Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1155-1161

  Pérez Faginas, Paula ^a   Aranda, M Teresa ^a   García López, M Teresa ^a   Snoeck, Robert ^b   Andrei, Graciela ^b   Balzarini, Jan ^b   González Muñiz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Turn conformation; Antiviral agents; Azetidine containing peptides; Cytomegalovirus; Solid phase synthesis

Indexed keywords

2 BENZYL 1 (9 FLUORENYLMETHOXY)CARBONYL 2 CARBOXYAZETIDINE; 2 BENZYL 1 BENZYLOXYCARBONYL 2 ((1' CARBAMOYL 3' METHYL)BUTYL)CARBAMOYLAZETIDINE; 2 BENZYL 1 BENZYLOXYCARBONYL 2 ((1' CARBAMOYL)ETHYL) CARBAMOYLAZETIDINE; 2 BENZYL 1 BENZYLOXYCARBONYL 2 ((1' ISOBUTYLCARBA MOYL)ETHYL)CARBAMOYLAZETIDINE; 2 BENZYL 1 BENZYLOXYCARBONYL 2 ((1' TERTBUTYLCARBA MOYL)ETHYL)CARBAMOYLAZETIDINE; 2 BENZYL 1 BENZYLOXYCARBONYL 2 (1' CARBAMOYL 2' METHYL)PROPYL)CARBAMOYLAZETIDINE; 2 BENZYL 2 ((1' CARBAMOYL)ETHYL)CARBAMOYL 1 (2 NAPHTYL) SULFONYLAZETIDINE; 2 BENZYL 2 ((1' CARBAMOYL)ETHYL)CARBAMOYL 1 PHENETYL CARBONYLAZETIDINE; 2 BENZYL 2 ((1' CARBAMOYL)ETHYL)CARBAMOYL 1(1 NAPHTHYLOXY)CARBONYLAZETIDINE; 2 BENZYL 2 ((1'' CARBAMOYL)ETHYL)CARBAMOYL 1 ((1' PHENYL)ETHYL)CARBAMOYLAZETIDINE; AZETIDINE DERIVATIVE; DIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CYTOSTASIS; DRUG SYNTHESIS; HUMAN CYTOMEGALOVIRUS; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; AZETIDINES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DIPEPTIDES; HUMANS; MAGNETIC RESONANCE IMAGING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

CYTOMEGALOVIRUS;

EID: 79551495636     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.052     Document Type: Article

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