Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 516-526

  Zhu, Yiming ^a   Bertics, Paul J ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; EOTAXIN; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5; LEUKOTRIENE C4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LYN; RANTES; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; UPREGULATION;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ASTHMA; EOSINOPHILS; HL-60 CELLS; HUMANS; INTERLEUKIN-3; INTERLEUKIN-5; LEUKOTRIENE C4; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 79251575558     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000955     Document Type: Article

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