Two distinct mechanisms for TIM barrel prenyltransferases in bacteria

Journal of the American Chemical Society

Volumn 133, Issue 5, 2011, Pages 1270-1273

  Doud, Emma H ^a,b   Perlstein, Deborah L ^b   Wolpert, Manuel ^b   Cane, David E ^c   Walker, Suzanne ^b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYMES; BOND ROTATIONS; DOUBLE BONDS; INTERMOLECULAR COUPLING; PRENYLTRANSFERASE; REACTION MECHANISM; TIM BARRELS;

ANTIBIOTICS; BACTERIOLOGY; BIOCHEMISTRY; CATALYSIS; ENZYMES; GLYCEROL; ISOMERIZATION; ISOMERS;

REACTION INTERMEDIATES;

DIMETHYLALLYLTRANSFERASE; GLYCEROPHOSPHATE;

ARTICLE; BACTERIUM; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; ENZYME MECHANISM; ISOMERIZATION; NONHUMAN;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; BACTERIA; DIMETHYLALLYLTRANSTRANSFERASE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; TRIOSE-PHOSPHATE ISOMERASE;

EID: 79551705489     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja109578b     Document Type: Article

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51. Using homology searches, we have identified a putative new subfamily of TIM barrel PTs that are highly conserved in Gram-negative bacteroides, and we predict that these enzymes also use G1P as a substrate and produce a trans product (Figure S4).