-
1
-
-
3843116771
-
Diabetes mellitus: Pathogenesis and treatment strategies
-
Skyler, J. S. Diabetes mellitus: pathogenesis and treatment strategies. J. Med. Chem., 2004, 47, 4113-4117.
-
(2004)
J. Med. Chem
, vol.47
, pp. 4113-4117
-
-
Skyler, J.S.1
-
2
-
-
1842454125
-
Chemistry and biochemistry of type 2 diabetes
-
Ross, S.A.; Gulve, E.A.; Wang, M. Chemistry and biochemistry of type 2 diabetes. Chem. Rev., 2004, 104, 1255-1282.
-
(2004)
Chem. Rev
, vol.104
, pp. 1255-1282
-
-
Ross, S.A.1
Gulve, E.A.2
Wang, M.3
-
3
-
-
0026572747
-
Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: A balanced overview
-
DeFronzo, R.A.; Bonadonna, R.C.; Ferrannini, E. Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: a balanced overview. Diabetologia, 1992. 35, 389-397.
-
(1992)
Diabetologia
, vol.35
, pp. 389-397
-
-
Defronzo, R.A.1
Bonadonna, R.C.2
Ferrannini, E.3
-
4
-
-
0033857387
-
Treatment of insulin resistance with peroxisome proliferators-activated receptor agonists
-
Olefsky, J. M. Treatment of insulin resistance with peroxisome proliferators-activated receptor agonists. J. Clin. Invest., 2000, 106, 467-472.
-
(2000)
J. Clin. Invest
, vol.106
, pp. 467-472
-
-
Olefsky, J.M.1
-
5
-
-
0029995670
-
Thiazolidinediones in the treatment of insulin resistance and type II diabetes
-
Saltiel, A. R.; Olefsky, J. M. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes, 1996, 45, 1661-1669.
-
(1996)
Diabetes
, vol.45
, pp. 1661-1669
-
-
Saltiel, A.R.1
Olefsky, J.M.2
-
6
-
-
0034681773
-
Thiazolidinediones: An update
-
Schoonjans, K.; Auwers, J. Thiazolidinediones: an update. Lancet, 2000, 355, 1008-1010.
-
(2000)
Lancet
, vol.355
, pp. 1008-1010
-
-
Schoonjans, K.1
Auwers, J.2
-
7
-
-
0035124186
-
New oral therapies for type 2 diabetes mellitus: The Glitazones or Insulin Sensitizers
-
Mudaliar, S.; Henry, R. R. New oral therapies for type 2 diabetes mellitus: The Glitazones or Insulin Sensitizers. Ann. Rev. Med., 2001, 52, 239-257.
-
(2001)
Ann. Rev. Med
, vol.52
, pp. 239-257
-
-
Mudaliar, S.1
Henry, R.R.2
-
8
-
-
0038460622
-
Thiazolidinediones in type 2 diabetes mellitus
-
Diamant, M.; Heine, R. J. Thiazolidinediones in type 2 diabetes mellitus. Drugs, 2003, 63, 1373-1405.
-
(2003)
Drugs
, vol.63
, pp. 1373-1405
-
-
Diamant, M.1
Heine, R.J.2
-
9
-
-
0027983920
-
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
-
Nolan, J.J.; Ludvik, B.; Beerdsen, P.; Joyce, M.; Olefsky, J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med., 1994, 331, 1188-1193.
-
(1994)
N. Engl. J. Med
, vol.331
, pp. 1188-1193
-
-
Nolan, J.J.1
Ludvik, B.2
Beerdsen, P.3
Joyce, M.4
Olefsky, J.5
-
10
-
-
0032568310
-
Effect of troglitazone in insulin-treated patients with type II diabetes mellitus
-
Schwartz, S.; Raskin, P.; Fonseca, V.; Graveline, J. F. Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. N. Engl. J. Med., 1998, 338, 861-866.
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 861-866
-
-
Schwartz, S.1
Raskin, P.2
Fonseca, V.3
Graveline, J.F.4
-
11
-
-
0032568257
-
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
-
Inzucchi, S. E.; Maggs, D.G.; Spollet, G. R.; Page, S. L.; Rife, F. S.; Walton, V.; Schulman, G. I. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N. Engl. J. Med., 1998, 338, 867-872.
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 867-872
-
-
Inzucchi, S.E.1
Maggs, D.G.2
Spollet, G.R.3
Page, S.L.4
Rife, F.S.5
Walton, V.6
Schulman, G.I.7
-
12
-
-
0033022510
-
Troglitazone: A review of its use in the management of type 2 diabetes mellitus
-
Plosker, G. L.; Faulds, D. Troglitazone: A review of its use in the management of type 2 diabetes mellitus. Drugs, 1999, 57, 409-438.
-
(1999)
Drugs
, vol.57
, pp. 409-438
-
-
Plosker, G.L.1
Faulds, D.2
-
13
-
-
0035832506
-
Lessons from the glitazones: A story of drug development
-
Gale, E. A. Lessons from the glitazones: a story of drug development. Lancet, 2001, 357, 1870-1875.
-
(2001)
LanCet
, vol.357
, pp. 1870-1875
-
-
Gale, E.A.1
-
14
-
-
31444449995
-
Troglitazone: The lesson that nobody learned?
-
Gale, E. A. Troglitazone: the lesson that nobody learned?. Diabetologia, 2006, 49, 1-6.
-
(2006)
Diabetologia
, vol.49
, pp. 1-6
-
-
Gale, E.A.1
-
15
-
-
0034068059
-
Troglitazone-induced fulminant hepatic failure
-
Murphy, E. J.; Davern, T. J.; Shakil, A. O.; Shick, L.; Masharani, U.; Chow, H.; Freise, C.; Lee, W. M.; Bass, N. M. Troglitazone-induced fulminant hepatic failure. Dig. Dis. Sci., 2000, 45, 549-553.
-
(2000)
Dig. Dis. Sci
, vol.45
, pp. 549-553
-
-
Murphy, E.J.1
Davern, T.J.2
Shakil, A.O.3
Shick, L.4
Masharani, U.5
Chow, H.6
Freise, C.7
Lee, W.M.8
Bass, N.M.9
-
16
-
-
0038650658
-
Mechanisms of troglitazone hepatotoxicity
-
Smith, M. T. Mechanisms of troglitazone hepatotoxicity. Chem. Res. Toxicol., 2003, 16, 679-687.
-
(2003)
Chem. Res. ToxiCol
, vol.16
, pp. 679-687
-
-
Smith, M.T.1
-
17
-
-
15144357821
-
-
EP 0139421
-
Yoshioka, T.; Kitazawa, E.; Yamazaki, M.; Hasegawa, K. Thiazolidinedione derivatives, their preparation and compositions containing them. EP 0139421, 1984.
-
(1984)
Thiazolidinedione Derivatives, their Preparation and Compositions Containing Them
-
-
Yoshioka, T.1
Kitazawa, E.2
Yamazaki, M.3
Hasegawa, K.4
-
18
-
-
0024516539
-
Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation
-
Yoshioka, T.; Fujita, T.; Kanai, T.; Aizawa, Y.; Kurumada, T.; Hasegawa, K.; Horikoshi, H. Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation. J. Med. Chem., 1989, 32, 421-428.
-
(1989)
J. Med. Chem
, vol.32
, pp. 421-428
-
-
Yoshioka, T.1
Fujita, T.2
Kanai, T.3
Aizawa, Y.4
Kurumada, T.5
Hasegawa, K.6
Horikoshi, H.7
-
19
-
-
33847801898
-
A reagent for, α, β-reduction of conjugated nitriles
-
Watt, S. D.; Profitt, J. A.; Corey, E. J.; A reagent for, α, β-reduction of conjugated nitriles. J. Org. Chem., 1975, 40, 127-128.
-
(1975)
J. Org. Chem
, vol.40
, pp. 127-128
-
-
Watt, S.D.1
Profitt, J.A.2
Corey, E.J.3
-
20
-
-
13044268072
-
Preparation of benzylidenethiazolidines as lipid peroxide formation inhibitors. EP 454 501, 1991;
-
Takebayashi, T.; Onodera, T.; Hasegawa, K.; Fujita, T.; Yoshioka, T. Preparation of benzylidenethiazolidines as lipid peroxide formation inhibitors. EP 454 501, 1991; Chem. Abstr. 1992, 116, 59361k.
-
(1992)
Chem. Abstr
, vol.116
-
-
Takebayashi, T.1
Onodera, T.2
Hasegawa, K.3
Fujita, T.4
Yoshioka, T.5
-
21
-
-
0012069184
-
Novel antidiabetic and hypolipidemic agents. 5. Hydroxyl versus benzyloxy containing chroman derivatives
-
Reddy, K. A.; Lohray, B. B.; Bhushan, V.; Reddy, A. S.; Rao, N. V. S. M.; Reddy, P. P.; Saibaba, V.; Reddy, N. J.; Suryaprakash, A.; Misra, P.; Vikra-madithyan, R. K.; Rajagopalan, R. Novel antidiabetic and hypolipidemic agents. 5. Hydroxyl versus benzyloxy containing chroman derivatives. J. Med. Chem., 1999, 42, 3265-3278.
-
(1999)
J. Med. Chem
, vol.42
, pp. 3265-3278
-
-
Reddy, K.A.1
Lohray, B.B.2
Bhushan, V.3
Reddy, A.S.4
Rao, N.V.S.M.5
Reddy, P.P.6
Saibaba, V.7
Reddy, N.J.8
Suryaprakash, A.9
Misra, P.10
Vikra-madithyan, R.K.11
Rajagopalan, R.12
-
22
-
-
0033519652
-
Novel antidiabetic and hypolipidemic agents. 3. Benzofuran-containing thiazolidinediones
-
Reddy, K. A.; Lohray, B. B.; Bhushan, V.; Bajji, A. C.; Reddy, K. V.; Reddy, P. R.; Krishna, T. H.; Rao, I. N.; Ja-joo, H. K.; Rao, N. V. S. M.; Chakrabarti, R.; Dileepkumar, T.; Rajagopalan, R. Novel antidiabetic and hypolipidemic agents. 3. Benzofuran-containing thiazolidinediones. J. Med. Chem., 1999, 42, 1927-1940.
-
(1999)
J. Med. Chem
, vol.42
, pp. 1927-1940
-
-
Reddy, K.A.1
Lohray, B.B.2
Bhushan, V.3
Bajji, A.C.4
Reddy, K.V.5
Reddy, P.R.6
Krishna, T.H.7
Rao, I.N.8
Ja-joo, H.K.9
Rao, N.V.S.M.10
Chakrabarti, R.11
Dileepkumar, T.12
Rajagopalan, R.13
-
23
-
-
84951658186
-
6-Hydroxychroman-2-carboxylic acids: Novel antioxidants
-
Scott, J. W.; Cort, W. M.; Harley, H.; Parrish, D. R.; Saucy, G. 6-Hydroxychroman-2-carboxylic acids: Novel antioxidants. J. Am. Oil Chem. Soc., 1974, 51, 200-203.
-
(1974)
J. Am. Oil Chem. Soc
, vol.51
, pp. 200-203
-
-
Scott, J.W.1
Cort, W.M.2
Harley, H.3
Parrish, D.R.4
Saucy, G.5
-
24
-
-
0020353926
-
1) Synthesis of 5-[4-(1-methylcyclohexyl-methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives
-
1) Synthesis of 5-[4-(1-methylcyclohexyl-methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives. Chem. Pharm. Bull., 1982, 30, 3580-3600.
-
(1982)
Chem. Pharm. Bull
, vol.30
, pp. 3580-3600
-
-
Sohda, T.1
Mizuno, K.2
Tawada, H.3
Sugiyama, Y.4
Fujita, T.5
Kawanatsu, Y.6
-
25
-
-
0020552510
-
Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexyl methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878, U, 63287, ciglitazone), a new antidiabetic agent
-
Fujita, T.; Sugiyama, Y.; Taketomi, S.; Sohda, T.; Kawamastsu, Y.; Iwatsuka, H.; Suzuoki, Z. Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexyl methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878, U, 63287, ciglitazone), a new antidiabetic agent. Diabetes, 1983, 32, 804-810.
-
(1983)
Diabetes
, vol.32
, pp. 804-810
-
-
Fujita, T.1
Sugiyama, Y.2
Taketomi, S.3
Sohda, T.4
Kawamastsu, Y.5
Iwatsuka, H.6
Suzuoki, Z.7
-
26
-
-
0020561695
-
Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic chinese hamsters, and normal and streptozotocin-diabetic rats
-
Chang, A. Y.; Wyse, B. M.; Gilchrist, B. J.; Peterson, T.; Diani, A. R. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes, 1983, 32, 830-838.
-
(1983)
Diabetes
, vol.32
, pp. 830-838
-
-
Chang, A.Y.1
Wyse, B.M.2
Gilchrist, B.J.3
Peterson, T.4
Diani, A.R.5
-
27
-
-
0020572164
-
Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice
-
Chang, A. Y.; Wyse, B. M.; Gilchrist, B. J. Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice. Diabetes, 1983, 32, 839-845.
-
(1983)
Diabetes
, vol.32
, pp. 839-845
-
-
Chang, A.Y.1
Wyse, B.M.2
Gilchrist, B.J.3
-
28
-
-
0002013864
-
Subchronic toxicity of the thiazolidinedione, tanabe 174, in rat and dog
-
(abstr. 186)
-
Williams, D. G.; Deldar, A.; Jordan, W. H.; Gries, C.; Long, G. G.; Dimarchi, R. D. Subchronic toxicity of the thiazolidinedione, tanabe 174, in rat and dog. Diabetes, 1993, 42 (Suppl. 1), 59A (abstr. 186).
-
(1993)
Diabetes
, vol.42
, Issue.SUPPL. 1
-
-
Williams, D.G.1
Deldar, A.2
Jordan, W.H.3
Gries, C.4
Long, G.G.5
Dimarchi, R.D.6
-
29
-
-
0008192265
-
Pathogenesis of thiazolidinedione induced haemotoxocity in the dog
-
(abstr. 179)
-
Deldar, A.; William, G.; Stevenes, C. Pathogenesis of thiazolidinedione induced haemotoxocity in the dog. Diabetes, 1993, 42 (Suppl. 1) 57A (abstr. 179).
-
(1993)
Diabetes
, vol.42
, Issue.SUPPL. 1
-
-
Deldar, A.1
William, G.2
Stevenes, C.3
-
30
-
-
0020397038
-
Studies on antidiabetic agents. I. Synthesis of 5-[4-(2-methyl-2-phenylpropoxy)-benzyl]thiazolidine-2,4-dione (AL-321) and related compounds
-
Sohda, T.; Mizuno, K.; Tawada, H.; Sugiyama, Y.; Fujita, T.; Kawamatsu, Y. Studies on antidiabetic agents. I. Synthesis of 5-[4-(2-methyl-2-phenylpropoxy)-benzyl]thiazolidine-2,4-dione (AL-321) and related compounds. Chem. Pharm. Bull., 1982, 30, 3563-3573.
-
(1982)
Chem. Pharm. Bull
, vol.30
, pp. 3563-3573
-
-
Sohda, T.1
Mizuno, K.2
Tawada, H.3
Sugiyama, Y.4
Fujita, T.5
Kawamatsu, Y.6
-
31
-
-
0018875869
-
Studies on antihyperlipidemic agents. II. Synthesis and biological activities of 2-chloro-3-arylpropionic acids
-
Kawamatsu, Y.; Asakawa, H.; Saraie, T.; Imamiya, E.; Nishikawa, K.; Hamuro, Y. Studies on antihyperlipidemic agents. II. Synthesis and biological activities of 2-chloro-3-arylpropionic acids. Arzneim.-Forsch., 1980, 30, 585-589.
-
(1980)
Arzneim.-Forsch
, vol.30
, pp. 585-589
-
-
Kawamatsu, Y.1
Asakawa, H.2
Saraie, T.3
Imamiya, E.4
Nishikawa, K.5
Hamuro, Y.6
-
32
-
-
0018865453
-
Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quaternary carbon atom
-
Kawamatsu, Y.; Asakawa, H.; Saraie, T.; Mizuno, K.; Imamiya, E.; Nishikawa, K.; Hamuro, Y. Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quaternary carbon atom. Arzneim.-Forsch., 1980, 30, 751-758.
-
(1980)
Arzneim.-Forsch
, vol.30
, pp. 751-758
-
-
Kawamatsu, Y.1
Asakawa, H.2
Saraie, T.3
Mizuno, K.4
Imamiya, E.5
Nishikawa, K.6
Hamuro, Y.7
-
33
-
-
0025194289
-
Synthesis and anti-hyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidine-diones
-
Zask, A.; Jirkovsky, I.; Nowicki, J. W.; McCaleb, M. L. Synthesis and anti-hyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidine-diones. J. Med. Chem., 1990, 33, 1418-1423.
-
(1990)
J. Med. Chem
, vol.33
, pp. 1418-1423
-
-
Zask, A.1
Jirkovsky, I.2
Nowicki, J.W.3
McCaleb, M.L.4
-
34
-
-
0026030226
-
Substituted dihydrobenzopyran and dihydro-benzofuran thiazolidine-2,4-diones as hypoglycemic agents
-
Clark, D. A.; Goldstein, S. W.; Volkmann, R. A.; Eggler, J. F.; Holland, G. F.; Hulin, B.; Stevenson, R. W.; Kreutter, D. K.; Gibbs, E. M.; Krupp, M. N.; Merrigan, P.; Kelbaugh, P. L.; Andrews, E. G.; Tickner, D. L.; Suleske, R. T.; Lamphere, C. H.; Rajeckas, F. J.; Kappeler, W. H.; McDermott, R. E.; Hutson, N. J.; Johnson, M. R. Substituted dihydrobenzopyran and dihydro-benzofuran thiazolidine-2,4-diones as hypoglycemic agents. J. Med. Chem., 1991, 34, 319-325.
-
(1991)
J. Med. Chem
, vol.34
, pp. 319-325
-
-
Clark, D.A.1
Goldstein, S.W.2
Volkmann, R.A.3
Eggler, J.F.4
Holland, G.F.5
Hulin, B.6
Stevenson, R.W.7
Kreutter, D.K.8
Gibbs, E.M.9
Krupp, M.N.10
Merrigan, P.11
Kelbaugh, P.L.12
Andrews, E.G.13
Tickner, D.L.14
Suleske, R.T.15
Lamphere, C.H.16
Rajeckas, F.J.17
Kappeler, W.H.18
McDermott, R.E.19
Hutson, N.J.20
Johnson, M.R.21
more..
-
35
-
-
15144354645
-
Thiazolidinedione derivatives as hypoglycemics and their preparation
-
US. Patent 4 738 972; 1988;
-
Eggler, J.; Holland, G.; Johnson, M.; Volkmann, R. Thiazolidinedione derivatives as hypoglycemics and their preparation. US. Patent 4 738 972; 1988; Chem. Abstr. 1989, 110, 75483h.
-
(1989)
Chem. Abstr
, vol.110
-
-
Eggler, J.1
Holland, G.2
Johnson, M.3
Volkmann, R.4
-
38
-
-
84975874144
-
Action of phosphorus halides on alkylformanilides. A new method for the preparation of secondary and tertiary p-alkylaminonobenzaldehydes
-
Vilsmeier, A.; Haack, A. Action of phosphorus halides on alkylformanilides. A new method for the preparation of secondary and tertiary p-alkylaminonobenzaldehydes. Chem. Ber., 1927, 60, 119.
-
(1927)
Chem. Ber
, vol.60
, pp. 119
-
-
Vilsmeier, A.1
Haack, A.2
-
39
-
-
21544450820
-
α-Haloethers. IV. Synthesis of aromatic aldehydes with dichloromethyl alkyl ethers
-
Rieche, A.; Gross, H.; Hoft, E. α-Haloethers. IV. Synthesis of aromatic aldehydes with dichloromethyl alkyl ethers. Chem. Ber., 1960, 93, 88.
-
(1960)
Chem. Ber
, vol.93
, pp. 88
-
-
Rieche, A.1
Gross, H.2
Hoft, E.3
-
40
-
-
33947089482
-
Formylation of aromatic compounds with hexamethylenetetra-mine and trifluoroacetic acid
-
Smith, W. E. Formylation of aromatic compounds with hexamethylenetetra-mine and trifluoroacetic acid. J. Org. Chem., 1972, 37, 3972.
-
(1972)
J. Org. Chem
, vol.37
, pp. 3972
-
-
Smith, W.E.1
-
41
-
-
0026776281
-
Novel thiazolidine-2,4-diones as potent euglycemic agents
-
Hulin, B.; Clark, D. A.; Goldstein, S. W.; McDermott, R. E.; Dambek, P. J.; Kappeler, W. H.; Lamphere, C. H.; Lewis, D. M.; Rizzi, J. P. Novel thiazolidine-2,4-diones as potent euglycemic agents. J. Med. Chem., 1992, 35, 1853-1864.
-
(1992)
J. Med. Chem
, vol.35
, pp. 1853-1864
-
-
Hulin, B.1
Clark, D.A.2
Goldstein, S.W.3
McDermott, R.E.4
Dambek, P.J.5
Kappeler, W.H.6
Lamphere, C.H.7
Lewis, D.M.8
Rizzi, J.P.9
-
42
-
-
0029793540
-
Hypoglycemic activity of a series of -alkylthio and -alkoxy carboxylic acids related to ciglitazone
-
Hulin, B.; Newton, L. S.; Lewis, D. M.; Genereux, P. E.; Gibbs, E. M.; Clark, D. A. Hypoglycemic activity of a series of -alkylthio and -alkoxy carboxylic acids related to ciglitazone. J. Med. Chem., 1996, 39, 3897-3907.
-
(1996)
J. Med. Chem
, vol.39
, pp. 3897-3907
-
-
Hulin, B.1
Newton, L.S.2
Lewis, D.M.3
Genereux, P.E.4
Gibbs, E.M.5
Clark, D.A.6
-
43
-
-
0033851704
-
Pioglitazone
-
Gillies, P. S.; Dunn, C. J. Pioglitazone. Drugs, 2000, 60, 333-343.
-
(2000)
Drugs
, vol.60
, pp. 333-343
-
-
Gillies, P.S.1
Dunn, C.J.2
-
44
-
-
0025055470
-
Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones
-
Sohda, T.; Momose, Y.; Meguro, K.; Kawanatsu, Y.; Sugiyama, Y.; Ikeda, H. Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones. Arzneim.-Forsch., 1990, 40, 37-42.
-
(1990)
Arzneim.-Forsch
, vol.40
, pp. 37-42
-
-
Sohda, T.1
Momose, Y.2
Meguro, K.3
Kawanatsu, Y.4
Sugiyama, Y.5
Ikeda, H.6
-
45
-
-
0025022272
-
Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals
-
Ikeda, H.; Taketomi, S.; Sugiyama, Y.; Shimura, Y.; Sohda, T.; Meguro, K.; Fujita, T. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneim.-Forsch., 1990, 40, 156-162.
-
(1990)
Arzneim.-Forsch
, vol.40
, pp. 156-162
-
-
Ikeda, H.1
Taketomi, S.2
Sugiyama, Y.3
Shimura, Y.4
Sohda, T.5
Meguro, K.6
Fujita, T.7
-
46
-
-
0025267698
-
Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats
-
Sugiyama, Y.; Taketomi, S.; Shimura, Y.; Ikeda, H.; Fujita, T. Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. Arzneim.-Forsch., 1990, 40, 263-267.
-
(1990)
Arzneim.-Forsch
, vol.40
, pp. 263-267
-
-
Sugiyama, Y.1
Taketomi, S.2
Shimura, Y.3
Ikeda, H.4
Fujita, T.5
-
47
-
-
0025214262
-
Effects of pioglitazone on hepatic and peripheral insulin resistance in Wistar fatty rats
-
Sugiyama, Y.; Shimura, Y.; Ikeda, H. Effects of pioglitazone on hepatic and peripheral insulin resistance in Wistar fatty rats. Arzneim.-Forsch., 1990, 40, 436-440.
-
(1990)
Arzneim.-Forsch
, vol.40
, pp. 436-440
-
-
Sugiyama, Y.1
Shimura, Y.2
Ikeda, H.3
-
48
-
-
0025769847
-
1 Synthesis and biological activities of pioglitazone and related compounds
-
1 Synthesis and biological activities of pioglitazone and related compounds. Chem. Pharm. Bull., 1991, 39, 1440-1445.
-
(1991)
Chem. Pharm. Bull
, vol.39
, pp. 1440-1445
-
-
Momose, Y.1
Meguro, K.2
Ikeda, H.3
Hatanaka, C.4
Oi, S.5
Sohda, T.6
-
49
-
-
0026724981
-
Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents
-
Sohda, T.; Mizuno, K.; Momose, Y.; Ikeda, H.; Fujita, T.; Meguro, K. Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents. J. Med. Chem., 1992, 35, 2617-2626.
-
(1992)
J. Med. Chem
, vol.35
, pp. 2617-2626
-
-
Sohda, T.1
Mizuno, K.2
Momose, Y.3
Ikeda, H.4
Fujita, T.5
Meguro, K.6
-
50
-
-
0029612201
-
Studies on antidiabetic agents. XII.1) Synthesis and activity of the metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (pioglitazone)
-
Sohda, T.; Ikeda, H.; Meguro, K. Studies on antidiabetic agents. XII.1) Synthesis and activity of the metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (pioglitazone). Chem. Pharm. Bull., 1995, 43, 2168-2172.
-
(1995)
Chem. Pharm. Bull
, vol.43
, pp. 2168-2172
-
-
Sohda, T.1
Ikeda, H.2
Meguro, K.3
-
51
-
-
0030459837
-
Synthesis and biological activity of metabolites of the antidiabetic, antihyperglyce-mic agent pioglitazone
-
Tanis, S. P.; Parker, T. T.; Colca, J. R.; Fisher, R. M.; Kletzein, R. F. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglyce-mic agent pioglitazone. J. Med. Chem., 1996, 39, 5053-5063.
-
(1996)
J. Med. Chem
, vol.39
, pp. 5053-5063
-
-
Tanis, S.P.1
Parker, T.T.2
Colca, J.R.3
Fisher, R.M.4
Kletzein, R.F.5
-
52
-
-
0036749123
-
Process development and scale-up of the potential thiazolidinedione antidiabetic candidate PNU-91325
-
Carpenter, D. E.; Imbordino, R. J.; Maloney, M. T.; Moeslein, J. A.; Reeder, M. R.; Scott, A. Process development and scale-up of the potential thiazolidinedione antidiabetic candidate PNU-91325. Org. Process Res. Dev., 2002, 6, 721-728.
-
(2002)
Org. Process Res. Dev
, vol.6
, pp. 721-728
-
-
Carpenter, D.E.1
Imbordino, R.J.2
Maloney, M.T.3
Moeslein, J.A.4
Reeder, M.R.5
Scott, A.6
-
53
-
-
1842454309
-
Optimization of the reduction of a 5-benzylidenethiazolidine-2,4-dione derivative supported by the reaction response surface analysis: Synthesis of pioglitazone hydrochloride
-
Lés, A.; Pucko, W.; Szelejewski, W. Optimization of the reduction of a 5-benzylidenethiazolidine-2,4-dione derivative supported by the reaction response surface analysis: synthesis of pioglitazone hydrochloride. Org. Process Res. Dev., 2004, 8, 157-162.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 157-162
-
-
Lés, A.1
Pucko, W.2
Szelejewski, W.3
-
54
-
-
42949110308
-
Synthesis of polymeric thiazolidinedione and fibrate conjugates
-
Kim, Y.; Kang, B.; Jeon, R. Synthesis of polymeric thiazolidinedione and fibrate conjugates. Arch. Pharm. Res., 2008, 31, 148-153.
-
(2008)
Arch. Pharm. Res
, vol.31
, pp. 148-153
-
-
Kim, Y.1
Kang, B.2
Jeon, R.3
-
55
-
-
0036343675
-
Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus
-
Wagstaff, A. J.; Goa, K. L. Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus. Drugs, 2002, 62, 1805-1837.
-
(2002)
Drugs
, vol.62
, pp. 1805-1837
-
-
Wagstaff, A.J.1
Goa, K.L.2
-
56
-
-
36849081979
-
Rosiglitazone: A review of its use in type 2 diabetes mellitus
-
Deeks, E. D.; Keam, S. J. Rosiglitazone: A review of its use in type 2 diabetes mellitus. Drugs, 2007, 67, 2747-2779.
-
(2007)
Drugs
, vol.67
, pp. 2747-2779
-
-
Deeks, E.D.1
Keam, S.J.2
-
57
-
-
0027988554
-
[[-(Heterocyclyl-amino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents
-
Cantello, B. C.; Cawthorne, M. A.; Cottam, G. P.; Duff, P. T.; Haigh, D.; Hindley, R. M.; Lister, C. A.; Smith, S. A.; Thurlby, P. L. [[-(Heterocyclyl-amino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J. Med. Chem., 1994, 37, 3977-3985.
-
(1994)
J. Med. Chem
, vol.37
, pp. 3977-3985
-
-
Cantello, B.C.1
Cawthorne, M.A.2
Cottam, G.P.3
Duff, P.T.4
Haigh, D.5
Hindley, R.M.6
Lister, C.A.7
Smith, S.A.8
Thurlby, P.L.9
-
58
-
-
0028335891
-
The synthesis of BRL 49653-a novel and potent antihypergly-cemic agent
-
Cantello, B. C.; Cawthorne, M. A.; Haigh, D.; Hindley, R. M.; Smith, S. A.; Thurlby, P. L. The synthesis of BRL 49653-a novel and potent antihypergly-cemic agent. Bioorg. Med. Chem. Lett., 1994, 4, 1181-1184.
-
(1994)
Bioorg. Med. Chem. Lett
, vol.4
, pp. 1181-1184
-
-
Cantello, B.C.1
Cawthorne, M.A.2
Haigh, D.3
Hindley, R.M.4
Smith, S.A.5
Thurlby, P.L.6
-
59
-
-
15144348713
-
Novel euglycemic and hypolipidemic agents 1
-
Lohray, B. B.; Bhushan, V.; Rao, B. P.; Madhavan, G. R.; Murali, N.; Rao, K. N.; Reddy, K. A.; Rajesh, B. M.; Reddy, P. G.; Chakrabarti, R.; Vikra-madithyan, R. K.; Rajagopalan, R.; Rao, N. V. S. Mamidi; Jajoo, H. K.; Subramaniam, S. Novel euglycemic and hypolipidemic agents 1. J. Med. Chem., 1998, 41, 1619-1630.
-
(1998)
J. Med. Chem
, vol.41
, pp. 1619-1630
-
-
Lohray, B.B.1
Bhushan, V.2
Rao, B.P.3
Madhavan, G.R.4
Murali, N.5
Rao, K.N.6
Reddy, K.A.7
Rajesh, B.M.8
Reddy, P.G.9
Chakrabarti, R.10
Vikra-madithyan, R.K.11
Rajagopalan, R.12
Rao, N.V.S.M.13
Jajoo, H.K.14
Subramaniam, S.15
-
60
-
-
0033566136
-
Novel euglycemic and hypolipidemic agents. 4. Pyridyl-and quinolinyl-containing thiazolidinediones
-
Lohray, B. B.; Bhushan, V.; Reddy, A. S.; Rao, B. P.; Reddy, N. J.; Harikishore, P.; Haritha, N.; Vikramadithyan, R. K.; Chakrabarti, R.; Rajagopalan, R.; Katneni, K. Novel euglycemic and hypolipidemic agents. 4. Pyridyl-and quinolinyl-containing thiazolidinediones. J. Med. Chem., 1999, 42, 2569-2581.
-
(1999)
J. Med. Chem
, vol.42
, pp. 2569-2581
-
-
Lohray, B.B.1
Bhushan, V.2
Reddy, A.S.3
Rao, B.P.4
Reddy, N.J.5
Harikishore, P.6
Haritha, N.7
Vikramadithyan, R.K.8
Chakrabarti, R.9
Rajagopalan, R.10
Katneni, K.11
-
61
-
-
0034632802
-
Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
-
Oguchi, M.; Wada, K.; Honma, H.; Tanaka, A.; Kaneko, T.; Sakakibara, S.; Ohsumi, J.; Serizawa, N.; Fujiwara, T.; Horikoshi, H.; Fujita, T. Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones. J. Med. Chem., 2000, 43, 3052-3066.
-
(2000)
J. Med. Chem
, vol.43
, pp. 3052-3066
-
-
Oguchi, M.1
Wada, K.2
Honma, H.3
Tanaka, A.4
Kaneko, T.5
Sakakibara, S.6
Ohsumi, J.7
Serizawa, N.8
Fujiwara, T.9
Horikoshi, H.10
Fujita, T.11
-
62
-
-
0021715682
-
Studies on antidiabetic agents. VI. Asymmetric transformation of (±)-5-[4-(1-methylcyclohexylmethoxy)ben-zyl]-2,4-thiazolidinedione(ciglitazone) with optically active 1-phenylethyl-amines
-
Sohda, T.; Mizuno, K.; Kawamatsu, Y. Studies on antidiabetic agents. VI. Asymmetric transformation of (±)-5-[4-(1-methylcyclohexylmethoxy)ben-zyl]-2,4-thiazolidinedione(ciglitazone) with optically active 1-phenylethyl-amines. Chem. Pharm. Bull., 1984, 32, 4460-4465.
-
(1984)
Chem. Pharm. Bull
, vol.32
, pp. 4460-4465
-
-
Sohda, T.1
Mizuno, K.2
Kawamatsu, Y.3
-
63
-
-
37049068182
-
Facile biocatalytic reduction of the carbon-carbon double bond of 5-benzylidene-thiazolidine-2,4-diones. Synthesis of (±)-5-(4-{2-[methyl(2-pyridyl)amino] ethoxy}benzyl)thiazo-lidine-2,4-dione (BRL 49653), its (R)-(+)-enantiomer and analogs
-
Cantello, B. C. C.; Eggleston, D. S.; Haigh, D.; Haltiwanger, R. C.; Heath, C. M.; Hindley, R. M.; Jennings, K. R.; Sime, J. T.; Woroniecki, S. R. Facile biocatalytic reduction of the carbon-carbon double bond of 5-benzylidene-thiazolidine-2,4-diones. Synthesis of (±)-5-(4-{2-[methyl(2-pyridyl)amino] ethoxy}benzyl)thiazo-lidine-2,4-dione (BRL 49653), its (R)-(+)-enantiomer and analogs. Chem. Soc., Perkin Trans. 1, 1994, 3319-3324.
-
(1994)
Chem. Soc., Perkin Trans
, vol.1
, pp. 3319-3324
-
-
Cantello, B.C.C.1
Eggleston, D.S.2
Haigh, D.3
Haltiwanger, R.C.4
Heath, C.M.5
Hindley, R.M.6
Jennings, K.R.7
Sime, J.T.8
Woroniecki, S.R.9
-
64
-
-
0032534845
-
Differential activity of rosiglitazone enantiomers at PPAR
-
Parks, D. J.; Tomkinson, N. C. O.; Villeneuve, M. S.; Blanchard, S. G.; Willson, T. M. Differential activity of rosiglitazone enantiomers at PPAR. Bioorg. Med. Chem. Lett., 1998, 8, 3657-3658.
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 3657-3658
-
-
Parks, D.J.1
Tomkinson, N.C.O.2
Villeneuve, M.S.3
Blanchard, S.G.4
Willson, T.M.5
-
65
-
-
0032505096
-
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-
-
Nolte, R. T.; Wisely, G. B.; Westin, S.; Cobb, J. E.; Lambert, M. H.; Kuro-kawa, R.; Rosenfeld, M. G.; Willson, T. M.; Glass, C. K.; Milburn, M. V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-. Nature, 1998, 395, 137-143.
-
(1998)
Nature
, vol.395
, pp. 137-143
-
-
Nolte, R.T.1
Wisely, G.B.2
Westin, S.3
Cobb, J.E.4
Lambert, M.H.5
Kuro-kawa, R.6
Rosenfeld, M.G.7
Willson, T.M.8
Glass, C.K.9
Milburn, M.V.10
-
66
-
-
0037187361
-
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidine-dione derivatives as insulin sensitizers with antidiabetic activities
-
Momose, Y.; Maekawa, T.; Yamano, T.; Kawada, M.; Odaka, H.; Ikeda, H.; Sohda, T. Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidine-dione derivatives as insulin sensitizers with antidiabetic activities. J. Med. Chem., 2002, 45, 1518-1534.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1518-1534
-
-
Momose, Y.1
Maekawa, T.2
Yamano, T.3
Kawada, M.4
Odaka, H.5
Ikeda, H.6
Sohda, T.7
-
67
-
-
2442489096
-
Rapid racemization in thiazolidinediones: A quantum chemical study
-
Bharatam, P. V.; Khanna, S. Rapid racemization in thiazolidinediones: A quantum chemical study. J. Phys. Chem. A, 2004, 108, 3784-3788.
-
(2004)
J. Phys. Chem. A
, vol.108
, pp. 3784-3788
-
-
Bharatam, P.V.1
Khanna, S.2
-
68
-
-
0033593916
-
(3-Substituted Benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents
-
Nomura, M.; Kinoshita, S.; Satoh, H.; Maeda, T.; Murakami, K.; Tsunoda, M.; Miyachi, H.; Awano, K. (3-Substituted Benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorg. Med. Chem. Lett., 1999, 9, 533-538.
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 533-538
-
-
Nomura, M.1
Kinoshita, S.2
Satoh, H.3
Maeda, T.4
Murakami, K.5
Tsunoda, M.6
Miyachi, H.7
Awano, K.8
-
69
-
-
85195237378
-
Synthesis of new antidiabetic agent KRP-297
-
Wang, Q.; Wang, Q.; Yan, D.; Wang, Z.; Cheng, M. Synthesis of new antidiabetic agent KRP-297. Zhongguo Yiyao Gongye Zazhi., 2003. 34, 313-314.
-
(2003)
Zhongguo Yiyao Gongye Zazhi
, vol.34
, pp. 313-314
-
-
Wang, Q.1
Wang, Q.2
Yan, D.3
Wang, Z.4
Cheng, M.5
-
70
-
-
0037260712
-
Vanadyl-thiazolidinedione combination agents for diabetes therapy
-
Storr, T.; Mitchell, D.; Buglyó, P.; Thompson, K. H.; Yuen, V. G.; McNeill, J. H.; Orvig, C. Vanadyl-thiazolidinedione combination agents for diabetes therapy. Bioconjug. Chem., 2003, 14, 212-221.
-
(2003)
Bioconjug. Chem
, vol.14
, pp. 212-221
-
-
Storr, T.1
Mitchell, D.2
Buglyó, P.3
Thompson, K.H.4
Yuen, V.G.5
McNeill, J.H.6
Orvig, C.7
-
71
-
-
26844439202
-
Synthesis of N-substituted 2,4-thiazolidine-diones from oxazolidinethiones
-
Mendoza, G.; Hernández, H.; Quintero, L.; Sosa-Rivadeneyra, M.; Bernès, S.; Sansinenea, E.; Ortiz, A. Synthesis of N-substituted 2,4-thiazolidine-diones from oxazolidinethiones. Tetrahedron Lett., 2005, 46, 7867-7870.
-
(2005)
Tetrahedron Lett
, vol.46
, pp. 7867-7870
-
-
Mendoza, G.1
Hernández, H.2
Quintero, L.3
Sosa-Rivadeneyra, M.4
Bernès, S.5
Sansinenea, E.6
Ortiz, A.7
-
72
-
-
33745850802
-
Design and synthesis of the first generation of dithiolane thiazolidinedione-and phenylacetic acid-based PPAR agonists
-
Chittiboyina, A. G.; Venkatraman, M. S.; Mizuno, C. S.; Desai, P. V.; Patny, A.; Benson, S. C.; Ho, C. I.; Kurtz, T. W.; Pershadsingh, H.A.; Avery, M.A. Design and synthesis of the first generation of dithiolane thiazolidinedione-and phenylacetic acid-based PPAR agonists. J. Med. Chem., 2006, 49, 4072-4084.
-
(2006)
J. Med. Chem
, vol.49
, pp. 4072-4084
-
-
Chittiboyina, A.G.1
Venkatraman, M.S.2
Mizuno, C.S.3
Desai, P.V.4
Patny, A.5
Benson, S.C.6
Ho, C.I.7
Kurtz, T.W.8
Pershadsingh, H.A.9
Avery, M.A.10
-
73
-
-
0347361637
-
Benzoxazinones as PPAR agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model
-
Rybczynski, P. J.; Zeck, R. E.; Dudash, J.; Combs, D. W.; Burris, T. P.; Yang, M.; Osborne, M. C.; Chen, X.; Demarest, K. T. Benzoxazinones as PPAR agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model. J. Med. Chem., 2004, 47, 196-209.
-
(2004)
J. Med. Chem
, vol.47
, pp. 196-209
-
-
Rybczynski, P.J.1
Zeck, R.E.2
Dudash, J.3
Combs, D.W.4
Burris, T.P.5
Yang, M.6
Osborne, M.C.7
Chen, X.8
Demarest, K.T.9
-
74
-
-
0032406145
-
Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555
-
Upton, R.; Widdowson, P. S.; Ishii, S.; Tanaka, H.; Williams, G. Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555. Br. J. Pharmacol., 1998, 125, 1708-1714.
-
(1998)
Br. J. Pharmacol
, vol.125
, pp. 1708-1714
-
-
Upton, R.1
Widdowson, P.S.2
Ishii, S.3
Tanaka, H.4
Williams, G.5
-
75
-
-
0031728308
-
The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment
-
Pickavance, L.; Widdowson, P. S.; King, P.; Ishii, S.; Tanaka, H.; Williams, G. The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment. Br. J. Pharmacol., 1998, 125, 767-770.
-
(1998)
Br. J. Pharmacol
, vol.125
, pp. 767-770
-
-
Pickavance, L.1
Widdowson, P.S.2
King, P.3
Ishii, S.4
Tanaka, H.5
Williams, G.6
-
76
-
-
0032484224
-
A potent antidiabetic thiazolidinedione with unique peroxisome proliferators-activated receptor -activating properties
-
Reginato, M. J.; Bailey, S. T.; Krakow, S. L.; Minami, C.; Ishii, S.; Tanaka, H.; Lazar, M. A. A potent antidiabetic thiazolidinedione with unique peroxisome proliferators-activated receptor -activating properties. J. Biol. Chem., 1998, 273, 32679-32684.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 32679-32684
-
-
Reginato, M.J.1
Bailey, S.T.2
Krakow, S.L.3
Minami, C.4
Ishii, S.5
Tanaka, H.6
Lazar, M.A.A.7
-
77
-
-
85195237169
-
Preparation of 5-(benzyloxy-2-naphthyl)methyl-2,4-thiazolidinediones as antidiabetic agents and antihyper-tensives
-
Ueno, H.; Oe, T.; Suehiro, I.; Sekiya, A. Preparation of 5-(benzyloxy-2-naphthyl)methyl-2,4-thiazolidinediones as antidiabetic agents and antihyper-tensives. JP 10139768, 1998.
-
(1998)
JP 10139768
-
-
Ueno, H.1
Oe, T.2
Suehiro, I.3
Sekiya, A.4
-
78
-
-
33646779132
-
MCC-555 (Mitsubishi-Tokyo Pharmaceuticals)
-
Velussi, M. MCC-555 (Mitsubishi-Tokyo Pharmaceuticals). IDrugs, 2001, 4, 586-589.
-
(2001)
IDrugs
, vol.4
, pp. 586-589
-
-
Velussi, M.1
-
79
-
-
85195240599
-
Improvement of synthesis of novel antidiabetic agent MCC-555
-
Sun, L.; Wu, Y.; Zheng, G.; Piao, H. Improvement of synthesis of novel antidiabetic agent MCC-555. Yanbian Daxue Yixue Xuebao., 2006, 29, 172-174.
-
(2006)
Yanbian Daxue Yixue Xuebao
, vol.29
, pp. 172-174
-
-
Sun, L.1
Wu, Y.2
Zheng, G.3
Piao, H.4
-
82
-
-
85195236575
-
-
JP2008044932
-
Nakamura, Y.; Satoh, C.; Miyamoto, H.; Kajino, H. Pharmaceutical compositions containing thiazolidinedione compounds, and preparation thereof. JP2008044932, 2008.
-
(2008)
Pharmaceutical Compositions Containing Thiazolidinedione Compounds, and Preparation Thereof
-
-
Nakamura, Y.1
Satoh, C.2
Miyamoto, H.3
Kajino, H.4
-
83
-
-
85195237957
-
-
WO2007100027
-
Ohsumi, J.; Wada, K.; Matsui, Y.; Ogata, T. Preparation of optically active thiazolidin-edione derivative, with high affinity for PPAR. WO2007100027, 2007.
-
(2007)
Preparation of Optically Active Thiazolidin-edione Derivative, With High Affinity For PPAR
-
-
Ohsumi, J.1
Wada, K.2
Matsui, Y.3
Ogata, T.4
-
85
-
-
57449120900
-
Model-based development of a PPAR agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs
-
Rohatagi, S.; Carrothers, T. J.; Jin, J. Y.; Jusko, W. J.; Khariton, T.; Walker, J.; Truitt, K.; Salazar, D. E. Model-based development of a PPAR agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs. J. Clin. Pharmacol., 2008, 48, 1420-1429.
-
(2008)
J. Clin. Pharmacol
, vol.48
, pp. 1420-1429
-
-
Rohatagi, S.1
Carrothers, T.J.2
Jin, J.Y.3
Jusko, W.J.4
Khariton, T.5
Walker, J.6
Truitt, K.7
Salazar, D.E.8
-
86
-
-
34147131103
-
Drug evaluation: Rivoglitazone, a new oral therapy for the treatment of type 2 diabetes
-
Schimke, K.; Davis, T. M. Drug evaluation: rivoglitazone, a new oral therapy for the treatment of type 2 diabetes. Curr. Opin. Invest. Drugs, 2007, 8, 338-344.
-
(2007)
Curr. Opin. Invest. Drugs
, vol.8
, pp. 338-344
-
-
Schimke, K.1
Davis, T.M.2
-
87
-
-
60549094788
-
Rivoglitazone hydrochloride - PPAR agonist, insulin sensitizer, treatment of diabetes
-
Davies, S.; Castaner, R.; Bolos, J. Rivoglitazone hydrochloride - PPAR agonist, insulin sensitizer, treatment of diabetes. Drugs Fut., 2008, 33, 926-931.
-
(2008)
Drugs Fut
, vol.33
, pp. 926-931
-
-
Davies, S.1
Castaner, R.2
Bolos, J.3
-
88
-
-
0142009510
-
Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione de-rivatives
-
Kim, B. Y.; Ahn, J. B.; Lee, H. W.; Moon, K. S.; Sim, T. B.; Shin, J. S.; Ahn, S. K.; Hong, C. I. Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione de-rivatives. Chem. Pharm. Bull., 2003, 51, 276-285.
-
(2003)
Chem. Pharm. Bull
, vol.51
, pp. 276-285
-
-
Kim, B.Y.1
Ahn, J.B.2
Lee, H.W.3
Moon, K.S.4
Sim, T.B.5
Shin, J.S.6
Ahn, S.K.7
Hong, C.I.8
-
89
-
-
1942455433
-
Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione
-
Kim, B. Y.; Ahn, J. B.; Lee, H. W.; Kang, S. K.; Lee, J. H.; Shin, J. S.; Ahn, S. K.; Hong, C. I.; Yoon, S. S. Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione. Eur. J. Med. Chem., 2004, 39, 433-447.
-
(2004)
Eur. J. Med. Chem
, vol.39
, pp. 433-447
-
-
Kim, B.Y.1
Ahn, J.B.2
Lee, H.W.3
Kang, S.K.4
Lee, J.H.5
Shin, J.S.6
Ahn, S.K.7
Hong, C.I.8
Yoon, S.S.9
-
90
-
-
25444495496
-
Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione
-
Lee, H. W.; Kim, B. Y.; Ahn, J. B.; Kang, S. K.; Lee, J. H.; Shin, J. S.; Ahn, S. K.; Lee, S. J.; Yoon, S. S. Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione. Eur. J. Med. Chem., 2005, 40, 862-874.
-
(2005)
Eur. J. Med. Chem
, vol.40
, pp. 862-874
-
-
Lee, H.W.1
Kim, B.Y.2
Ahn, J.B.3
Kang, S.K.4
Lee, J.H.5
Shin, J.S.6
Ahn, S.K.7
Lee, S.J.8
Yoon, S.S.9
-
91
-
-
34247258462
-
Process development and scale-up of PPAR/ dual agonist lobeglitazone sulfate (CKD-501)
-
Lee, H. W.; Ahn, J. B.; Kang, S. K.; Ahn, S. K.; Ha, D.-C. Process development and scale-up of PPAR/ dual agonist lobeglitazone sulfate (CKD-501). Org. Process Res. Dev., 2007, 11, 190-199.
-
(2007)
Org. Process Res. Dev
, vol.11
, pp. 190-199
-
-
Lee, H.W.1
Ahn, J.B.2
Kang, S.K.3
Ahn, S.K.4
Ha, D.-C.5
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