High-throughput profiling of N-linked oligosaccharides in therapeutic antibodies using a microfluidic CD platform and MALDI-MS

Analytical and Bioanalytical Chemistry

Volumn 399, Issue 4, 2011, Pages 1601-1611

  Thuy, Tran Thi ^a   Inganäs, Mats ^b   Thorsén, Gunnar ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b Gyros AB   (Sweden)

Author keywords

Biotechnological products; Glycosylation profiling; MALDI MS; Microfluidic CD; Microfluidics Microfabrication; Recombinant therapeutic antibodies

Indexed keywords

AUTOIMMUNE DISEASE; BIOLOGICAL ACTIVITIES; BIOTECHNOLOGICAL PRODUCTS; CELL LINES; COMPACT DISC; CRYSTALLISATION; GLYCANS; GRAPHITIZED CARBON BLACK; HIGH-THROUGHPUT; IMMUNOGENIC PROPERTIES; MALDI-MS; MALDI-TOF; MANUFACTURING PROCESS; MEDICAL CONDITIONS; MICROFLUIDICS/MICROFABRICATION; N-LINKED; PROTEIN A; RECOMBINANT THERAPEUTIC ANTIBODIES; SAMPLE PREPARATION; SEQUENTIAL PROCESS; THERAPEUTIC ANTIBODIES; THERAPEUTIC USE;

BIOTECHNOLOGY; CARBON BLACK; CELL CULTURE; DISEASES; ESTERIFICATION; GLYCOSYLATION; MICROFLUIDICS; OLIGOSACCHARIDES; QUALITY CONTROL;

ANTIBODIES;

MONOCLONAL ANTIBODY; OLIGOSACCHARIDE;

ANIMAL; ARTICLE; CHEMISTRY; CHO CELL; CRICETULUS; GLYCOSYLATION; HAMSTER; HUMAN; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; MICROFLUIDIC ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; GLYCOSYLATION; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; OLIGOSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 79451474585     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4469-y     Document Type: Article

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