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Volumn 53, Issue 2, 2011, Pages 695-704

Development of molecularly targeted therapies in biliary tract cancers: Reassessing the challenges and opportunities

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ARRY 438162; BEVACIZUMAB; CAPECITABINE; CEDIRANIB; CETUXIMAB; CISPLATIN; DOCETAXEL; ERLOTINIB; GEMCITABINE; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; SELUMETINIB; SORAFENIB; UNCLASSIFIED DRUG; VANDETANIB;

EID: 79251469043     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24145     Document Type: Article
Times cited : (65)

References (80)
  • 1
    • 15744389434 scopus 로고    scopus 로고
    • Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
    • Shaib YH, El-Serag HB, Davila JA, Morgan R, McGlynn KA. Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology 2005; 128: 620-626.
    • (2005) Gastroenterology , vol.128 , pp. 620-626
    • Shaib, Y.H.1    El-Serag, H.B.2    Davila, J.A.3    Morgan, R.4    McGlynn, K.A.5
  • 3
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 5
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 7
    • 68049124818 scopus 로고    scopus 로고
    • KRAS mutations and susceptibility to cetuximab and panitumumab in colorectal cancer
    • Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG. KRAS mutations and susceptibility to cetuximab and panitumumab in colorectal cancer. Cancer J 2009; 15: 110-113.
    • (2009) Cancer J , vol.15 , pp. 110-113
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 8
    • 77955285782 scopus 로고    scopus 로고
    • Genetics of biliary tract cancers and emerging targeted therapies
    • Hezel AF, Deshpande V, Zhu AX. Genetics of biliary tract cancers and emerging targeted therapies. J Clin Oncol 2010; 28: 3531-3540.
    • (2010) J Clin Oncol , vol.28 , pp. 3531-3540
    • Hezel, A.F.1    Deshpande, V.2    Zhu, A.X.3
  • 9
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: the first 30 years
    • Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003; 3: 459-465.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 10
    • 0037624602 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
    • Tannapfel A, Sommerer F, Benicke M, Katalinic A, Uhlmann D, Witzigmann H, et al. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut 2003; 52: 706-712.
    • (2003) Gut , vol.52 , pp. 706-712
    • Tannapfel, A.1    Sommerer, F.2    Benicke, M.3    Katalinic, A.4    Uhlmann, D.5    Witzigmann, H.6
  • 11
    • 0036793788 scopus 로고    scopus 로고
    • K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China
    • Rashid A, Ueki T, Gao YT, Houlihan PS, Wallace C, Wang BS, et al. K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin Cancer Res 2002; 8: 3156-3163.
    • (2002) Clin Cancer Res , vol.8 , pp. 3156-3163
    • Rashid, A.1    Ueki, T.2    Gao, Y.T.3    Houlihan, P.S.4    Wallace, C.5    Wang, B.S.6
  • 12
    • 0025933890 scopus 로고
    • Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
    • Levi S, Urbano-Ispizua A, Gill R, Thomas DM, Gilbertson J, Foster C, et al. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 1991; 51: 3497-3502.
    • (1991) Cancer Res , vol.51 , pp. 3497-3502
    • Levi, S.1    Urbano-Ispizua, A.2    Gill, R.3    Thomas, D.M.4    Gilbertson, J.5    Foster, C.6
  • 13
    • 0032976479 scopus 로고    scopus 로고
    • Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
    • Hanada K, Tsuchida A, Iwao T, Eguchi N, Sasaki T, Morinaka K, et al. Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Am J Gastroenterol 1999; 94: 1638-1642.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1638-1642
    • Hanada, K.1    Tsuchida, A.2    Iwao, T.3    Eguchi, N.4    Sasaki, T.5    Morinaka, K.6
  • 14
    • 0033756536 scopus 로고    scopus 로고
    • Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    • Tannapfel A, Benicke M, Katalinic A, Uhlmann D, Kockerling F, Hauss J, et al. Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver. Gut 2000; 47: 721-727.
    • (2000) Gut , vol.47 , pp. 721-727
    • Tannapfel, A.1    Benicke, M.2    Katalinic, A.3    Uhlmann, D.4    Kockerling, F.5    Hauss, J.6
  • 15
    • 4544385478 scopus 로고    scopus 로고
    • Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability
    • Saetta AA, Papanastasiou P, Michalopoulos NV, Gigelou F, Korkolopoulou P, Bei T, et al. Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability. Virchows Arch 2004; 445: 179-182.
    • (2004) Virchows Arch , vol.445 , pp. 179-182
    • Saetta, A.A.1    Papanastasiou, P.2    Michalopoulos, N.V.3    Gigelou, F.4    Korkolopoulou, P.5    Bei, T.6
  • 16
    • 34547605884 scopus 로고    scopus 로고
    • Frequent activation of mitogen-activated protein kinase relative to Akt in extrahepatic biliary tract cancer
    • Hori H, Ajiki T, Mita Y, Horiuchi H, Hirata K, Matsumoto T, et al. Frequent activation of mitogen-activated protein kinase relative to Akt in extrahepatic biliary tract cancer. J Gastroenterol 2007; 42: 567-572.
    • (2007) J Gastroenterol , vol.42 , pp. 567-572
    • Hori, H.1    Ajiki, T.2    Mita, Y.3    Horiuchi, H.4    Hirata, K.5    Matsumoto, T.6
  • 18
    • 34147160767 scopus 로고    scopus 로고
    • Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer
    • Jimeno A, Rubio-Viqueira B, Amador ML, Grunwald V, Maitra A, Iacobuzio-Donahue C, et al. Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer. Mol Cancer Ther 2007; 6: 1079-1088.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1079-1088
    • Jimeno, A.1    Rubio-Viqueira, B.2    Amador, M.L.3    Grunwald, V.4    Maitra, A.5    Iacobuzio-Donahue, C.6
  • 19
    • 3042658493 scopus 로고    scopus 로고
    • A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model
    • Horiuchi H, Kawamata H, Fujimori T, Kuroda Y. A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model. Int J Oncol 2003; 23: 957-963.
    • (2003) Int J Oncol , vol.23 , pp. 957-963
    • Horiuchi, H.1    Kawamata, H.2    Fujimori, T.3    Kuroda, Y.4
  • 20
    • 33645689431 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma
    • Leone F, Cavalloni G, Pignochino Y, Sarotto I, Ferraris R, Piacibello W, et al. Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma. Clin Cancer Res 2006; 12: 1680-1685.
    • (2006) Clin Cancer Res , vol.12 , pp. 1680-1685
    • Leone, F.1    Cavalloni, G.2    Pignochino, Y.3    Sarotto, I.4    Ferraris, R.5    Piacibello, W.6
  • 21
    • 27144523155 scopus 로고    scopus 로고
    • Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    • Gwak GY, Yoon JH, Shin CM, Ahn YJ, Chung JK, Kim YA, et al. Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas. J Cancer Res Clin Oncol 2005; 131: 649-652.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 649-652
    • Gwak, G.Y.1    Yoon, J.H.2    Shin, C.M.3    Ahn, Y.J.4    Chung, J.K.5    Kim, Y.A.6
  • 22
    • 21344438897 scopus 로고    scopus 로고
    • Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    • Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, Ooi A. Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol 2005; 206: 356-365.
    • (2005) J Pathol , vol.206 , pp. 356-365
    • Nakazawa, K.1    Dobashi, Y.2    Suzuki, S.3    Fujii, H.4    Takeda, Y.5    Ooi, A.6
  • 23
    • 77649339494 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder
    • Shafizadeh N, Grenert JP, Sahai V, Kakar S. Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. Hum Pathol 2010; 41: 485-492.
    • (2010) Hum Pathol , vol.41 , pp. 485-492
    • Shafizadeh, N.1    Grenert, J.P.2    Sahai, V.3    Kakar, S.4
  • 24
    • 77953636872 scopus 로고    scopus 로고
    • Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines
    • Xu L, Hausmann M, Dietmaier W, Kellermeier S, Pesch T, Stieber-Gunckel M, et al. Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines. BMC Cancer 2010; 10: 302.
    • (2010) BMC Cancer , vol.10 , pp. 302
    • Xu, L.1    Hausmann, M.2    Dietmaier, W.3    Kellermeier, S.4    Pesch, T.5    Stieber-Gunckel, M.6
  • 26
    • 0035476235 scopus 로고    scopus 로고
    • Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma
    • Kiguchi K, Carbajal S, Chan K, Beltran L, Ruffino L, Shen J, et al. Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. Cancer Res 2001; 61: 6971-6976.
    • (2001) Cancer Res , vol.61 , pp. 6971-6976
    • Kiguchi, K.1    Carbajal, S.2    Chan, K.3    Beltran, L.4    Ruffino, L.5    Shen, J.6
  • 27
    • 34248580938 scopus 로고    scopus 로고
    • Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model
    • Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, et al. Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer Res 2007; 67: 3794-3800.
    • (2007) Cancer Res , vol.67 , pp. 3794-3800
    • Wu, Q.1    Kiguchi, K.2    Kawamoto, T.3    Ajiki, T.4    Traag, J.5    Carbajal, S.6
  • 28
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376: 687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6
  • 30
    • 0038645938 scopus 로고    scopus 로고
    • Identification of novel cellular targets in biliary tract cancers using global gene expression technology
    • Hansel DE, Rahman A, Hidalgo M, Thuluvath PJ, Lillemoe KD, Shulick R, et al. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol 2003; 163: 217-229.
    • (2003) Am J Pathol , vol.163 , pp. 217-229
    • Hansel, D.E.1    Rahman, A.2    Hidalgo, M.3    Thuluvath, P.J.4    Lillemoe, K.D.5    Shulick, R.6
  • 31
    • 32544448409 scopus 로고    scopus 로고
    • Expression of IGF-I, IGF-II, and IGF-IR in gallbladder carcinoma. A systematic analysis including primary and corresponding metastatic tumours
    • Kornprat P, Rehak P, Ruschoff J, Langner C. Expression of IGF-I, IGF-II, and IGF-IR in gallbladder carcinoma. A systematic analysis including primary and corresponding metastatic tumours. J Clin Pathol 2006; 59: 202-206.
    • (2006) J Clin Pathol , vol.59 , pp. 202-206
    • Kornprat, P.1    Rehak, P.2    Ruschoff, J.3    Langner, C.4
  • 32
    • 33745710682 scopus 로고    scopus 로고
    • Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
    • Alvaro D, Barbaro B, Franchitto A, Onori P, Glaser SS, Alpini G, et al. Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol 2006; 169: 877-888.
    • (2006) Am J Pathol , vol.169 , pp. 877-888
    • Alvaro, D.1    Barbaro, B.2    Franchitto, A.3    Onori, P.4    Glaser, S.S.5    Alpini, G.6
  • 33
    • 76649103697 scopus 로고    scopus 로고
    • Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance
    • Wolf S, Lorenz J, Mossner J, Wiedmann M. Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance. World J Gastroenterol 2010; 16: 156-166.
    • (2010) World J Gastroenterol , vol.16 , pp. 156-166
    • Wolf, S.1    Lorenz, J.2    Mossner, J.3    Wiedmann, M.4
  • 34
    • 33745856213 scopus 로고    scopus 로고
    • Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
    • Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, et al. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest 2006; 116: 1843-1852.
    • (2006) J Clin Invest , vol.116 , pp. 1843-1852
    • Xu, X.1    Kobayashi, S.2    Qiao, W.3    Li, C.4    Xiao, C.5    Radaeva, S.6
  • 35
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006; 127: 265-275.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 36
    • 2142758177 scopus 로고    scopus 로고
    • P53 is a tumor suppressor gene
    • 1 p following S69.
    • Levine AJ, Finlay CA, Hinds PW. P53 is a tumor suppressor gene. Cell 2004; 116: S67-S69. 1 p following S69.
    • (2004) Cell , vol.116
    • Levine, A.J.1    Finlay, C.A.2    Hinds, P.W.3
  • 37
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague J. TGFbeta in Cancer. Cell 2008; 134: 215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 38
    • 1842428729 scopus 로고    scopus 로고
    • Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China
    • Ueki T, Hsing AW, Gao YT, Wang BS, Shen MC, Cheng J, et al. Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China. Clin Cancer Res 2004; 10: 1717-1725.
    • (2004) Clin Cancer Res , vol.10 , pp. 1717-1725
    • Ueki, T.1    Hsing, A.W.2    Gao, Y.T.3    Wang, B.S.4    Shen, M.C.5    Cheng, J.6
  • 39
    • 0028981089 scopus 로고
    • Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers
    • Yoshida S, Todoroki T, Ichikawa Y, Hanai S, Suzuki H, Hori M, et al. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. Cancer Res 1995; 55: 2756-2760.
    • (1995) Cancer Res , vol.55 , pp. 2756-2760
    • Yoshida, S.1    Todoroki, T.2    Ichikawa, Y.3    Hanai, S.4    Suzuki, H.5    Hori, M.6
  • 40
    • 0034107937 scopus 로고    scopus 로고
    • Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer
    • Suto T, Habano W, Sugai T, Uesugi N, Funato O, Kanno S, et al. Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer. J Surg Oncol 2000; 73: 158-163.
    • (2000) J Surg Oncol , vol.73 , pp. 158-163
    • Suto, T.1    Habano, W.2    Sugai, T.3    Uesugi, N.4    Funato, O.5    Kanno, S.6
  • 41
    • 0034050615 scopus 로고    scopus 로고
    • Mutations of p53 tumor suppressor gene, apoptosis, and proliferation in intrahepatic cholangiocellular carcinoma of the liver
    • Tannapfel A, Weinans L, Geissler F, Schutz A, Katalinic A, Kockerling F, et al. Mutations of p53 tumor suppressor gene, apoptosis, and proliferation in intrahepatic cholangiocellular carcinoma of the liver. Dig Dis Sci 2000; 45: 317-324.
    • (2000) Dig Dis Sci , vol.45 , pp. 317-324
    • Tannapfel, A.1    Weinans, L.2    Geissler, F.3    Schutz, A.4    Katalinic, A.5    Kockerling, F.6
  • 43
    • 0035312199 scopus 로고    scopus 로고
    • Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts
    • Argani P, Shaukat A, Kaushal M, Wilentz RE, Su GH, Sohn TA, et al. Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. Cancer 2001; 91: 1332-1341.
    • (2001) Cancer , vol.91 , pp. 1332-1341
    • Argani, P.1    Shaukat, A.2    Kaushal, M.3    Wilentz, R.E.4    Su, G.H.5    Sohn, T.A.6
  • 44
    • 33746126998 scopus 로고    scopus 로고
    • Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice
    • Farazi PA, Zeisberg M, Glickman J, Zhang Y, Kalluri R, DePinho RA. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res 2006; 66: 6622-6627.
    • (2006) Cancer Res , vol.66 , pp. 6622-6627
    • Farazi, P.A.1    Zeisberg, M.2    Glickman, J.3    Zhang, Y.4    Kalluri, R.5    DePinho, R.A.6
  • 45
    • 0032984141 scopus 로고    scopus 로고
    • Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
    • Su GH, Hruban RH, Bansal RK, Bova GS, Tang DJ, Shekher MC, et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 1999; 154: 1835-1840.
    • (1999) Am J Pathol , vol.154 , pp. 1835-1840
    • Su, G.H.1    Hruban, R.H.2    Bansal, R.K.3    Bova, G.S.4    Tang, D.J.5    Shekher, M.C.6
  • 47
    • 33845296152 scopus 로고    scopus 로고
    • Biological characteristics of cancers in the gallbladder and biliary tract and targeted therapy
    • Thomas MB. Biological characteristics of cancers in the gallbladder and biliary tract and targeted therapy. Crit Rev Oncol Hematol 2007; 61: 44-51.
    • (2007) Crit Rev Oncol Hematol , vol.61 , pp. 44-51
    • Thomas, M.B.1
  • 49
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324: 1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 50
    • 38549139744 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    • Yoshikawa D, Ojima H, Iwasaki M, Hiraoka N, Kosuge T, Kasai S, et al. Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer 2008; 98: 418-425.
    • (2008) Br J Cancer , vol.98 , pp. 418-425
    • Yoshikawa, D.1    Ojima, H.2    Iwasaki, M.3    Hiraoka, N.4    Kosuge, T.5    Kasai, S.6
  • 51
    • 33747873394 scopus 로고    scopus 로고
    • Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas
    • Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, et al. Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas. J Surg Oncol 2006; 94: 242-247.
    • (2006) J Surg Oncol , vol.94 , pp. 242-247
    • Giatromanolaki, A.1    Sivridis, E.2    Simopoulos, C.3    Polychronidis, A.4    Gatter, K.C.5    Harris, A.L.6
  • 52
    • 33645796263 scopus 로고    scopus 로고
    • The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma
    • Park BK, Paik YH, Park JY, Park KH, Bang S, Park SW, et al. The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma. Am J Clin Oncol 2006; 29: 138-142.
    • (2006) Am J Clin Oncol , vol.29 , pp. 138-142
    • Park, B.K.1    Paik, Y.H.2    Park, J.Y.3    Park, K.H.4    Bang, S.5    Park, S.W.6
  • 53
    • 0032774271 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is an independent negative predictor in extrahepatic biliary tract carcinomas
    • Hida Y, Morita T, Fujita M, Miyasaka Y, Horita S, Fujioka Y, et al. Vascular endothelial growth factor expression is an independent negative predictor in extrahepatic biliary tract carcinomas. Anticancer Res 1999; 19: 2257-2260.
    • (1999) Anticancer Res , vol.19 , pp. 2257-2260
    • Hida, Y.1    Morita, T.2    Fujita, M.3    Miyasaka, Y.4    Horita, S.5    Fujioka, Y.6
  • 54
    • 68949207800 scopus 로고    scopus 로고
    • Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma
    • Okabe H, Beppu T, Hayashi H, Horino K, Masuda T, Komori H, et al. Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma. Ann Surg Oncol 2009; 16: 2555-2564.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2555-2564
    • Okabe, H.1    Beppu, T.2    Hayashi, H.3    Horino, K.4    Masuda, T.5    Komori, H.6
  • 55
    • 67449098972 scopus 로고    scopus 로고
    • Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma
    • Chuaysri C, Thuwajit P, Paupairoj A, Chau-In S, Suthiphongchai T, Thuwajit C. Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma. Oncol Rep 2009; 21: 957-969.
    • (2009) Oncol Rep , vol.21 , pp. 957-969
    • Chuaysri, C.1    Thuwajit, P.2    Paupairoj, A.3    Chau-In, S.4    Suthiphongchai, T.5    Thuwajit, C.6
  • 56
    • 20244366575 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1
    • Zen Y, Harada K, Sasaki M, Chen TC, Chen MF, Yeh TS, et al. Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1. Lab Invest 2005; 85: 572-581.
    • (2005) Lab Invest , vol.85 , pp. 572-581
    • Zen, Y.1    Harada, K.2    Sasaki, M.3    Chen, T.C.4    Chen, M.F.5    Yeh, T.S.6
  • 57
    • 0037373855 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells
    • Benckert C, Jonas S, Cramer T, Von Marschall Z, Schafer G, Peters M, et al. Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res 2003; 63: 1083-1092.
    • (2003) Cancer Res , vol.63 , pp. 1083-1092
    • Benckert, C.1    Jonas, S.2    Cramer, T.3    Von Marschall, Z.4    Schafer, G.5    Peters, M.6
  • 59
    • 43549116605 scopus 로고    scopus 로고
    • Systemic therapy for biliary tract cancers
    • Hezel AF, Zhu AX. Systemic therapy for biliary tract cancers. Oncologist 2008; 13: 415-423.
    • (2008) Oncologist , vol.13 , pp. 415-423
    • Hezel, A.F.1    Zhu, A.X.2
  • 60
    • 70350205992 scopus 로고    scopus 로고
    • Gemcitabine with or without cisplatin in patients (pts) with advanced or metastatic biliary tract cancer (ABC): results of a multicenter, randomized phase III trial (the UK ABC-02 trial)
    • In:
    • Valle JW, Palmer DD, Cunningham D, Anthoney DA, Maraveyas A, Hughes SK, et al. Gemcitabine with or without cisplatin in patients (pts) with advanced or metastatic biliary tract cancer (ABC): results of a multicenter, randomized phase III trial (the UK ABC-02 trial). In: ASCO Annual Meeting; 2009.
    • (2009) ASCO Annual Meeting
    • Valle, J.W.1    Palmer, D.D.2    Cunningham, D.3    Anthoney, D.A.4    Maraveyas, A.5    Hughes, S.K.6
  • 61
    • 37049013090 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas
    • Paule B, Herelle MO, Rage E, Ducreux M, Adam R, Guettier C, et al. Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas. Oncology 2007; 72: 105-110.
    • (2007) Oncology , vol.72 , pp. 105-110
    • Paule, B.1    Herelle, M.O.2    Rage, E.3    Ducreux, M.4    Adam, R.5    Guettier, C.6
  • 62
    • 33748680142 scopus 로고    scopus 로고
    • Gemcitabine in combination with EGF-receptor antibody (cetuximab) as a treatment of cholangiocarcinoma: a case report
    • Sprinzl MF, Schimanski CC, Moehler M, Schadmand-Fischer S, Galle PR, Kanzler S. Gemcitabine in combination with EGF-receptor antibody (cetuximab) as a treatment of cholangiocarcinoma: a case report. BMC Cancer 2006; 6: 190.
    • (2006) BMC Cancer , vol.6 , pp. 190
    • Sprinzl, M.F.1    Schimanski, C.C.2    Moehler, M.3    Schadmand-Fischer, S.4    Galle, P.R.5    Kanzler, S.6
  • 65
    • 77249126014 scopus 로고    scopus 로고
    • Preliminary experience of cetuximab in the treatment of advanced-stage biliary tract cancer
    • Chang PY, Cheng MF, Lee HS, Hsieh CB, Yao NS. Preliminary experience of cetuximab in the treatment of advanced-stage biliary tract cancer. Onkologie 2010; 33: 45-47.
    • (2010) Onkologie , vol.33 , pp. 45-47
    • Chang, P.Y.1    Cheng, M.F.2    Lee, H.S.3    Hsieh, C.B.4    Yao, N.S.5
  • 66
    • 78649581706 scopus 로고    scopus 로고
    • Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: a phase 2 study
    • Gruenberger B, Schueller J, Heubrandtner U, Wrba F, Tamandl D, Kaczirek K, et al. Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: a phase 2 study. Lancet Oncol 2010; 11: 1142-1148.
    • (2010) Lancet Oncol , vol.11 , pp. 1142-1148
    • Gruenberger, B.1    Schueller, J.2    Heubrandtner, U.3    Wrba, F.4    Tamandl, D.5    Kaczirek, K.6
  • 67
    • 73249117423 scopus 로고    scopus 로고
    • A multi-center, randomized phase II trial of gemcitabine and oxaliplatin (GEMOX) alone or in combination with biweekly cetuximab in the first-line treatment of advanced biliary cancer: Interim analysis of the BINGO trial
    • In:
    • Malka D, Fartoux L, Mendiboure J, de la Fouchardière C, Viret F, Assenat E, et al. A multi-center, randomized phase II trial of gemcitabine and oxaliplatin (GEMOX) alone or in combination with biweekly cetuximab in the first-line treatment of advanced biliary cancer: Interim analysis of the BINGO trial. In: ASCO Annual Meeting; 2009: 27; 4520
    • (2009) ASCO Annual Meeting , vol.27 , pp. 4520
    • Malka, D.1    Fartoux, L.2    Mendiboure, J.3    de la Fouchardière, C.4    Viret, F.5    Assenat, E.6
  • 68
    • 73249128451 scopus 로고    scopus 로고
    • Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study
    • Zhu AX, Meyerhardt JA, Blaszkowsky LS, Kambadakone AR, Muzikansky A, Zheng H, et al. Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol 2010; 11: 48-54.
    • (2010) Lancet Oncol , vol.11 , pp. 48-54
    • Zhu, A.X.1    Meyerhardt, J.A.2    Blaszkowsky, L.S.3    Kambadakone, A.R.4    Muzikansky, A.5    Zheng, H.6
  • 69
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 70
    • 74249098818 scopus 로고    scopus 로고
    • Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial
    • Bengala C, Bertolini F, Malavasi N, Boni C, Aitini E, Dealis C, et al. Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer 2010; 102: 68-72.
    • (2010) Br J Cancer , vol.102 , pp. 68-72
    • Bengala, C.1    Bertolini, F.2    Malavasi, N.3    Boni, C.4    Aitini, E.5    Dealis, C.6
  • 71
    • 38349043328 scopus 로고    scopus 로고
    • A phase II study of sorafenib (BAY 43-9006) as single agent in patients (pts) with unresectable or metastatic gallbladder cancer or cholangiocarcinomas
    • El-Khoueiry AB, Rankin C, Lenz HJ, Philip P, Rivkin SE, Blanke CD. A phase II study of sorafenib (BAY 43-9006) as single agent in patients (pts) with unresectable or metastatic gallbladder cancer or cholangiocarcinomas. Proc Am Soc Clin Oncol 2007; 25: 4639.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 4639
    • El-Khoueiry, A.B.1    Rankin, C.2    Lenz, H.J.3    Philip, P.4    Rivkin, S.E.5    Blanke, C.D.6
  • 72
    • 79251476078 scopus 로고    scopus 로고
    • A multi-institutional study of AZD6244 (ARRY-142886) in patients with advanced biliary cancers.
    • In: Denver, CO.
    • Bekaii-Saab TMP, Li X, Saji M, Kosuri K, Goff L, Kauh J, et al. A multi-institutional study of AZD6244 (ARRY-142886) in patients with advanced biliary cancers. In: AACR Annual Meeting; 2009; Denver, CO.
    • (2009) AACR Annual Meeting
    • Bekaii-Saab, T.M.P.1    Li, X.2    Saji, M.3    Kosuri, K.4    Goff, L.5    Kauh, J.6
  • 73
    • 77955293298 scopus 로고    scopus 로고
    • Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II consortium study
    • Lubner SJ, Mahoney MR, Kolesar JL, Loconte NK, Kim GP, Pitot HC, et al. Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II consortium study. J Clin Oncol 2010; 28: 3491-3497.
    • (2010) J Clin Oncol , vol.28 , pp. 3491-3497
    • Lubner, S.J.1    Mahoney, M.R.2    Kolesar, J.L.3    Loconte, N.K.4    Kim, G.P.5    Pitot, H.C.6
  • 74
    • 33947387077 scopus 로고    scopus 로고
    • Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials
    • Eckel F, Schmid RM. Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 2007; 96: 896-902.
    • (2007) Br J Cancer , vol.96 , pp. 896-902
    • Eckel, F.1    Schmid, R.M.2
  • 75
    • 0035134978 scopus 로고    scopus 로고
    • More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages
    • Yanagisawa N, Mikami T, Saegusa M, Okayasu I. More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. Cancer Res 2001; 61: 19-22.
    • (2001) Cancer Res , vol.61 , pp. 19-22
    • Yanagisawa, N.1    Mikami, T.2    Saegusa, M.3    Okayasu, I.4
  • 76
    • 0035870269 scopus 로고    scopus 로고
    • Beta-catenin mutations in biliary tract cancers: a population-based study in China
    • Rashid A, Gao YT, Bhakta S, Shen MC, Wang BS, Deng J, et al. Beta-catenin mutations in biliary tract cancers: a population-based study in China. Cancer Res 2001; 61: 3406-3409.
    • (2001) Cancer Res , vol.61 , pp. 3406-3409
    • Rashid, A.1    Gao, Y.T.2    Bhakta, S.3    Shen, M.C.4    Wang, B.S.5    Deng, J.6
  • 77
    • 0036105548 scopus 로고    scopus 로고
    • Mutation and altered expression of beta-catenin during gallbladder carcinogenesis
    • Chang HJ, Jee CD, Kim WH. Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. Am J Surg Pathol 2002; 26: 758-766.
    • (2002) Am J Surg Pathol , vol.26 , pp. 758-766
    • Chang, H.J.1    Jee, C.D.2    Kim, W.H.3
  • 78
    • 0035839308 scopus 로고    scopus 로고
    • Genetic alterations in gallbladder adenoma, dysplasia and carcinoma
    • Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, et al. Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. Cancer Lett 2001; 169: 59-68.
    • (2001) Cancer Lett , vol.169 , pp. 59-68
    • Kim, Y.T.1    Kim, J.2    Jang, Y.H.3    Lee, W.J.4    Ryu, J.K.5    Park, Y.K.6
  • 79
    • 0032776233 scopus 로고    scopus 로고
    • Histological and genetic changes in malignant transformation of gallbladder adenoma
    • Watanabe H, Date K, Itoi T, Matsubayashi H, Yokoyama N, Yamano M, et al. Histological and genetic changes in malignant transformation of gallbladder adenoma. Ann Oncol 1999; 10( Suppl 4): 136-139.
    • (1999) Ann Oncol , vol.10 , Issue.SUPPL 4 , pp. 136-139
    • Watanabe, H.1    Date, K.2    Itoi, T.3    Matsubayashi, H.4    Yokoyama, N.5    Yamano, M.6
  • 80
    • 0028828499 scopus 로고
    • Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: relation to gross tumor morphology
    • Ohashi K, Nakajima Y, Kanehiro H, Tsutsumi M, Taki J, Aomatsu Y, et al. Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: relation to gross tumor morphology. Gastroenterology 1995; 109: 1612-1617.
    • (1995) Gastroenterology , vol.109 , pp. 1612-1617
    • Ohashi, K.1    Nakajima, Y.2    Kanehiro, H.3    Tsutsumi, M.4    Taki, J.5    Aomatsu, Y.6


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