DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups

Diabetes

Volumn 53, Issue 8, 2004, Pages 2158-2163

  Cruz, Thomas D ^a   Valdes, Ana M ^a   Santiago, Alma ^b   Frazer De Llado, Teresa ^c   Raffel, Leslie J ^d   Zeidler, Adina ^e   Rotter, Jerome I ^d   Erlich, Henry A ^f   Rewers, Marian ^g   Bugawan, Teodorica ^f   Noble, Janelle A ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b Pontifical Catholic University of Puerto Rico   (Puerto Rico)

^c PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f ROCHE MOLECULAR SYSTEMS   (United States)

^g UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN;

ALLELE; ARTICLE; CONTROLLED STUDY; ETHNIC GROUP; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIGH RISK POPULATION; HISPANIC; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PUERTO RICAN; PUERTO RICO;

CALIFORNIA; COLORADO; DIABETES MELLITUS, TYPE 1; ETHNIC GROUPS; GENETIC PREDISPOSITION TO DISEASE; HISPANIC AMERICANS; HLA-D ANTIGENS; HLA-DP ANTIGENS; HUMANS; MEXICAN AMERICANS; PUERTO RICO;

EID: 3242750623     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.8.2158     Document Type: Article

References (22)

1. Tisch R, McDevitt H: Insulin-dependent diabetes mellitus. Cell 85:291-297, 1996
2. Pociot F, McDermott MF: Genetics of type 1 diabetes mellitus. Genes Immun 3:235-249, 2002
3. Raffel LJ, Rotter JI: Type 1 diabetes mellitus. In Genetic Basis of Common Diseases. 2nd ed. King RA, Rotter JI, Motulsky AG, Eds. New York, Oxford University Press, 2002, p. 431-456
4. Rotter JI, Landaw EM: Measuring the genetic contribution of a single locus to a multilocus disease. Clin Genet 26:529-542, 1984
5. Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA: The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 59:1134-1148, 1996
6. Noble JA, Valdes AM, Bugawan TL, Apple RJ, Thomson G, Erlich HA: The HLA class I A locus affects susceptibility to type 1 diabetes. Hum Immunol 63:657-664, 2002
7. Erlich HA, Rotter JI, Chang JD, Shaw SD, Raffel LJ, Klitz W, Bugawan TL, Zeidler A: Association of HLA-DPB1ß0301 with insulin dependent diabetes mellitus in Mexican-Americans. Diabetes 45:610-614, 1996
8. Bugawan TL, Klitz W, Alejandrino M, Ching J, Panelo A, Solfelix CM, Petrone A, Buzzetti R, Pozzilli P, Erlich HA: The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. Tissue Antigens 59:452-469, 2002
9. Balducci-Silano PL, Layrisse ZE: HLA-DP and susceptibility to insulin-dependent diabetes mellitus in an ethnically mixed population: associations with other HLA-alleles. J Autoimmun 8:425-437, 1995
10. Noble JA, Valdes AM, Thomson G, Erlich HA: The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Diabetes 49:121-125, 2000
11. Cucca F, Dudbridge F, Loddo M, Mulargia AP, Lampis R, Angius E, De Virgiliis S, Koeleman BP, Bain SC, Barnett AH, Gilchrist F, Cordell H, Welsh K, Todd JA: The HLA-DPB1-associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. Diabetes 50:1200-1205, 2001
12. Johansson S, Lie BA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Thorsby E, Undlien DE: HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes. Tissue Antigens 61:344-351, 2003
13. Lie BA, Akselsen HE, Joner G, Dahl-Jorgensen K, Ronningen KS, Thorsby E, Undlien DE: HLA associations in insulin-dependent diabetes mellitus: no independent association to particular DP genes. Hum Immunol 55: 170-175, 1997
14. Thomson G: HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet 36:1309-1317, 1984
15. Vadheim CM, Zeidler A, Rotter JI, Langbaum M, Shulman IA, Spencer MR, Costin G, Riley WJ, Maclaren NK: Different HLA haplotypes in Mexican Americans with IDDM. Diabetes Care 12:497-500, 1989
16. Erlich HA, Zeidler A, Chang J, Shaw S, Raffel LJ, Klitz W, Beshkov Y, Costin G, Pressman S, Bugawan T, et al.: HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat Genet 3:358-364, 1993
17. WHO Diamond Project Group: WHO multinational project for childhood diabetes. Diabetes Care 13:1062-1068, 1990
18. Frazer de Llado TE, Gonzalez de Pijem L, Hawk B: Incidence of IDDM in children living in Puerto Rico: Puerto Rican IDDM Coalition. Diabetes Care 21:744-746, 1998
19. Rewers M, Bugawan TL, Norris JM, Blair A, Beaty B, Hoffman M, McDuffie RS Jr, Hamman RF, Klingensmith G, Eisenbarth GS, Erlich HA: Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia 39:807-812, 1996
20. Bugawan TL, Apple R, Erlich HA: A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes. Tissue Antigens 44:137-147, 1994
21. Steiner LL, McCurdy DK, Cavalli A, Moonsamy PV, Begovich AB: Two new DPB1 alleles identified in a study of the genetics of susceptibility to pauciarticular juvenile rheumatoid arthritis. Tissue Antigens 49:262-266, 1997
22. Excoffier L, Slatkin M: Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921-927, 1995