Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 24, 2003, Pages 4511-4513

  McGuigan, Christopher ^a   Brancale, Andrea ^a   Andrei, Graciela ^b   Snoeck, Robert ^b   De Clercq, Erik ^b   Balzarini, Jan ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 6 [9 (BUTOXY)NONYL] 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; ANTIVIRUS AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN CYTOMEGALOVIRUS; NONHUMAN; VARICELLA ZOSTER VIRUS; VIRUS INHIBITION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 5;

EID: 0345358454     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.028     Document Type: Article

References (10)

1. McGuigan C., Yarnold C.J., Jones G., Velázquez S., Barucki H., Brancale A., Andrei G., Snoeck R., De Clercq E., Balzarini J. J. Med. Chem. 42:1999;4479.
2. McGuigan C., Barucki H., Brancale A., Blewett S., Carangio A., Jones G., Pathirana R., Srinivasan S., Velázquez S., Yarnold C.J., Alvarez R., Andrei G., Snoeck R., De Clercq E., Balzarini J. Drugs Future. 25:2000;1151.
3. Brancale A., McGuigan C., Andrei G., Snoeck R., De Clercq E., Balzarini J. Bioorg. Med. Chem. Lett. 10:2000;1215.
4. Srinivasan S., McGuigan C., Andrei G., Snoeck R., De Clercq E., Balzarini J. Bioorg. Med. Chem. Lett. 11:2001;391.
5. McGuigan C., Barucki H., Blewett S., Carangio A., Erichsen J.T., Andrei G., Snoeck R., De Clercq E., Balzarini J. J. Med. Chem. 43:2000;4993.
6. Brancale A., Srinivasan S., McGuigan C., Andrei G., Snoeck R., De Clercq E., Balzarini J. Antivir. Chem. Chemother. 11:2000;383.
7. 6Na requires 473.2628).
8. 50 is the compound concentration required to inhibit HEL cell proliferation by 50%. For full details, see: Andrei G., Snoeck R., Reymen D., Liesnard C., Goubau P., Desmyter J., De Clercq E. Eur. J. Clin. Microbiol. Infect. Dis. 14:1995;318.
9. Sienaert R., Naesens L., Brancale A., De Clercq E., McGuigan C., Balzarini J. Mol. Pharmacol. 61:2002;249.
10. For full details of the HCMV assay see: Snoeck R., Andrei G., Bodaghi B., Lagneaux L., Daelemans D., de Clercq E., Neyts J., Schols D., Naesens L., Michelson S., Bron D., Otto M.J., Bousseau A., Nemecek C., Roy C. Antiviral Res. 55:2002;413.