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Volumn 17, Issue 23, 1998, Pages 6972-6978

A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα

Author keywords

Cofactor; HMG CoA synthase; Mitochondria; Nuclear hormone receptor; Transcription

Indexed keywords

CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MITOCHONDRIAL ENZYME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 0032403084     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.23.6972     Document Type: Article
Times cited : (74)

References (42)
  • 2
    • 0025352338 scopus 로고
    • Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl CoA synthases are encoded by two different genes
    • Ayté, J., Gil-Gómez, G., Haro, D., Marrero, P.F. and Hegardt, F.G. (1990) Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl CoA synthases are encoded by two different genes. Proc. Natl Acad. Sci. USA. 87, 3874-3878.
    • (1990) Proc. Natl Acad. Sci. USA. , vol.87 , pp. 3874-3878
    • Ayté, J.1    Gil-Gómez, G.2    Haro, D.3    Marrero, P.F.4    Hegardt, F.G.5
  • 3
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α -β and -γ in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauca, M. and Wahli, W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α -β and -γ in the adult rat. Endocrinology, 137, 354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 4
    • 0028053823 scopus 로고
    • Human mitochondrial HMG CoA synthase: Liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13 and possible role in vertebrate evolution
    • Boukafane, Y., Duncan, A., Wang, S., Labuda, D., Robert, M.-F., Sarrazin, J., Schappert, K. and Mitchel, G.A. (1994) Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13 and possible role in vertebrate evolution. Genomics, 23, 552-559.
    • (1994) Genomics , vol.23 , pp. 552-559
    • Boukafane, Y.1    Duncan, A.2    Wang, S.3    Labuda, D.4    Robert, M.-F.5    Sarrazin, J.6    Schappert, K.7    Mitchel, G.A.8
  • 6
    • 0030740253 scopus 로고    scopus 로고
    • Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    • Chen, H.W., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y. and Evans, R.M. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell, 90, 569-580.
    • (1997) Cell , vol.90 , pp. 569-580
    • Chen, H.W.1    Lin, R.J.2    Schiltz, R.L.3    Chakravarti, D.4    Nash, A.5    Nagy, L.6    Privalsky, M.L.7    Nakatani, Y.8    Evans, R.M.9
  • 7
    • 0029913512 scopus 로고    scopus 로고
    • Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor α
    • Chu, R., Lin, Y., Rao, S. and Reddy, J.K. (1996) Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor α. J. Biol. Chem., 271, 27670-27676.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27670-27676
    • Chu, R.1    Lin, Y.2    Rao, S.3    Reddy, J.K.4
  • 8
    • 0029015912 scopus 로고
    • How can the product of a single gene be localized to more than one intracellular compartment?
    • Danpure, C.J. (1995) How can the product of a single gene be localized to more than one intracellular compartment? Trends Cell Biol., 5, 230-238.
    • (1995) Trends Cell Biol. , vol.5 , pp. 230-238
    • Danpure, C.J.1
  • 10
    • 1842295133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators and corepressors
    • DiRenzo, J., Söderström, M., Kurokawa, R., Ogliastro, M.H., Ricote, M., Ingrey, S., Horlein, A., Rosenfeld, M.G. and Glass, C.K. (1997) Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators and corepressors. Mol. Cell. Biol., 17, 2166-2176.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2166-2176
    • DiRenzo, J.1    Söderström, M.2    Kurokawa, R.3    Ogliastro, M.H.4    Ricote, M.5    Ingrey, S.6    Horlein, A.7    Rosenfeld, M.G.8    Glass, C.K.9
  • 11
    • 0021722336 scopus 로고
    • Synthesis of a major integral membrane polypeptide of rat liver peroxisomes on free polysomes
    • Fujiki, Y., Rachubinski, R.A. and Lazarow, P.B. (1984) Synthesis of a major integral membrane polypeptide of rat liver peroxisomes on free polysomes. Proc. Natl Acad. Sci. USA, 81, 7127-7131.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 7127-7131
    • Fujiki, Y.1    Rachubinski, R.A.2    Lazarow, P.B.3
  • 12
    • 0022970291 scopus 로고
    • Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a synthase from the hamster. I. Isolation and sequencing of a full-length cDNA
    • Gil, G., Goldstein, J.L., Slaughter, C.A. and Brown, M.S. (1986) Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA. J. Biol. Chem., 261, 3710-3716.
    • (1986) J. Biol. Chem. , vol.261 , pp. 3710-3716
    • Gil, G.1    Goldstein, J.L.2    Slaughter, C.A.3    Brown, M.S.4
  • 14
    • 0030986236 scopus 로고    scopus 로고
    • A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    • Heery, D.M., Kalkhoven, E., Hoare, S. and Parker, M.G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature, 387, 733-736.
    • (1997) Nature , vol.387 , pp. 733-736
    • Heery, D.M.1    Kalkhoven, E.2    Hoare, S.3    Parker, M.G.4
  • 15
    • 0031239891 scopus 로고    scopus 로고
    • Acetylation of general transcription factors by histone acetyltransferases
    • Imhof, A., Yang, X.J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P. and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol., 7, 689-692.
    • (1997) Curr. Biol. , vol.7 , pp. 689-692
    • Imhof, A.1    Yang, X.J.2    Ogryzko, V.V.3    Nakatani, Y.4    Wolffe, A.P.5    Ge, H.6
  • 16
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C.Y., Ting, A.T. and Seed, B. (1998) PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.Y.1    Ting, A.T.2    Seed, B.3
  • 17
    • 0242587820 scopus 로고    scopus 로고
    • A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    • Kamei, Y. et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 85, 403-414.
    • (1996) Cell , vol.85 , pp. 403-414
    • Kamei, Y.1
  • 18
    • 0026705751 scopus 로고
    • Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
    • Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A. and Evans, R.M. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature, 358, 771-774.
    • (1992) Nature , vol.358 , pp. 771-774
    • Kliewer, S.A.1    Umesono, K.2    Noonan, D.J.3    Heyman, R.A.4    Evans, R.M.5
  • 21
    • 0030841936 scopus 로고    scopus 로고
    • Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism
    • Latruffe, N. and Vamecq, J. (1997) Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie, 79, 81-94.
    • (1997) Biochimie , vol.79 , pp. 81-94
    • Latruffe, N.1    Vamecq, J.2
  • 22
    • 0029731662 scopus 로고
    • Peroxisome proliferator-activaled receptors: A nuclear receptor signaling pathway in lipid physiology
    • Lemberger, T., Desvergne, B. and Wahli, W. (1961) Peroxisome proliferator-activaled receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol., 12, 335-363.
    • (1961) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 23
    • 0027214910 scopus 로고
    • Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehvdrogenase and fatty acyl-CoA oxidase genes hut differentially induce expression
    • Marcus, S.L., Miyata, K.S., Zhang, B., Subramani, S., Rachubinski, R.A. and Capone, J.P. (1993) Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehvdrogenase and fatty acyl-CoA oxidase genes hut differentially induce expression. Proc. Natl Acad. Sci. USA, 90, 5723-5727.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 5723-5727
    • Marcus, S.L.1    Miyata, K.S.2    Zhang, B.3    Subramani, S.4    Rachubinski, R.A.5    Capone, J.P.6
  • 24
    • 0028948686 scopus 로고
    • Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase
    • Mascaró, C., Buesa, C., Ortiz, J., Haro, D. and Hegardt, F.G. (1995) Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase. Arch. Biochem. Biophys., 317, 385-390.
    • (1995) Arch. Biochem. Biophys. , vol.317 , pp. 385-390
    • Mascaró, C.1    Buesa, C.2    Ortiz, J.3    Haro, D.4    Hegardt, F.G.5
  • 25
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • McGarry, J.D. and Foster, D.W. (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem., 49, 395-120.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 395-1120
    • McGarry, J.D.1    Foster, D.W.2
  • 26
    • 0027290892 scopus 로고
    • Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling
    • Miyata, K.S., Zhang, B., Marcus, S.L., Capone, J.P. and Rachubinski, R.A. (1993) Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling. J. Biol. Chem., 268, 19169-19172.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19169-19172
    • Miyata, K.S.1    Zhang, B.2    Marcus, S.L.3    Capone, J.P.4    Rachubinski, R.A.5
  • 27
    • 0029931972 scopus 로고    scopus 로고
    • The orphan nuclear hormone receptor LXRα interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling
    • Miyata, K.S., McCaw, S.E., Patel, H.V., Rachubinski, R.A. and Capone, J.P. (1996) The orphan nuclear hormone receptor LXRα interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J. Biol. Chem., 271, 9189-9192.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9189-9192
    • Miyata, K.S.1    McCaw, S.E.2    Patel, H.V.3    Rachubinski, R.A.4    Capone, J.P.5
  • 28
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
    • Nagy, L., Tontonoz, P., Alvarez, J.G.A., Chen, H.W. and Evans, R.M. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell, 93, 229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.W.4    Evans, R.M.5
  • 29
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivators p300 and CBP are histone acetyltransferases
    • Ogryzko, V.V., Shiltz, R.L., Russanova, V., Howard, B.H. and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87, 953-959.
    • (1996) Cell , vol.87 , pp. 953-959
    • Ogryzko, V.V.1    Shiltz, R.L.2    Russanova, V.3    Howard, B.H.4    Nakatani, Y.5
  • 30
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z.D., Park, C.W., Graves, R., Wright, M. and Spiegelman, B.M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92, 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.D.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 31
    • 0028186422 scopus 로고
    • The role of mitochondrial HMG-CoA synthase in regulation of ketogenesis
    • Quant, P.A. (1994) The role of mitochondrial HMG-CoA synthase in regulation of ketogenesis. Essays Biochem., 28, 13-25.
    • (1994) Essays Biochem. , vol.28 , pp. 13-25
    • Quant, P.A.1
  • 32
    • 0030964828 scopus 로고    scopus 로고
    • Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors
    • Roderick, H.L., Campbell, A.K. and Llewellyn, D.H. (1997) Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors. FEBS Lett., 405, 181-185.
    • (1997) FEBS Lett. , vol.405 , pp. 181-185
    • Roderick, H.L.1    Campbell, A.K.2    Llewellyn, D.H.3
  • 33
    • 0028276397 scopus 로고
    • Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
    • Rodriguez, J.C., Gil-Gomez, G., Hegardt, F.G. and Haro, D. (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem., 269, 18767-18772.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18767-18772
    • Rodriguez, J.C.1    Gil-Gomez, G.2    Hegardt, F.G.3    Haro, D.4
  • 34
    • 0028908866 scopus 로고
    • Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver
    • Royo, T., Pedragosa, M.J., Ayte, J., Gil-Gomez, G., Vilaro, S. and Hegardt, F.G. (1995) Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver. J. Cell Physiol., 162, 103-109.
    • (1995) J. Cell Physiol. , vol.162 , pp. 103-109
    • Royo, T.1    Pedragosa, M.J.2    Ayte, J.3    Gil-Gomez, G.4    Vilaro, S.5    Hegardt, F.G.6
  • 35
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
    • Schoonjans.K., Staels, B. and Auwerx, J. (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta, 1302, 93-109.
    • (1996) Biochim. Biophys. Acta , vol.1302 , pp. 93-109
    • SchoonjansK1    Staels, B.2    Auwerx, J.3
  • 36
    • 0029875291 scopus 로고    scopus 로고
    • The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control
    • Serra, D., Bellido, D., Asins, G., Arias, G., Vilaró, S. and Hegardt, F.G. (1996) The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control. Eur. J. Biochem., 237, 16-24.
    • (1996) Eur. J. Biochem. , vol.237 , pp. 16-24
    • Serra, D.1    Bellido, D.2    Asins, G.3    Arias, G.4    Vilaró, S.5    Hegardt, F.G.6
  • 38
    • 0030737945 scopus 로고    scopus 로고
    • The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors
    • Thompson, C.C. and Bottcher, M. (1997) The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc. Natl Acad. Sci. USA, 94, 8527-8532.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8527-8532
    • Thompson, C.C.1    Bottcher, M.2
  • 39
    • 0026541591 scopus 로고
    • The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
    • Tugwood, J.D., Issemann, I. anderson, R.G., Bundell, K.R., McPheat, W.L. and Green, S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11, 433-439.
    • (1992) EMBO J. , vol.11 , pp. 433-439
    • Tugwood, J.D.1    Issemann, I.2    Anderson, R.G.3    Bundell, K.R.4    McPheat, W.L.5    Green, S.6
  • 40
    • 0032518944 scopus 로고    scopus 로고
    • The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
    • Voegel, J.J., Heine, M.J.S., Tini, M., Vivat, V., Chambon, P. and Gronemeyer, H. (1998) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J., 17, 507-519.
    • (1998) EMBO J. , vol.17 , pp. 507-519
    • Voegel, J.J.1    Heine, M.J.S.2    Tini, M.3    Vivat, V.4    Chambon, P.5    Gronemeyer, H.6
  • 41
    • 0026756096 scopus 로고
    • Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
    • Zhang, B., Marcus, S.L., Sajjadi, F.G., Alvares, K., Reddy, J.K., Subramani, S., Rachubinski, R.A. and Capone, J.P. (1992) Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl Acad. Sci. USA, 89, 7541-7545.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7541-7545
    • Zhang, B.1    Marcus, S.L.2    Sajjadi, F.G.3    Alvares, K.4    Reddy, J.K.5    Subramani, S.6    Rachubinski, R.A.7    Capone, J.P.8
  • 42
    • 0027265115 scopus 로고
    • Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene
    • Zhang, B., Marcus, S.L., Miyata, K.S., Subramani, S., Capone, J.P. and Rachubinski, R.A. (1993) Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene. J. Biol. Chem., 268, 12939-12945.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12939-12945
    • Zhang, B.1    Marcus, S.L.2    Miyata, K.S.3    Subramani, S.4    Capone, J.P.5    Rachubinski, R.A.6


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