Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 449-452

  Pinto, Ivan L ^a   Jarvest, Richard L ^a   Clarke, Brian ^a   Dabrowski, Christine E ^a   Fenwick, Ashley ^a   Gorczyca, Michele M ^a   Jennings, L John ^a   Lavery, Patrick ^a   Sternberg, Edmund J ^a   Tew, David G ^a   West, Andrew ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENEDIONE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; THIENO[2,3 D]OXAZINONE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ALKYLATION; ARTICLE; CYTOMEGALOVIRUS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

ACYLATION; ALKYLATION; CELL SURVIVAL; MODELS, MOLECULAR; OXAZINES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0033535103     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00005-0     Document Type: Article

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