The artificial silicon retina in retinitis pigmentosa patients (an american ophthalmological association thesis)

Transactions of the American Ophthalmological Society

Volumn 108, Issue , 2010, Pages 120-154

  Chow, Alan Y ^a,b   Bittner, Ava K ^a,b   Pardue, Machelle T ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Department of Optobionics ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; NEUROTROPHIC FACTOR;

ADULT; AGED; ARTICLE; ARTIFICIAL ORGAN; ARTIFICIAL RETINA; BIOCOMPATIBILITY; CLINICAL ARTICLE; COLOR VISION; DISEASE SEVERITY; ELECTROSTIMULATION; EQUIPMENT DESIGN; EYE EXAMINATION; FEMALE; HISTOPATHOLOGY; HUMAN; INTERMETHOD COMPARISON; MALE; NEUROPROTECTION; PATIENT ASSESSMENT; PATIENT SAFETY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SILICONE PROSTHESIS; TREATMENT OUTCOME; VISION TEST; VISUAL ACUITY; VISUAL IMPAIRMENT;

ARTIFICIAL ORGANS; COLOR VISION; EQUIPMENT DESIGN; FEASIBILITY STUDIES; FOLLOW-UP STUDIES; HUMANS; PILOT PROJECTS; RETINA; RETINITIS PIGMENTOSA; SILICON; TIME FACTORS; TREATMENT OUTCOME; VISION TESTS; VISION, LOW; VISION, OCULAR; VISUAL ACUITY;

EID: 79251487556     PISSN: None     EISSN: 15456110     Source Type: Journal    
DOI: None     Document Type: Article

References (87)

1. Flannery JG, Farber DB, Bird AC, Bok D. Degenerative changes in a retina affected with autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 1989;30:191-211.
2. Santos A, Humayun MS, de Juan EJ, et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol 1997;115:511-515.
3. Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci 1996;37:1236-1249.
4. Berson EL, Rosner B, Sandberg MA, et al. A randomized trial of vitamin A and vitamin E supplementation for retinitis. Arch Ophthalmol 1993;111:761-772.
5. Acland GM, Aguirre GD, Ray J, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 2001;28:92-95.
6. del Cerro M, Gash DM, Rao GN, et al. Retinal transplants into the anterior chamber of the rat eye. Neuroscience 1987;21:707-723.
7. Armant RB, Seiler MJ. Transplanted sheets of human retina and retinal pigmented epithelium develop normally in nude rats. Exp Eye Res 2002;75:115-125.
8. Humayun MS, Prince M, de Juan EJ, et al. Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa. Invest Ophthalmol Vis Sci 1999;40:143-148.
9. Brindley GS. The site of electrical excitation of the human eye. J Physiol 1955;127:189-200.
10. Brindley GS. Beats produced by simultaneous stimulation of the human eye with intermittent light and intermittent or alternating electric current. J Physiol 1962;164:157-167.
11. Brindley GS. A new interaction of light and electricity in stimulating the human retina. J Physiol 1964;171:514-520.
12. Potts AM, Inoue J, Buffum D. The electrically evoked response (EER) of the visual system. Invest Ophthalmol Vis Sci 1968;7:269-278.
13. Carpenter RH. Electrical stimulation of the human eye in different adaptational states. J Physiol 1972;221:137-148.
14. Potts AM, Inoue J. The electrically evoked response (EER) of the visual system. II. Effect of adaptation and retinitis pigmentosa. Invest Ophthalmol 1969;8:605-612.
15. Potts AM, Inoue J. The electrically evoked response of the visual system (EER). III. Further consideration to the origin of the EER. Invest Ophthalmol 1970;9:814-819.
16. Dowling JE, Sidman RL. Inherited retinal dystrophy in the rat. J Cell Biol 1962;14:73-109.
17. Dawson WW, Radtke ND. The electrical stimulation of the retina by indwelling electrodes. Invest Ophthalmol Vis Sci 1977;16:249-252.
18. Humayun MS, de Juan E Jr, Dagnelie G, et al. Visual perception elicited by electrical stimulation of retina in blind humans. Arch Ophthalmol 1996;114:40-46.
19. Knighton RW. An electrically evoked slow potential of the frog's retina. I. Properties of the response. J Neurophysiol 1975;38:185-197.
20. Knighton RW. An electrically evoked slow potential of the frog's retina. II. Identification with PII component of electroretinogram. J Neurophysiol 1975;38:198-209.
21. Chow AY, inventor. Artificial retina device. US patent 5,016,633. May 21, 1991.
22. Chow AY, Chow VY. Subretinal electrical stimulation of the rabbit retina. Neurosci Lett 1997;225:13-16.
23. Peyman G, Chow AY, Liang C, et al. Subretinal semiconductor microphotodiode array. Ophthalmic Surg Lasers 1998;29:234-241.
24. Chow AY, Chow VY, Packo KH, et al. The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch Ophthalmol 2004;122:460-469.
25. Humayun MS, Weiland JD, Fujii GY, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res 2003;43:2573-2581.
26. Caspi A, Dorn JD, McClure KH, et al. Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant. Arch Ophthalmol 2009;127:398-401.
27. Roessler G, Laube T, Brockmann C, et al. Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial. Invest Ophthalmol Vis Sci 2009;50:3003-3008.
28. Zrenner E, Stett A, Weiss S, et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 1999;39:2555-2567.
29. Chow AY, Peachey NS. The subretinal microphotodiode array retinal prosthesis [letter and comment]. Ophthalmic Res 1998;30:195-198.
30. Eckmiller R. Learning retina implants with epiretinal contacts. Ophthalmic Res 1997;29:281-289.
31. Rizzo JF, Wyatt J, Loewenstein J, et al. Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. Invest Ophthalmol Vis Sci 2003;44:5362-5369.
32. Veraart C, Raftopoulos C, Mortimer JT, et al. Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode. Brain Res 1998;813:181-186.
33. Brelén ME, Duret F, Gérard B. Creating a meaningful visual perception in blind volunteers by optic nerve stimulation. J Neural Eng 2005;2:22-28.
34. Brindley GS, Lewin WS. The sensations produced by electrical stimulation of the visual cortex. J Physiol 1968;196:479-493.
35. Brindley G, Rushton D. Implanted stimulators of the visual cortex as visual prosthetic devices. Trans Am Acad Ophthalmol Otolaryngol 1974;78:OP-741-OP-745.
36. Dobelle WH, Mladejovsky MG. Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a prosthesis for the blind. J Physiol 1974;243:553-576.
37. Normann RA, Maynard EM, Rousche PJ, et al. A neural interface for a cortical vision prosthesis. Vision Res 1999;39:2577-2587.
38. Fernández E, Pelayo F, Romero S, et al. Development of a cortical visual neuroprosthesis for the blind: the relevance of neuroplasticity. J Neural Eng 2005;2:1-12.
39. Chow AY, inventor. Independent photoelectric artificial retina device and method of using same. US patent 5,397,350. March 14, 1995.
40. Zrenner E, Miliczek KD, Gabel VP, et al. The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. Ophthalmic Res 1997;29:269-280.
41. Peachey NS, Chow AY. Subretinal implantation of semiconductor-based photodiodes: progress and challenges. J Rehabil Res Dev 1999;36:371-376.
42. Chow AY, Pardue MT, Chow VY, et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans Neural Syst Rehabil Eng 2001;9:86-95.
43. Pardue MT, Stubbs JR, Perlman JI, et al. Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp Eye Res 2001;73:333-343.
44. Peachey NS, Chow AY, Pardue MT, et al. Response characteristics of subretinal microphotodiode-based implant mediated cortical potentials. In: Hollyfield J, ed. Retinal Degenerative Diseases and Experimental Therapy. New York: Plenum Publishers; 1999:471-478.
45. Zrenner E, Stett A, Weiss S, et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 1999;39:2555-2567.
46. Pardue MT, Ball SL, Hetling JR, et al. Visual evoked potentials to infrared stimulation in normal cats and rats. Doc Ophthalmol 2001;103:155-162.
47. Lagey CL, Roelofs JM, Janssen LW, et al. Electrical stimulation of bone growth with direct current. Clin Orthop 1986;204:303-312.
48. Kane WJ. Direct current electrical bone growth stimulation for spinal fusion. Spine 1988;13:363-365.
49. Politis MJ, Zanakis MF. Short term efficacy of applied electric fields in the repair of the damaged rodent spinal cord: behavioral and morphological results. Neurosurgery 1988;23:582-588.
50. Leake PA, Hradek GT, Snyder RL. Chronic electrical stimulation by a cochlear implant promotes survival of spiral ganglion neurons after neonatal deafness. J Comp Neurol 1999;412:543-562.
51. Leake PA, Hradek GT, Rebscher SJ, Snyder RL. Chronic intracochlear electrical stimulation induces selective survival of spiral ganglion neurons in neonatally deafened cats. Hear Res 1991;54:251-271.
52. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 2000;20:2602-2608.
53. Al-Majed AA, Brushart TM, Gordon T. Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci 2000;12:4381-4390.
54. The Deep-Brain Stimulation for Parkinson's Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001;345:956-963.
55. Carvalho GA, Nikkhah G. Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp Neurol 2001;171:405-417.
56. Andrews RJ. Neuroprotection for the new millennium: matchmaking pharmacology and technology. Ann N Y Acad Sci 2001;939:114-125.
57. Goldberg JL, Espinose JS, Xu Y, Davidson N, Kovasx GT, Barres BA. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron 2002;33:689-702.
58. Watanabe M, Fukuda Y. Survival and axonal regeneration of retinal ganglion cells in adult cats. Prog Retin Eye Res 2002;21:529-553.
59. Morimoto T, Miyoshi T, Fujikado T, Tano Y, Fukuda Y. Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo. Neuroreport 2002;13:227-230.
60. Chaum E. Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem 2003;88:57-75.
61. Wen R, Song Y, Cheng T, et al. Injury-induced upregulation of bFGF and CNTF mRNAs in the rat retina. J Neurosci 1995;15:7377-7385.
62. Ikeda K, Tanihara H, Tatsuno T, Noguchi H, Nakayama C. Brainderived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light damage. J Neurochem 2003;87:290-296.
63. Faktorovich EG, Steinberg RH, Yasumura D, et al. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 1990;347:83-86.
64. LaVail MM, Unoki K, Yasumura D, et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A 1992;89:11249-11253.
65. Lau D, McGee LH, Zhou S, et al. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest Ophthalmol Vis Sci 2000;41:3622-3633.
66. Bok D, Yasumura D, Matthes MT, et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 2002;74:719-735.
67. Okoye G, Zimmer J, Sung J, et al. Increased expression of brainderived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci 2003;23:4164-4172.
68. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 1992;12:3554-3567.
69. Humphrey MF, Parker C, Chu Y, Constable IJ. Transient preservation of photoreceptors on the flanks of argon laser lesions in the RCS rat. Curr Eye Res 1993;12:367-372.
70. Cao W, Li F, Steinberg RH, LaVail MM. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP, and IGF-I in the rat retina. Exp Eye Res 2001;72:591-604.
71. Pardue MT, Phillips MJ, Yin H, et al. Neuroprotective effect of subretinal implants in the RCS rat. Invest Ophthalmol Vis Sci 2005;46:674-682.
72. D'Cruz PM, Yasumura D, Weir J, et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 2000;9:645-651.
73. Bok D, Hall MO. The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J Cell Biol 1971;49:664-682.
74. Mullen RJ, LaVail MM. Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras. Science 1976;192:799-801.
75. LaVail MM, Battelle BA. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res 1975;21:167-192.
76. Chow AY, Pardue MT, Perlman JI, et al. Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J Rehabil Res Dev 2002;39:313-321.
77. Ciavatta VT, Kim M, Wong P, et al. Retinal expression of Fgf2 in RCS rats with subretinal microphotodiode array. Invest Ophthalmol Vis Sci 2009;50:4523-4530. Epub 2004 Mar 5.
78. Bowman KJ. A method for quantitative scoring of the Farnsworth Panel D-15. Acta Ophthalmol 1982;60:907-916.
79. Atchison DA, Bowman KJ, Vingrys AJ. Quantitative scoring methods for D15 panel tests in the diagnosis of congenital color vision deficiencies. Optom Vis Sci 1991;68:41-48.
80. Marc RE, Jones BW, Watt CB, et al. Neural remodeling in retinal degeneration. Prog Retin Eye Res 2003;22:607-655.
81. Brady GS. Silicon. In: Brady GS, ed. Materials Handbook. 13th ed. New York: McGraw-Hill, Inc; 1991:739-741.
82. Rizzo JF, Wyatt J, Loewenstein J, et al. Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. Invest Ophthalmol Vis Sci 2003;44:5355-5361.
83. Pardue MT, Phillips MJ, Hanzlicek B, et al. Neuroprotection of photoreceptors in the RCS rat after implantation of a subretinal implant in the superior or inferior retina. Adv Exp Med Biol 2006;572:321-326.
84. Friedman DS, Munoz B, Massof RW, et al. Grating visual acuity using the preferential-looking method in elderly nursing home residents. Invest Ophthalmol Vis Sci 2002;43:2572-2578.
85. Stiers P, Vanderkelen R, Vandenbussche E. Optotype and grating visual acuity in patients with ocular and cerebral visual impairment. Invest Ophthalmol Vis Sci 2004;45:4333-4339.
86. Thayaparan K, Crossland MD, Rubin GS. Clinical assessment of two novel contrast sensitivity charts. Br J Ophthalmol 2007;91:749-752.
87. Cole BL, Orenstein JM. Does the Farnsworth D15 test predict the ability to name colours? Clin Exp Optom 2003;86:221-229.