Higher bioavailability of isoflavones after a single ingestion of aglycone-rich fermented soybeans compared with glucoside-rich non-fermented soybeans in Japanese postmenopausal women

Journal of the Science of Food and Agriculture

Volumn 91, Issue 4, 2011, Pages 658-663

  Okabe, Yuki ^a   Shimazu, Tsukasa ^a   Tanimoto, Hiroyuki ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

Bioavailability; Fermented soybeans; Isoflavone aglycone; Postmenopausal women

Indexed keywords

GLUCOSIDE; ISOFLAVONE DERIVATIVE; PLANT EXTRACT;

AGED; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FERMENTATION; HUMAN; JAPAN; MICROBIOLOGY; MIDDLE AGED; PLANT SEED; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SOYBEAN; URINE;

AGED; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FERMENTATION; GLUCOSIDES; HUMANS; ISOFLAVONES; JAPAN; MIDDLE AGED; PLANT EXTRACTS; POSTMENOPAUSE; SEEDS; SOYBEANS;

GLYCINE MAX;

EID: 79551634890     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.4228     Document Type: Article

References (37)

1. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139: 4252-4263 (1998).
2. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, et al, Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res 17: 1904-1912 (2002).
3. Ali AA, Velasquez MT, Hansen CT, Mohamed AI and Bhathena SJ, Modulation of carbohydrate metabolism and peptide hormones by soybean isoflavones and probiotics in obesity and diabetes. J Nutr Biochem 16: 693-699 (2005).
4. Naaz A, Yellayi S, Zakroczymski MA, Bunick D, Doerge DR, Lubahn DB, et al, The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 144: 3315-3320 (2003).
5. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF and Erdman Jr JW, Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68: 1375S-1379S (1998).
6. Han KK, Soares Jr JM, Haidar MA, de Lima GR and Baracat EC, Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 99: 389-394 (2002).
7. Wei H, Saladi R, Lu Y, Wang Y, Palep SR, Moore J, et al, Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr 133: 3811S-3819S (2003).
8. Wang H and Murphy PA, Isoflavone content in commercial soybean foods. J Agric Food Chem 42: 1666-1673 (1994).
9. Piskula MK, Yamakoshi J and Iwai Y, Daidzein and genistein but not their glucosides are absorbed from the rat stomach. FEBS Lett 447: 287-291 (1999).
10. Setchell KD, Brown NM, Zimmer-Nechemias L, Brashear WT, Wolfe BE, Kirschner AS, et al, Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 76: 447-453 (2002).
11. Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, Saito M, et al, Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 130: 1695-1699 (2000).
12. Kano M, Takayanagi T, Harada K, Sawada S and Ishikawa F, Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J Nutr 136: 2291-2296 (2006).
13. Holzapfel WH, Haberer P, Snel J, Schillinger U and Huis in't Veld JH, Overview of gut flora and probiotics. Int J Food Microbiol 41: 85-101 (1998).
14. Sudo N, Stress and intestinal flora. J Intest Microbiol 19: 25-29 (2005).
15. Toda T, Tamura J and Okuhira T, Isoflavone content in commercial soybean foods. Foods Foods Ingred J Jpn 172: 83-89 (1997).
16. Murphy P, Song T, Buseman G, Barua K, Beecher G, Trainer D, et al, Isoflavones in retail and institutional soy foods. J Agric Food Chem 47: 2697-2704 (1999).
17. Wang L, Yin L, Li D, Zou L, Saito M, Tatsumi E, et al, Influences of processing and NaCl supplementation on isoflavone contents and composition during douchi manufacturing. Food Chem 101: 1247-1253 (2007).
18. Okabe Y and Tanimoto H, Effects of dietary intake of isoflavone aglycone-rich fermented soybeans on bone metabolism in ovariectomized rats. J Health Sci 54: 315-323 (2008).
19. Kudou S, Fleury Y and Welti D, Malonylisoflavone glycosides in soybean seeds (Glycine max MERILL). Agric Biol Chem 55: 2227-2233 (1991).
20. Larkin T, Price WE and Astheimer L, The key importance of soy isoflavone bioavailability to understanding health benefits. Crit Rev Food Sci Nutr 48: 538-552 (2008).
21. Turner NJ, Thomson BM and Shaw IC, Bioactive isoflavones in functional foods: the importance of gut microflora on bioavailability. Nutr Rev 61: 204-213 (2003).
22. Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, et al, Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver [beta]-glucosidase activity. FEBS Lett 436: 71-75 (1998).
23. Sfakianos J, Coward L, Kirk M and Barnes S, Intestinal uptake and biliary excretion of the isoflavone genistein in rats. J Nutr 127: 1260-1268 (1997).
24. Yuan JP, Wang JH and Liu X, Metabolism of dietary soy isoflavones to equol by human intestinal microflora-implications for health. Mol Nutr Food Res 51: 765-781 (2007).
25. 13C-labeled tracers in premenopausal women. Am J Clin Nutr 77: 411-419 (2003).
26. Song KB, Atkinson C, Frankenfeld CL, Jokela T, Wahala K, Thomas WK, et al, Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls. J Nutr 136: 1347-1351 (2006).
27. Akaza H, Miyanaga N, Takashima N, Naito S, Hirao Y, Tsukamoto T, et al, Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents. Jpn J Clin Oncol 34: 86-89 (2004).
28. Lampe JW, Karr SC, Hutchins AM and Slavin JL, Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 217: 335-339 (1998).
29. Bolca S, Possemiers S, Herregat A, Huybrechts I, Heyerick A, De Vriese S, et al, Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women. J Nutr 137: 2242-2246 (2007).
30. Ohta A, Uehara M, Sakai K, Takasaki M, Adlercreutz H, Morohashi T, et al, A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice. J Nutr 132: 2048-2054 (2002).
31. Cassidy A, Brown JE, Hawdon A, Faughnan MS, King LJ, Millward J, et al, Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 136: 45-51 (2006).
32. Eunmi K and Alyson EM, Urinary isoflavone excretion in Korean adults: comparisons of fermented soybean paste and unfermented soy flour. J Sci Food Agric 87: 2112-2120 (2007).
33. Tsangalis D, Wilcox G, Shah NP and Stojanovska L, Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria. Br J Nutr 93: 867-887 (2005).
34. Richelle M, Pridmore-Merten S, Bodenstab S, Enslen M and Offord EA, Hydrolysis of isoflavone glycosides to aglycones by {beta}-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. J Nutr 132: 2587-2592 (2002).
35. Maskarinec G, Watts K, Kagihara J, Hebshi SM and Franke AA, Urinary isoflavonoid excretion is similar after consuming soya milk and miso soup in Japanese-American women. Br J Nutr 100: 424-429 (2008).
36. Zubik L and Meydani M, Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am J Clin Nutr 77: 1459-1465 (2003).
37. Rufer CE, Bub A, Moseneder J, Winterhalter P, Sturtz M and Kulling SE, Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study. Am J Clin Nutr 87: 1314-1323 (2008).