Water administration of the medium-chain fatty acid caprylic acid produced variable efficacy against enteric Campylobacter colonization in broilers

Poultry Science

Volumn 90, Issue 2, 2011, Pages 494-497

  Metcalf, J H ^a   Donoghue, A M ^b   Venkitanarayanan, K ^c   Reyes Herrera, I ^a   Aguiar, V F ^a   Blore, P J ^a   Donoghue, D J ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Broiler; Campylobacter; Caprylic acid; Sodium octanoate; Water

Indexed keywords

AVES; CAMPYLOBACTER;

EID: 79251491388     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.3382/ps.2010-00891     Document Type: Article

References (29)

1. Allos, B. M. 2001. Campylobacter jejuni infections: Update on emerging issues and trends. Clin. Infect. Dis. 32:1201-1206.
2. Amalaradjou, M. A. R., T. Annamalai, P. Marek, P. Rezamand, D. Schreiber, T. Hoagland, and K. Venkitanarayanan. 2006. Inactivation of Escherichia coli O157:H7 in cattle drinking water by sodium caprylate. J. Food Prot. 69:2248-2252.
3. Bergsson, G., J. Arnfinnsson, S. M. Karlsson, Ó. Steingrímsson, and H. Thormar. 1998. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 42:2290-2294.
4. Bergsson, G., J. Arnfinnsson, Ó. Steingrímsson, and H. Thormar. 2001. Killing of gram-positive cocci by fatty acids and monoglycerides. APMIS 109:670-678.
5. Byrd, J. A., R. C. Anderson, T. R. Callaway, R. W. Moore, K. D. Knape, L. F. Kubena, R. L. Ziprin, and D. J. Nisbet. 2003. Effect of experimental chlorate product administration in the drinking water on Salmonella Typhimurium contamination of broilers. Poult. Sci. 82:1403-1406.
6. Centers for Disease Control and Prevention. 2010. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food-10 states, United States, 2009. MMWR Morb. Mortal. Wkly. Rep. 59:418-422.
7. Charman, W. N., C. J. Porter, S. Mithani, and J. B. Dressman. 1997. Physiochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH. J. Pharm. Sci. 86:269-282.
8. Chaveerach, P., D. A. Keuzenkamp, L. J. Lipman, and F. Van Knapen. 2004. Effect of organic acids in drinking water for young broilers on Campylobacter infection, volatile fatty acid production, gut microflora and histological cell changes. Poult. Sci. 83:330-334.
9. Cole, K., M. B. Farnell, A. M. Donoghue, N. J. Stern, E. A. Svetoch, B. N. Eruslanov, L. I. Volodina, Y. N. Kovalev, V. V. Perelygin, E. V. Mitsevich, I. P. Mitsevich, V. P. Levchuk, V. D. Pokhilenko, V. N. Borzenkov, O. E. Svetoch, T. Y. Kudryavtseva, I. Reyes-Herrera, P. J. Blore, F. Solis de los Santos, and D. J. Donoghue. 2006. Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults. Poult. Sci. 85:1570-1575.
10. Custodio, J. M., C. Y. Wu, and L. Z. Benet. 2008. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv. Drug Deliv. Rev. 60:717-733.
11. Farnell, M. B., A. M. Donoghue, K. Cole, I. Reyes-Herrera, P. J. Blore, and D. J. Donoghue. 2005. Campylobacter susceptibility to ciprofloxacin and corresponding fluoroquinolone concentrations within the gastrointestinal tracts of chickens. J. Appl. Microbiol. 99:1043-1050.
12. Friedman, C. R., R. M. Hoekstra, M. Samuel, R. Marcus, J. Bender, B. Shiferaw, S. Reddy, S. D. Ahuja, D. L. Helfrick, F. Hardnett, M. Carter, B. Anderson, and R. V. Tauxe. 2004. Risk factors for sporadic Campylobacter infection in the United States: A case-control study in FoodNet sites. Clin. Infect. Dis. 38(Suppl. 3):S285-S296.
13. Friedman, C. R., J. Neimann, H. C. Wegener, and R. V. Tauxe. 2000. Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations. Pages 121-138 in Campylobacter. 2nd ed. I. Nachamkin and M. J. Blaser, ed. ASM Press, Washington, DC.
14. Hermans, D., A. Martel, K. Van Deun, M. Verlinden, F. Van Immerseel, A. Garmyn, W. Messens, M. Heyndrickx, F. Haesebrouck, and F. Pasmans. 2010. Intestinal mucus protects Campylobacter jejuni in the ceca of colonized broiler chickens against the bactericidal effects of medium-chain fatty acids. Poult. Sci. 89:1144-1155.
15. Hilmarsson, H., H. Thormar, J. H. Thrainsson, E. Gunnarsson, and S. Dadadottir. 2006. Effect of glycerol monocaprate (monocaprin) on broiler chickens: An attempt at reducing intestinal Campylobacter infection. Poult. Sci. 85:588-592.
16. Hörter, D., and J. B. Dressman. 2001. Influence of physiochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. Rev. 46:75-87.
17. Jones, H. M., N. Parrott, G. Ohlenbusch, and T. Lave. 2006. Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling. Clin. Pharmacokinet. 45:1213-1226.
18. Line, J. E. 2001. Development of a selective differential agar for isolation and enumeration of Campylobacter spp. J. Food Prot. 64:1711-1715.
19. Loc Carrillo, C., R. J. Atterbury, A. el-Shibiny, P. L. Connerton, E. Dillon, A. Scott, and I. F. Connerton. 2005. Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens. Appl. Environ. Microbiol. 71:6554-6563.
20. Martinez, M. N., and G. L. Amidon. 2002. A mechanistic approach to understanding the factors affecting drug absorption: A review of fundamentals. J. Clin. Pharmacol. 42:620-643.
21. SAS Institute. 2002. SAS/STAT User's Guide: Release 9.03 Edition. SAS Inst. Inc., Cary, NC.
22. Serajuddin, A. T. M. 2007. Salt formation to improve drug solubility. Adv. Drug Deliv. Rev. 59:603-616.
23. Solis de los Santos, F., A. M. Donoghue, K. Venkitanarayanan, M. L. Dirain, I. Reyes-Herrera, P. J. Blore, and D. J. Donoghue. 2008a. Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni colonization in ten-day-old broiler chickens. Poult. Sci. 87:800-804.
24. Solis de los Santos, F., A. M. Donoghue, K. Venkitanarayanan, J. H. Metcalf, I. Reyes-Herrera, M. L. Dirain, V. F. Aguiar, P. J. Blore, and D. J. Donoghue. 2009. The natural feed additive caprylic acid decreases Campylobacter jejuni colonization in market-aged broiler chickens. Poult. Sci. 88:61-64.
25. Solis de los Santos, F., A. M. Donoghue, K. Venkitanarayanan, I. Reyes-Herrera, J. H. Metcalf, M. L. Dirain, V. F. Aguiar, P. J. Blore, and D. J. Donoghue. 2008b. Therapeutic supplementation of caprylic acid in feed reduces Campylobacter jejuni colonization in broiler chicks. Appl. Environ. Microbiol. 74:4564-4566.
26. Solis de los Santos, F. M. Hume, K. Venkitanarayanan, A. M. Donoghue, I. Hanning, M. F. Slavik, V. F. Aguiar, J. H. Metcalf, I. Reyes-Herrera, P. J. Blore, and D. J. Donoghue. 2010. Caprylic acid reduces enteric Campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations. J. Food Prot. 73:251-257.
27. Thormar, H., H. Hilmarsson, and G. Bergsson. 2006. Stable concentrated emulsions of the 1 monoglyceride of capric acid (monocaprin) with microbicidal activities against the food-borne bacteria Campylobacter jejuni, Salmonella spp., and Escherichia coli. Appl. Environ. Microbiol. 72:522-526.
28. US Food and Drug Administration. 1981. Code of Federal Regulations 21CFR 184.1025. The Office of the Federal Register National Archives and Records Administration, Washington, DC.
29. Vasudevan, P., P. Marek, M. K. Nair, T. Annamalai, M. Darre, M. Khan, and K. Venkitanarayanan. 2005. In vitro inactivation of Salmonella Enteritidis in autoclaved chicken cecal contents by caprylic acid. J. Appl. Poult. Res. 14:122-125.