Original fluorescent ligand-based assays open new perspectives in G-protein coupled receptor drug screening

Pharmaceuticals

Volumn 4, Issue 1, 2011, Pages 202-214

  Cottet, Martin ^a,b,c   Faklaris, Orestis ^a,b,c   Zwier, Jurriaan M ^d   Trinquet, Eric ^d   Pin, Jean Philippe ^a,b,c   Durroux, Thierry ^a,b,c  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d CIS Bio International   (France)

Author keywords

Fluorescence; GPCR; Lanthanides; Screening assay; Time resolved FRET

Indexed keywords

FLUORESCENT DYE; G PROTEIN COUPLED RECEPTOR; LANTHANIDE;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CHEMICAL LABELING; COMPLEX FORMATION; DRUG SCREENING; FLUORESCENCE ANALYSIS; FLUORESCENCE POLARIZATION IMMUNOASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HETEROLOGOUS EXPRESSION; HIGH THROUGHPUT SCREENING; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR PROBE; OLIGOMERIZATION; PROTEIN STRUCTURE; REVIEW; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO;

EID: 79551599571     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph4010202     Document Type: Review

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