Caprylic acid reduces enteric Campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations

Journal of Food Protection

Volumn 73, Issue 2, 2010, Pages 251-257

  De Los Santos, Fausto Solís ^a   Hume, Michael ^b   Venkitanarayanan, Kumar ^c   Donoghue, Ann M ^d   Hanning, Irene ^a   Slavik, Michael F ^a   Aguiar, Vivian F ^a   Metcalf, Joel H ^a   Reyes Herrera, Ixchel ^a   Blore, Pamela J ^a   Donoghue, Dan J ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

^b SOUTHERN PLAINS AGRICULTURAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVES; CAMPYLOBACTER; CAMPYLOBACTER JEJUNI; GALLUS GALLUS;

EID: 77649162828     PISSN: 0362028X     EISSN: None     Source Type: Journal    
DOI: 10.4315/0362-028X-73.2.251     Document Type: Article

References (54)

1. Allen, V. M., S. A. Bull, J. E. Conry, G. Domingue, F. Jørgensen. J. A. Fnist, R. Whyte, A. Gonzalez, N. Elviss, and T. J. Humphrey, 2007. Campylobacter spp. contamination of chicken carcasses during processing in relation to flock colonization. Int. J. Food Microbiol. 113:54-61.
2. Annamalai,T.,M.K.MohanNair,P.Marek,P.Vasudevan,D.Schreiber.R.Knight,T. Hoagland.andK.Venkitanarayanan.2004.InvitroinactivationofEscherichiacob0157: H7inbovinerumenfluidbycaprylicacid.J.FoodProt.67:884-1881(Pubitemid38610912)
3. Apajalahti. J. H., A. Kettunen. M. R. Bedford, and W. E. Holben. 2001. Percent G - C profiling accurately reveals diet-related differences in the gastrointestinal microbial community of broiler chickens. Appl. Environ. Microbiol. 67:5656-5667.
4. Beery, J. T., M. B. Hugdahl, and M. P. Doyle. 1988. Colonization of gastrointestinal tracts of chicks by Campylobacter jejuni. Appl. Environ. Microbiol. 54:2365-2370.
5. Bergsson,G.,O.Steingrimsson,andH.Thormar.1999. InvitrosusceptibilitiesofNeisseriagonorrhoeae-fattyacidsandmonoglycerides. Antimicrob.AgentsChemother.43:2790-2792.(Pubitemid29519567)
6. Berrang. M. E., R. J. Buhr, and J. A. Cason. 2000. Campylobacter recovery from external and internal organs of commercial broiler carcasses prior to scalding. Poult. Sci. 79:286-290.
7. Byrd,J.A.,R.C.Anderson.T.R.Callaway,R.W.Moore,K.D.Knape,L.F. Kuběna,R.L.,Ziprin,andD.J.Nisbet.2003. EffectofexperimentalchlorateproductadministrationinthedrinkingwateronSalmonella typhimuriumcontaminationofbroilers.Poult.Sci.82:1403-1406.(Pubitemid38641635)
8. Byrd,J.A.,D.E.Corrier.M.E.Hume,R.H.Bailey,L.H.Stanker.andB.M.Hargis.1998. IncidenceofCampylobacterincropsofpreharvestmarket-agebroilerchickens.Poult.Sci. 77:1303-1305.(Pubitemid128525082)
9. Cason.J.A.,A.Hinton.Jr.,J.K.Northcutt.R.J.Buhr,K.D.Ingram,D.P.Smith,andN. A.Cox.2007. Partitioningofexternalandinternalbacteriacarriedbybroilerchickensbeforeprocessi ng.J.FoodProt.70:2056-2062.(Pubitemid47479842)
10. Centers for Disease Control and Prevention. 2009. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food-K) states, United States. 2008. Morn. Mortal. Wkly. Rep. 58:333-337.
11. Clench, M. H., and J. R. Mathias. 1995. The avian cecum: a review. Wilson Bull. 107:93-121.
12. Cole, K., M. B. Farnell, A. M. Donoghue. N. J. Stern, E. A. Svetoch. B. N. Eruslanov, L. I. Volodina, Y. N. Kovalev, V. V. Perelygin, E. V. Mitsevich, I. P. Mitsevich, V. P. Levchuk, V. D. Pokhilenko, V. N. Borzenkov, O. E. Svetoch, T.Y.. Kudryavtseva, I.Reyes-Herrera, P. J. Blore, F. Solis de los Santos, and D. J. Donoghue. 2006. Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults. Poult. Sci 5:1570-1575.
13. Corrier,D.E.,J.A.Byrd,B.M.Hargis,M.E.Hume,R.H.Bailey,andL.H.Stanker.1999. PresenceofSalmonellainthecropandcecaofbroilerchickensbeforeandafterpreslaugh terfeedwithdrawal.Poult.Sei.78:45-49.(Pubitemid129554717)
14. Farnell, M. B., A. M. Donoghue, K. Cole, I. Reyes-Herrera, P. J. Blore, and D. J. Donoghue. 2005. Campylobacter susceptibility to ciprofloxacin and corresponding fluoroquinolone concentrations within the gastrointestinal tracts of chickens. J. Appl. Microbiol. 99:1043-1059.
15. Friedman, C. R., R. M. Hoekstra, M. Samuel, R. Marcus, J. Bender, B. Shiferaw, S. Reddy, S. D. Ahuja, D. L. Helfrick, F. Hardnett, M. Carter, B. Anderson, and R. V. Tauxe. 2004. Risk factors for sporadic Campylobacter infection in the United States: a case-control study in FoodNet sites. Clin. Infect. Dis. 38:S285-296.
16. Guo.F.C.B.A.Williams.R.P.Kwakkel.H.S.Li.X.P.Li,J.Y.Luo.W.K,Li.andM.W.A. Verstegen.2004,Effectsofmushroomandherbpolysaccharides, asalternativesforanantibiotic,onthececalmicrobialecosysteminbroilerchickens, Poult.Sei.83:175-182.(Pubitemid39197276)
17. Hume, M. E., S. Clemente-Hernández, and E. O. Oviedo-Rondon. 2006. Effects of feed additives and mixed Eimeria species infection on intestinal microbial ecology of broilers. Poult. Sei. 85:2106-2111.
18. Hume. M. E., L. F. Kuběna, T. S. Edrington, C. J. Donskey, R. W. Moore, S. C. Ricke, and D. J. Nisbet. 2003. Poultry digestive microflora biodiversity as indicated by denaturing gradient gel electrophoresis. Poult. Sci. 82:1100-1107.
19. Jensen, R. G. 2002. The composition of bovine milk lipids: January 1995 to December 2000. J. Dairy Sci. 85:295-350.
20. Jensen, R. G.. A. M. Ferris, C. J. Lammi-Keef'e. and R. A. Henderson. 1990. Lipids of bovine and human milks: a comparison. J. Dairy Sci. 73:223-240,
21. Johansen. C. H., L. Bjerrum, K. Finster, and K. Pedersen. 2006. Effects of a Campylobacter jejuni infection on lhe development of the intestinal microflora of broiler chickens. Poult. Sei. 85:579-587.
22. Lee, D. H.. Y.-Z. Zo. and S.-J. Kim. 1996. Nonradioactive methods to study genetic profiles of natural bacterial communities by PCRsingle-strand- confonnation polymorphism. Appl. Environ. Microbiol. 62:3112-3120.
23. Lindqvist, R.. and M. Lindblad. 2008. Quantitative risk assessment of thermophilic Campylobacter spp. and cross-coniamination during handling of raw broiler chickens evaluating strategies at the producer level to reduce human campylobacteriosis in Sweden. Int. J. Food Microbiol. 121:41-52. (Pubitemid 350284630)
24. Line.J.E.2001. DevelopmentofaselectivedifferentialagarforisolationandenumerationofCampylobac terspp,J.FoodProt.64:1711-1715.(Pubitemid34010086)
25. Loe Carillo. C. R. J. Atterbury, A. El-Shibiny, P. L. Connerton, E. Dillon, A. Scott, and I. F. Connerton. 2005. Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens. Appl. Environ. Microbiol. 11:6554-6563. (Pubitemid 43194136)
26. McLelland, J. 1993. Aparatus digestorius (systema alimentarium), p. 301-327. In J. J. Baumel, A. S. King, J. E. Breazile, H. E. Evans, and J. C. Vanden Berge (ed.), Handbook of avian anatomy: nomina anatómica avium. 2nd ed. Publications of the Nuttall Ornithological Club No. 23, Cambridge, MA.
27. Mead. G. C. 2002. Factors affecting intestinal colonization of poultry by Campylobacter and role of microflora in control. Worlds Poult. Sci. I. 58:169-178.
28. Mead, G. C. M. J. Scott, T. J. Humphrey, and K. McAlpine. 1996. Observations on the control of Campylobacter jejuni infection of poultry by "competitive exclusion." Avian Path. 25:69-79.
29. Meinersmann, R. J. W. E. Rigsby, N. J. Stern, L. C. Kelley. J. E. Hill. and M. P. Doyle. 1991. Comparative study of colonizing and noncolonizing Campylobacter jejuni. Am. J. Vet. Res. 52:1518-1522.
30. Morishita T. Y, P. P. Aye, B. S. Harr, C. W. Cobb, and J. R. Clifford. 1997. Evaluation of an avian-specific probiotic to reduce the colonization and shedding of Campylobacter jejuni in broilers. Avian Dis. 41:850-855.
31. Murray, A. E., J. T. Hollibaugh, and C. Orrego. 1996. Phylogenese compositions of bacterioplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments. Appl. Environ. Microbiol. 62:2676-2680.
32. Muyzer,G.,E.C.DeWaal,andA.G.Litterlinden.1993. Profilingofcomplexmicrobialpopulationsbydenaturinggradientgelelectro- phoresisanalysisofpolymerasechainreactionamplifiedgenescodingfor165rRNA.Appl. Environ.Microbiol.59:695-700.(Pubitemid23072343)
33. Nair, M.. K. J. Joy. P. Vasudevan. L. Hinckley, T. A. Hoagland, and K. S. Venkitanarayanan. 2005. Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. J. Dairy Sci. 88:3488-3495.
34. Northcutt. J. K. S. I. Savage, and L. R. Vest. 1997. Relationship between feed withdrawal and viscera condition. Poult. Sci. 76:410-414.
35. Oosterom, J., C. H. den Uyl. J. R. J. Banf'fer, and J. Huisman. 1984. Epidemiological investigations on Campylobacter jejuni in households with primary infection. J. Hye. (Cumb. j 92:325-332. 36.
36. Papa, C. M. and J. A. Dickens, 1989. Lower gut contents and defecatory responses of broiler chickens as affected by feed withdrawal and electrical treatment at slaughter. Poult. Sci. 68: 1478-1484.
37. Ramirez. G. A.. L. L. Sarlin, D. J. Caldwell. C. R. Yezak. Jr.. M. E. Hume, D. E. Corrier. J. R. Deloach. and B. M. Hargis. 1997. Effect of feed withdrawal on the incidence of Salmonella in the crops and ceca of market age broiler chickens. Poult. Sei. 76:654-656.
38. Reysenbach, A.-L. L. J. Giver, G. S. Wickham. and N. R. Pace. 1992. Differential amplification of rRNA genes by polymerase chain reaction. Appl. Environ. Microbiol. 58:3417-3418.
39. Rosenquist, H., N. L. Nielsen, H. M. Sommer, B. Norrung, and B. B. Christensen. 2003. Quantitative risk assessment of human campylobacteriosis associated with thermophilic Campylobacter species in chickens. Int. J. Food Microbiol. 83:87-103. (Pubitemid 36379126)
40. Rosenquist. H.. H. M. Sommer. N. L. Nielsen. and B. B. Christensen. 2006. The effect of slaughter operations on the contamination of chicken carcasses with thermoiolerant Campylobacter. Int. J. Food Microbiol. 108:226-232.
41. SAS Institute, Inc. 2002. SAS/STAT® user's guide: release 9.03 edition. SAS Institute, Inc., Cary. NC.
42. Sheffield, V. C. D. R. Cox, L. S. Lerman, and R. M. Myers. 1989. Attachment of a 40-base-pair GC-rich sequence (GC clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Proc. Natl. Acad. Sci. USA 86:232-236.
43. Skřivanova, E., M. Marounek. G. Dlouhá, and J. Kanka. 2007. Susceptibility of Clostridium perfriitgens to C-C fatty acids. Lett. Appl. Microbiol. 41:77-81.
44. Skřivanova, E. Z. Molatová, and M. Marounek. 2008. Effects of caprylic acid and triacylglycerols of both caprylic and capric acid in rabbits experimentally infected with enteropathogenic Escherichia coli O103. Vet. Microbiol. 126:372-376. (Pubitemid 350199606)
45. Solis de los Santos, F., A. M. Donoghue. K. Venkitanarayanan, M. L. Dirain. I. Reyes-Herrera. P. J. Blore. and D. J. Donoghue. 2008. Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni colonization in young broiler chickens. Poult. Sci. 87:800-804.
46. Solis de los Santos. F.. A. M. Donoghue. K. Venkitanarayanan. J. H. Metcalf, M. L. Dirain, V. F. Aguiar. L. Reyes-Herrera, P. J. Blore. and D. J. Donoghue. 2008. Therapeutic supplementation of caprylic acid in feed reduces Campylobacter jejuni in broiler chicks. Appl. Environ. Microbiol. 74:4564-4566.
47. Solis de los Santos, F.. A. M. Donoghue. K. Venkitanarayanan, J. H. Metcalf, M. L. Dirain, V. F. Aguiar. I. Reyes-Herrera. P. J. Blore. and D. J. Donoghue. 2009. The natural feed additive, caprylic acid reduces Campylobacter jejuni colonization in market aged broiler chickens. Poult. Sci. 88:61-64.
48. Sprong, R. C. M. F. E. Hulstein, and R. van der Meer. 2001. Bactericidal activities of milk lipids. Antimicrob. Agents Chemother. 45:1298-1301.
49. Stem, N. J. 1994. Mucosal competitive exclusion to diminish colonization of chickens by Campylobacter jejuni. Poult. Sci. 73: 402-407.
50. Thompson, K. L., and T. J. Applegate. 2006. Feed withdrawal alters small-intestinal morphology and mucus of broilers. Poult. Sci. 85: 1535-1540.
51. Thomiar, H., H. Hilmarsson. and G. Bergsson. 2006. Stable concentrated emulsions of the 1-monoglyceride of capric acid (monocaprin) with microbicidal activities against the food-borne bacteria Campylobacter jejími. Salmonella spp.. and Escherichia coli. Appl. Environ. Microbiol. 72:522-526.
52. Van lniinerseel, F., J. Dc Buck, F. Boyen, L. Bohez, F. Pasmans, J. VoIf, M. Sevcik, I. Ryclilik, F. Haesebrouck, and R. Ducatclle. 2004, Medium-chain fatty acids decrease colonization and invasion through hil A suppression shortly after infection of chickens with Salmonella entérica serovar Entcritidis. Appl. Environ. Microbiol. 70:3582-3587.
53. Vasudevan.P.,M.Patrick.M.Nair.T.Annamalai.M.Darre.M.Khan,andK. Venkitanarayanan.2005. InvitroinactivationofSalmonellaEnteritidisinchickencecalcontentsbycaprylicacid. J.Appl.Poult.Res.14:122-125.(Pubitemid40441118)
54. Wallace, J. S., K. N. Stanley, and K. Jones. 1998. The colonization of turkeys by thermophilic Campylobacters. J. Appl. Microbiol. 85:224-230.