Human tyrosine hydroxylase natural allelic variation: Influence on autonomic function and hypertension

Cellular and Molecular Neurobiology

Volumn 30, Issue 8, 2010, Pages 1391-1394

  Rao, Fangwen ^a,b   Zhang, Kuixing ^a,b   Zhang, Lian ^a,b   Rana, Brinda K ^a,b   Wessel, Jennifer ^a,b   Fung, Maple M ^a,b   Rodriguez Flores, Juan L ^a,b   Taupenot, Laurent ^a,b   Ziegler, Michael G ^a,b   O’Connor, Daniel T ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Catecholamine; Chromaffin; Stress

Indexed keywords

ADRENALIN; ALANINE; CYTOSINE; GLYCINE; NORADRENALIN; NUCLEOTIDE; THYMINE; TRANSCRIPTION FACTOR; TYROSINE 3 MONOOXYGENASE;

ADRENALIN BLOOD LEVEL; ADRENERGIC ACTIVITY; ALLELE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR RISK; CATECHOLAMINE METABOLISM; CATECHOLAMINE RELEASE; CATECHOLAMINE SYNTHESIS; CELL NUCLEUS; CHROMATIN; CONFERENCE PAPER; ENVIRONMENTAL STRESS; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC RISK; GENETIC TRAIT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HAPLOTYPE; HERITABILITY; HUMAN; HYPERTENSION; IN VIVO STUDY; INTRON; MICROSATELLITE MARKER; NONHUMAN; NORADRENALIN BLOOD LEVEL; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN MOTIF; SINGLE NUCLEOTIDE POLYMORPHISM; TH GENE;

EID: 79151482968     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-010-9535-7     Document Type: Conference Paper

References (13)

1. V Albanese NF Biguet H Kiefer E Bayard J Mallet R Meloni 2001 Quantitative effects on gene silencing by allelic variation at a tetranucleotide microsatellite Hum Mol Genet 10 1785 1792 1:CAS:528:DC%2BD3MXntFCitb4%3D 10.1093/hmg/10.17.1785 11532988
2. P Barbeau MS Litaker RW Jackson FA Treiber 2003 A tyrosine hydroxylase microsatellite and hemodynamic response to stress in a multi-ethnic sample of youth Ethn Dis 13 186 192 12785414
3. D Boomsma A Busjahn L Peltonen 2002 Classical twin studies and beyond Nat Rev Genet 3 872 882 1:CAS:528:DC%2BD38Xotlersbk%3D 10.1038/nrg932 12415317
4. SW Chitbangonsyn P Mahboubi D Walker BK Rana KL Diggle DS Timberlake RJ Parmer DT O'Connor 2003 Physical mapping of autonomic/sympathetic candidate genetic loci for hypertension in the human genome: a somatic cell radiation hybrid library approach J Hum Hypertens 17 319 324 1:CAS:528: DC%2BD3sXjvVagt7c%3D 10.1038/sj.jhh.1001550 12756404
5. T Flatmark RC Stevens 1999 Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms Chem Rev 99 2137 2160 1:CAS:528:DyaK1MXkvF2kt7Y%3D 10.1021/cr980450y 11849022
6. B Grima A Lamouroux C Boni JF Julien F Javoy-Agid J Mallet 1987 A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics Nature 326 707 711 1:CAS:528:DyaL2sXkslWrur8%3D 10.1038/326707a0 2882428
7. B Kennedy MG Ziegler 1990 A more sensitive and specific radioenzymatic assay for catecholamines Life Sci 47 2143 2153 1:CAS:528:DyaK3MXjs1WjsQ%3D%3D 10.1016/0024-3205(90)90314-H 2266783
8. F Rao L Zhang J Wessel K Zhang G Wen BP Kennedy BK Rana M Das JL Rodriguez-Flores DW Smith PE Cadman RM Salem SK Mahata NJ Schork L Taupenot MG Ziegler DT O'Connor 2007 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo Circulation 116 993 1006 1:CAS:528:DC%2BD2sXpt1GmtL4%3D 10.1161/CIRCULATIONAHA.106.682302 17698732
9. P Sharma A Hingorani H Jia M Ashby R Hopper D Clayton MJ Brown 1998 Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension Hypertension 32 676 682 1:CAS:528:DyaK1cXnt1WgtLk%3D 9774362
10. n repeat in the first intron of the human tyrosine hydroxylase gene Life Sci 61 1341 1347 1:CAS:528: DyaK2sXlvVGjtLc%3D 10.1016/S0024-3205(97)00679-6 9335223
11. L Zhang F Rao J Wessel BP Kennedy BK Rana L Taupenot EO Lillie M Cockburn NJ Schork MG Ziegler DT O'Connor 2004 Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins Physiol Genomics 19 277 291 10.1152/physiolgenomics.00151.2004 15367723
12. Zhang K, Zhang L, Rao F, Brar B, Rodriguez-Flores JL, Taupenot L, O'Connor DT (2010) Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter. Circ Cardiovasc Genet 3:187-198
13. QY Zhou CJ Quaife RD Palmiter 1995 Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development Nature 374 640 643 1:CAS:528:DyaK2MXltVOhsL0%3D 10.1038/374640a0 7715703