메뉴 건너뛰기




Volumn 10, Issue 2, 2011, Pages 250-260

Impact of BCR-ABL mutations on patients with chronic myeloid leukemia

Author keywords

BCR ABL; Bosutinib; Chronic myeloid leukemia; Dasatinib; Drug resistance; Imatinib; Mutation; Nilotinib

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; NILOTINIB;

EID: 79551536292     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.2.14537     Document Type: Review
Times cited : (60)

References (101)
  • 1
    • 66049150292 scopus 로고    scopus 로고
    • Sustained durability of responses and improved progression-free and overall survival with imatinib treatment for accelerated phase and blast crisis chronic myeloid leukemia: Long-term follow-up of the STI571 0102 and 0109 trials
    • Silver RT, Cortes J, Waltzman R, Mone M, Kantarjian H. Sustained durability of responses and improved progression-free and overall survival with imatinib treatment for accelerated phase and blast crisis chronic myeloid leukemia: Long-term follow-up of the STI571 0102 and 0109 trials. Haematologica 2009; 94:743-4.
    • (2009) Haematologica , vol.94 , pp. 743-744
    • Silver, R.T.1    Cortes, J.2    Waltzman, R.3    Mone, M.4    Kantarjian, H.5
  • 2
    • 57349124075 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: Outcome of the patients alive after a 6 year follow-up
    • Palandri F, Castagnetti F, Testoni N, Luatti S, Marzocchi G, Bassi S, et al. Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: Outcome of the patients alive after a 6 year follow-up. Haematologica 2008; 93:1792-6.
    • (2008) Haematologica , vol.93 , pp. 1792-1796
    • Palandri, F.1    Castagnetti, F.2    Testoni, N.3    Luatti, S.4    Marzocchi, G.5    Bassi, S.6
  • 3
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247:824-30.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 4
    • 77954947022 scopus 로고    scopus 로고
    • Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis
    • Castagnetti F, Testoni N, Luatti S, Marzocchi G, Mancini M, Kerim S, et al. Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis. J Clin Oncol 2010; 28:2748-54.
    • (2010) J Clin Oncol , vol.28 , pp. 2748-2754
    • Castagnetti, F.1    Testoni, N.2    Luatti, S.3    Marzocchi, G.4    Mancini, M.5    Kerim, S.6
  • 5
    • 34447628963 scopus 로고    scopus 로고
    • Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia
    • Kreil S, Pfirrmann M, Haferlach C, Waghorn K, Chase A, Hehlmann R, et al. Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia. Blood 2007; 110:1283-90.
    • (2007) Blood , vol.110 , pp. 1283-1290
    • Kreil, S.1    Pfirrmann, M.2    Haferlach, C.3    Waghorn, K.4    Chase, A.5    Hehlmann, R.6
  • 6
    • 47949128478 scopus 로고    scopus 로고
    • BCR-ABL in chronic myelogenous leukemia - How does it work?
    • Goldman JM, Melo JV. BCR-ABL in chronic myelogenous leukemia - how does it work? Acta Haematol 2008; 119:212-7.
    • (2008) Acta Haematol , vol.119 , pp. 212-217
    • Goldman, J.M.1    Melo, J.V.2
  • 8
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247:1079-82.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 9
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
    • Koptyra M, Falinski R, Nowicki MO, Stoklosa T, Majsterek I, Nieborowska-Skorska M, et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 2006; 108:319-27.
    • (2006) Blood , vol.108 , pp. 319-327
    • Koptyra, M.1    Falinski, R.2    Nowicki, M.O.3    Stoklosa, T.4    Majsterek, I.5    Nieborowska-Skorska, M.6
  • 12
    • 1042289336 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) prevents the mutator phenotype of Bcr-Abl in hematopoietic cell lines
    • van der Kuip H, Moehring A, Wohlbold L, Miething C, Duyster J, Aulitzky WE. Imatinib mesylate (STI571) prevents the mutator phenotype of Bcr-Abl in hematopoietic cell lines. Leuk Res 2004; 28:405-8.
    • (2004) Leuk Res , vol.28 , pp. 405-408
    • Van Der Kuip, H.1    Moehring, A.2    Wohlbold, L.3    Miething, C.4    Duyster, J.5    Aulitzky, W.E.6
  • 14
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, Druker BJ, Branford S, Foroni L, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23:1054-61.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3    Druker, B.J.4    Branford, S.5    Foroni, L.6
  • 17
    • 73349122639 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
    • Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009; 27:6041-51.
    • (2009) J Clin Oncol , vol.27 , pp. 6041-6051
    • Baccarani, M.1    Cortes, J.2    Pane, F.3    Niederwieser, D.4    Saglio, G.5    Apperley, J.6
  • 18
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010; 362:2260-70.
    • (2010) N Engl J Med , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3    Cortes, J.4    Shah, S.5    Ayala, M.6
  • 21
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 2007; 8:1018-29.
    • (2007) Lancet Oncol , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 22
    • 77956908206 scopus 로고    scopus 로고
    • BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib
    • Sherbenou DW, Hantschel O, Kaupe I, Willis S, Bumm T, Turaga LP, et al. BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib. Blood 2010; 116:3278-85.
    • (2010) Blood , vol.116 , pp. 3278-3285
    • Sherbenou, D.W.1    Hantschel, O.2    Kaupe, I.3    Willis, S.4    Bumm, T.5    Turaga, L.P.6
  • 25
    • 33745283618 scopus 로고    scopus 로고
    • The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
    • Tokarski JS, Newitt JA, Chang CY, Cheng JD, Wittekind M, Kiefer SE, et al. The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res 2006; 66:5790-7.
    • (2006) Cancer Res , vol.66 , pp. 5790-5797
    • Tokarski, J.S.1    Newitt, J.A.2    Chang, C.Y.3    Cheng, J.D.4    Wittekind, M.5    Kiefer, S.E.6
  • 27
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65:4500-5.
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3    Jia, T.4    Manley, P.W.5    Mestan, J.6
  • 28
    • 49649108911 scopus 로고    scopus 로고
    • Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib
    • Vajpai N, Strauss A, Fendrich G, Cowan-Jacob SW, Manley PW, Grzesiek S, et al. Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib. J Biol Chem 2008; 283:18292-302.
    • (2008) J Biol Chem , vol.283 , pp. 18292-18302
    • Vajpai, N.1    Strauss, A.2    Fendrich, G.3    Cowan-Jacob, S.W.4    Manley, P.W.5    Grzesiek, S.6
  • 30
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E, Kantarjian H, Jones D, Talpaz M, Bekele N, O'Brien S, et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006; 20:1767-73.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Talpaz, M.4    Bekele, N.5    O'Brien, S.6
  • 31
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, La Rosée P, Müller MC, Lahaye T, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16:2190-6.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3    La Rosée, P.4    Müller, M.C.5    Lahaye, T.6
  • 32
    • 20144388183 scopus 로고    scopus 로고
    • Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5 year follow-up
    • Lahaye T, Riehm B, Berger U, Paschka P, Müller MC, Kreil S, et al. Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5 year follow-up. Cancer 2005; 103:1659-69.
    • (2005) Cancer , vol.103 , pp. 1659-1669
    • Lahaye, T.1    Riehm, B.2    Berger, U.3    Paschka, P.4    Müller, M.C.5    Kreil, S.6
  • 33
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102:276-83.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6
  • 34
    • 33846228789 scopus 로고    scopus 로고
    • Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Colarossi S, Gnani A, Rosti G, Castagnetti F, Poerio A, et al. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin Cancer Res 2006; 12:7374-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 7374-7379
    • Soverini, S.1    Colarossi, S.2    Gnani, A.3    Rosti, G.4    Castagnetti, F.5    Poerio, A.6
  • 36
    • 85011937545 scopus 로고    scopus 로고
    • Dynamics of mutant BCR-ABL positive clones after cessation of tyrosine kinase inhibitor therapy
    • Epub December 6
    • Hanfstein B, Müller MC, Kreil S, Schenk T, Lorentz C, Schwindel U, et al. Dynamics of mutant BCR-ABL positive clones after cessation of tyrosine kinase inhibitor therapy. Haematologica 2010; Epub December 6.
    • (2010) Haematologica
    • Hanfstein, B.1    Müller, M.C.2    Kreil, S.3    Schenk, T.4    Lorentz, C.5    Schwindel, U.6
  • 37
    • 70249107459 scopus 로고    scopus 로고
    • Reduction of BCR-ABL1 mutant clones after discontinuation of TKI therapy
    • Beel K, Janssens A, Verhoef G, Vandenberghe P. Reduction of BCR-ABL1 mutant clones after discontinuation of TKI therapy. Leuk Res 2009; 33:1703-5.
    • (2009) Leuk Res , vol.33 , pp. 1703-1705
    • Beel, K.1    Janssens, A.2    Verhoef, G.3    Vandenberghe, P.4
  • 38
    • 4344672552 scopus 로고    scopus 로고
    • Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
    • Hochhaus A, La Rosée P. Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia 2004; 18:1321-31.
    • (2004) Leukemia , vol.18 , pp. 1321-1331
    • Hochhaus, A.1    La Rosée, P.2
  • 40
    • 70350509806 scopus 로고    scopus 로고
    • Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib
    • Press RD, Willis SG, Laudadio J, Mauro MJ, Deininger MW. Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib. Blood 2009; 114:2598-605.
    • (2009) Blood , vol.114 , pp. 2598-2605
    • Press, R.D.1    Willis, S.G.2    Laudadio, J.3    Mauro, M.J.4    Deininger, M.W.5
  • 41
    • 20844447330 scopus 로고    scopus 로고
    • Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations
    • Branford S, Rudzki Z, Parkinson I, Grigg A, Taylor K, Seymour JF, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood 2004; 104:2926-32.
    • (2004) Blood , vol.104 , pp. 2926-2932
    • Branford, S.1    Rudzki, Z.2    Parkinson, I.3    Grigg, A.4    Taylor, K.5    Seymour, J.F.6
  • 42
    • 33644516935 scopus 로고    scopus 로고
    • The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib- Treated patients with chronic myeloid leukemia
    • Wang L, Knight K, Lucas C, Clark RE. The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib- treated patients with chronic myeloid leukemia. Haematologica 2006; 91:235-9.
    • (2006) Haematologica , vol.91 , pp. 235-239
    • Wang, L.1    Knight, K.2    Lucas, C.3    Clark, R.E.4
  • 43
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28-37.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3    Branford, S.4    Radich, J.5    Kaeda, J.6
  • 44
    • 50849107667 scopus 로고    scopus 로고
    • ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia
    • Ernst T, Hoffmann J, Erben P, Hanfstein B, Leitner A, Hehlmann R, et al. ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia. Haematologica 2008; 93:1389-93.
    • (2008) Haematologica , vol.93 , pp. 1389-1393
    • Ernst, T.1    Hoffmann, J.2    Erben, P.3    Hanfstein, B.4    Leitner, A.5    Hehlmann, R.6
  • 45
    • 70349147868 scopus 로고    scopus 로고
    • A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib
    • Ernst T, Gruber FX, Pelz-Ackermann O, Maier J, Pfirrmann M, Müller MC, et al. A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib. Haematologica 2009; 94:1227-35.
    • (2009) Haematologica , vol.94 , pp. 1227-1235
    • Ernst, T.1    Gruber, F.X.2    Pelz-Ackermann, O.3    Maier, J.4    Pfirrmann, M.5    Müller, M.C.6
  • 46
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Martinelli G, Rosti G, Bassi S, Amabile M, Poerio A, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005; 23:4100-9.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3    Bassi, S.4    Amabile, M.5    Poerio, A.6
  • 47
    • 24744443720 scopus 로고    scopus 로고
    • High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
    • Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D, et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005; 106:2128-37.
    • (2005) Blood , vol.106 , pp. 2128-2137
    • Willis, S.G.1    Lange, T.2    Demehri, S.3    Otto, S.4    Crossman, L.5    Niederwieser, D.6
  • 48
    • 33847191776 scopus 로고    scopus 로고
    • Mutations of the BCRABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib
    • Sherbenou DW, Wong MJ, Humayun A, McGreevey LS, Harrell P, Yang R, et al. Mutations of the BCRABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib. Leukemia 2007; 21:489-93.
    • (2007) Leukemia , vol.21 , pp. 489-493
    • Sherbenou, D.W.1    Wong, M.J.2    Humayun, A.3    McGreevey, L.S.4    Harrell, P.5    Yang, R.6
  • 49
    • 54349089682 scopus 로고    scopus 로고
    • Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression
    • Khorashad JS, de Lavallade H, Apperley JF, Milojkovic D, Reid AG, Bua M, et al. Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression. J Clin Oncol 2008; 26:4806-13.
    • (2008) J Clin Oncol , vol.26 , pp. 4806-4813
    • Khorashad, J.S.1    De Lavallade, H.2    Apperley, J.F.3    Milojkovic, D.4    Reid, A.G.5    Bua, M.6
  • 50
    • 55349096650 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Molecular monitoring in clinical practice
    • Branford S. Chronic myeloid leukemia: molecular monitoring in clinical practice. Hematology Am Soc Hematol Educ Program 2007; 2007:376-83.
    • (2007) Hematology Am Soc Hematol Educ Program , vol.2007 , pp. 376-383
    • Branford, S.1
  • 51
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam M, Latek RR, Daley GQ. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 2003; 112:831-43.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 52
    • 0038375012 scopus 로고    scopus 로고
    • Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • DOI 10.1182/blood-2002-12-3659
    • Corbin AS, La Rosée P, Stoffregen EP, Druker BJ, Deininger MW. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 2003; 101:4611-4. (Pubitemid 36857835)
    • (2003) Blood , vol.101 , Issue.11 , pp. 4611-4614
    • Corbin, A.S.1    La, R.P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 53
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2:117-25.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6
  • 54
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
    • von Bubnoff N, Schneller F, Peschel C, Duyster J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 2002; 359:487-91.
    • (2002) Lancet , vol.359 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 55
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293:876-80.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6
  • 56
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(varphi)-LMC GROUP)
    • Nicolini FE, Corm S, Lê QH, Sorel N, Hayette S, Bories D, et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(varphi)-LMC GROUP). Leukemia 2006; 20:1061-6.
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm, S.2    Lê, Q.H.3    Sorel, N.4    Hayette, S.5    Bories, D.6
  • 57
    • 64049099666 scopus 로고    scopus 로고
    • Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy
    • Jabbour E, Kantarjian HM, Jones D, Shan J, O'Brien S, Reddy N, et al. Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy. Blood 2009; 113:2154-60.
    • (2009) Blood , vol.113 , pp. 2154-2160
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3    Shan, J.4    O'Brien, S.5    Reddy, N.6
  • 58
    • 74949086656 scopus 로고    scopus 로고
    • Kinase domain mutations and responses to dose escalation in chronic myeloid leukemia resistant to standard dose imatinib mesylate
    • Rajappa S, Mallavarapu KM, Gundeti S, Roshnipaul T, Jacob RT, Digumarti R. Kinase domain mutations and responses to dose escalation in chronic myeloid leukemia resistant to standard dose imatinib mesylate. Leuk Lymphoma 2010; 51:79-84.
    • (2010) Leuk Lymphoma , vol.51 , pp. 79-84
    • Rajappa, S.1    Mallavarapu, K.M.2    Gundeti, S.3    Roshnipaul, T.4    Jacob, R.T.5    Digumarti, R.6
  • 59
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
    • Nagar B, Bornmann WG, Pellicena P, Schindler T, Veach DR, Miller WT, et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res 2002; 62:4236-43. (Pubitemid 34827278)
    • (2002) Cancer Research , vol.62 , Issue.15 , pp. 4236-4243
    • Nagar, B.1    Bornmann, W.G.2    Pellicena, P.3    Schindler, T.4    Veach, D.R.5    Miller, W.T.6    Clarkson, B.7    Kuriyan, J.8
  • 60
    • 0348140591 scopus 로고    scopus 로고
    • Mechanisms and implications of imatinib resistance mutations in BCR-ABL
    • Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol 2004; 11:35-43.
    • (2004) Curr Opin Hematol , vol.11 , pp. 35-43
    • Nardi, V.1    Azam, M.2    Daley, G.Q.3
  • 62
    • 34548721201 scopus 로고    scopus 로고
    • Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation
    • Nicolini FE, Hayette S, Corm S, Bachy E, Bories D, Tulliez M, et al. Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation. Haematologica 2007; 92:1238-41.
    • (2007) Haematologica , vol.92 , pp. 1238-1241
    • Nicolini, F.E.1    Hayette, S.2    Corm, S.3    Bachy, E.4    Bories, D.5    Tulliez, M.6
  • 63
    • 72949110861 scopus 로고    scopus 로고
    • Analysis of Bcr-Abl kinase domain mutations in Korean chronic myeloid leukaemia patients: Poor clinical outcome of P-loop and T315I mutation is disease phase dependent
    • Kim SH, Kim D, Kim DW, Goh HG, Jang SE, Lee J, et al. Analysis of Bcr-Abl kinase domain mutations in Korean chronic myeloid leukaemia patients: poor clinical outcome of P-loop and T315I mutation is disease phase dependent. Hematol Oncol 2009; 27:190-7.
    • (2009) Hematol Oncol , vol.27 , pp. 190-197
    • Kim, S.H.1    Kim, D.2    Kim, D.W.3    Goh, H.G.4    Jang, S.E.5    Lee, J.6
  • 64
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E, Kantarjian H, Jones D, Breeden M, Garcia-Manero G, O'Brien S, et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 2008; 112:53-5.
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Breeden, M.4    Garcia-Manero, G.5    O'Brien, S.6
  • 66
    • 33746058730 scopus 로고    scopus 로고
    • Long term observation of CML patients after imatinib resistance associated with BCR-ABL mutations
    • Hochhaus A, Ernst T, Erben P, Müller MC, Emig M, Kreil S, et al. Long term observation of CML patients after imatinib resistance associated with BCR-ABL mutations. Blood 2005; 106:1086.
    • (2005) Blood , vol.106 , pp. 1086
    • Hochhaus, A.1    Ernst, T.2    Erben, P.3    Müller, M.C.4    Emig, M.5    Kreil, S.6
  • 67
    • 33746934638 scopus 로고    scopus 로고
    • Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity and substrate utilization, irrespective of sensitivity to imatinib
    • Griswold IJ, MacPartlin M, Bumm T, Goss VL, O'Hare T, Lee KA, et al. Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity and substrate utilization, irrespective of sensitivity to imatinib. Mol Cell Biol 2006; 26:6082-93.
    • (2006) Mol Cell Biol , vol.26 , pp. 6082-6093
    • Griswold, I.J.1    MacPartlin, M.2    Bumm, T.3    Goss, V.L.4    O'Hare, T.5    Lee, K.A.6
  • 68
    • 33845893074 scopus 로고    scopus 로고
    • Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants
    • Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, et al. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci USA 2006; 103:19466-71.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19466-19471
    • Skaggs, B.J.1    Gorre, M.E.2    Ryvkin, A.3    Burgess, M.R.4    Xie, Y.5    Han, Y.6
  • 70
    • 58549088155 scopus 로고    scopus 로고
    • Activity of bosutinib, dasatinib and nilotinib against 18 imatinib-resistant BCR/ABL mutants
    • Redaelli S, Piazza R, Rostagno R, Magistroni V, Perini P, Marega M, et al. Activity of bosutinib, dasatinib and nilotinib against 18 imatinib-resistant BCR/ABL mutants. J Clin Oncol 2009; 27:469-71.
    • (2009) J Clin Oncol , vol.27 , pp. 469-471
    • Redaelli, S.1    Piazza, R.2    Rostagno, R.3    Magistroni, V.4    Perini, P.5    Marega, M.6
  • 71
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825) and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • Bradeen HA, Eide CA, O'Hare T, Johnson KJ, Willis SG, Lee FY, et al. Comparison of imatinib mesylate, dasatinib (BMS-354825) and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood 2006; 108:2332-8.
    • (2006) Blood , vol.108 , pp. 2332-2338
    • Bradeen, H.A.1    Eide, C.A.2    O'Hare, T.3    Johnson, K.J.4    Willis, S.G.5    Lee, F.Y.6
  • 72
    • 33745069351 scopus 로고    scopus 로고
    • Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)
    • von Bubnoff N, Manley PW, Mestan J, Sanger J, Peschel C, Duyster J. Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107). Blood 2006; 108:1328-33.
    • (2006) Blood , vol.108 , pp. 1328-1333
    • Von Bubnoff, N.1    Manley, P.W.2    Mestan, J.3    Sanger, J.4    Peschel, C.5    Duyster, J.6
  • 73
    • 34247506325 scopus 로고    scopus 로고
    • Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study
    • Ray A, Cowan-Jacob SW, Manley PW, Mestan J, Griffin JD. Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study. Blood 2007; 109:5011-5.
    • (2007) Blood , vol.109 , pp. 5011-5015
    • Ray, A.1    Cowan-Jacob, S.W.2    Manley, P.W.3    Mestan, J.4
  • 74
    • 73949105873 scopus 로고    scopus 로고
    • Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations
    • Müller MC, Cortes JE, Kim DW, Druker BJ, Erben P, Pasquini R, et al. Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations. Blood 2009; 114:4944-53.
    • (2009) Blood , vol.114 , pp. 4944-4953
    • Müller, M.C.1    Cortes, J.E.2    Kim, D.W.3    Druker, B.J.4    Erben, P.5    Pasquini, R.6
  • 75
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E, Kantarjian HM, Jones D, Reddy N, O'Brien S, Garcia-Manero G, et al. Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 2008; 112:4839-42.
    • (2008) Blood , vol.112 , pp. 4839-4842
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3    Reddy, N.4    O'Brien, S.5    Garcia-Manero, G.6
  • 76
    • 79551516839 scopus 로고    scopus 로고
    • Response and outcomes to nilotinib at 24 months in imatinib-resistant chronic myeloid leukemia patients in chronic phase (CML-CP) and accelerated phase (CML-AP) with and without BCR-ABL mutations
    • Radich JP, Martinelli G, Hochhaus A, Gottardi E, Soverini S, Branford S, et al. Response and outcomes to nilotinib at 24 months in imatinib-resistant chronic myeloid leukemia patients in chronic phase (CML-CP) and accelerated phase (CML-AP) with and without BCR-ABL mutations. Blood 2009; 114:1130.
    • (2009) Blood , vol.114 , pp. 1130
    • Radich, J.P.1    Martinelli, G.2    Hochhaus, A.3    Gottardi, E.4    Soverini, S.5    Branford, S.6
  • 77
    • 70349245253 scopus 로고    scopus 로고
    • Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations
    • Jabbour E, Jones D, Kantarjian HM, O'Brien S, Tam C, Koller C, et al. Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations. Blood 2009; 114:2037-43.
    • (2009) Blood , vol.114 , pp. 2037-2043
    • Jabbour, E.1    Jones, D.2    Kantarjian, H.M.3    O'Brien, S.4    Tam, C.5    Koller, C.6
  • 78
    • 70249105789 scopus 로고    scopus 로고
    • Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
    • Hughes T, Saglio G, Branford S, Soverini S, Kim DW, Müller MC, et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J Clin Oncol 2009; 27:4204-10.
    • (2009) J Clin Oncol , vol.27 , pp. 4204-4210
    • Hughes, T.1    Saglio, G.2    Branford, S.3    Soverini, S.4    Kim, D.W.5    Müller, M.C.6
  • 79
    • 37049003546 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors
    • Cortes J, Jabbour E, Kantarjian H, Yin CC, Shan J, O'Brien S, et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110:4005-11.
    • (2007) Blood , vol.110 , pp. 4005-4011
    • Cortes, J.1    Jabbour, E.2    Kantarjian, H.3    Yin, C.C.4    Shan, J.5    O'Brien, S.6
  • 80
    • 70349254450 scopus 로고    scopus 로고
    • Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- Or third-line tyrosine kinase inhibitors
    • Soverini S, Gnani A, Colarossi S, Castagnetti F, Abruzzese E, Paolini S, et al. Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors. Blood 2009; 114:2168-71.
    • (2009) Blood , vol.114 , pp. 2168-2171
    • Soverini, S.1    Gnani, A.2    Colarossi, S.3    Castagnetti, F.4    Abruzzese, E.5    Paolini, S.6
  • 81
    • 41349085814 scopus 로고    scopus 로고
    • In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib
    • Khorashad JS, Milojkovic D, Mehta P, Anand M, Ghorashian S, Reid AG, et al. In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib. Blood 2008; 111:2378-81.
    • (2008) Blood , vol.111 , pp. 2378-2381
    • Khorashad, J.S.1    Milojkovic, D.2    Mehta, P.3    Anand, M.4    Ghorashian, S.5    Reid, A.G.6
  • 82
    • 77951648806 scopus 로고    scopus 로고
    • Comparative in vitro cellular data alone are insufficient to predict clinical responses and guide the choice of BCR-ABL inhibitor for treating imatinib-resistant chronic myeloid leukemia
    • Laneuville P, DiLea C, Yin OQ, Woodman RC, Mestan J, Manley PW. Comparative In vitro cellular data alone are insufficient to predict clinical responses and guide the choice of BCR-ABL inhibitor for treating imatinib-resistant chronic myeloid leukemia. J Clin Oncol 2010; 28:169-71.
    • (2010) J Clin Oncol , vol.28 , pp. 169-171
    • Laneuville, P.1    DiLea, C.2    Yin, O.Q.3    Woodman, R.C.4    Mestan, J.5    Manley, P.W.6
  • 83
    • 76249090055 scopus 로고    scopus 로고
    • Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: Does the BCR-ABL mutation status really matter?
    • Branford S, Melo JV, Hughes TP. Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter? Blood 2009; 114:5426-35.
    • (2009) Blood , vol.114 , pp. 5426-5435
    • Branford, S.1    Melo, J.V.2    Hughes, T.P.3
  • 84
    • 67549089898 scopus 로고    scopus 로고
    • Structural modeling of V299L and E459K Bcr-Abl mutation and sequential therapy of tyrosine kinase inhibitors for the compound mutations
    • Kim D, Kim DW, Cho BS, Goh HG, Kim SH, Kim WS, et al. Structural modeling of V299L and E459K Bcr-Abl mutation and sequential therapy of tyrosine kinase inhibitors for the compound mutations. Leuk Res 2009; 33:1260-5.
    • (2009) Leuk Res , vol.33 , pp. 1260-1265
    • Kim, D.1    Kim, D.W.2    Cho, B.S.3    Goh, H.G.4    Kim, S.H.5    Kim, W.S.6
  • 85
    • 45749156841 scopus 로고    scopus 로고
    • Dasatinib treatment can overcome imatinib and nilotinib resistance in CML patient carrying F359I mutation of BCR-ABL oncogene
    • Baranska M, Lewandowski K, Gniot M, Iwola M, Lewandowska M, Komarnicki M. Dasatinib treatment can overcome imatinib and nilotinib resistance in CML patient carrying F359I mutation of BCR-ABL oncogene. J Appl Genet 2008; 49:201-3.
    • (2008) J Appl Genet , vol.49 , pp. 201-203
    • Baranska, M.1    Lewandowski, K.2    Gniot, M.3    Iwola, M.4    Lewandowska, M.5    Komarnicki, M.6
  • 86
    • 79952969114 scopus 로고    scopus 로고
    • Nilotinib lowers the incidence of BCR-ABL mutations and improves the molecular response kinetics compared with imatinib in patients with newly diagnosed chronic myeloid leukemia
    • Hochhaus A, Saglio G, Larson RA, Kim DW, Flinn IW, Goh YT, et al. Nilotinib lowers the incidence of BCR-ABL mutations and improves the molecular response kinetics compared with imatinib in patients with newly diagnosed chronic myeloid leukemia. Blood 2010; 3431.
    • (2010) Blood , vol.3431
    • Hochhaus, A.1    Saglio, G.2    Larson, R.A.3    Kim, D.W.4    Flinn, I.W.5    Goh, Y.T.6
  • 87
    • 77950394312 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the Bcr-Abl T315I mutation-results of an ongoing multicenter phase 2/3 study
    • Cortes-Franco J, Khoury HJ, Nicolini FE, Corm S, Lipton JH, Jones D, et al. Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the Bcr-Abl T315I mutation-results of an ongoing multicenter phase 2/3 study. Blood 2009; 114:644.
    • (2009) Blood , vol.114 , pp. 644
    • Cortes-Franco, J.1    Khoury, H.J.2    Nicolini, F.E.3    Corm, S.4    Lipton, J.H.5    Jones, D.6
  • 88
    • 51649120694 scopus 로고    scopus 로고
    • Therapeutic options against BCR-ABL1 T315I-positive chronic myelogenous leukemia
    • Quintas-Cardama A, Cortes J. Therapeutic options against BCR-ABL1 T315I-positive chronic myelogenous leukemia. Clin Cancer Res 2008; 14:4392-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 4392-4399
    • Quintas-Cardama, A.1    Cortes, J.2
  • 89
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009; 16:401-12.
    • (2009) Cancer Cell , vol.16 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.3    Eide, C.A.4    Rivera, V.M.5    Wang, F.6
  • 90
    • 77949674913 scopus 로고    scopus 로고
    • A phase 1 trial of oral AP24534 in patients with refractory chronic myeloid leukemia and other hematologic malignancies: First results of safety and clinical activity against T315I and resistant mutations
    • Cortes J, Talpaz M, Deininger M, Shah N, Flinn IW, Mauro MJ, et al. A phase 1 trial of oral AP24534 in patients with refractory chronic myeloid leukemia and other hematologic malignancies: first results of safety and clinical activity against T315I and resistant mutations. Blood 2009; 114:643.
    • (2009) Blood , vol.114 , pp. 643
    • Cortes, J.1    Talpaz, M.2    Deininger, M.3    Shah, N.4    Flinn, I.W.5    Mauro, M.J.6
  • 91
    • 43749086323 scopus 로고    scopus 로고
    • SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib
    • O'Hare T, Eide CA, Tyner JW, Corbin AS, Wong MJ, Buchanan S, et al. SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib. Proc Natl Acad Sci USA 2008; 105:5507-12.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5507-5512
    • O'Hare, T.1    Eide, C.A.2    Tyner, J.W.3    Corbin, A.S.4    Wong, M.J.5    Buchanan, S.6
  • 92
    • 31644438945 scopus 로고    scopus 로고
    • Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680
    • Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH, III, et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006; 66:1007-14.
    • (2006) Cancer Res , vol.66 , pp. 1007-1014
    • Young, M.A.1    Shah, N.P.2    Chao, L.H.3    Seeliger, M.4    Milanov, Z.V.5    Biggs III, W.H.6
  • 93
    • 34247615972 scopus 로고    scopus 로고
    • Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680
    • Cheetham GM, Charlton PA, Golec JM, Pollard JR. Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett 2007; 251:323-9.
    • (2007) Cancer Lett , vol.251 , pp. 323-329
    • Cheetham, G.M.1    Charlton, P.A.2    Golec, J.M.3    Pollard, J.R.4
  • 94
    • 33846240316 scopus 로고    scopus 로고
    • MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
    • DOI 10.1182/blood-2006-05-025049
    • Giles FJ, Cortes J, Jones D, Bergstrom D, Kantarjian H, Freedman SJ. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007; 109:500-2. (Pubitemid 46105945)
    • (2007) Blood , vol.109 , Issue.2 , pp. 500-502
    • Giles, F.J.1    Cortes, J.2    Jones, D.3    Bergstrom, D.4    Kantarjian, H.5    Freedman, S.J.6
  • 95
    • 77953216577 scopus 로고    scopus 로고
    • Danusertib (formerly PHA-739358) - A novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor
    • Gontarewicz A, Brummendorf TH. Danusertib (formerly PHA-739358) - a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor. Recent Results Cancer Res 2010; 184:199-214.
    • (2010) Recent Results Cancer Res , vol.184 , pp. 199-214
    • Gontarewicz, A.1    Brummendorf, T.H.2
  • 96
    • 60549088370 scopus 로고    scopus 로고
    • Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity
    • Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, et al. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 2009; 52:379-88.
    • (2009) J Med Chem , vol.52 , pp. 379-388
    • Howard, S.1    Berdini, V.2    Boulstridge, J.A.3    Carr, M.G.4    Cross, D.M.5    Curry, J.6
  • 97
    • 68949138161 scopus 로고    scopus 로고
    • Preliminary clinical activity in a phase I trial of the BCR-ABL/IGF-1R/aurora kinase inhibitor XL228 in patients with Ph+ leukemias with either failure to multiple TKI therapies or with T315I mutation
    • Cortes J, Paquette R, Talpaz M, Pinilla J, Asatiani E, Wetzler M, et al. Preliminary clinical activity in a phase I trial of the BCR-ABL/IGF-1R/aurora kinase inhibitor XL228 in patients with Ph+ leukemias with either failure to multiple TKI therapies or with T315I mutation. Blood 2008; 112:3232.
    • (2008) Blood , vol.112 , pp. 3232
    • Cortes, J.1    Paquette, R.2    Talpaz, M.3    Pinilla, J.4    Asatiani, E.5    Wetzler, M.6
  • 99
    • 77950930479 scopus 로고    scopus 로고
    • ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells
    • Wu J, Meng F, Ying Y, Peng Z, Daniels L, Bornmann WG, et al. ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells. Leukemia 2010; 24:869-72.
    • (2010) Leukemia , vol.24 , pp. 869-872
    • Wu, J.1    Meng, F.2    Ying, Y.3    Peng, Z.4    Daniels, L.5    Bornmann, W.G.6
  • 100
    • 75749146563 scopus 로고    scopus 로고
    • Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
    • Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 2010; 463:501-6.
    • (2010) Nature , vol.463 , pp. 501-506
    • Zhang, J.1    Adrian, F.J.2    Jahnke, W.3    Cowan-Jacob, S.W.4    Li, A.G.5    Iacob, R.E.6
  • 101
    • 68949087742 scopus 로고    scopus 로고
    • Switch pocket inhibitors of the ABL tyrosine kinase: Distinct kinome inhibition profiles and in vivo efficacy in mouse models of CML and B-lymphoblastic leukemia induced by BCR-ABL T315I
    • Van Etten RA, Chan WW, Zaleskas VM, Walz C, Evangelista P, Lazarides K, et al. Switch pocket inhibitors of the ABL tyrosine kinase: distinct kinome inhibition profiles and in vivo efficacy in mouse models of CML and B-lymphoblastic leukemia induced by BCR-ABL T315I. Blood 2008; 112:576.
    • (2008) Blood , vol.112 , pp. 576
    • Van Etten, R.A.1    Chan, W.W.2    Zaleskas, V.M.3    Walz, C.4    Evangelista, P.5    Lazarides, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.