Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-κB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7

Phytomedicine

Volumn 17, Issue 10, 2010, Pages 732-739

  Israf, D A ^a   Tham, C L ^a   Syahida, A ^a   Lajis, N H ^a   Sulaiman, M R ^a   Mohamad, A S ^a   Zakaria, Z A ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Atrovirinone; COX 2; Cytokines; Garcinia atroviridis; iNOS; MAPK; NF B

Indexed keywords

1,4 BENZOQUINONE DERIVATIVE; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; [2 (1''' METHOXYCARBONYL 4''',6''' DIHYDROXYPHENOL) 3 METHOXY 5,6 DI(3 METHYL 2 BUTENYL) 1,4 BENZOQUINONE];

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GARCINIA; GARCINIA ATROVIRIDIS; MONOCYTE MACROPHAGE PRECURSOR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

GARCINIA ATROVIRIDIS; MURINAE;

EID: 79151484740     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.02.006     Document Type: Article

References (33)

1. Abate, A., Oberle, S., Schröder, H., 1998. Lipopolysaccharide- induced expression of cyclooxygenase-2 in mouse macrophages is inhibited by chloromethylketones and a direct inhibitor of NF-κB translocation. Prostaglandins Other Lipid Mediators 56, 277-290.
2. Ajizian, S.J., English, B.K., Meals, E.A., 1999. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-γ. J. Inf. Dis. 179, 939-944.
3. Brunmark, A., Cadenas, E., 1988. Reductive addition of glutathione to p-benzoquinone, 2-hydroxy-p-benzoquinone, and p-benzoquinone epoxides. Effect of the hydroxy- and glutathionyl substituents on p-benzohydroquinone autoxidation. Chem-Biol. Interact. 68, 273-298.
4. Carter, A.B., Monick, M.M., Hunninghake, G.W., 1999. Both Erk and p38 kinases are necessary for cytokine gene transcription. Am. J. Respir. Cell. Mol. Biol. 20, 751-758.
5. Chan, E.D., Riches, D.W.H, 1998. Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNF-α. Biochem. Biophys. Res. Commun. 253, 790-796.
6. Closs, E.I., Sharafi, M., Fflrsiermann, U., 1996. L-arginine supply of no synthases in endothelial cells. FASEB J. 10, A435.
7. Davis, R.J., 1994. MAPKs: New JNK expands the group. Trends Biochem. Sci. 19, 470-473.
8. Fitzpatrick, F.A., 2001. Inflammation, carcinogenesis and cancer. Int. Immuno-pharmacol. 1, 1651-1667.
9. Forsythe, P., Gilchrist, M., Kulka, M., Befus, A.Dean, 2001. Mast cells and nitric oxide: control of production, mechanisms of response. Int. Immunopharmacol. 1, 1525-1541. (Pubitemid 32622796)
10. Griscavage, J.M., Wilk, S., Ignarro, L.J., 1996. Inhibitors of the proteasomes pathway interfere with induction of nitric oxide synthase in macrophage by blocking activation of transcription factor NF-κB. Proc Natl. Acad. Sci. USA 93, 3308-3312.
11. Hanada, T., Yoshimura, A., 2002. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 13, 413-421.
12. Hayashi, T., Ueno, V., Okamoto, T., 1993. Oxido reductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268, 11380-11388.
13. Jiang, X., Takahashi, N., Ando, K., Otsuka, T., Tetsuka, T., Okamoto, T., 2003. NF-κB p65 transactivation domain is involved in the NF-κB-inducing kinase pathway. Biochem. Biophys. Res. 301, 583-590.
14. Jijon, H., Allard, B., Jobin, C, 2004. NF-κB inducing kinase activates NF-κB transcriptional activity independentlt of IκB kinase γ through a p38 MAPK-dependent RelA phosphorylation pathway. Cell Signal. 16, 1023-1032.
15. Kaminska, B., 2005. MAPK signalling pathways as molecular targets for antiinflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754, 253-262.
16. Kang, Y.J., Lee, B.K., Lee, Y.S., Seo, H.G., Park, M.K., Kim, H.J., Pyo, H.S., Chong, W.S., Jung, H.J., Yun-Choi, H.S., Lee, D.H., Chang, K.C., 2003. Suppression of tumor necrosis factor-α and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphthyl-benzylisoquinoline alkaloid. Biochem. Pharmacol. 65, 457-464.
17. Kiemer, A.K., Hartung, T., Huber, C, Vollmar, A., 2003. Phyllanthus amarus has antiinflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway. J. Hepatol. 38, 289-297.
18. Kubatka, P., Ahlers, I., Ahlersová, E., Adámeková, E., Luk, P., Bojková, B., Marková, M., 2003. Chemoprevention of mammary carcinogenesis in female rats by rofecoxib. Cancer Lett. 202, 131-136.
19. Laskin, D.L, Laskin, J.D., 2001. Role of macrophages and inflammatory mediators in chemically induced toxicity. Toxicology 160, 111-118.
20. Lee, Y.W., Han, S.H., Lee, M., Yang, K.H., Kim, H.M., Jeon, Y.J., 2000. 2-Amino-3-methylimidazo[4, 5-f]quinoline inhibits nitric oxide production in lipopoly-saccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation. Cancer Lett. 156, 133-139.
21. Lee, S.H., Lee, S.Y., Son, D.J., Lee, H., Yoo, H.S., Song, S., Oh, K.W., Han, D.C., Kwon, B.M., Hong, J.T., 2005. Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells. Biochem. Pharmacol. 69, 791-799.
22. Lewis, A.J., Manning, A.A., 1999. New targets for anti-inflammatory drugs. Curr. Opin. Chem. Biol. 3, 489-494.
23. Liang, Y.C., Huang, Y.T., Tsai, S.H., Lin-Shiau, S.Y., Chen, C.F., Lin, J.K., 1999. Suppression of inducible cyclooxygena se and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20, 1945-1952.
24. Makarov, S.S., 2000. NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol. Med. Today 6, 441-448.
25. 2 production in experimental acute and chronic gastric lesions. Int. Immunopharmacol. 5, 369-379.
26. Nasuhara, Y., Adcock, I.M., Catley, M., Barnes, P.J., Newton, R., 1999. Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells. J. Biol. Chem. 274, 19965-19972.
27. Okamoto, T., Ogiwara, H., Hayashi, T., Mitsui, A., Kawabe, T., Yodoi, J., 1992. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Int. Immunol. 4, 811-819.
28. Pan, M.H., Lin-Shiau, S.Y., Lin, J.K., 2000. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages. Biochem. Pharmacol. 60, 1665-1670.
29. Pando, M.P., Verma, I.M., 2000. Signal-dependent and -independent degradation of free and NF-κB-bound IκBα. J. Biol. Chem. 275, 21278-21286.
30. Permana, D., Lajis, N.H., Mackeen, M.M., Ali, A.M., Aimi, N., Kitajima, M., Takayama, H., 2001. Isolation and bioactivities of constitutents of the roots of Garcinia atroviridis. J. Nat. Prod. 64, 976-979.
31. Podolak, I., Galanty, A., Janeezko, Z., 2005. Cytotoxic activity of embelin from Lysimachia punctata. Fitoterapia 76, 333-335.
32. Surh, Y., Chun, K., Cha, H., Han, S.S., Keum, Y., Park, K., Lee, S.S., 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. Fund. Mol. Med. 480, 243-268.
33. Syahida, A., Israf, D.A., Permana, D., Lajis, N.H., Khozirah, S., Afiza, A.W., Khaizurin, T.A., Somchit, M.N., Sulaiman, M.R., Nasaruddin, A.A., 2006. Atrovirinone inhibits pro-inflammatory mediator release from murine macrophages and human whole blood. Immunol. Cell. Biol. 84, 1-9.