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Volumn 17, Issue 2, 2011, Pages 104-114

Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: A promising model for improving transplantation efficiency with tissue engineering

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; POLY(LEVO LACTIC ACID); POLYMER; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; UREA;

EID: 79551504497     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22200     Document Type: Article
Times cited : (47)

References (56)
  • 1
    • 0025912865 scopus 로고
    • Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation
    • Gupta S, Aragona E, Vemuru RP, Bhargava KK, Burk RD, Chowdhury JR,. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. HEPATOLOGY 1991; 14: 144-149.
    • (1991) HEPATOLOGY , vol.14 , pp. 144-149
    • Gupta, S.1    Aragona, E.2    Vemuru, R.P.3    Bhargava, K.K.4    Burk, R.D.5    Chowdhury, J.R.6
  • 2
    • 0026501424 scopus 로고
    • Hepatocyte transplantation: Back to the future
    • Gupta S, Chowdhary JR,. Hepatocyte transplantation: back to the future. HEPATOLOGY 1992; 15: 156-162.
    • (1992) HEPATOLOGY , vol.15 , pp. 156-162
    • Gupta, S.1    Chowdhary, J.R.2
  • 5
    • 0034529733 scopus 로고    scopus 로고
    • Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation
    • Kobayashi N, Ito M, Nakamura J, Cai J, Hammel JM, Fox IJ,. Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation. Cell Transplant 2000; 9: 671-673.
    • (2000) Cell Transplant , vol.9 , pp. 671-673
    • Kobayashi, N.1    Ito, M.2    Nakamura, J.3    Cai, J.4    Hammel, J.M.5    Fox, I.J.6
  • 7
  • 8
    • 33646452424 scopus 로고    scopus 로고
    • Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation
    • Hughes RD, Mitry RR, Dhawan A, Lehec SC, Girlanda R, Rela M, et al. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation. Liver Transpl 2006; 12: 713-717.
    • (2006) Liver Transpl , vol.12 , pp. 713-717
    • Hughes, R.D.1    Mitry, R.R.2    Dhawan, A.3    Lehec, S.C.4    Girlanda, R.5    Rela, M.6
  • 10
    • 0032471714 scopus 로고    scopus 로고
    • Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels
    • Kim SS, Utsunomiya H, Koski JA, Wu BM, Cima MJ, Sohn J, et al. Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann Surg 1998; 228: 8-13.
    • (1998) Ann Surg , vol.228 , pp. 8-13
    • Kim, S.S.1    Utsunomiya, H.2    Koski, J.A.3    Wu, B.M.4    Cima, M.J.5    Sohn, J.6
  • 13
    • 70349207748 scopus 로고    scopus 로고
    • Human hepatocyte transplantation: State of the art
    • Fitzpatrick E, Mitry RR, Dhawan A,. Human hepatocyte transplantation: state of the art. J Intern Med 2009; 266: 339-357.
    • (2009) J Intern Med , vol.266 , pp. 339-357
    • Fitzpatrick, E.1    Mitry, R.R.2    Dhawan, A.3
  • 14
    • 0037176516 scopus 로고    scopus 로고
    • Hepatocyte transplantation as a treatment for glycogen storage disease type 1a
    • Muraca M, Gerunda G, Neri D, Vilei MT, Granato A, Feltracco P, et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 2002; 359: 317-318.
    • (2002) Lancet , vol.359 , pp. 317-318
    • Muraca, M.1    Gerunda, G.2    Neri, D.3    Vilei, M.T.4    Granato, A.5    Feltracco, P.6
  • 15
    • 0041335271 scopus 로고    scopus 로고
    • Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: Technique, safety, and metabolic follow-up
    • Sokal EM, Smets F, Bourgois A, Van Maldergem L, Buts JP, Reding R, et al. Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up. Transplantation 2003; 76: 735-738.
    • (2003) Transplantation , vol.76 , pp. 735-738
    • Sokal, E.M.1    Smets, F.2    Bourgois, A.3    Van Maldergem, L.4    Buts, J.P.5    Reding, R.6
  • 16
    • 2542531481 scopus 로고    scopus 로고
    • Hepatocyte transplantation
    • Horslen SP, Fox IJ,. Hepatocyte transplantation. Transplantation 2004; 77: 1481-1486.
    • (2004) Transplantation , vol.77 , pp. 1481-1486
    • Horslen, S.P.1    Fox, I.J.2
  • 18
    • 0026355641 scopus 로고
    • Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits
    • Chowdhury JR, Grossman M, Gupta S, Chowdhury NR, Baker JR Jr, Wilson JM,. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 1991; 254: 1802-1805.
    • (1991) Science , vol.254 , pp. 1802-1805
    • Chowdhury, J.R.1    Grossman, M.2    Gupta, S.3    Chowdhury, N.R.4    Baker Jr., J.R.5    Wilson, J.M.6
  • 20
    • 0030022230 scopus 로고    scopus 로고
    • Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia
    • Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ III, Kolansky DM, et al. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann Surg 1996; 223: 116-126.
    • (1996) Ann Surg , vol.223 , pp. 116-126
    • Raper, S.E.1    Grossman, M.2    Rader, D.J.3    Thoene, J.G.4    Clark III, B.J.5    Kolansky, D.M.6
  • 21
    • 0026586140 scopus 로고
    • Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes
    • Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Ponder KP, et al. Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl Acad Sci U S A 1992; 89: 89-93.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 89-93
    • Kay, M.A.1    Baley, P.2    Rothenberg, S.3    Leland, F.4    Fleming, L.5    Ponder, K.P.6
  • 23
    • 0031057947 scopus 로고    scopus 로고
    • The effect of donor and recipient age on engraftment of tissue-engineered liver
    • Cusick RA, Lee H, Sano K, Pollok JM, Utsunomiya H, Ma PX, et al. The effect of donor and recipient age on engraftment of tissue-engineered liver. J Pediatr Surg 1997; 32: 357-360.
    • (1997) J Pediatr Surg , vol.32 , pp. 357-360
    • Cusick, R.A.1    Lee, H.2    Sano, K.3    Pollok, J.M.4    Utsunomiya, H.5    Ma, P.X.6
  • 24
    • 0031573495 scopus 로고    scopus 로고
    • Long-term differentiated function of heterotopically transplanted hepatocytes on three-dimensional polymer matrices
    • Kneser U, Kaufmann PM, Fiegel HC, Pollok JM, Kluth D, Herbst H, Rogiers X,. Long-term differentiated function of heterotopically transplanted hepatocytes on three-dimensional polymer matrices. J Biomed Mater Res 1999; 47: 494-503.
    • (1999) J Biomed Mater Res , vol.47 , pp. 494-503
    • Kneser, U.1    Kaufmann, P.M.2    Fiegel, H.C.3    Pollok, J.M.4    Kluth, D.5    Herbst, H.6    Rogiers, X.7
  • 25
    • 0031697599 scopus 로고    scopus 로고
    • Formation of spheroidal aggregates of hepatocytes on biodegradable polymers under continuous-flow bioreactor conditions
    • Pollok JM, Kluth D, Cusick RA, Lee H, Utsunomiya H, Ma PX, et al. Formation of spheroidal aggregates of hepatocytes on biodegradable polymers under continuous-flow bioreactor conditions. Eur J Pediatr Surg 1998; 8: 195-199.
    • (1998) Eur J Pediatr Surg , vol.8 , pp. 195-199
    • Pollok, J.M.1    Kluth, D.2    Cusick, R.A.3    Lee, H.4    Utsunomiya, H.5    Ma, P.X.6
  • 26
    • 17844395194 scopus 로고    scopus 로고
    • Hepatic tissue engineering on 3-dimensional biodegradable polymers within a pulsatile flow bioreactor
    • Torok E, Pollok JM, Ma PX, Vogel C, Dandri M, Petersen J, et al. Hepatic tissue engineering on 3-dimensional biodegradable polymers within a pulsatile flow bioreactor. Dig Surg 2001; 18: 196-203.
    • (2001) Dig Surg , vol.18 , pp. 196-203
    • Torok, E.1    Pollok, J.M.2    Ma, P.X.3    Vogel, C.4    Dandri, M.5    Petersen, J.6
  • 27
    • 17744382574 scopus 로고    scopus 로고
    • Optimization of hepatocyte spheroid formation for hepatic tissue engineering on three-dimensional biodegradable polymer within a flow bioreactor prior to implantation
    • Torok E, Pollok JM, Ma PX, Kaufmann PM, Dandri M, Petersen J, et al. Optimization of hepatocyte spheroid formation for hepatic tissue engineering on three-dimensional biodegradable polymer within a flow bioreactor prior to implantation. Cells Tissues Organs 2001; 169: 34-41.
    • (2001) Cells Tissues Organs , vol.169 , pp. 34-41
    • Torok, E.1    Pollok, J.M.2    Ma, P.X.3    Kaufmann, P.M.4    Dandri, M.5    Petersen, J.6
  • 28
    • 33746700168 scopus 로고    scopus 로고
    • Morphological and functional analysis of rat hepatocyte spheroids generated on poly(l-lactic acid) polymer in a pulsatile flow bioreactor
    • Torok E, Vogel C, Lutgehetmann M, Ma PX, Dandri M, Petersen J, et al. Morphological and functional analysis of rat hepatocyte spheroids generated on poly(l-lactic acid) polymer in a pulsatile flow bioreactor. Tissue Eng 2006; 12: 1881-1890.
    • (2006) Tissue Eng , vol.12 , pp. 1881-1890
    • Torok, E.1    Vogel, C.2    Lutgehetmann, M.3    Ma, P.X.4    Dandri, M.5    Petersen, J.6
  • 29
    • 0033080604 scopus 로고    scopus 로고
    • Morphology and mechanical function of long-term in vitro engineered cartilage
    • Ma PX, Langer R,. Morphology and mechanical function of long-term in vitro engineered cartilage. J Biomed Mater Res 1999; 44: 217-221.
    • (1999) J Biomed Mater Res , vol.44 , pp. 217-221
    • Ma, P.X.1    Langer, R.2
  • 30
    • 0033057074 scopus 로고    scopus 로고
    • Interference of soluble mediators into liver matrix triggered dedifferentiation of human hepatocytes
    • Blaheta RA, Kronenberger B, Woitaschek D, Schick C, Oppermann E, Auth MK, et al. Interference of soluble mediators into liver matrix triggered dedifferentiation of human hepatocytes. Transplant Proc 1999; 31: 502-504.
    • (1999) Transplant Proc , vol.31 , pp. 502-504
    • Blaheta, R.A.1    Kronenberger, B.2    Woitaschek, D.3    Schick, C.4    Oppermann, E.5    Auth, M.K.6
  • 31
    • 0028939143 scopus 로고
    • Effects of proinflammatory cytokines on cultivated primary human hepatocytes. Fluorometric measurement of intercellular adhesion molecule-1 and human leukocyte antigen-A, -B, -C, and -DR expression
    • Schroder AJ, Blaheta RA, Scholz M, Kronenberger B, Encke A, Markus BH,. Effects of proinflammatory cytokines on cultivated primary human hepatocytes. Fluorometric measurement of intercellular adhesion molecule-1 and human leukocyte antigen-A, -B, -C, and -DR expression. Transplantation 1995; 59: 1023-1028.
    • (1995) Transplantation , vol.59 , pp. 1023-1028
    • Schroder, A.J.1    Blaheta, R.A.2    Scholz, M.3    Kronenberger, B.4    Encke, A.5    Markus, B.H.6
  • 33
    • 0026506025 scopus 로고
    • Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia
    • Asonuma K, Gilbert JC, Stein JE, Takeda T, Vacanti JP,. Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia. J Pediatr Surg 1992; 27: 298-301.
    • (1992) J Pediatr Surg , vol.27 , pp. 298-301
    • Asonuma, K.1    Gilbert, J.C.2    Stein, J.E.3    Takeda, T.4    Vacanti, J.P.5
  • 34
    • 0026874277 scopus 로고
    • Cell transplantation as replacement therapy for the future
    • Asonuma K, Vacanti JP,. Cell transplantation as replacement therapy for the future. Crit Care Nurs Clin North Am 1992; 4: 249-254.
    • (1992) Crit Care Nurs Clin North Am , vol.4 , pp. 249-254
    • Asonuma, K.1    Vacanti, J.P.2
  • 35
    • 0034529712 scopus 로고    scopus 로고
    • Long-term culture of glutamine synthetase-transfected HepG2 cells in circulatory flow bioreactor for development of a bioartificial liver
    • Enosawa S, Miyashita T, Suzuki S, Li XK, Tsunoda M, Amemiya H, et al. Long-term culture of glutamine synthetase-transfected HepG2 cells in circulatory flow bioreactor for development of a bioartificial liver. Cell Transplant 2000; 9: 711-715.
    • (2000) Cell Transplant , vol.9 , pp. 711-715
    • Enosawa, S.1    Miyashita, T.2    Suzuki, S.3    Li, X.K.4    Tsunoda, M.5    Amemiya, H.6
  • 36
    • 0037241895 scopus 로고    scopus 로고
    • Efficacy of a polyurethane foam/spheroid artificial liver by using human hepatoblastoma cell line (Hep G2)
    • Fukuda J, Okamura K, Nakazawa K, Ijima H, Yamashita Y, Shimada M, et al. Efficacy of a polyurethane foam/spheroid artificial liver by using human hepatoblastoma cell line (Hep G2). Cell Transplant 2003; 12: 51-58.
    • (2003) Cell Transplant , vol.12 , pp. 51-58
    • Fukuda, J.1    Okamura, K.2    Nakazawa, K.3    Ijima, H.4    Yamashita, Y.5    Shimada, M.6
  • 38
    • 0037241894 scopus 로고    scopus 로고
    • Hepatocyte transplantation in the treatment of acute liver failure: Microencapsulated hepatocytes versus hepatocytes attached to an autologous biomatrix
    • Ambrosino G, Varotto S, Basso SM, Cecchetto A, Carraro P, Naso A, et al. Hepatocyte transplantation in the treatment of acute liver failure: microencapsulated hepatocytes versus hepatocytes attached to an autologous biomatrix. Cell Transplant 2003; 12: 43-49.
    • (2003) Cell Transplant , vol.12 , pp. 43-49
    • Ambrosino, G.1    Varotto, S.2    Basso, S.M.3    Cecchetto, A.4    Carraro, P.5    Naso, A.6
  • 40
    • 0035696442 scopus 로고    scopus 로고
    • The effect of coculture with nonparenchymal cells on porcine hepatocyte function
    • Gregory PG, Connolly CK, Gillis BE, Sullivan SJ,. The effect of coculture with nonparenchymal cells on porcine hepatocyte function. Cell Transplant 2001; 10: 731-738.
    • (2001) Cell Transplant , vol.10 , pp. 731-738
    • Gregory, P.G.1    Connolly, C.K.2    Gillis, B.E.3    Sullivan, S.J.4
  • 41
    • 0036920129 scopus 로고    scopus 로고
    • Progress in human hepatocytes: Isolation, culture & cryopreservation
    • Mitry RR, Hughes RD, Dhawan A,. Progress in human hepatocytes: isolation, culture & cryopreservation. Semin Cell Dev Biol 2002; 13: 463-467.
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 463-467
    • Mitry, R.R.1    Hughes, R.D.2    Dhawan, A.3
  • 42
    • 0026769067 scopus 로고
    • Switching from differentiation to growth in hepatocytes: Control by extracellular matrix
    • Mooney D, Hansen L, Vacanti J, Langer R, Farmer S, Ingber D,. Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Physiol 1992; 151: 497-505.
    • (1992) J Cell Physiol , vol.151 , pp. 497-505
    • Mooney, D.1    Hansen, L.2    Vacanti, J.3    Langer, R.4    Farmer, S.5    Ingber, D.6
  • 43
    • 0028076807 scopus 로고
    • Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth
    • Hansen LK, Mooney DJ, Vacanti JP, Ingber DE,. Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Cell 1994; 5: 967-975.
    • (1994) Mol Biol Cell , vol.5 , pp. 967-975
    • Hansen, L.K.1    Mooney, D.J.2    Vacanti, J.P.3    Ingber, D.E.4
  • 44
    • 0032796902 scopus 로고    scopus 로고
    • Influence of pancreatic islets on growth and differentiation of hepatocytes in co-culture
    • Kaufmann PM, Fiegel HC, Kneser U, Pollok JM, Kluth D, Rogiers X,. Influence of pancreatic islets on growth and differentiation of hepatocytes in co-culture. Tissue Eng 1999; 5: 583-596.
    • (1999) Tissue Eng , vol.5 , pp. 583-596
    • Kaufmann, P.M.1    Fiegel, H.C.2    Kneser, U.3    Pollok, J.M.4    Kluth, D.5    Rogiers, X.6
  • 45
    • 0029928703 scopus 로고    scopus 로고
    • Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium
    • Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, et al. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 1996; 132: 1133-1149.
    • (1996) J Cell Biol , vol.132 , pp. 1133-1149
    • Block, G.D.1    Locker, J.2    Bowen, W.C.3    Petersen, B.E.4    Katyal, S.5    Strom, S.C.6
  • 47
    • 34247505574 scopus 로고    scopus 로고
    • Human hepatocytes: Isolation, cryopreservation and applications in drug development
    • Li AP,. Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem Biol Interact 2007; 168: 16-29.
    • (2007) Chem Biol Interact , vol.168 , pp. 16-29
    • Li, A.P.1
  • 48
    • 0242355262 scopus 로고    scopus 로고
    • Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes
    • Ostrowska A, Bode DC, Pruss J, Bilir B, Smith GD, Zeisloft S,. Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes. Cell Tissue Bank 2000; 1: 55-68.
    • (2000) Cell Tissue Bank , vol.1 , pp. 55-68
    • Ostrowska, A.1    Bode, D.C.2    Pruss, J.3    Bilir, B.4    Smith, G.D.5    Zeisloft, S.6
  • 49
    • 2542637875 scopus 로고    scopus 로고
    • One liver, three recipients: Segment IV from split-liver procedures as a source of hepatocytes for cell transplantation
    • Mitry RR, Dhawan A, Hughes RD, Bansal S, Lehec S, Terry C, et al. One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation. Transplantation 2004; 77: 1614-1616.
    • (2004) Transplantation , vol.77 , pp. 1614-1616
    • Mitry, R.R.1    Dhawan, A.2    Hughes, R.D.3    Bansal, S.4    Lehec, S.5    Terry, C.6
  • 50
    • 29744446670 scopus 로고    scopus 로고
    • Primary human hepatocytes in spheroid formation to study hepatitis C infection
    • Chong TW, Smith RL, Hughes MG, Camden J, Rudy CK, Evans HL, et al. Primary human hepatocytes in spheroid formation to study hepatitis C infection. J Surg Res 2006; 130: 52-57.
    • (2006) J Surg Res , vol.130 , pp. 52-57
    • Chong, T.W.1    Smith, R.L.2    Hughes, M.G.3    Camden, J.4    Rudy, C.K.5    Evans, H.L.6
  • 51
    • 33745766692 scopus 로고    scopus 로고
    • Enhancing the drug metabolism activities of C3A - A human hepatocyte cell line - By tissue engineering within alginate scaffolds
    • Elkayam T, Amitay-Shaprut S, Dvir-Ginzberg M, Harel T, Cohen S,. Enhancing the drug metabolism activities of C3A - a human hepatocyte cell line - by tissue engineering within alginate scaffolds. Tissue Eng 2006; 12: 1357-1368.
    • (2006) Tissue Eng , vol.12 , pp. 1357-1368
    • Elkayam, T.1    Amitay-Shaprut, S.2    Dvir-Ginzberg, M.3    Harel, T.4    Cohen, S.5
  • 52
    • 33746772098 scopus 로고    scopus 로고
    • Growth and metabolism of human hepatocytes on biomodified collagen poly(lactic-co-glycolic acid) three-dimensional scaffold
    • Li J, Li L, Yu H, Cao H, Gao C, Gong Y,. Growth and metabolism of human hepatocytes on biomodified collagen poly(lactic-co-glycolic acid) three-dimensional scaffold. ASAIO J 2006; 52: 321-327.
    • (2006) ASAIO J , vol.52 , pp. 321-327
    • Li, J.1    Li, L.2    Yu, H.3    Cao, H.4    Gao, C.5    Gong, Y.6
  • 54
    • 0043175185 scopus 로고    scopus 로고
    • Hydrogel-coated textile scaffolds as candidate in liver tissue engineering: II. Evaluation of spheroid formation and viability of hepatocytes
    • Risbud MV, Karamuk E, Schlosser V, Mayer J,. Hydrogel-coated textile scaffolds as candidate in liver tissue engineering: II. Evaluation of spheroid formation and viability of hepatocytes. J Biomater Sci Polym Ed 2003; 14: 719-731.
    • (2003) J Biomater Sci Polym Ed , vol.14 , pp. 719-731
    • Risbud, M.V.1    Karamuk, E.2    Schlosser, V.3    Mayer, J.4
  • 56
    • 33749838238 scopus 로고    scopus 로고
    • Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements
    • Sohlenius-Sternbeck AK,. Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro 2006; 20: 1582-1586.
    • (2006) Toxicol in Vitro , vol.20 , pp. 1582-1586
    • Sohlenius-Sternbeck, A.K.1


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