Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget

Journal of Biological Chemistry

Volumn 280, Issue 31, 2005, Pages 28468-28475

  Zhang, Zhiming ^a   Olland, Andrea M ^a   Zhu, Yuan ^a   Cohen, Jeff ^a   Berrodin, Tom ^a   Chippari, Susan ^a   Appavu, Chandrasekaran ^a   Li, Shen ^a   Wilhem, James ^a   Chopra, Raj ^a   Fensome, Andrew ^a   Zhang, Puwen ^a   Wrobel, Jay ^a   Unwalla, Rayomand J ^a   Lyttle, C Richard ^a   Winneker, Richard C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CRYSTAL STRUCTURE; ENZYMES; HEALTH; HORMONES; PHARMACODYNAMICS;

BINDING AFFINITY; PROGESTATIONAL POTENCY; PROGESTERONE RECEPTOR (PR); STEROID RECEPTORS;

MOLECULAR BIOLOGY;

CYTOCHROME P450; GESTAGEN; MEDROXYPROGESTERONE ACETATE; NONSTEROIDAL PROGESTERONE RECEPTOR AGONIST; PROGESTERONE RECEPTOR; STEROID; STEROID RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; TANAPROGET; TRIMEGESTONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; HEALTH; HORMONAL THERAPY; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; ORAL CONTRACEPTION; OVULATION INHIBITION; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; REPRODUCTION; SIDE EFFECT;

ALKALINE PHOSPHATASE; AMINO ACID SUBSTITUTION; BENZOXAZINES; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; HUMANS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROMEGESTONE; PYRROLES; RECEPTORS, PROGESTERONE; RECOMBINANT PROTEINS; X-RAY DIFFRACTION;

ANIMALIA; MAMMALIA;

EID: 23344449647     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504144200     Document Type: Article

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