 (4 Pt 1):G928-G936
284. Naccache H, Simard PL, Trahan L, Brodeur JM, Demers M, Lachapelle D, Bernard PM. 1992. Factors affecting the ingestion of fluoride dentifrice by children. J Public Health Dent 52:222-226.
285. Nakano, O., C. Sakamoto, H. Nishisaki, Y. Konda, K. Matsuda, K. Wada, M. Nagao, and T. Matozaki. 1990. Difference in effects of sodium fluoride and cholecystokinin on diacylglycerol accumulation and calcium increase in guinea pig gastric chief cells. Life Sci 47(7):647-654. (Pubitemid 20264309)
286. National Research Council. 1993. Health effects of ingested fluoride. Washington DC: National Academy Press.
287. National Research Council. 2006. Fluoride in drinking water: a scientific review of EPA's standards. Washington D.C: National Academies Press.
288. National Toxicology Program (NTP). 1990. Toxicology and carcinogenesis studies of sodium fluoride in F344/N rats and B6C3f1 mice. Technical report Series No. 393. NIH Publ. No 91-2848. Research Triangle Park, N.C: National Institute of Environmental Health Sciences.
289. Needleman HL, Pueschel SM, Rothman KJ. 1974. Fluoridation and the occurrence of Down's syndrome. N Engl J Med 291:821-823.
290. Nesin BC. 1956. A water supply perspective of the fluoridation discussion. J Maine Water Utilities Assoc J Maine Water Util Assoc 32:33-47.
291. Neurath C. 2005. Tooth decay trends for 12 year olds in nonfluoridated and fluoridated countries. Fluoride 38:324-325.
292. Newbrun E. 1986. Fluorides and dental caries. 3rd ed. Springfield, IL: Charles C. Thomas.
293. Newbrun E. 1992. Current regulations and recommendations concerning water fluoridation, fluoride supplements, and topical fluoride agents. J Dent Res 71:1255-1265.
294. Newbrun E. 1999. The case for reducing the current Council on Dental Therapeutics fluoride supplementation schedule. J Public Health Dent 59:263-268.
295. Newhouse PA, Potter A, Levin ED. 1997. Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics. Drugs Aging 11:206-228. (Pubitemid 27421319)
296. Ng AHM, Hercz G, Kandel R, Grynpas MD. 2004. Association between fluoride, magnesium, aluminum and bone quality in renal osteodystrophy. Bone 34:216-224. [Abstract] (Pubitemid 38145593)
297. Nourjah P, Horowitz AM, Wagener DK. 1994. Factors associated with the use of fluoride supplements and fluoride dentifrice by infants and toddlers. J Public Health Dent 54:47-54.
298. Nowak A, Nowak MV. 1989. Fluoride concentration of bottled and processed waters. Iowa Dent J 7:28.
299. NRC (National Research Council). 1977. Drinking Water and Health, Vol. 1. Washington, DC: National Academy Press.
300. NTP (National Toxicology Program). 2002. The National Toxicology Program. Annual Plan, Fiscal Year 2002. NIH Publication No. 03-5309. National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, NC.
301. Ogilvie AL. 1953. Histologic findings in the kidney, liver, pancreas, adrenal, and thyroid glands of the rat following sodium fluoride administration. J Dent Res 32:386-397.
302. Oguro A, Kawase T, Orikasa M. 2003. NaF induces early differentiation of murine bone marrow cells along the granulocytic pathway but not the monocytic or preosteoclastic pathway in vitro. In Vitro Cell Dev Biol Anim 39:243-248. (Pubitemid 37475291)
303. Okuda A, Kanehisa J, Heersche JN. 1990. The effects of sodium fluoride on the resorptive activity of osteoclasts. J Bone Miner Res 5(Suppl 1):S115-S120. (Pubitemid 20284896)
304. Oliveby, A., S. Twetman, and J. Ekstrand. 1990. Diurnal fluoride concentration in whole saliva in children living in a high- and a low-fluoride area. Caries Res 24(1):44-47. (Pubitemid 20067291)
305. Olsen, G.W., T.R. Church, E.B. Larson, G. van Belle, J.K. Lundberg, K.J. Hansen, J.M. Burris, J.H. Mandel, and L.R. Zobel. 2004. Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington. Chemosphere 54(11):1599-1611. (Pubitemid 38147855)
306. Olsen, G.W., T.R. Church, J.P. Miller, J.M. Burris, K.J. Hansen, J.K. Lundberg, J.B. Armitage, R.M. Herron, Z. Medhdizadehkashi, J.B. Nobiletti, E.M. O'Neill, J.H. Mandel, and L.R. Zobel. 2003. Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environ. Health Perspect 111(16):1900.
307. Olson, S.C., S.R. Tyagi, and J.D. Lambeth. 1990. Fluoride activates diradylglycerol and superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways. FEBS Lett 272(1-2):19-24. (Pubitemid 20348972)
308. Opinya GN, Bwibo N, Valderhaug J, Birkeland JM, Lökken P. 1991. Intake offluoride and excretion in mothers' milk in a high fluoride (9 ppm) area in Kenya. Eur J Clin Nutr 45:37-41.
309. Ophaug RH, Singer L, Harland BF. 1980. Estimated fluoride intake of average two-year old children in four dietary regions of the United States. J Dent Res 59:777-781. (Pubitemid 10038949)
310. Ophaug RH, Singer L, Harland BF. 1985. Dietary fluoride intake of 6-months and 2-year-old children in four dietary regions of the United States. J Clin Nutr 42:701-707. (Pubitemid 15245068)
311. Orcel P, de Vernejoul MC, Prier A, Miravet L, Kuntz D, Kaplan G. 1990. Stress fractures of the lower limbs in osteoporotic patients treated with fluoride. J Bone Miner Res 5(Suppl 1):S191-S194. (Pubitemid 20284907)
312. Ortiz-Perez D, Rodriguez-Martinez M, Martinez F, Borja-Aburto VH, Castelo J, Grimaldo JI, de la Cruz E, Carrizales L, Diaz-Barriga F. 2003. Fluorideinduced disruption of reproductive hormones in men. Environ Res 93:20-30. (Pubitemid 36809221)
313. O'Shea JJ, Urdahl KB, Luong HT, Chused TM, Samelson LE, Klausner RD. 1987. Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells. J Immunol 139:3463-3469. (Pubitemid 18022002)
314. Pang D, Phillips CL, Bawden JW. 1992. Fluoride intake from beverage consumption in a sample of North Carolina children. J Dent Res 71:1382-1388.
315. Parkins FM, Tinanoff N, Moutinho M, Anstey MB, Waziri MH. 1974. Relationships of human plasma fluoride and bone fluoride to age. Calcif Tiss Res 16:335-338.
316. Pashley DH, Allison NB, Easmann RP, McKinney RV, Horner JA, Whitford GM. 1984. The effects of fluoride on the gastric mucosa of the rat. J Oral Pathol 13:535-545. (Pubitemid 14048039)
317. Pendrys DG, Katz RV, Morse DE. 1994. Risk factors for enamel fluorosis in a fluoridated population. Am J Epidemiol 140:461-471. (Pubitemid 24281717)
318. Pessan, J.P., M.L. Pin, C.C. Martinhon, S.M. de Silva, J.M. Granjeiro, and M.A. Buzalaf. 2005. Analysis of fingernails and urine as biomarkers of fluoride exposure from dentifrice and varnish in 4- to 7-year-old children. Caries Res 39(5):363-370. (Pubitemid 41191589)
319. Petraborg HT. 1977. Hydrofluorosis in the fluoridated Milwaukee area. Fluoride 10:165-168. (Pubitemid 8188491)
320. PHS (Public Health Service). 1991. Review of fluoride benefits and risks: report of the Ad Hoc Subcommittee on Fluoride Committee of the Committee to Coordinate Environmental Health and Related Programs. Public Health Service, U.S. Department of Health and Human Services, Washington, DC.
321. Pivonello R, ColaoA, Di Somma C, Facciolli G, Klain M, Faggiano A, Salvatore M, Lombardi G. 1998. Impairment of bone status in patients with central diabetes insipidus. J Clin Endocrinol Metab 83:2275-2280. (Pubitemid 28503013)
322. Poisindex. 2006. Sodium fluoride. Vol. 126. Englewood, CO: Micromedex, Inc.
323. Powell JJ, Thompson RP. 1993. The chemistry of aluminum in the gastrointestinal lumen and its uptake and absorption. Proc Nutr Soc 52:241-253.
324. Pradhan KM, Arora NK, Jena A, Susheela AK, Bhan MK. 1995. Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatr 84:555-560.
325. Qin LS, Cui SY. 1990. The Influence of drinking water fluoride on pupils IQ, as measured by Rui Weǹs standards [in Chinese]. Chinese J Control Endemic Dis 5:203-204.
326. Rao HV, Beliles RP, Whitford GM, Turner CH. 1995. A physiologically-based pharmaco-kinetic model for fluoride uptake by bone. Regul Toxicol Pharmacol 22:30-42.
327. Rapaport I. 1957. Contribution a l'etude etiologique du mongolisme. Role des inhibiteurs enzymatiques. Encephale 46:468-481.
328. Rapaport I. 1963. Oligophrenie mongolienne et caries dentaires. Rev Stomatol 64:207-218.
329. Record S, Montgomery DF, Milano M. 2000. Fluoride supplementation and caries prevention. J Pediatr Health Care 14:247-249.
330. Reprotox. 2004. Fluorides. Vol. 126. Englewood, CO: Micromedex, Inc.
331. Richards A, Mosekilde L, Søgaard CH. 1994. Normal age-related changes in fluoride content of vertebral trabecular bone - Relation to bone quality. Bone 15:21-26. (Pubitemid 24107937)
332. Rimoli C, Carducci CN, Dabas C, Vescina C, Quindimil ME, Mascaro A. 1991. Relationship between serum concentrations of flecainide and fluoride in humans. Boll Chim Farm 130:279-282.
333. Robinson C, Kirkham J, Weatherell JA. 1996. Fluoride in teeth and bone. In: Fejerskov O, Ekstrand J, Burt BA, editors. Fluoride in Dentistry. 2nd ed. Copenhagen: Munksgaard; pp 69-87.
334. Roholm K. 1937. Fluoride intoxication: a clinical-hygienic study with a review of the literature and some experimental investigations. London: H.K. Lewis Ltd.
335. Rojas-Sanchez F, Kelly SA, Drake KM, Eckert GJ, Stookey GK, Dunipace AJ. 1999. Fluoride intake from foods, beverages and dentifrice by young children in communities with negligibly and optimally fluoridated water: a pilot study. Community Dent Oral Epidemiol 27:288-297.
336. Rolla G, Ekstrand J. 1996. Fluoride in oral fluids and dental plaque. In: Fejerskov O, Ekstrand J, Burt B, editors. Fluoride in dentistry. 2nd ed. Denmark: Munksgaard; pp 215-229.
337. Saka O, Hallac P, Urgancioglu I. 1965. The effect of fluoride on the thyroid of the rat. New Istanbul Contrib Clin Sci 8(2):87-90.
338. Sapov K, Gedalia I, Grobler S, Lewinstein I, Roman I, Shapira L, Hirschfeld Z, Teotia S. 1999. A laboratory assessment of enamel hypoplasia of teeth with varying severities of dental fluorosis. J Oral Rehabil 26:672-677.
339. Sauerbrunn BJ, Ryan DM, Shaw JF. 1965. Chronic fluoride intoxication with fluorotic radiculomyelopathy. Ann Intern Med 63:1074-1078.
340. Schamschula RG, Sugar E, Un PS, Toth K, Barmes DE, Adkins BL. 1985. Physiological indicators of fluoride exposure and utilization: an epidemiological study. Community Dent Oral Epidemiol 13:104-107.
341. Scheffrahn RH, Bodalbhai L, Su NY. 1992. Residues of methyl bromide and sulfuryl fluoride in manufacturer-packaged household foods following fumigation. Bull Environ Contam Toxicol 48:821-827.
342. Scheffrahn RH, Hsu RC, Su NY. 1989. Fluoride residues in frozen foods fumigated with sulfuryl fluoride. Bull Environ Contam Toxicol 43:899-903. (Pubitemid 20052931)
343. Schiffl HH, Binswanger U. 1980. Human urinary fluoride excretion as influenced by renal functional impairment. Nephron 26:69-72. (Pubitemid 10093178)
344. Schottenfeld D, Fraumeni JF. 1996. Cancer epidemiology and prevention. 2nd ed. New York: Oxford University Press.
345. Schulze-Specking, A., J. Duyster, P.J. Gebicke-Haerter, S. Wurster, and P. Dieter. 1991. Effect of fluoride, pertussis and cholera toxin on the release of arachidonic acid and the formation of prostaglandin E2, D2, superoxide and inositol phosphates in rat liver macrophages. Cell Signal 3(6):599-606. (Pubitemid 121006233)
346. Selwitz RH. 1994. Strategies for improving methods of assessing fluoride accumulation in body fluids and tissues. Adv Dent Res 8:111-112.
347. Seow WK, Thomsett MJ. 1994. Dental fluorosis as a complication of hereditary diabetes insipidus: studies of six affected patients. Pediatr Dent 16:128-132.
348. Shashi A. 2003. Histopathological investigation of fluoride-induced neurotoxicity in rabbits. Fluoride 36:95-105. (Pubitemid 36935063)
349. Shashi A, Singh JP, Thapar SP. 2002. Toxic effects of fluoride on rabbit kidney. Fluoride 35:38-50. (Pubitemid 34664158)
350. Shayiq RM, Raza H, Kidwai AM. 1984. Alteration in gastric secretion of rats administered NaF. Fluoride 17:178-182. (Pubitemid 14073998)
351. Shu WS, Zhang ZQ, Lan CY, Wong MH. 2003. Fluoride and aluminum concentrations of tea plants and tea products from Sichuan Province, PR China. Chemosphere 52:1475-1482.
352. Shulman JD, Lalumandier JA, Grabenstein JD. 1995. The average daily dose of fluoride: a model based on fluid consumption. Pediatr Dent 17:13-18.
353. Silverman DH, Small GW. 2002. Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditions. Am J Psychiatry 159:1482-1488. (Pubitemid 35006727)
354. Simard PL, Naccache H, Lachapelle D, Brodeur JM. 1991. Ingestion of fluoride from dentifrices by children aged 12 to 24 months. Clin Pediar 30:614-617.
355. Singer L, Ophaug RH, Harland BF. 1985. Dietary fluoride intake of 15-19- year-old male adults residing in the United States. J Dent Res 64:1302-1305. (Pubitemid 16227209)
356. Singh PP, Barjatiya MK, Dhing S, Bhatnagar R, Kothari S, Dhar V. 2001. Evidence suggesting that high intake of fluoride provokes nephrolithiasis in tribal populations. Urol Res 29:238-244. (Pubitemid 32822055)
357. Sjögren B. 2004. Fluoride exposure and respiratory symptoms in welders. Int J Occup Environ Health 10:310-312. (Pubitemid 39167260)
358. Smith MC, Smith HV. 1940. Observations on the durability of mottled teeth. Am J Public Health 30:1050-1052.
359. Sogaard CH, Mosekilde L, Richards A, Mosekilde L. 1994. Marked decrease in trabecular bone quality after five years of sodium fluoride therapy- assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients. Bone 15:393-399.
360. Sogaard CH, Mosekilde L, Schwartz W, Leidig G, Minne HW, Ziegler R. 1995. Effects of fluoride on rat vertebral body biomechanical competence and bone mass. Bone 16:163-169.
361. Sogaard CH, Mosekilde L, Thomsen JS, Richards A, McOsker JE. 1997. A comparison of the effects of two anabolic agents (fluoride and PTH) on ash density and bone strength assessed in an osteopenic rat model. Bone 20:439-449. (Pubitemid 27230448)
362. Sokoloff L. 1966. Cerebral circulatory and metabolic changes associated with aging. Res Publ Assoc Res Nerv Ment Dis 41:237-254.
363. Spak CJ, Hardell LI, De Chateau P. 1983. Fluoride in human milk. Acta Paediatr Scand 72:699-701. (Pubitemid 13048791)
364. Spencer H, Kramer L, Gatza C, Norris C, Wiatrowski E, Gandhi VC. 1980. Fluoride metabolism in patients with chronic renal failure. Arch Intern Med 140:1331-1335. (Pubitemid 10008734)
365. Spittle B. 1994. Psychopharmacology of fluoride: a review. Int Clin Psychopharmacol 9:79-82. (Pubitemid 24160561)
366. Stannard J, Rovero J, Tsamtsouris A, Gavris V. 1990. Fluoride content of some bottled waters and recommendations for fluoride supplementation. J Pedod 14:103-107. (Pubitemid 20089179)
367. Stannard JG, Shim YS, Kritsineli M, Labropoulou P, Tsamtsouris A. 1991. Fluoride levels and fluoride contamination of fruit juices. J Clin Pediatr Dent 16:38-40.
368. Starkstein SE, Vazquez S, Migliorelli R, Teson A, Sabe L, Leiguarda R. 1995. A singlephoton emission computed tomographic study of anosognosia in Alzheimer's disease. Arch Neurol 52:415-420.
369. Sternweis PC, Gilman AG. 1982. Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci USA 79:4888-4891. (Pubitemid 12004137)
370. Stokinger HE, Ashenburg NJ, DeVoldre J, Scott JK, Smith FA. 1950. Acute inhalation toxicity of beryllium. II. The enhancing effect of the inhalation of hydrogen fluoride vapor on beryllium sulfate poisoning in animals. Arch Ind Hyg Occup Med 1:398-410.
371. Stolc V, Podoba J. 1960. Effect of fluoride on the biogenesis of thyroid hormones. Nature 188 (4753):855-856.
372. Stone R. 2004. Iceland's doomsday scenario? Science 306:1278-1281. (Pubitemid 39532479)
373. Strunecka A, Strunecky O, Patocka J. 2002. Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information. Physiol Res 51(6):557-564. (Pubitemid 36168662)
374. Suay LL, Ballester DF. 2002. Review of studies on exposure to aluminum and Alzheimer's disease [in Spanish]. Rev Esp Salud Publica 76:645-658.
375. Sundstrom B. 1971. Thyroidal C-cells and short term, experimental fluorosis in the rat. Acta Pathol Microbiol Scand A 79:407-409.
376. Susheela AK, and Das TK. 1988. Chronic fluoride toxicity: A scanning electron microscopic study of duodenal mucosa. J Toxicol Clin Toxicol 26(7):467-476. (Pubitemid 19078776)
377. Szpunar SM, Burt BA. 1990. Fluoride exposure in Michigan schoolchildren. J Public Health Dent 50:18-23.
378. Takahashi K. 1998. Fluoride-linked down syndrome births and their estimated occurrence due to water fluoridation. Fluoride 31:61-73. (Pubitemid 28288160)
379. Teotia, S.P., M. Teotia, R.K. Singh, D.R. Taves, and S. Heels. 1978. Endocrine aspects of endemic skeletal fluorosis. J Assoc Physicians India 26(11):995-1000.
380. Teotia M, Rodgers A, Teotia SP, Wandt AE, Nath M. 1991. Fluoride metabolism and fluoride content of stones from children with endemic vesical stones. Br J Urol 68:425-429.
381. Teotia M, Teotia SP, Singh KP. 1998. Endemic chronic fluoride toxicity and dietary calcium deficiency interaction syndromes of metabolic bone disease and deformities in India: year 2000. Indian J Pediatr 65:371-381.
382. Thylstrup A, Fejerskov O. 1978. Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes. Community Dent Oral Epidemiol 6:315-328. (Pubitemid 9076505)
383. Toumba KJ, Levy S, Curzon ME. 1994. The fluoride content of bottled drinking waters. Br Dent J 176:266-268.
384. Torra M, Rodamilans M, Corbella J. 1998. Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population. Sci Total Environ 220:81-85. (Pubitemid 28548681)
385. Turner CH, Akhter MP, Heaney RP. 1992. The effects of fluoridated water on bone strength. J Orthop Res 10:581-57.
386. Turner CH, Boivin G, Meunier PJ. 1993. A mathematical model for fluoride uptake by the skeleton. Calcif Tissue Res 52:130-138. (Pubitemid 23087943)
387. Turner CH, Hasegawa K, Zhang W, Wilson M, Li Y, Dunipace AJ. 1995. Fluoride reduces bone strength in older rats. J Dent Res 74:1475-1481.
388. Turner CH, Owan I, Brizendine EJ, Zhang W, Wilson ME, Dunipace AJ. 1996. High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency. Bone 19:595-601. (Pubitemid 27035838)
389. Urbansky ET. 2002. Fate of fluorosilicate drinking water additives. Chem Rev 102:2837-2854. (Pubitemid 35377632)
390. Urbansky ET, Schock MR. 2000. Can fluoridation affect lead(II) in portable water? Hexafluorosiliciate and fluoride in aqueous solution. Int J Environ Studies 57:597-637.
391. U.S. Army. 1983. Water Consumption Planning Factors Study. Directorate of Combat Developments, U. S. Army Quartermaster School, Fort Lee, VA.
392. USASMA (U.S. Army Sergeants Major Academy). 2003. Revised Fluid Replacement Policy for Warm Weather Training. Health Promotion Office, U.S. Army Sergeants Major Academy [online].
393. USDA (United States Department of Agriculture). 2004. USDA National Fluoride Database of Selected Beverages and Food. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture.
394. Vanden Heuvel JP, Kuslikis BI, Van Rafelghem MJ, Peterson RE. 1991. Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats. J Biochem Toxicol 6:83-92.
395. van Kesteren RG, Duursma SA, Visser WJ, van der Sluys Veer J, Backer Dirks O. 1982. Fluoride in serum and bone during treatment of osteoporosis with sodium fluoride, calcium and vitamin D. Metab Bone Dis Relat Res 4:31-37.
396. Van Winkle S, Levy SM, Kiritsy MC, Heilman JR, Wefel JS, Marshall T. 1995. Water and formula fluoride concentrations: significance for infants fed formula. Pediatr Dent 17:305-310.
397. Varner JA, Jensen KF, Horvath W, Isaacson RL. 1998. Chronic administration of aluminum-fluoride and sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res 784:284-298. (Pubitemid 28137871)
398. Vieira AP, Hancock R, Limeback H, Maia R, Grynpas MD. 2004. Is fluoride concentration in dentin and enamel a good indicator of dental fluorosis? J Dent Res 83:76-80. (Pubitemid 41756863)
399. Vieira, A.P.G.F., M. Mousny, R. Maia, R. Hancock, E.T. Everett, and M.D. Grynpas. 2005. Assessment of teeth as biomarkers for skeletal fluoride exposure. Osteoporos Int 16(12):1576-1582. (Pubitemid 41790861)
400. Vine MF. 1994. Biological markers: their use in quantitative assessments. Adv Dent Res 8(1):92-99.
401. Virtanen JI, Bloigu RS, Larmas MA. 1994. Timing of eruption of permanent teeth: standard Finnish patient documents. Community Dent Oral Epidemiol 22:286-288.
402. Wagener DK, Nourjah P, Horowitz AM. 1992. Trends in childhood use of dental care products containing fluoride: United States, 1983-1989. Hyattsville, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control.
403. Waldbott GL. 1956. Incipient fluorine intoxication from drinking water. Acta Med Scand 156:157-168.
404. Wang R. 2005. Anisotropic fracture in bovine root and coronal dentin. Dent Mater 21:429-436. (Pubitemid 40467032)
405. Wang D, Qian M. 1989. Report on the village use of the recension Chinese combined Raven's Test. Inform Phychol Sci 5:23-27.
406. Warnakulasuriya S, Harris C, Gelbier S, Keating J, Peters T. 2002. Fluoride content of alcoholic beverages. Clin Chim Acta 320:1-4. (Pubitemid 34450815)
407. Warren DP, Henson A, Chan JT. 1996. Comparison of fluoride content in caffeinated, decaffeinated and instant coffee. Fluoride 29:147-150. (Pubitemid 26291454)
408. Warren JJ, Levy SL. 1999. Systemic fluoride: sources, amounts, and effects of ingestion. Dent Clin North Am 43:695-711.
409. Waterhouse C, Taves D, Munzer A. 1980. Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption. Clin Sci 58:145-152. (Pubitemid 10021928)
410. Weast R, editor. 1989. Chemistry and Physics CRC Handbook. 69th Edition. CRC press. p. B-17. Fluoride 41120-41124.
411. Weinberger SJ. 1991. Bottled drinking waters: a the fluoride concentrations shown on the labels accurate? Int J Pediatr Dent 1:143-146.
412. Weiner MF, Wighton-Benn WH, Risser R, Svetlik D, Tintner R, Hom J, Rosenberg, Bonte FJ. 1993. Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: what is typical? J Neuropsychiatry Clin Neurosci 5:415-418. (Pubitemid 23326592)
413. Westendorf J. 1975. The kinetics of acetylcholinesterase inhibition and the influence of fluoride and fluoride complexes on the permeability of erythrocyte membranes. Ph.D. thesis, University of Hamburg, Hamburg, Germany, 1975.
414. Whitford GM. 1994. Intake and metabolism of fluoride. Adv Dent Res 8:5-14.
415. Whitford GM. 1996. The metabolism and Toxicity of Fluoride. 2nd Rev. Ed. Monographs in Oral Science Vol. 16. New York: Karger.
416. Whitford GM. 1999. Fluoride metabolism and excretion in children. J Pub Health Dent 59:224-228.
417. Whitford GM, Bawden JW, Bowen WH, Brown LJ, Ciardi JE, Clarkson TW, Imrey PB, Kleerekoper M, Marthaler TM, McGuire S, Ophaug RH, Robinson C, Schultz JS, Stookey GK, Tochman MS, Venkateswarlu P, Zero DT. 1994. Report for Working Group I: strategies for improving the assessment of fluoride accumulation in body fluids and tissues. Adv Dent Res 8:113-115.
418. Whitford GM, Biles ED, Birdsong-Whitford NL. 1991. A comparative study of fluoride pharmacokinetics in five species. J Dent Res 70:948-951.
419. Whitford GM, Buzalaf MA, Bijella MF, Waller JL. 2005. Plaque fluoride concentrations in a community without water fluoridation: effects of calcium and use of a fluoride or placebo dentifrice. Caries Res 39:100-107. (Pubitemid 40463209)
420. Whitford GM, Sampaio FC, Arneberg P, von der Fehr FR. 1999a. Fingernail fluoride: a method for monitoring fluoride exposure. Caries Res 33:462-467.
421. Whitford GM, Thomas JE, Adair SM. 1999b. Fluoride in whole saliva, parotid ductal saliva and plasma in children. Arch Oral Biol 44:785-788. (Pubitemid 29448979)
422. Whiting, P., M. MacDonagh, and J. Kleijnen. 2001. Association of Down's syndrome and water fluoride level: A systematic review of the evidence. BMC Public Health 1(1):6.
423. Whyte, M.P., K. Essmyer, F.H. Gannon, and W.R. Reinus. 2005. Skeletal fluorosis and instant tea. Am J Medicine 118(1):78-82. (Pubitemid 40082462)
424. Wilkinson, P.C. 1983. Effects of fluoride on locomotion of human blood leucocytes in vitro. Arch Oral Biol 28(5):415-418.
425. Winterer G, Goldman D. 2003. Genetics of human prefrontal function. Brain Res Rev 43:134-163. (Pubitemid 37130084)
426. Wong MH, Fung KF, Carr HP. 2003. Aluminum and fluoride content in tea, with emphasis on brick tea, and their health implications. Toxicol Lett 137:111-120. (Pubitemid 36044043)
427. World Health Organization. 2002. Environmental Health Criteria 227: fluorides. Geneva: World Health Organization.
428. Xiang Q, Liang Y, Chen C, Wang C, Chen B, Chen X, Zhou M. 2003a. Effect of fluoride in drinking water on children's intelligence. Fluoride 36:84-94. (Pubitemid 36935062)
429. Xiang Q, Liang Y, Zhou M, Zang H. 2003b. Blood lead of children in Wamiao- Xinhuai intelligence study. Fluoride 36:198-199. (Pubitemid 37087123)
430. Yamamoto, S., K. Katagiri, M. Ando, and X.Q. Chen. 2001. Suppression of pulmonary antibacterial defenses mechanisms and lung damage in mice exposed to fluoride aerosol. J Toxicol Environ Health A 62(6):485-494. (Pubitemid 32225429)
431. Yang, C.Y., M.F. Cheng, S.S. Tsai, and C.F. Hung. 2000. Fluoride in drinking water and cancer mortality in Taiwan. Environ Res 82(3):189-193.
432. Yatani A, Brown AM. 1991. Mechanism of fluoride activation of G protein-gatedmuscarinic atrial K+ channels. J Biol Chem 266:22872-22877. (Pubitemid 21908732)
433. Zero DT, Raubertas RF, Fu J, Pedersen AM, Hayes AL, Featherstone JD. 1992. Fluoride concentrations in plaque, whole saliva, and ductal saliva after application of home-use topical fluorides. J Dent Res 71:1768-1775.
434. Zerwekh JE, Antich P, Pak CY. 1996. Fluoride and the FDA (letter). J Bone Miner Res 11:1370-1371.
435. Zhao LB, Liang GH, Zhang DN, Wu XR. 1996. Effect of high-fluoride water supply on children's intelligence. Fluoride 29:190-192. (Pubitemid 26364357)
436. Zhao W, Zhu H, Yu Z, Aoki K, Misumi J, Zhang X. 1998. Long-term effects of various iodine and fluorine doses on the thyroid and fluorosis in mice. Endocr Regul 32:63-70. (Pubitemid 28321813)
437. Zipkin I, McClure FJ, Leone KC, et al. 1958. Fluoride deposition in human bones after prolonged ingestion of fluoride in drinking water. Public Health Rep 73:732-740.