Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain

Neurotoxicology and Teratology

Volumn 24, Issue 6, 2002, Pages 751-757

  Long, Yi Guo ^a   Wang, Ya Nan ^a   Chen, Jia ^a   Jiang, Su Fen ^a   Nordberg, Agneta ^b   Guan, Zhi Zhong ^a,b,c  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Brain; Fluoride; Nicotinic acetylcholine receptors; Toxicity

Indexed keywords

ALPHA 4 SUBUNIT PROTEIN; ALPHA 7 SUBUNIT PROTEIN; ALPHA BUNGAROTOXIN; FLUORIDE; NICOTINIC RECEPTOR; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; BRAIN DYSFUNCTION; BRAIN LEVEL; COGNITION; CONTROLLED STUDY; FEMALE; FLUOROSIS; LEARNING; LIGAND BINDING; MALE; MEMORY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BRAIN; BUNGAROTOXINS; CHRONIC DISEASE; COGNITION DISORDERS; DOWN-REGULATION; FEMALE; FLUORIDE POISONING; FLUORIDES; MALE; NEURONS; ORGANELLES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; SEX CHARACTERISTICS; SYNAPTIC TRANSMISSION;

EID: 18744374872     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(02)00273-8     Document Type: Article

References (40)

1. Alder L.E., Olincy A., Waldo M., Harris J.G., Griffith J., Stevens K., Flach K., Nagamoto H., Bickford P., Leonard S., Freedman R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr. Bull. 24:1998;189-202.
2. Burgstahler A.W. Fluoride and Down's syndrome (mongolism). editorial review Fluoride. 8:1975;1-11.
3. Capone G.T. Down syndrome: advances in molecular biology and the neurosciences. J. Dev. Behav. Pediatr. 22:2001;40-59.
4. Couturier S., Bertrand D., Matter J.M., Hernandez M.C., Bertrand S., Millar N., Valera S., Barkas T., Ballivet M. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron. 5:1990;847-856.
5. Du L., Wang S.W., Liu J.L. The effect of fluorine on the developing human brain. Chin. J. Pathol. (Chin.). 21:1992;218-220.
6. Editorial review (anonymous author): Nonskeletal fluorosis, Fluoride 11 (1978) 111-114.
7. Engidawork E., Gulesserian T., Balic N., Cairns N., Lubec G.J. Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. Neural Transm. Suppl. 61:2001;211-222.
8. Farooqui A.A., Horrocks L.A. Lipid peroxides in the free radical pathophysiology of brain diseases. Cell Mol. Neurobiol. 18:1998;599-608.
9. Fong T.M., McNamee M.G. Correlation between acetylcholine receptor function and structural properties of membranes. Biochemistry. 25:1986;830-840.
10. Fong T.M., McNamee M.G. Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes. Biochemistry. 26:1987;3871-3880.
11. Geeraerts F., Gijs G., Finne E., Crokaert R. Kinetics of fluoride penetration in liver and brain. Fluoride. 19:1986;108-112.
12. Gotti C., Fornasari D., Clementi F. Human neuronal nicotinic receptors. Prog. Neurobiol. 53:1997;199-237.
13. Guan Z.Z., Wang Y.N., Xiao K.Q., Dai D.Y., Chen Y.H., Liu J.L., Sinderlar P., Dallner G. Influence of chronic fluorosis on membrane lipids in rat brain. Neurotoxicol. Teratol. 20:1998;537-542.
14. Guan Z.Z., Yang P.S., Yu N.D., Zhuang Z.J. An experimental study of blood biochemical diagnostic indices for chronic fluorosis. Fluoride. 3:1989;112-118.
15. Guan Z.Z., Yu Y.L., Liu J.L. A study on the histopathology of the brain of the offspring from rats with chronic fluorosis. Chin. J. Pathol. (Chin.). 4:1986;297-301.
16. Guan Z.Z., Zhang X., Blennow K., Nordberg A. Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain. NeuroReport. 10:1999;1779-1782.
17. Guan Z.Z., Zhang X., Mousavi M., Tian J.Y., Unger C., Nordberg A. Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells. J. Neurosci. Res. 66:2001;551-558.
18. Guan Z.Z., Zhang X., Nordberg A. Influence of lipid peroxidation on the nicotinic acetylcholine receptors in PC12 cells. Neurosci. Lett. 286:2000;163-166.
19. Guan Z.Z., Zhang X., Ravid R., Nordberg A. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J. Neurochem. 74:2000;237-243.
20. Hall L.L., Smith F.A., Hodge H.C. Direct determination of ionic fluoride in biological fluids. Clin. Chem. 18:1972;1455-1460.
21. Jones S., Sudweeks S., Yakel J.L. Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci. 22:1999;555-561.
22. Li J.X., Cao S.R. Recent studies on endemic fluorosis in China. Fluoride. 3:1994;125-128.
23. Li Y., Li X., Wei S. Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism. Acta Hauxi Med. Univ. (Chin.). 252:1994;188-191.
24. Li X.S., Zhi J.L., Gao R.O. Effect of fluoride exposure on intelligence in children. Fluoride. 28:1995;189-192.
25. Lindström J. Nicotinic acetylcholine receptors in health and disease. Mol. Neurobiol. 15:1997;193-222.
26. Liu W.X., Dong Z., Liu J.L. Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat. Chin. J. Pathol. (Chin.). 18:1989;290-292.
27. Meyer E.M., Tay E.T., Papke R.L., Meyers C., Huang G.L., de Fiebre C.M. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res. 768:1997;49-56.
28. Mulienix P.J., Denbesten P.K., Schunior A., Kernan W.J. Neurotoxicity of sodium fluoride in rats. Neurotoxicol. Teratol. 17:1995;169-177.
29. Why EPA's headquarters union of scientists opposes fluoridation. Fluoride. 32:1999;179-186.
30. Newhouse P.A., Potter A., Levin E.D. Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics. Drugs Aging. 11:1997;206-228.
31. Nordberg A. Human nicotinic receptors - their role in aging and dementia. Neurochem. Int. 25:1994;93-97.
32. Paterson D., Nordberg A. Neuronal nicotinic receptors in the human brain. Prog. Neurobiol. 61:2000;75-111.
33. Rasband W.S., Bright D.S. NIH image: Public domain image processing program for the Macintosh. Microbeam Anal. Soc. 4:1995;137-149.
34. Seguela P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.K. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
35. Sharma A., Chinoy N.J. Role of free radicals in fluoride-induced toxicity in liver and kidney of mice and its reversal. Fluoride. 31:1998;S26.
36. Shashi A., Singh J.P., Thapar S.P. Effect of long-term administration of fluoride on levels of protein, free amino acids and RNA in rabbit brain. Fluoride. 3:1994;155-159.
37. Takahashi K. Fluoride-linked Down syndrome births and their estimated occurrence due to water fluoridation. Fluoride. 31:1998;61-73.
38. Waldbott G.L., Burgstahler A.W., McKinney L.H. The great dilemma. Waldbott G.L., Burgstahler A.W., McKinney L.H. Fluoridation. 1978;160-161 Coronado Press, Kansas.
39. Whitford G.M., Pashley D.H., Reynold K.E. Fluoride tissue distribution: short-term kinetics. Am. J. Physiol. 236:1979;141-148.
40. Zahvoronkov A.A., Strochkova L.S. Fluorosis: geographical pathology and some experimental findings. Fluoride. 14:1981;183-191.