Evaluation on hepatotoxicity caused by Dioscorea bulbifera based on analysis of bile acids

Yaoxue Xuebao

Volumn 46, Issue 1, 2011, Pages 39-44

  Xu, Ying ^a   Chen, Chong Chong ^a   Yang, Li ^a,b   Wang, Jun Ming ^a   Ji, Li Li ^a,b   Wang, Zheng Tao ^a,b   Hu, Zhi Bi ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

Bile acid; Correlation analysis; Diosbulbin B; Dioscorea bulbifera L.; Partial least square discriminant analysis; Principle components analysis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; CHOLIC ACID; DIOSCOREA BULBIFERA EXTRACT; GLYCINE DERIVATIVE; PLANT EXTRACT; TAURINE DERIVATIVE; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; LIVER INJURY; LIVER TOXICITY; MOUSE; NONHUMAN; QUADRUPOLE MASS SPECTROMETRY; STATISTICAL ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; YAM;

ANIMALS; BILE ACIDS AND SALTS; CHOLIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOSCOREA; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; LEAST-SQUARES ANALYSIS; MALE; MICE; MICE, INBRED ICR; PLANTS, MEDICINAL; PRINCIPAL COMPONENT ANALYSIS; RHIZOME; TANDEM MASS SPECTROMETRY; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID;

EID: 79551486549     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Shi JM. Pharmacognostical study of Rhizoma Dioscoreae bulbifera [J]. Guiding J Tradit Chin Med Pharm, 2008, 14: 78-81.
2. Li YJ, Liu SM, Luo MM, et al. The express and principle study of liver toxicity of Dioscorea bulbifera L. [J]. Chin J Exp Tradit Med Formulae, 2005, 11: 40-42.
3. Zhu FL, Jia L. Research progress of Rhizoma dioscoreae bulbiferae [J]. Lishizhen Med Mater Med Res, 2006, 1: 851-853.
4. Du LX, Luo MM, Liu SM. Current toxicological research progress of Rhizoma Dioscorea bulbifera [J]. J Liaoning Univ Tradit Chin Med, 2007, 9: 71-72.
5. Wang JM, Ji LL, Liu H, et al. Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice [J]. Biosci Trends, 2010, 4: 79-85.
6. 4- and r-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry [J]. Chem Res Toxicol, 2008, 21: 2280-2288.
7. Hofmann AF. The continuing importance of bile acids in liver and intestinal disease [J]. Arch Intern Med, 1999, 159: 2647-2658.
8. Jaeschke H, Gores GJ, Cederbaum AI, et al. Mechanisms of hepatotoxicity [J]. Toxicol Sci, 2002, 65: 166-176.
9. Nunes de Paiva MJ, Pereira Bastos de Siqueira ME. Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops [J]. Biomarkers, 2005, 10: 456-463.
10. Zhang XY, Yang J, Yin XF, et al. Hepatobiliary transport of glutathione and its role in cholestasis [J]. Acta Pharm Sin, 2009, 44: 327-332.
11. Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology and therapeutics [J]. Cell Mol Life Sci, 2008, 65: 2461-2483.
12. Tan XQ, Ruan JL, Chen HS, et al. Study on anti-inflammatory constituents of Dioscorea bulbifera L. [J]. Acad J Second Mil Med Univ, 2003, 24: 677-679.
13. Luo X, Bi KS, Wang X, et al. Quality assessment of the Chinese traditional medicine by chemical pattern recognition [J]. Acta Pharm Sin, 1993, 28: 936-940.
14. Liu CX. Difficulty and hot-points on pharmacokinetics studies of traditional Chinese medicine [J]. Acta Pharm Sin, 2005, 40: 395-401.