Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice

BioScience Trends

Volumn 4, Issue 2, 2010, Pages 79-85

  Wang, Junming ^a   Ji, Lili ^a,b   Liu, Hai ^a   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

D. Bulbifera; EtOAc fraction; Hepatotoxicity; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBOXYMETHYLCELLULOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; PLANT EXTRACT; SUPEROXIDE DISMUTASE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DOSE RESPONSE; LIPID PEROXIDATION; METABOLISM; MOUSE; PHYSIOLOGY; RHIZOME; TOXIC HEPATITIS; YAM;

ALANINE TRANSAMINASE; ANALYSIS OF VARIANCE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBOXYMETHYLCELLULOSE; DIOSCOREA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MICE; PLANT EXTRACTS; RHIZOME; SUPEROXIDE DISMUTASE;

EID: 77956896340     PISSN: 18817815     EISSN: 18817823     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Gao H, Kuroyanagi M, Wu L, Kawahara N, Yasuno T, Nakamura Y. Antitumor-promoting constituents from Dioscorea bulbifera L. in JB6 mouse epidermal cells. Biol Pharm Bull. 2002; 25:1241-1243.
2. Murray RDH, Jorge Z, Khan NH, Shahjahan M, Quaisuddin M. Diosbulbin D and 8-epidiosbulbin E acetate, norclerodane diterpenoids from Dioscorea bulbifera tubers. Phytochemistry. 1984; 23:623-625.
3. Su L, Zhu JH, Cheng LB. Experimental pathological study of subacute intoxication by Dioscorea bulbifera L. Fa Yi Xue Za Zhi. 2003; 19:81-83. (in Chinese)
4. Tan XQ, Ruan JL, Chen HS, Wang JY. Studies on livertoxicity in rhizome of Dioscorea bulbifera. Zhongguo Zhong Yao Za Zhi. 2003; 28:661-663. (in Chinese)
5. Chen YH, Lin FY, Liu PL, Huang YT, Chiu JH, Chang YC, Man KM, Hong CY, Ho YY, Lai MT. Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats. Arch Pharm Res. 2009; 32:221-228.
6. dos Santos NA, Martins NM, Curti C, Pires Bianchi Mde L, dos Santos AC. Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chem Biol Interact. 2007; 170:177-186.
7. Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res. 2009; 42:93-98.
8. Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Suyasunanont D, Klaikeaw N. Curcumin decreased oxidative stress, inhibited NF-kappa B activation, and improved liver pathology in ethanol-induced liver injury in rats. J Biomed Biotechnol. 2009; 2009:981963.
9. Uraz S, Tahan V, Aygun C, Eren F, Unluguzel G, Yuksel M, Senturk O, Avsar E, Haklar G, Celikel C, Hulagu S, Tozun N. Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci. 2008; 53:1071-1077.
10. van der Vliet A, O'Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S. Determination of lowmolecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol. 1999; 276:289-296.
11. Obici S, Otobone FJ, Silva Sela VR, Ishida K, Silva JC, Nakamura CV, Garcia Cortez DA, Audi EA. Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats. J Ethnopharm. 2008; 115:131-139.
12. Kamei T, Asano K, Nakamura S. Determination of serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase by using L-glutamate oxidase. Chem Pharm Bull. 1986; 34:409-412.
13. Hogberg J, Larson RE, Kristoferson A, Orrenius S. NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity. Biochem Biophys Res Commun. 1974; 56:836-842.
14. Oh IS, Kim TW, Ahn JH, Keum JW, Choi CY, Kim DM. Use of L-buthionine sulfoximine for the efficient expression of disulfide-containing proteins in cell-free extracts of Escberibia coli. Biotechnol Bioprocess Eng. 2007; 12:574-578.
15. Aebi H. Catalse in vitro. Methods Enzymol. 1984; 105:121-126.
16. Marklund SL, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974; 47:469-474.
17. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973; 179:588-590.
18. Habig WH, Jakoby WB. Assay for differentiation of glutathione S-transferases. Methods Enzymol. 1981; 77:398-405.
19. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol. 1985; 113:484-490.
20. Zheng SZ, Fu YM, Chen AP. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation, Free Radic Biol Med. 2007; 43:444-453.
21. Hassan L, Bueno P, Ferrón-Celma I, Ramia JM, Garrote D, Muffak K, García-Navarro A, Mansilla A, Villar JM, Ferrón JA. Time course of antioxidant enzyme activities in liver transplant recipients. Transplant Proc. 2005; 37:3932-3935.
22. Kozer E, Evans S, Barr J, Greenberg R, Soriano I, Bulkowstein M, Petrov I, Chen-Levi Z, Barzilay B, Berkovitch M. Glutathione, glutathione-dependent enzymes and antioxidant status in erythrocytes from children treated with high-dose paracetamol. Br J Clin Pharmacol. 2003; 55:234-240.
23. Liang QN, Liu TY, Ji LL, Min Y, Xia YY. Pyrrolizidine alkaloid clivorine-induced oxidative stress injury in human normal liver L-02 cells. Drug Discov Ther. 2009; 3:247-251.
24. Dadkhah A, Fatemi F, Kazemnejad S, Rasmi Y, Ashrafi-Helan J, Allameh A. Differential effects of acetaminophen on enzymatic and non-enzymatic antioxidant factors and plasma total antioxidant capacity in developing and adult rats. Mol Cell Biochem. 2006; 281:145-152.
25. Limón-Pacheco J, Gonsebatt ME. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res. 2009; 674:137-147.
26. Łuczaj W, Skrzydlewska E. Antioxidant properties of black tea in alcohol intoxication. Food Chem Toxicol. 2004; 42:2045-2051.
27. Yuan GJ, Ma JC, Gong ZJ, Sun XM, Zheng SH, Li X. Modulation of liver oxidant-antioxidant system by ischemic preconditioning during ischemia/ reperfusion injury in rats. World J Gastroenterol. 2005; 11:1825-1828.
28. Romero FJ, Bosch-Morell F, Romero MJ, Jareño EJ, Romero B, Marín N, Romá J. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect. 1998; 106:1229-1234.
29. Yilmaz HR, Turkoz Y, Yuksel E, Orun I. An investigation of antioxidant enzymes activities in liver of Cyprinus carpio taken from different stations in the Karakaya Dam Lake. Int J Sci Technol. 2006; 1:1-6.
30. Carbonell LF, Nadal JA, Llanos MC, Hernández I, Nava E, Díaz J. Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model. Crit Care Med. 2000; 28:2002-2006.
31. Han D, Hanawa N, Saberi B, Kaplowitz N. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006; 291:G1-G7.
32. Ansaldo M, Luquet CM, Evelson PA, Polo JM, Llesuy S. Antioxidant levels from different antarctic fish caught around South Georgia Island and Shag Rocks. Polar Biol. 2000; 23:160-165.