Detection of potential (anti)progestagenic endocrine disruptors using a recombinant human progesterone receptor binding and transactivation assay

Molecular and Cellular Endocrinology

Volumn 295, Issue 1-2, 2008, Pages 1-9

  Viswanath, Gunda ^a   Halder, Sujata ^a   Divya, Gunda ^a   Majumder, Chandrajeet B ^a   Roy, Partha ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Competitive binding; Endocrine disruptor; Progesterone receptor; Transactivation assay

Indexed keywords

ENDOCRINE DISRUPTOR; INDUSTRIAL CHEMICAL; INSECTICIDE; LUCIFERASE; MIFEPRISTONE; PROGESTERONE RECEPTOR; RECOMBINANT RECEPTOR;

ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EFFLUENT; ENZYME ACTIVITY; GENETIC TRANSFECTION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; RECEPTOR BINDING; REPORTER GENE; SCREENING TEST; TRANSACTIVATION; UPREGULATION; WASTE WATER TREATMENT PLANT; WATER SAMPLING;

BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ENVIRONMENTAL MONITORING; GENES, REPORTER; HORMONE ANTAGONISTS; HUMANS; PROGESTERONE; PROGESTINS; RECEPTORS, PROGESTERONE; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; WATER POLLUTANTS, CHEMICAL;

EID: 54949146037     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.08.021     Document Type: Article

References (60)

1. Allen Y., Scott A.P., Matthiesen P., Haworth S., Thain J.E., and Feist S. Survey of estrogenic activity in United Kingdom estuarine and coastal waters and its effects on gonad development of the flounder Platichthys flesus. Environ. Toxicol. Chem. 18 (1999) 1791-1800
2. Anderson H.R., Vinggaard A.M., Rasmussen T.H., Gjermandsen I.M., and Bonefeld-Jorgensen E.C. Effects of currently used pesticides in assays for estrogenecity, androgenecity and aromatase activity in vitro. Toxicol. Appl. Pharmacol. 179 (2002) 1-12
3. Beck C.A., Weigel N.L., Moyer M.L., Nordeen S.K., and Edwards D.P. The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 4441-4445
4. Boyd G.R., Reemtsma H., Grimm D.A., and Mitra S. Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada. Sci. Total Environ. 311 (2003) 135-149
5. Cargouët M., Perdiz D., Mouatassim-Souali A., Tamisier-Korolak S., and Levi Y. Assessment of river contamination by estrogenic compounds in Paris area (France). Sci. Total Environ. 324 (2004) 55-66
6. Chatterjee S., Majumder C.B., and Roy P. Development of a yeast-based assay to determine the (anti)androgenic contaminants from pulp and paper mill effluents in India. Environ. Toxicol. Pharmacol. 24 (2007) 114-121
7. Chatterjee S., Kumar V., Majumder C.B., and Roy P. Screening of some antiprogestin endocrine disruptors using a recombinant yeast based in vitro bioassay. Toxicol. In Vitro 22 (2008) 788-798
8. Chen J., Ahn K.C., Gee N.A., Gee S.L., Hammock B.D., and Lasley B.L. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol. Appl. Pharmacol. 221 (2007) 278-284
9. Christiaens V., Berckmans P., Haelens A., Witters H., and Claessens F. Comparison of different androgen bioassays in the screening for environmental (anti)androgenic activity. Environ. Toxicol. Chem. 24 (2005) 251-262
10. Death A.K., McGrath K.C.Y., Kazlauskas R., and Handelsman D.J. Tetrahydrogestrione is a potent androgen and progestin. J. Clin. Endocrinol. Metab. 89 (2004) 2498-2500
11. DeCherney A. Physiologic and pharmacologic effects of estrogen and progestins on bone. J. Reprod. Med. 38 (1993) 1007-1014
12. Desbrow C., Routeledge E.J., Brighty G.C., Sumpter J.P., and Waldock M. Identification of estrogenic chemicals in STW effluents. Chemical fractionation and in vitro biological screening. Environ. Sci. Technol. 32 (1998) 1549-1558
13. De Ziegler D., and Fanchin R. Progesterone and progestins: applications in gynecology. Steroids 65 (2000) 671-679
14. Folmar L.C., Denslow N.D., Rao V., Chow M., Crain D.A., Enblom J., Marcino J., and Guillette Jr. L.J. Vitellogenin induction and reduced serum testosterone concentration in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ. Health Perspect. 104 (1996) 1096-1100
15. Freyberger A., and Ahr H.-J. Development and standardization of a simple binding assay for the detection of compounds with affinity for the androgen receptor. Toxicology 195 (2004) 113-126
16. Gaido K.W., Leonard L.S., Lovell S., Gould J.C., Babai D., Portier C.J., and McDonnell D.P. Evaluation of chemicals with endocrine modulating activity in yeast-based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143 1 (1997) 205-212
17. Guillette L.J., and Gunderson M.P. Alterations in development of reproductive and endocrine systems of wildlife populations exposed to endocrine-disrupting contaminants. Reproduction 122 (2001) 857-864
18. Hansen P., Dizer H., Hock B., Marx A., Sherry J., and Mcmaster M. Vitellogenin-a biomarker for endocrine disruptors. Trends Anal. Chem. 17 (1998) 448-451
19. Hrdina P.D., Singhal R.S., and Ling G.M. DDT and related chlorinated hydrocarbon insecticides: pharmacological basis of their toxicity in mammals. Adv. Pharmacol. Chemother. 12 (1975) 31-88
20. Hutchinson T.H. Reproductive and developmental effects of endocrine disrupters in invertebrates: in vitro and in vivo approaches. Toxicol. Lett. 131 (2002) 75-81
21. Jin L., Tran Q., Ide C.F., McLachlan J.A., and Arnold S.F. Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. Biochem. Biophys. Res. Comm. 233 (1997) 139-146
22. Jobling S., Nolan M., Tyler C.R., Brighty G., and Sumpter J.P. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 32 (1998) 2498-2506
23. Jung K.K., Kim S.Y., Kim T.G., Kang J.H., Kang S.Y., Cho J.Y., and Kim S.H. Differential regulation of thyroid hormone receptor-mediated function by endocrine disruptors. Arch. Pharm. Res. 30 (2007) 616-623
24. Kastner P., Krust A., Turcotte B., et al. Two distinct estrogen regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9 (1990) 1603-1614
25. Klotz D.M., Ladlie B.L., Vonier P.M., McLachlan J.A., and Arnold S.F. o,p-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells. Mol. Cell. Endocrinol. 129 (1997) 63-71
26. Kojima H., Katsura E., Takeuchi S., Niyama K., and Kobayashi K. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 112 (2004) 695-702
27. Kumar V., Chakraborty A., Viswanath G., and Roy P. Androgenic endocrine disruptors in wastewater treatment plant effluents in India: their influence on reproductive processes and systemic toxicity in male rats. Toxicol. Appl. Phramacol. 226 (2008) 60-73
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
29. Laws S.C., Carey S.A., Kelce W.R., Cooper R.L., and Gray Jr. L.E. Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro. Toxicology 112 (1996) 173-182
30. Lebel G., Dodin S., Ayotte P., Marcoux S., Ferron L.A., and Dewailly E. Organochlorine exposure and the risk of endometriosis. Fertil. Steril. 69 (1998) 221-228
31. Lemaire G., Terouanne B., Mauvais P., Michel S., and Rahmani R. Effect of organochlorine pesticides on human androgen receptor activation in vitro. Toxicol. Appl. Pharmacol. 196 (2004) 235-246
32. Lundberg C., and Kihlstrom J.E. DDT and the frequency of implanted ova in the mouse. Bull. Environ. Contam. Toxicol. 9 (1973) 267-270
33. Lundholm C.E. The effects of DDE, PCB and chlordane on the binding of progesterone to its cytoplasmic receptor in the eggshell gland mucosa of birds and the endometrium of mammalian uterus. Comp. Biochem. Physiol. 89 (1988) 361-368
34. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., and Evans R.M. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
35. Mendes J.J.A. The endocrine disrupters: a major medical challenge. Food Chem. Toxicol. 40 (2002) 781-788
36. Metcalfe C.D., Metcalfe T.L., Kiparissis Y., Koenig B.G., Kan C., Hughes R.J., Croley T.R., March R.E., and Potter T. Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes). Environ. Toxicol. Chem. 20 (2001) 297-308
37. Michelini E., Leskinen P., Virta M., Karp M., and Roda A. A new recombinant cell-based bioluminescent assay for sensitive androgen-like compound detection. Biosens. Bioelectron. 20 (2005) 2261-2267
38. Michelini E., Magliulo M., Leskinen P., Virta M., Karp M., and Roda A. Recombinant cell-based bioactivity determination in clinical samples. Clin. Chem. 51 (2005) 1995-1998
39. Molina-Molina J.-M., Hillenweck A., Jouanin I., Zalko D., Cravedi J.P., Fernández M.-F., Pillon A., Nicolas J.-C., Olea N., and Balaguer P. Steroid receptor profiling of vinclozolin and its primary metabolites. Toxicol. Appl. Pharmacol. 216 (2006) 44-54
40. Nawaz Z., Baniahmad C., Burris T.P., Stillman D.J., O'Malley B.W., and Tsai M.-J. The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activity of GAL4 and HAP1 activator. Mol. Gen. Genet. 245 (1994) 724-733
41. Ohlson C.-G., and Hardell L. Testicular cancer and occupational exposures with a focus on xenoestrogens in polyvinyl chloride plastics. Chemosphere 40 (2000) 1277-1282
42. Pepe G.J., and Albrecht E.D. Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr. Rev. 16 (1995) 608-648
43. Pickford D.B., and Morris I.D. Effects of endocrine-disrupting contaminants on amphibian oogenesis: methoxychlor inhibits progesterone induced maturation of Xenopus laevis oocytes in vitro. Environ. Health Perspect. 107 (1999) 285-292
44. Pieber D., Allport V.C., Hills F., Johnson M., and Bennett P.R. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Mol. Hum. Reprod. 7 (2001) 875-879
45. Pillon A., Boussioux A., Escand A., Aissa S., Gomez E., Fenet H., Ruff M., Moras D., Vignon F., Duchesne M.J., Casellas C., Nicolas J.C., and Balaguer P. Binding of estrogenic compounds to recombinant estrogen receptor-α: application to environmental analysis. Environ. Health Perspect. 133 (2005) 278-284
46. Roy P., Salminen H., Koskimies P., Simola J., Smeds A., Saukko P., and Huhtaniemi I.T. Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay. J. Steroid Biochem. Mol. Biol. 88 (2004) 157-166
47. Sarmah A.K., Northcott G.L., Leusch F.D.L., and Tremblay L.A. A survey of endocrine disrupting chemicals (EDCs) in municipal sewage and animal waste effluents in the Waikato region of New Zealand. Sci. Total Environ. 355 (2006) 135-144
48. Scippo M.-L., Argiris C., Weerdt C.V.D., Muller M., Willemsen P., Martial J., and Maghuin-Rogister G. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal. Bioanal. Chem. 378 (2004) 664-669
49. Schoonen W.E.J., de Ries R.J.H., Joosten J.W.H., Mathijssen-Mommers G.J.W., and Kloosterboer H.J. Development of a high-throughput in vitro bioassay to assess potencies of progestagenic compounds using Chinese hamster ovarian cells stably transfected with the human progesterone receptor and a luciferase reporter system. Anal. Biochem. 261 (1998) 222-224
50. Sharpe R.M. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol. Lett. 120 (2001) 221-232
51. Snyder S.A., Keith T.L., Verbrugge D.A., Snyder E.M., Gross T.S., Kannan K., and Giesy J.P. Analytical methods for detection of selected estrogenic compounds in aqueous mixtures. Environ. Sci. Technol. 33 (1999) 2814-2820
52. Spencer T.E., and Bazer F.W. Conceptus signals for establishment and maintenance of pregnancy. Reprod. Biol. Endocrinol. 2 (2004) 49-56
53. Sumpter J.P. Xenoendocrine disruptors-environmental impacts. Toxicol. Lett. 102-103 (1998) 337-342
54. Svenson A., Allard A.S., and Ek M. Removal of estrogenicity in Swedish municipal sewage treatment plants. Water Res. 37 (2003) 4433-4443
55. Ternes T.A., Stumpf M., Mueller J., Haberer K., Wilken R.D., and Servos M. Behavior and occurrence of estrogens in municipal sewage treatment plants-I. Investigations in Germany, Canada and Brazil. Sci. Total Environ. 225 (1999) 81-90
56. Tran D.Q., Koltz D.M., Ladlie B.L., Ide C.F., McLachlan J.A., and Arnold S.F. Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem. Biophys. Res. Commun. 233 (1996) 139-146
57. Vonier P.M., Crain D.A., McLachlan J.A., Guillette L.J., and Arnold S.F. Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Environ. Health Perspect. 104 12 (1996) 1318-1322
58. Willemsen P., Scippo M.-L., Kausel G., Fifueroa J., Maghuin-Rogister G., Martial J.A., and Muller M. Use of reporter cell lines for detection of endocrine-disruptor activity. Anal. Bioanal. Chem. 378 (2004) 655-663
59. Wójtowicz A.K., Milewicz T., and Gregoraszczuk E.Ł. DDT and its metabolite DDE alter steroid hormone secretion in human term placental explants by regulation of aromatase activity. Toxicol. Lett. 173 (2007) 24-30
60. Xu L.C., Sun H., Chen J.F., Bian Q., Qian J., Song L., and Wang X.R. Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro. Toxicology 216 (2005) 196-203