Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Kook, Hyun ^a,b   Kee, Hae Jin ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; HEAT SHOCK PROTEIN 70; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 2A; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 9; HISTONE DEACETYLASE INHIBITOR; KRUPPEL LIKE FACTOR 4; MYOCYTE ENHANCER FACTOR 2; SYNAPTOJANIN; SYNAPTOJANIN F; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRESS; DEACETYLATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; HEART ARRHYTHMIA; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HUMAN; ISCHEMIC HEART DISEASE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PATHOPHYSIOLOGY; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CARDIOMEGALY; ENZYMOLOGY; METABOLISM; METHODOLOGY; MOLECULARLY TARGETED THERAPY; MOUSE;

ANIMALS; CARDIOMEGALY; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MICE; MOLECULAR TARGETED THERAPY;

EID: 79251588033     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/928326     Document Type: Review

References (94)

1. Hunter J. J., Chien K. R., Signaling pathways for cardiac hypertrophy and failure New England Journal of Medicine 1999 341 17 1276 1283
2. Rajabi M., Kassiotis C., Razeghi P., Taegtmeyer H., Return to the fetal gene program protects the stressed heart: a strong hypothesis Heart Failure Reviews 2007 12 3-4 331 343
3. Osaki J., Haneda T., Kashiwagi Y., Oi S., Fukuzawa J., Sakai H., Kikuchi K., Pressure-induced expression of heat shock protein 70mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems Journal of Hypertension 1998 16 8 1193 1200
4. Sadoshima J.-I., Takahashi T., Jahn L., Izumo S., Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes Proceedings of the National Academy of Sciences of the United States of America 1992 89 20 9905 9909
5. Gradman A. H., Alfayoumi F., From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease Progress in Cardiovascular Diseases 2006 48 5 326 341
6. Dobaczewski M., Bujak M., Li N., Gonzalez-Quesada C., Mendoza L. H., Wang X. F., Frangogiannis N. G., Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction Circulation research 2010 107 3 418 428
7. Subramaniam V., Lip G. Y. H., Hypertension to heart failure: a pathophysiological spectrum relating blood pressure, drug treatments and stroke Expert Review of Cardiovascular Therapy 2009 7 6 703 713
8. Kahan T., The importance of left ventricular hypertrophy in human hypertension Journal of Hypertension, Supplement 1998 16 7 S23 S29
9. Vakili B. A., Okin P. M., Devereux R. B., Prognostic implications of left ventricular hypertrophy American Heart Journal 2001 141 3 334 341
10. Levy D., Anderson K. M., Savage D. D., Kannel W. B., Christiansen J. C., Castelli W. P., Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham heart study Annals of Internal Medicine 1988 108 1 7 13
11. Hamamori Y., Schneider M. D., HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy Journal of Clinical Investigation 2003 112 6 824 826
12. Liu F., Levin M. D., Petrenko N. B., Lu M. M., Wang T., Yuan L. J., Stout A. L., Epstein J. A., Patel V. V., Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin Journal of Molecular and Cellular Cardiology 2008 45 6 715 723
13. Gallo P., Latronico M. V. G., Gallo P., Grimaldi S., Borgia F., Todaro M., Jones P., Gallinari P., De Francesco R., Ciliberto G., Steinkhler C., Esposito G., Condorelli G., Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure Cardiovascular Research 2008 80 3 416 424
14. Kee H. J., Sohn I. S., Nam K. I., Park J. E., Qian Y. R., Yin Z., Ahn Y., Jeong M. H., Bang Y.-J., Kim N., Kim J.-K., Kim K. K., Epstein J. A., Kook H., Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding Circulation 2006 113 1 51 59
15. Kong Y., Tannous P., Lu G., Berenji K., Rothermel B. A., Olson E. N., Hill J. A., Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy Circulation 2006 113 22 2579 2588
16. Zhao T. C., Cheng G., Zhang L. X., Tseng Y. T., Padbury J. F., Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury Cardiovascular Research 2007 76 3 473 481
17. Granger A., Abdullah I., Huebner F., Stout A., Wang T., Huebner T., Epstein J. A., Gruber P. J., Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice FASEB Journal 2008 22 10 3549 3560
18. Lee T.-M., Lin M.-S., Chang N.-C., Inhibition of histone deacetylase on ventricular remodeling in infarcted rats American Journal of Physiology 2007 293 2 H968 H977
19. Berry J. M., Cao D. J., Rothermel B. A., Hill J. A., Histone deacetylase inhibition in the treatment of heart disease Expert Opinion on Drug Safety 2008 7 1 53 67
20. Kook H., Lepore J. J., Gitler A. D., Lu M. M., Yung W. W.-M., Mackay J., Zhou R., Ferrari V., Gruber P., Epstein J. A., Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop Journal of Clinical Investigation 2003 112 6 863 871
21. Cho Y. K., Eom G. H., Kee H. J., Kim H. -S., Choi W. -Y., Nam K. -I., Ma J. S., Kook H., Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats Circulation Journal 2010 74 4 760 770
22. Antos C. L., McKinsey T. A., Dreitz M., Hollingsworth L. M., Zhang C.-L., Schreiber K., Rindt H., Gorczynski R. J., Olson E. N., Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors Journal of Biological Chemistry 2003 278 31 28930 28937
23. Liu Z., Li T., Liu Y., Jia Z., Li Y., Zhang C., Chen P., Ma K., Affara N., Zhou C., WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1 Biochimica et Biophysica Acta 2009 1793 2 300 311
24. Lagger G., O'Carroll D., Rembold M., Khier H., Tischler J., Weitzer G., Schuettengruber B., Hauser C., Brunmeir R., Jenuwein T., Seiser C., Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression EMBO Journal 2002 21 11 2672 2681
25. Montgomery R. L., Davis C. A., Potthoff M. J., Haberland M., Fielitz J., Qi X., Hill J. A., Richardson J. A., Olson E. N., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility Genes and Development 2007 21 14 1790 1802
26. Trivedi C. M., Luo Y., Yin Z., Zhang M., Zhu W., Wang T., Floss T., Goettlicher M., Noppinger P. R., Wurst W., Ferrari V. A., Abrams C. S., Gruber P. J., Epstein J. A., Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity Nature Medicine 2007 13 3 324 331
27. Trivedi C. M., Min M. L., Wang Q., Epstein J. A., Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy Journal of Biological Chemistry 2008 283 39 26484 26489
28. Montgomery R. L., Potthoff M. J., Haberland M., Qi X., Matsuzaki S., Humphries K. M., Richardson J. A., Bassel-Duby R., Olson E. N., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice Journal of Clinical Investigation 2008 118 11 3588 3597
29. Vega R. B., Matsuda K., Oh J., Barbosa A. C., Yang X., Meadows E., McAnally J., Pomajzl C., Shelton J. M., Richardson J. A., Karsenty G., Olson E. N., Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis Cell 2004 119 4 555 566
30. Chang S., McKinsey T. A., Zhang C. L., Richardson J. A., Hill J. A., Olson E. N., Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development Molecular and Cellular Biology 2004 24 19 8467 8476
31. Zhang C. L., McKinsey T. A., Chang S., Antos C. L., Hill J. A., Olson E. N., Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy Cell 2002 110 4 479 488
32. Kee H. J., Eom G. H., Joung H., Shin S., Kim J.-R., Cho Y. K., Choe N., Sim B.-W., Jo D., Jeong M. H., Kim K. K., Seo J.-S., Kook H., Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy Circulation Research 2008 103 11 1259 1269
33. Pflum M. K. H., Tong J. K., Lane W. S., Schreiber S. L., Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation Journal of Biological Chemistry 2001 276 50 47733 47741
34. Sun J.-M., Chen H. Y., Moniwa M., Litchfield D. W., Seto E., Davie J. R., The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2 Journal of Biological Chemistry 2002 277 39 35783 35786
35. Tsai S.-C., Seto E., Regulation of histone deacetylase 2 by protein kinase CK2 Journal of Biological Chemistry 2002 277 35 31826 31833
36. Lee H., Rezai-Zadeh N., Seto E., Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A Molecular and Cellular Biology 2004 24 2 765 773
37. Chen F., Kook H., Milewski R., Gitler A. D., Lu M. M., Li J., Nazarian R., Schnepp R., Jen K., Biben C., Runke G., Mackay J. P., Novotny J., Schwartz R. J., Harvey R. P., Mullins M. C., Epstein J. A., Hop is an unusual homeobox gene that modulates cardiac development Cell 2002 110 6 713 723
38. Kee H. J., Kook H., Krppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy Journal of Molecular and Cellular Cardiology 2009 47 6 770 780
39. Liao X., Haldar S. M., Lu Y., Jeyaraj D., Paruchuri K., Nahori M., Cui Y., Kaestner K. H., Jain M. K., Krppel-like factor 4 regulates pressure-induced cardiac hypertrophy Journal of Molecular and Cellular Cardiology 2010 49 2 334 338
40. Zhu W., Trivedi C. M., Zhou D., Yuan L., Lu M. M., Epstein J. A., Inpp5f Is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness Circulation Research 2009 105 12 1240 1247
41. Miska E. A., Karlsson C., Langley E., Nielsen S. J., Pines J., Kouzarides T., HDAC4 deacetylase associates with and represses the MEF2 transcription factor EMBO Journal 1999 18 18 5099 5107
42. Zhou X., Marks P. A., Rifkind R. A., Richon V. M., Cloning and characterization of a histone deacetylase, HDAC9 Proceedings of the National Academy of Sciences of the United States of America 2001 98 19 10572 10577
43. McKinsey T. A., Zhang C. L., Olson E. N., Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 Proceedings of the National Academy of Sciences of the United States of America 2000 97 26 14400 14405
44. Backs J., Song K., Bezprozvannaya S., Chang S., Olson E. N., CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy Journal of Clinical Investigation 2006 116 7 1853 1864
45. Vega R. B., Harrison B. C., Meadows E., Roberts C. R., Papst P. J., Olson E. N., McKinsey T. A., Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5 Molecular and Cellular Biology 2004 24 19 8374 8385
46. Margariti A., Zampetaki A., Xiao Q., Zhou B., Karamariti E., Martin D., Yin X., Mayr M., Li H., Zhang Z., De Falco E., Hu Y., Cockerill G., Xu Q., Zeng L., Histone deacetylase 7 controls endothelial cell growth through modulation of -Catenin Circulation Research 2010 106 7 1202 1211
47. McKinsey T. A., Olson E. N., Cardiac histone acetylationtherapeutic opportunities abound Trends in Genetics 2004 20 4 206 213
48. Morin S., Charron F., Robitaille L., Nemer M., GATA-dependent recruitment of MEF2 proteins to target promoters EMBO Journal 2000 19 9 2046 2055
49. Grozinger C. M., Schreiber S. L., Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization Proceedings of the National Academy of Sciences of the United States of America 2000 97 14 7835 7840
50. Kirsh O., Seeler J.-S., Pichler A., Gast A., Mller S., Miska E., Mathieu M., Harel-Bellan A., Kouzarides T., Melchior F., Dejean A., The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase EMBO Journal 2002 21 11 2682 2691
51. Zhao X., Sternsdorf T., Bolger T. A., Evans R. M., Yao T.-P., Regulation of MEF2 by histone beacetylase 4- and SIRT1 deacetylase-mediated lysine modifications Molecular and Cellular Biology 2005 25 19 8456 8464
52. Ago T., Liu T., Zhai P., Chen W., Li H., Molkentin J. D., Vatner S. F., Sadoshima J., A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy Cell 2008 133 6 978 993
53. Watson P. M. D., Riccio A., Nitric oxide and histone deacetylases a new relationship between old molecules Communitative and Integrative Biology 2009 2 1 11 13
54. Nott A., Watson P. M., Robinson J. D., Crepaldi L., Riccio A., S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons Nature 2008 455 7211 411 415
55. Hsu C.-P., Odewale I., Alcendor R. R., Sadoshima J., Sirt1 protects the heart from aging and stress Biological Chemistry 2008 389 3 221 231
56. Borradaile N. M., Pickering G., NAD+, sirtuins, and cardiovascular disease Current Pharmaceutical Design 2009 15 1 110 117
57. Alcendor R. R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., Tian B., Wagner T., Vatner S. F., Sadoshima J., Sirt1 regulates aging and resistance to oxidative stress in the heart Circulation Research 2007 100 10 1512 1521
58. Sundaresan N. R., Samant S. A., Pillai V. B., Rajamohan S. B., Gupta M. P., SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70 Molecular and Cellular Biology 2008 28 20 6384 6401
59. Vakhrusheva O., Smolka C., Gajawada P., Kostin S., Boettger T., Kubin T., Braun T., Bober E., Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice Circulation Research 2008 102 6 703 710
60. Balcerczyk A., Pirola L., Therapeutic potential of activators and inhibitors of sirtuins Biofactors 2010 36 5 383 393
61. Glozak M. A., Sengupta N., Zhang X., Seto E., Acetylation and deacetylation of non-histone proteins Gene 2005 363 1-2 15 23
62. Luo J., Nikolaev A. Y., Imai S.-I., Chen D., Su F., Shiloh A., Guarente L., Gu W., Negative control of p53 by Sir2α promotes cell survival under stress Cell 2001 107 2 137 148
63. Juan L.-J., Shia W.-J., Chen M.-H., Yang W.-M., Seto E., Lin Y.-S., Wu C.-W., Histone deacetylases specifically down-regulate p53-dependent gene activation Journal of Biological Chemistry 2000 275 27 20436 20443
64. Thevenet L., Mjean C., Moniot B., Bonneaud N., Galotti N., Aldrian-Herrada G., Poulat F., Berta P., Benkirane M., Boizet-Bonhoure B., Regulation of human SRY subcellular distribution by its acetylation/ deacetylation EMBO Journal 2004 23 16 3336 3345
65. Yuan Z.-L., Guan Y.-J., Chatterjee D., Chin Y. E., Stat3 dimerization regulated by reversible acetylation of a single lysine residue Science 2005 307 5707 269 273
66. Chanda D., Xie Y. -B., Choi H. -S., Transcriptional corepressor shp recruits sirt1 histone deacetylase to inhibit LRH-1 transactivation Nucleic Acids Research 2010 38 14 4607 4619
67. Gobinet J., Carascossa S., Cavaills V., Vignon F., Nicolas J.-C., Jalaguier S., SHP represses transcriptional activity via recruitment of histone deacetylases Biochemistry 2005 44 16 6312 6320
68. Martnez-Balbs M. A., Bauer U.-M., Nielsen S. J., Brehm A., Kouzarides T., Regulation of E2F1 activity by acetylation EMBO Journal 2000 19 4 662 671
69. Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W., Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO Journal 2004 23 12 2369 2380
70. Chen L.-F., Fischle W., Verdin E., Greene W. C., Duration of nuclear NF-κB action regulated by reversible acetylation Science 2001 293 5535 1653 1657
71. Parmigiani R. B., Xu W. S., Venta-Perez G., Erdjument-Bromage H., Yaneva M., Tempst P., Marks P. A., HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation Proceedings of the National Academy of Sciences of the United States of America 2008 105 28 9633 9638
72. Jeong J., Juhn K., Lee H., Kim S.-H., Min B.-H., Lee K.-M., Cho M.-H., Park G.-H., Lee K.-H., SIRT1 promotes DNA repair activity and deacetylation of Ku70 Experimental and Molecular Medicine 2007 39 1 8 13
73. Chuang H.-C., Chang C.-W., Chang G.-D., Yao T.-P., Chen H., Histone deacetylase 3 binds to and regulates the GCMa transcription factor Nucleic Acids Research 2006 34 5 1459 1469
74. Grnroos E., Hellman U., Heldin C.-H., Ericsson J., Control of Smad7 stability by competition between acetylation and ubiquitination Molecular Cell 2002 10 3 483 493
75. Grgoire S., Xiao L., Nie J., Zhang X., Xu M., Li J., Wong J., Seto E., Yang X.-J., Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2 Molecular and Cellular Biology 2007 27 4 1280 1295
76. Mal A., Sturniolo M., Schiltz R. L., Ghosh M. K., Harter M. L., A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program EMBO Journal 2001 20 7 1739 1753
77. Molkentin J. D., The zinc finger-containing transcription factors GATA-4, -5, and -6: ubiquitously expressed regulators of tissue-specific gene expression Journal of Biological Chemistry 2000 275 50 38949 38952
78. Pikkarainen S., Tokola H., Kerkel R., Ruskoaho H., GATA transcription factors in the developing and adult heart Cardiovascular Research 2004 63 2 196 207
79. Molkentin J. D., Lin Q., Duncan S. A., Olson E. N., Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis Genes and Development 1997 11 8 1061 1072
80. Hayakawa F., Towatari M., Ozawa Y., Tomita A., Privalsky M. L., Saito H., Functional regulation of GATA-2 by acetylation Journal of Leukocyte Biology 2004 75 3 529 540
81. Kawamura T., Ono K., Morimoto T., Wada H., Hirai M., Hidaka K., Morisaki T., Heike T., Nakahata T., Kita T., Hasegawa K., Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes Journal of Biological Chemistry 2005 280 20 19682 19688
82. Kume S., Haneda M., Kanasaki K., Sugimoto T., Araki S.-I., Isshiki K., Isono M., Uzu T., Guarente L., Kashiwagi A., Koya D., SIRT1 inhibits transforming growth factor -induced apoptosis in glomerular mesangial cells via Smad7 deacetylation Journal of Biological Chemistry 2007 282 1 151 158
83. Wang B., Hao J., Jones S. C., Yee M.-S., Roth J. C., Dixon I. M. C., Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart American Journal of Physiology 2002 282 5 H1685 H1696
84. Chandrasekaran S., Peterson R. E., Mani S. K., Addy B., Buchholz A. L., Xu L., Thiyagarajan T., Kasiganesan H., Kern C. B., Menick D. R., Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes FASEB Journal 2009 23 11 3851 3864
85. Yao Y.-L., Yang W.-M., Seto E., Regulation of transcription factor YY1 by acetylation and deacetylation Molecular and Cellular Biology 2001 21 17 5979 5991
86. Sucharov C. C., Dockstader K., McKinsey T. A., YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5 Molecular Biology of the Cell 2008 19 10 4141 4153
87. Sucharov C. C., Langer S., Bristow M., Leinwand L., Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A American Journal of Physiology 2006 291 5 C1029 C1037
88. Glenn D. J., Wang F., Chen S., Nishimoto M., Gardner D. G., Endothelin-stimulated human b-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2 Hypertension 2009 53 3 549 555
89. North B. J., Marshall B. L., Borra M. T., Denu J. M., Verdin E., The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase Molecular Cell 2003 11 2 437 444
90. Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., Matthias P., HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo EMBO Journal 2003 22 5 1168 1179
91. Hubbert C., Guardiola A., Shao R., Kawaguchi Y., Ito A., Nixon A., Yoshida M., Wang X.-F., Yao T.-P., HDAC6 is a microtubule-associated deacetylase Nature 2002 417 6887 455 458
92. Duvic M., Vu J., Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma Expert Opinion on Investigational Drugs 2007 16 7 1111 1120
93. Glaser K. B., HDAC inhibitors: clinical update and mechanism-based potential Biochemical Pharmacology 2007 74 5 659 671
94. Atmaca A., Al-Batran S.-E., Maurer A., Neumann A., Heinzel T., Hentsch B., Schwarz S. E., Hvelmann S., Gttlicher M., Knuth A., Jger E., Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial British Journal of Cancer 2007 97 2 177 182