Antioxidants suppress apoptosis

Journal of Nutrition

Volumn 134, Issue 11, 2004, Pages

  Zeisel, Steven H ^a  

^a The University of North Carolina at Chapel Hill   (United States)

Author keywords

Antioxidants; Apoptosis; Cancer therapy

Indexed keywords

ANTIOXIDANT; CATALASE; DNA; GLUTATHIONE PEROXIDASE; LIPID; PROTEIN; RNA; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; BRAIN TUMOR; CANCER THERAPY; CELL KILLING; CONFERENCE PAPER; DNA DAMAGE; DRUG MEGADOSE; HUMAN; RISK BENEFIT ANALYSIS; TUMOR VOLUME;

EID: 7944238269     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.11.3179s     Document Type: Conference Paper

References (34)

1. Steinmetz, K. A. & Potter, J. D. (1996) Vegetables, fruit, and cancer prevention: a review. J. Am. Diet Assoc. 96: 1027-1039.
2. Willett, W. C. & Trichopoulos, D. (1996) Nutrition and cancer: a summary of the evidence. Cancer Causes Control 7: 178-180.
3. Taylor, P. R., Qiao, Y. L., Abnet, C. C., Dawsey, S. M., Yang, C. S., Gunter, E. W., Wang, W., Blot, W. J., Dong, Z. W. & Mark, S. D. (2003) Prospective study of serum vitamin E levels and esophageal and gastric cancers. J. Natl. Cancer Inst. 95: 1414-1416.
4. Seifried, H. E., McDonald, S. S., Anderson, D. E., Greenwald, P. & Milner, J. A. (2003) The antioxidant conundrum in cancer. Cancer Res. 63: 4295-4298.
5. Cooke, M. S., Evans, M. D., Dizdaroglu, M. & Lunec, J. (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17:1195-1214.
6. Cerutti, P., Shah, G., Peskin, A. & Amstad, P. (1992) Oxidant carcinogenesis and antioxidant defense. Ann. N.Y. Acad. Sci. 663: 158-166.
7. Ames, B. N. (1999) Micronutrient deficiencies. A major cause of DNA damage. Ann. N.Y. Acad. Sci. 889: 87-106.
8. Prasad, K. N., Kumar, A., Kochupillai, V. & Cole, W. C. (1999) High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy. J. Am. Coll. Nutr. 18: 13-25.
9. Weijl, N. I., Cleton, F. J. & Osanto, S. (1997) Free radicals and antioxidants in chemotherapy-induced toxicity. Cancer Treat. Rev. 23: 209-240.
10. Kuipers, G. K. & Lafleur, M. V. (1998) Characterization of DNA damage induced by gamma-radiation-derived water radicals, using DNA repair enzymes. Int. J. Radiat. Biol. 74: 511-519.
11. Blumenthal, R. D., Lew, W., Reising, A., Soyne, D., Osorio, L., Ying, Z. & Goldenberg, D. M. (2000) Anti-oxidant vitamins reduce normal tissue toxicity induced by radio-immunotherapy. Int. J. Cancer 86: 276-280.
12. Kokileva, L. (1994) Multi-step chromatin degradation in apoptosis. Int. Arch. Allergy Immunol. 105: 339-343.
13. Zhivotovsky, B., Wade, D., Nicotera, P. & Orrenius, S. (1994) Role of nucleases in apoptosis. Int. Arch. Allergy Immunol. 105: 333-338.
14. Wyllie, A. H. (1987) Cell death. Int. Rev. Cytol. 17 (suppl.): 755-785.
15. Arends, M. J., Morris, R. G. & Wyllie, A. H. (1990) Apoptosis. The role of the endonuclease. Am. J. Pathol. 136: 593-608.
16. Lowe, S. W., Ruley, H. E., Jacks, T. & Housman, D. E. (1993) p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 34: 957-967.
17. Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
18. Tomlinson, I.P.M. & Bodmer, W. F. (1995) Failure of programmed cell death and differentiation as causes of tumors: Some simple mathematical models. Proc. Natl. Acad. Sci. U.S.A. 92: 11130-11134.
19. Albright, C. D., Salganik, R. I., Craciunescu, C. N., Mar, M. H. & Zeisel, S. H. (2003) Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes. J. Cell Biochem. 89: 254-261.
20. Vrablic, A. S., Albright, C. D., Craciunescu, C. N., Salganik, R. I. & Zeisel, S. H. (2001) Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methylrac-glycero-3-phosphocholine in p53-defective hepatocytes. FASEB J. 15: 1739-1744.
21. Slater, A. F., Nobel, C. S. & Orrenius, S. (1995) The role of intracellular oxidants in apoptosis. Biochim. Biophys. Acta 1271: 59-62.
22. Johnson, T. M., Yu, Z. X., Ferrans, V. J., Lowenstein, R. A. & Finkel, T. (1996) Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. U.S.A. 93: 11848-11852.
23. Sugiyama, H., Kashihara, N., Makino, H., Yamasaki, Y. & Ota, Z. (1996) Reactive oxygen spesies induce apoptosis in cultured human mesangial cells. J. Amer. Soc. Nephrol. 7: 2357-2363.
24. Hawkins, R. A., Sangster, K. & Arends, M. J. (1998) Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J. Pathol. 185: 61-70.
25. Takahashi, H., Kosaka, N. & Nakagawa, S. (1998) Alpha-tocopherol protects PC12 cells from hyperoxia-induced apoptosis. J. Neurosci. Res. 52: 184-191.
26. Salganik, R. I., Albright, C. D., Rodgers, J., Kim, J., Zeisel, S. H., Sivashinskiy, M. S. & Van Dyke, T. A. (2000) Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice. Carcinogenesis 21: 909-914.
27. Albright, C. D., Salganik, R. I. & Van Dyke, T. (2004) Dietary depletion of vitamin E and vitamin A inhibits mammary tumor growth and metastasis in transgenic mice. J. Nutr. 134: 1139-1144.
28. Coursin, D. B., Cihla, H. P., Sempf, J., Oberley, T. D. & Oberley, L. W. (1996) An immunohistochemical analysis of antioxidant and glutathione S-transferase enzyme levels in normal and neoplastic human lung. Histol. Histopathol. 11: 851-860.
29. Oberley, T. D., Sempf, J. M. & Oberley, L. W. (1996) Immunogold analysis of antioxidant enzymes in common renal cancers. Histol. Histopathol. 11: 153-160.
30. Oberley, T. D. & Oberley, L. W. (1997) Antioxidant enzyme levels in cancer. Histol. Histopathol. 12: 525-535.
31. Sztarovski, T. R. & Nathan, C. F. (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51: 794-798.
32. Toyokuni, S., Okamoto, K., Yodoi, J. & Hiai, H. (1995) Hypothesis: persistent oxidative stress in cancer. FEBS Lett. 358: 1-3.
33. De Luca, L. M. & Ross, S. A. (1996) Beta-carotene increases lung cancer incidence in cigarette smokers. Nutr. Rev. 54: 178-180.
34. Heinonen, O. P., Albanes, D., Virtamo, J., Taylor, P. R., Huttunen, J. K., Hartman, A. M., Haapakoski, J., Malila, N., Rautalahti, M., et al. (1998) Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J. Natl. Cancer Inst. 90: 440-446.