Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model

American Journal of Respiratory Cell and Molecular Biology

Volumn 24, Issue 4, 2001, Pages 469-474

  Kudlacz, E M ^a   Andresen, C J ^a   Salafia, M ^a   Whitney, C A ^a   Naclerio, B ^a   Changelian, P S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035044057     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.24.4.4266     Document Type: Article

References (31)

1. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells
2. Comparison of p561ck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lympoid cell lines
3. Association of the fyn protein-tyrusine kinase with the T-cell antigen receptor
4. Distinct p53/561yn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-α
5. Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail
6. Interleukin-7 activates p561ck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells
7. Activation of src family kinases in human pre-B cells by IL-7
8. Involvement of p59fynT in interleukin-5 receptor signaling
9. p59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
10. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
11. NKT cell development is selectively impaired in fyn-deficient mice
12. The src family tyrosine kinase fyn regulates natural killer T cell development
13. CD4+, NK1.1+T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
14. Detection of eosinophils using eosinophil peroxidase assay: Its use as an assay for eosinophil differentiation factors
15. Molecular basis for selective eosinophil trafficking in asthma: A multistep paradigm
16. Depletion of murine CD4+T lymphocytes prevents antigen-induced airway hyperre-activity and pulmonary eosinophilia
17. Induction of pulmonary allergic responses by antigen-specific TH2 cells
18. Effect of different sensitizing doses of antigen in a murine model of atopic asthma
19. Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice
20. Mitogenic lectins bind to the antigen receptor on human lymphocytes
21. Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3: Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production
22. Inhibitors of Src-family tyrosine kinases favour Th2 differentiation
23. Th1 and Th2 deviation of myelin-autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck, Fyn, and ZAP-70
24. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
25. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+T cells that promptly produce interleukin 4
26. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse
27. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
28. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
29. Fyn tyrosine kinase associated with Fc epsilon RII/CD23: Possible multiple roles in lymphocyte activation
30. Increased peripheral blood monocytes with Fc receptors for IgE in patients with severe allergic disorders
31. CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin