Molecular mechanisms underlying hypothermia-induced neuroprotection

Stroke Research and Treatment

Volumn , Issue , 2011, Pages

  Shintani, Yasushi ^a   Terao, Yasuko ^a   Ohta, Hiroyuki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CELL ADHESION MOLECULE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; OXYGEN REGULATED PROTEIN 150; PROTEIN C FOS; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

BLOOD BRAIN BARRIER; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL DEATH; DNA MICROARRAY; EXCITOTOXICITY; GENE EXPRESSION; HYPOTHERMIA; INTERNAL RIBOSOME ENTRY SITE; LIQUID CHROMATOGRAPHY; MENTAL DETERIORATION; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; NEUROPROTECTION; NONHUMAN; ONCOGENE C FOS; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 79251538042     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.4061/2011/809874     Document Type: Review

References (84)

1. Donnan G. A., Fisher M., Macleod M., Davis S. M., Stroke The Lancet 2008 371 9624 1612 1623
2. Warlow C. P., Epidemiology of stroke The Lancet 1998 352 3 1 4
3. Feigin V. L., Lawes C. M. M., Bennett D. A., Anderson C. S., Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century Lancet Neurology 2003 2 1 43 53
4. Kidwell C. S., Liebeskind D. S., Starkman S., Saver J. L., Trends in acute ischemic stroke trials through the 20th century Stroke 2001 32 6 1349 1359
5. Green A. R., Odergren T., Ashwood T., Animal models of stroke: do they have value for discovering neuroprotective agents? Trends in Pharmacological Sciences 2003 24 8 402 408
6. Yoshida H., Yanai H., Namiki Y., Fukatsu-Sasaki K., Furutani N., Tada N., Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury CNS Drug Reviews 2006 12 1 9 20
7. Yenari M. A., Lee J. E., Giffard R. G., Schaller B., Stress proteins and ischemic tolerance Cerebral Ischemic Tolerence 2004 Huntington, NY, USA Nova Science Publishers 103 121
8. Zheng Z., Lee J. E., Yenari M. A., Stroke: molecular mechanisms and potential targets for treatment Current Molecular Medicine 2003 3 4 361 372
9. Miyazawa T., Tamura A., Fukui S., Hossmann K.-A., Effect of mild hypothermia on focal cerebral ischemia. Review of experimental studies Neurological Research 2003 25 5 457 464
10. Yanamoto H., Nagata I., Niitsu Y., Zhang Z., Xue J.-H., Sakai N., Kikuchi H., Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia Stroke 2001 32 1 232 239
11. Kawai N., Okauchi M., Morisaki K., Nagao S., Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats Stroke 2000 31 8 1982 1989
12. Holzer M., Sterz F., Darby J. M., Padosch S. A., Kern K. B., Bttiger B. W., Polderman K. H., Girbes A. R.J., Holzer M., Bernard S. A., Buist M. D., Safar P., Kochanek P. M., Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest The New England Journal of Medicine 2002 346 8 549 556
13. Bernard S. A., Gray T. W., Buist M. D., Jones B. M., Silvester W., Gutteridge G., Smith K., Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia The New England Journal of Medicine 2002 346 8 557 563
14. Kil H. Y., Zhang J., Piantadosi C. A., Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats Journal of Cerebral Blood Flow and Metabolism 1996 16 1 100 106
15. Han H. S., Karabiyikoglu M., Kelly S., Sobel R. A., Yenari M. A., Mild hypothermia inhibits nuclear factor- B translocation in experimental stroke Journal of Cerebral Blood Flow and Metabolism 2003 23 5 589 598
16. Wang G. J., Deng H. Y., Maier C. M., Sun G. H., Yenari M. A., Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke Neuroscience 2002 114 4 1081 1090
17. Yenari M. A., Iwayama S., Cheng D., G. H. S., Fujimura M., Morita-Fujimura Y., Chan P. H., Steinberg G. K., Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke Journal of Cerebral Blood Flow and Metabolism 2002 22 1 29 38
18. Drury P. P., Bennet L., Gunn A. J., Mechanisms of hypothermic neuroprotection Seminars in Fetal and Neonatal Medicine 2010 15 5 287 292
19. Ohta H., Terao Y., Shintani Y., Kiyota Y., Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia Neuroscience Research 2007 57 3 424 433
20. Colbourne F., Sutherland G. R., Auer R. N., An automated system for regulating brain temperature in awake and freely moving rodents Journal of Neuroscience Methods 1996 67 2 185 190
21. DeBow S., Colbourne F., Brain temperature measurement and regulation in awake and freely moving rodents Methods 2003 30 2 167 171
22. Colbourne F., Sutherland G., Corbett D., Postischemic hypothermia: a critical appraisal with implications for clinical treatment Molecular Neurobiology 1997 14 3 171 201
23. Markarian G. Z., Lee J. H., Stein D. J., Hong S.-C., Mild hypothermia: therapeutic window after experimental cerebral ischemia Neurosurgery 1996 38 3 542 551
24. Maier C. M., Ahern K. V. B., Cheng M. L., Lee J. E., Yenari M. A., Steinberg G. K., Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation Stroke 1998 29 10 2171 2180
25. Colbourne F., Corbett D., Zhao Z., Yang J., Buchan A. M., Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model Journal of Cerebral Blood Flow and Metabolism 2000 20 12 1702 1708
26. Corbett D., Hamilton M., Colbourne F., Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion Experimental Neurology 2000 163 1 200 206
27. Schulze A., Downward J., Navigating gene expression using microarraysa technology review Nature Cell Biology 2001 3 8 E190 E195
28. Mills J. C., Roth K. A., Cagan R. L., Gordon J. I., DNA microarrays and beyond: completing the journey from tissue to cell Nature Cell Biology 2001 3 8 E175 E178
29. Mirnics K., Middleton F. A., Lewis D. A., Levitt P., Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse Trends in Neurosciences 2001 24 8 479 486
30. Akins P. T., Liu P. K., Hsu C. Y., Immediate early gene expression in response to cerebral ischemia: friend or foe? Stroke 1996 27 9 1682 1687
31. Koistinaho J., Hkfelt T., Altered gene expression in brain ischemia NeuroReport 1997 8 2 R1 R8
32. Sharp F. R., Lu A., Tang Y., Millhorn D. E., Multiple molecular penumbras after focal cerebral ischemia Journal of Cerebral Blood Flow and Metabolism 2000 20 7 1011 1032
33. Read S. J., Parsons A. A., Harrison D. C., Philpott K., Kabnick K., O'Brien S., Clark S., Brawner M., Bates S., Gloger I., Legos J. J., Barone F. C., Stroke genomics: approaches to identify, validate, and understand ischemic stroke gene expression Journal of Cerebral Blood Flow and Metabolism 2001 21 7 755 778
34. Lu A., Tang Y., Ran R., Clark J. F., Aronow B. J., Sharp F. R., Genomics of the periinfarction cortex after focal cerebral ischemia Journal of Cerebral Blood Flow and Metabolism 2003 23 7 786 810
35. Kawahara N., Wang Y., Mukasa A., Furuya K., Shimizu T., Hamakubo T., Aburatani H., Kodama T., Kirino T., Genome-wide gene expression analysis for induced ischemic tolerance and delayed neuronal death following transient global ischemia in rats Journal of Cerebral Blood Flow and Metabolism 2004 24 2 212 223
36. Lu X.-C. M., Williams A. J., Yao C., Berti R., Hartings J. A., Whipple R., Vahey M. T., Polavarapu R. G., Woller K. L., Tortella F. C., Dave J. R., Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion Journal of Neuroscience Research 2004 77 6 843 857
37. Denhardt D. T., Noda M., O'Regan A. W., Pavlin D., Berman J. S., Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival The Journal of Clinical Investigation 2001 107 9 1055 1061
38. Wang X., Louden C., Yue T.-L., Ellison J. A., Barone F. C., Solleveld H. A., Feuerstein G. Z., Delayed expression of osteopontin after focal stroke in the rat Journal of Neuroscience 1998 18 6 2075 2083
39. Ellison J. A., Barone F. C., Feuerstein G. Z., Matrix remodeling after stroke. De novo expression of matrix proteins and integrin receptors Annals of the New York Academy of Sciences 1999 890 204 222
40. Ellison J. A., Velier J. J., Spera P., Jonak Z. L., Wang X., Barone F. C., Feuerstein G. Z., Osteopontin and its integrin receptor (v) 3 are upregulated during formation of the glial scar after focal stroke Stroke 1998 29 8 1698 1707
41. Meller R., Stevens S. L., Minami M., Cameron J. A., King S., Rosenzweig H., Doyle K., Lessov N. S., Simon R. P., Stenzel-Poore M. P., Neuroprotection by osteopontin in stroke Journal of Cerebral Blood Flow and Metabolism 2005 25 2 217 225
42. Chen A., Liao W. P., Lu Q., Wong W. S.F., Wong P. T.-H., Upregulation of dihydropyrimidinase-related protein 2, spectrin II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats-A proteomics approach Neurochemistry International 2007 50 7-8 1078 1086
43. Yan S.-F., Fujita T., Lu J., Okada K., Shan Zou Y., Mackman N., Pinsky D. J., Stern D. M., Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress Nature Medicine 2000 6 12 1355 1361
44. Deng H., Han H. S., Cheng D., Sun G. H., Yenari M. A., Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation Stroke 2003 34 10 2495 2501
45. Szaflarski J., Burtrum D., Silverstein F. S., Finkelstein S., Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats Stroke 1995 26 6 1093 1100
46. Yenari M. A., Han H. S., Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NF B) Neurochemistry International 2006 49 2 164 169
47. Karabiyikoglu M., Han H. S., Yenari M. A., Steinberg G. K., Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling Journal of Neurosurgery 2003 98 6 1271 1276
48. Zimmermann-Ivol C. G., Burkhard P. R., Le Floch-Rohr J., Allard L., Hochstrasser D. F., Sanchez J.-C., Fatty acid binding protein as a serum marker for the early diagnosis of stroke: a pilot study Molecular and Cellular Proteomics 2004 3 1 66 72
49. Sironi L., Guerrini U., Tremoli E., Miller I., Gelosa P., Lascialfari A., Zucca I., Eberini I., Gemeiner M., Paoletti R., Gianazza E., Analysis of pathological events at the onset of brain damage in stroke-prone rats: a proteomics and magnetic resonance imaging approach Journal of Neuroscience Research 2004 78 1 115 122
50. Terao Y., Miyamoto S., Hirai K., Kamiguchi H., Ohta H., Shimojo M., Kiyota Y., Asahi S., Sakura Y., Shintani Y., Hypothermia enhances heat-shock protein 70 production in ischemic brains NeuroReport 2009 20 8 745 749
51. Garrido C., Gurbuxani S., Ravagnan L., Kroemer G., Heat shock proteins: endogenous modulators of apoptotic cell death Biochemical and Biophysical Research Communications 2001 286 3 433 442
52. Giffard R. G., Xu L., Zhao H., Carrico W., Ouyang Y., Qiao Y., Sapolsky R., Steinberg G., Hu B., Yenari M. A., Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury Journal of Experimental Biology 2004 207 18 3213 3220
53. Yenari M. A., Liu J., Zheng Z., Vexler Z. S., Lee J. E., Giffard R. G., Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection Annals of the New York Academy of Sciences 2005 1053 74 83
54. Schell M. T., Spitzer A. L., Johnson J. A., Lee D., Harris H. W., Heat shock inhibits NF-kB activation in a dose- and time-dependent manner Journal of Surgical Research 2005 129 1 90 93
55. Zheng Z., Kim J. Y., Ma H., Lee J. E., Yenari M. A., Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke Journal of Cerebral Blood Flow and Metabolism 2008 28 1 53 63
56. Vass K., Welch W. J., Nowak T. S. Jr., Localization of 70-kDa stress protein induction in gerbil brain after ischemia Acta Neuropathologica 1988 77 2 128 135
57. Currie R. W., Ellison J. A., White R. F., Feuerstein G. Z., Wang X., Barone F. C., Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27 Brain Research 2000 863 1-2 169 181
58. Kato K., Katoh-Semba R., Takeuchi I. K., Ito H., Kamei K., Responses of heat shock proteins hsp27, B-crystallin, and hsp70 in rat brain after kainic acid-induced seizure activity Journal of Neurochemistry 1999 73 1 229 236
59. Nowak T. S. Jr., Bond U., Schlesinger M. J., Heat shock RNA levels in brain and other tissues after hyperthermia and transient ischemia Journal of Neurochemistry 1990 54 2 451 458
60. Ren M., Leng Y., Jeong M., Leeds P. R., Chuang D.-M., Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction Journal of Neurochemistry 2004 89 6 1358 1367
61. Matsumori Y., Northington F. J., Hong S. M., Kayama T., Sheldon R. A., Vexler Z. S., Ferriero D. M., Weinstein P. R., Liu J., Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70 Stroke 2006 37 2 507 512
62. Hagiwara S., Iwasaka H., Matsumoto S., Noguchi T., Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells Inflammation Research 2007 56 7 297 303
63. Rubtsova M. P., Sizova D. V., Dmitriev S. E., Ivanov D. S., Prassolov V. S., Shatsky I. N., Distinctive properties of the 5′-untranslated region of human Hsp70 mRNA The Journal of Biological Chemistry 2003 278 25 22350 22356
64. Zheng Z., Yenari M. A., Post-ischemic inflammation: molecular mechanisms and therapeutic implications Neurological Research 2004 26 8 884 892
65. Furuichi Y., Noto T., Li J.-Y., Oku T., Ishiye M., Moriguchi A., Aramori I., Matsuoka N., Mutoh S., Yanagihara T., Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats Brain Research 2004 1014 1-2 120 130
66. Matsuo Y., Onodera H., Shiga Y., Shozuhara H., Ninomiya M., Kihara T., Tamatani T., Miyasaka M., Kogure K., Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat Brain Research 1994 656 2 344 352
67. Dimitrijevic O. B., Stamatovic S. M., Keep R. F., Andjelkovic A. V., Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury Journal of Cerebral Blood Flow and Metabolism 2006 26 6 797 810
68. Dimitrijevic O. B., Stamatovic S. M., Keep R. F., Andjelkovic A. V., Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice Stroke 2007 38 4 1345 1353
69. Terao Y., Ohta H., Oda A., Nakagaito Y., Kiyota Y., Shintani Y., Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia Neuroscience Research 2009 64 1 75 82
70. Charbonnier A.-S., Kohrgruber N., Kriehuber E., Stingl G., Rot A., Maurer D., Macrophage inflammatory protein 3 is involved in the constitutive trafficking of epidermal langerhans cells Journal of Experimental Medicine 1999 190 12 1755 1767
71. Cook D. N., Prosser D. M., Forster R., Zhang J., Kuklin N. A., Abbondanzo S. J., Niu X.-D., Chen S.-C., Manfra D. J., Wiekowski M. T., Sullivan L. M., Smith S. R., Greenberg H. B., Narula S. K., Lipp M., Lira S. A., CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue Immunity 2000 12 5 495 503
72. Serafini B., Columba-Cabezas S., Di Rosa F., Aloisi F., Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis American Journal of Pathology 2000 157 6 1991 2002
73. Utans-Schneitz U., Lorez H., Klinkert W. E.F., Da Silva J., Lesslauer W., A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation Journal of Neuroimmunology 1998 92 1-2 179 190
74. Prez-Caadillas J. M., Zaballos A., Gutirrez J., Varona R., Roncal F., Albar J. P., Mrquez G., Bruix M., NMR solution structure of murine CCL20/MIP-3, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through Its highly specific interaction with the -chemokine receptor CCR6 The Journal of Biological Chemistry 2001 276 30 28372 28379
75. Schutyser E., Struyf S., Van Damme J., The CC chemokine CCL20 and its receptor CCR6 Cytokine and Growth Factor Reviews 2003 14 5 409 426
76. Zoli M., Grimaldi R., Ferrari R., Zini I., Agnati L. F., Short- and long-term changes in striatal neurons and astroglia after transient forebrain ischemia in rats Stroke 1997 28 5 1049 1059
77. Ambrosini E., Columba-Cabezas S., Serafini B., Muscella A., Aloisi F., Astrocytes are the major intracerebral source of macrophage inflammatory protein-3 /CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro GLIA 2003 41 3 290 300
78. Wood P. L., Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia Neurological Research 1995 17 4 242 248
79. De Haas A. H., Van Weering H. R. J., De Jong E. K., Boddeke H. W. G. M., Biber K. P. H., Neuronal chemokines: versatile messengers in central nervous system cell interaction Molecular Neurobiology 2007 36 2 137 151
80. Rostne W., Kitabgi P., Parsadaniantz S. M., Chemokines: a new class of neuromodulator? Nature Reviews Neuroscience 2007 8 11 895 904
81. Chan P. H., Reactive oxygen radicals in signaling and damage in the ischemic brain Journal of Cerebral Blood Flow and Metabolism 2001 21 1 2 14
82. Kil H. Y., Zhang J., Piantadosi C. A., Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats Journal of Cerebral Blood Flow and Metabolism 1996 16 1 100 106
83. Liu L., Kim J. Y., Koike M. A., Yoon Y. J., Tang X. N., Hualong M., Lee H., K.Steinberg G., Lee J. E., Yenari M. A., FasL shedding is reduced by hypothermia in experimental stroke Journal of Neurochemistry 2008 106 2 541 550
84. Jong E. L., Yone J. Y., Moseley M. E., Yenari M. A., Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke Journal of Neurosurgery 2005 103 2 289 297