Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1+ monocytes

International Immunology

Volumn 23, Issue 2, 2011, Pages 97-108

  Aoyagi, Tetsuji ^a   Yamamoto, Natsuo ^a   Hatta, Masumitsu ^a   Tanno, Daiki ^a   Miyazato, Akiko ^a   Ishii, Keiko ^a   Suzuki, Kazuo ^b   Nakayama, Toshinori ^b   Taniguchi, Masaru ^c   Kunishima, Hiroyuki ^a   Hirakata, Yoichi ^a   Kaku, Mitsuo ^a   Kawakami, Kazuyoshi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

Acute lung injury; IFN ; NKT cells; TNF

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; INVARIANT NATURAL KILLER T CELL; MONOCYTE; MOUSE; NATURAL KILLER T CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

EID: 79551645340     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq460     Document Type: Article

References (57)

1. Ware, L. B. and Matthay, M. A. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342:1334.
2. Lee, N., Hui, D., Wu, A. et al. 2003. A major outbreak of severe acute respiratory syndrome in Hong Kong. N. Engl. J. Med. 348:1986.
3. Tran, T. H., Nguyen, T. L., Nguyen, T. D. et al. 2004. World Health Organization International Avian Influenza Investigative TeamA-vian influenza A (H5N1) in 10 patients in Vietnam. N. Engl. J. Med. 350:1179.
4. To, K. F., Chan, P. K., Chan, K. F. et al. 2001. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J. Med. Virol. 63:242.
5. de Jong, M. D., Simmons, C. P., Thanh, T. T. et al. 2006. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 12:1203.
6. Kash, J. C., Tumpey, T. M., Proll, S. C. et al. 2006. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578.
7. Park, W. Y., Goodman, R. B., Steinberg, K. P. et al. 2001. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 164:1896.
8. Bhatia, M. and Moochhala, S. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J. Pathol. 202:145.
9. Shimabukuro, D. W., Sawa, T. and Gropper, M. A. 2003. Injury and repair in lung and airways. Crit. Care Med. 31:524.
10. Kawano, T., Cui, J., Koezuka, Y. et al. 1997. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 28:1626.
11. Kitamura, H., Iwakabe, K., Yahata, T. et al. 1999. The natural killer T (NKT) cell ligand a-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 189:1121.
12. Hameg, A., Apostolou, I., Leite-De-Moraes, M. et al. 2000. A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the α-galactosylceramide antigen. J. Immunol 165:4917.
13. Kitamura, H., Ohta, A., Sekimoto, M. et al. 2000. α-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell. Immunol. 199:37.
14. Tomura, M., Yu, W. G., Ahn, H. J. et al. 1999. A novel function of Vα14+CD4+NKT cells: stimulation of IL-12 production by antigenpresenting cells in the innate immune system. J. Immunol. 163:93.
15. Dieli, F., Sireci, G., Russo, D. et al. 2000. Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. J. Exp. Med. 192:1645.
16. Emoto, M., Miyamoto, M., Yoshizawa, I. et al. 2002. Critical role of NK cells rather than Va14+ NKT cells in lipopolysaccharideinduced lethal shock in mice. J. Immunol. 169:1426.
17. Ito, H., Koide, N., Hassan, F. et al. 2006. Lethal endotoxic shock using α-galactosylceramide sensitization as a new experimental model of septic shock. Lab. Invest. 86:254.
18. Abraham, E. 2003. Neutrophils and acute lung injury. Crit. Care Med. 31:195.
19. O'Dea, K. P., Young, A. J., Yamamoto, H., Robotham, J. L., Brennan, F. M. and Takata, M. 2005. Lung-marginated monocytes modulate pulmonary microvascular injury during early endotoxemia. Am. J. Respir. Crit. Care Med. 172:1119.
20. O'Dea, K. P., Wilson, M. R., Dokpesi, J. O. et al. 2009. Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury. J. Immunol. 182:1155.
21. Geissmann, F., Jung, S. and Littman, D. R. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19:71.
22. Henderson, R. B., Hobbs, J. A., Mathies, M. and Hogg, N. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102:328.
23. Kawano, T., Cui, J., Koezuka, Y. et al. 1998. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Va14 NKT cells. Proc. Natl Acad. Sci. U S A 95:5690.
24. Fukuda, S., Ando, S., Sanou, O. et al. 1988. Simultaneous production of natural human tumor necrosis factor-α, -β and interferon-α from BALL-1 cells stimulated by HVJ. Lymphokine Res. 7:175.
25. Kawakami, K., Kohno, S., Morikawa, N., Kadota, J., Saito, A. and Hara, K. 1994. Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with Cryptococcus neoformans. Clin. Exp. Immunol. 96:230.
26. Kawakami, K., Yamamoto, N., Kinjo, Y. et al. 2003. Critical role of Vα14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection. Eur. J. Immunol. 33:3322.
27. Nakamatsu, M., Yamamoto, N., Hatta, M. et al. 2007. Role of interferon-γ in Vα14+ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs. Microbes Infect. 9:364.
28. Bastarache, J. A. and Blackwell, T. S. 2009. Development of animal models for the acute respiratory distress syndrome. Dis. Model. Mech. 2:218.
29. Matute-Bello, G., Frevert, C. W. and Martin, T. R. 2008. Animal models of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:379.
30. Nakagawa, R., Nagafune, I., Tazunoki, Y. et al. 2001. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by α-galactosylceramide in mice. J. Immunol. 166:6578.
31. Boyton, R. 2008. The role of natural killer T cells in lung inflammation. J. Pathol. 214:276.
32. Kawakami, K., Kinjo, Y., Yara, S. et al. 2001. Activation of Vα14+ natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect. Immun. 69:213.
33. Kimura, T., Ishii, Y., Morishima, Y. et al. 2004. Treatment with α-galactosylceramide attenuates the development of bleomycininduced pulmonary fibrosis. J. Immunol. 172:5782.
34. Ozmen, L., Pericin, M., Hakimi, J. et al. 1994. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180:907.
35. Doherty, G. M., Lange, J. R., Langstein, H. N., Alexander, H. R., Buresh, C. M. and Norton, J. A. 1992. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-α. J. Immunol. 149:1666.
36. Ortaldo, J. R., Young, H. A., Winkler-Pickett, R. T., Bere, E. W. Jr, Murphy, W. J. and Wiltrout, R. H. 2004. Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides. J. Immunol. 172:943.
37. Harada, M., Seino, K., Wakao, H. et al. 2004. Down-regulation of the invariant Vα14 antigen receptor in NKT cells upon activation. Int. Immunol. 16:241.
38. Carnaud, C., Lee, D., Donnars, O. et al. 1999. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:4647.
39. Zhang, T., Kawakami, K., Qureshi, M. H., Okamura, H., Kurimoto, M. and Saito, A. 1997. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of c interferon by natural killer cells. Infect. Immun. 65:3594.
40. Heremans, H., Dillen, C., van Damme, J. and Billiau, A. 1994. Essential role for natural killer cells in the lethal lipopolysaccharideinduced Shwartzman-like reaction in mice. Eur. J. Immunol. 24:1155.
41. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature 420:885.
42. Frank, J. A. and Matthay, M. A. 2003. Science review: mechanisms of ventilator-induced injury. Crit. Care 7:233.
43. Horinouchi, H., Wang, C. C., Shepherd, K. E. and Jones, R. 1996. TNF α gene and protein expression in alveolar macrophages in acute and chronic hyperoxia-induced lung injury. Am. J. Respir. Cell Mol. Biol. 14:548.
44. Brieland, J. K., Flory, C. M., Jones, M. L. et al. 1995. Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-a, and interleukin-1b. Am. J. Respir. Cell. Mol. Biol. 12:104.
45. Haziot, A., Tsuberi, B. Z. and Goyert, S. M. 1993. Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-α in response to lipopolysaccharide. J. Immunol. 150:5556.
46. Cassatella, M. A. 1995. The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16:21.
47. Reutershan, J., Basit, A., Galkina, E. V. and Ley, K. 2005. Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:807.
48. Sunderkötter, C., Nikolic, T., Dillon, M. J. et al. 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172:4410.
49. Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O'Shea, J. J. and Koyasu, S. 2001. IFN-γ production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22:556.
50. Rydström, A. and Wick, M. J. 2007. Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection. J. Immunol. 178:5789.
51. Nahrendorf, M., Swirski, F. K., Aikawa, E. et al. 2007. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204:3037.
52. Maus, U., von Grote, K., Kuziel, W. A. et al. 2002. The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice. Am. J. Respir. Crit. Care Med. 166:268.
53. Daley, J. M., Thomay, A. A., Connolly, M. D., Reichner, J. S. and Albina, J. E. 2008. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J. Leukoc. Biol. 83:64.
54. Kinjo, Y., Illarionov, P., Pei, B. et al. 2009. iNKT cell glycolipid antigens from Gram positive bacteria. The 39th Annual Meeting of the Japanese Society for Immunology, p. 60. 39.
55. Tupin, E., Kinjo, Y. and Kronenberg, M. 2007. The unique role of natural killer T cells in the response to microorganisms. Nat. Rev. Microbiol. 5:405.
56. Kinjo, Y., Wu, D., Kim, G. et al. 2005. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434:520.
57. Mattner, J., Debord, K. L., Ismail, N. et al. 2005. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525.