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Volumn 208, Issue 2, 2011, Pages 161-169

Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ELONGATION FACTOR 2; GLIBENCLAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN; PROTEIN S6; RAPAMYCIN; RP 8 BROMO CYCLIC AMP; UNCLASSIFIED DRUG;

EID: 78951489223     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-10-0372     Document Type: Article
Times cited : (5)

References (46)
  • 1
    • 33750805015 scopus 로고    scopus 로고
    • Thinking globally and acting locally with TOR
    • doi:10.1016/j.ceb.2006.09.005
    • Arsham AM & Neufeld TP 2006 Thinking globally and acting locally with TOR. Current Opinion in Cell Biology 18 589-597. (doi:10.1016/j.ceb.2006.09. 005)
    • (2006) Current Opinion in Cell Biology , vol.18 , pp. 589-597
    • Arsham, A.M.1    Neufeld, T.P.2
  • 2
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    • doi:10.1074/jbc.C200171200
    • Bolster DR, Crozier SJ, Kimball SR & Jefferson LS 2002 AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. Journal of Biological Chemistry 277 23977-23980. (doi:10.1074/jbc.C200171200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 3
    • 0036438894 scopus 로고    scopus 로고
    • Regulation of peptide-chain elongation in mammalian cells
    • doi:10.1046/j.1432-1033.2002.03290.x
    • Browne GJ & Proud CG 2002 Regulation of peptide-chain elongation in mammalian cells. European Journal of Biochemistry 269 5360-5368. (doi:10.1046/j.1432-1033.2002.03290.x)
    • (2002) European Journal of Biochemistry , vol.269 , pp. 5360-5368
    • Browne, G.J.1    Proud, C.G.2
  • 4
    • 1642328617 scopus 로고    scopus 로고
    • Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
    • doi:10.1074/jbc.M309773200
    • Browne GJ, Finn SG & Proud CG 2004 Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. Journal of Biological Chemistry 279 12220-12231. (doi:10.1074/jbc.M309773200)
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 12220-12231
    • Browne, G.J.1    Finn, S.G.2    Proud, C.G.3
  • 6
    • 1942469564 scopus 로고    scopus 로고
    • 2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status
    • DOI 10.1074/jbc.C300534200
    • Cheng SW, Fryer LG, Carling D & Shepherd PR 2004 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. Journal of Biological Chemistry 279 15719-15722. (doi:10.1074/jbc. C300534200) (Pubitemid 38509255)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.16 , pp. 15719-15722
    • Cheng, S.W.Y.1    Fryer, L.G.D.2    Carling, D.3    Shepherd, P.R.4
  • 7
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: A review of its metabolic effects
    • Cusi K & Defronzo RA 1998 Metformin: a review of its metabolic effects. Diabetes Reviews 6 89-131. (Pubitemid 28554676)
    • (1998) Diabetes Reviews , vol.6 , Issue.2 , pp. 89-131
    • Cusi, K.1    DeFronzo, R.A.2
  • 8
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • doi:10.1158/0008-5472.CAN-07-2310
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M & Sonenberg N 2007 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research 67 10804-10812. (doi:10.1158/0008-5472.CAN-07-2310)
    • (2007) Cancer Research , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 9
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • DOI 10.1074/jbc.275.1.223
    • El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M & Leverve X 2000 Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. Journal of Biological Chemistry 275 223-228. (doi:10.1074/jbc.275.1.223) (Pubitemid 30038975)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.-Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 10
    • 0035118777 scopus 로고    scopus 로고
    • Inhibition of protein synthesis sequentially impairs distinct steps of stimulus-secretion coupling in pancreatic beta cells
    • doi:10.1210/en.142.1.299
    • Garcia-Barrado MJ, Ravier MA, Rolland JF, Gilon P, Nenquin M& Henquin JC 2001 Inhibition of protein synthesis sequentially impairs distinct steps of stimulus-secretion coupling in pancreatic beta cells. Endocrinology 142 299-307. (doi:10.1210/en.142.1.299)
    • (2001) Endocrinology , vol.142 , pp. 299-307
    • Garcia-Barrado, M.J.1    Ravier, M.A.2    Rolland, J.F.3    Gilon, P.4    Nenquin, M.5    Henquin, J.C.6
  • 11
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • doi:10.1101/gad.887201
    • Gingras AC, Raught B & Sonenberg N 2001 Regulation of translation initiation by FRAP/mTOR. Genes and Development 15 807-826. (doi:10.1101/gad. 887201)
    • (2001) Genes and Development , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 12
  • 14
    • 0023205160 scopus 로고
    • Regulation of insulin release by ionic and electrical events in B cells
    • doi:10.1159/000180806
    • Henquin JC 1987 Regulation of insulin release by ionic and electrical events in B cells. Hormone Research 27 168-178. (doi:10.1159/000180806)
    • (1987) Hormone Research , vol.27 , pp. 168-178
    • Henquin, J.C.1
  • 15
    • 34247185346 scopus 로고    scopus 로고
    • Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer
    • doi:10.1038/sj.bjp.0707189
    • Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D & Van de Casteele M 2007 Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. British Journal of Pharmacology 150 1031-1043. (doi:10.1038/sj.bjp.0707189)
    • (2007) British Journal of Pharmacology , vol.150 , pp. 1031-1043
    • Hinke, S.A.1    Martens, G.A.2    Cai, Y.3    Finsi, J.4    Heimberg, H.5    Pipeleers, D.6    Van De Casteele, M.7
  • 16
    • 0029797603 scopus 로고    scopus 로고
    • Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
    • doi:10.1172/JCI118950
    • Hoorens A, Van de Casteele M, Kloppel G & Pipeleers D 1996 Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. Journal of Clinical Investigation 98 1568-1574. (doi:10.1172/JCI118950)
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 1568-1574
    • Hoorens, A.1    Van De Casteele, M.2    Kloppel, G.3    Pipeleers, D.4
  • 17
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • doi:10.1016/S0092-8674(03)00929-2
    • Inoki K, Zhu T & Guan KL 2003 TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 577-590. (doi:10.1016/S0092- 8674(03)00929-2)
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 18
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • doi:10.1128/MMBR.69.1.79-100.2005
    • Inoki K, Ouyang H, Li Y & Guan KL 2005 Signaling by target of rapamycin proteins in cell growth control. Microbiology and Molecular Biology Reviews 69 79-100. (doi:10.1128/MMBR.69.1.79-100.2005)
    • (2005) Microbiology and Molecular Biology Reviews , vol.69 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.L.4
  • 19
    • 0038363852 scopus 로고    scopus 로고
    • AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
    • DOI 10.1677/jme.0.0300151
    • Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D & Van de Casteele M 2003 AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. Journal of Molecular Endocrinology 30 151-161. (doi:10.1677/jme.0.0300151) (Pubitemid 36592509)
    • (2003) Journal of Molecular Endocrinology , vol.30 , Issue.2 , pp. 151-161
    • Kefas, B.A.1    Cai, Y.2    Ling, Z.3    Heimberg, H.4    Hue, L.5    Pipeleers, D.6    Van De, C.M.7
  • 20
    • 3042702709 scopus 로고    scopus 로고
    • Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis
    • doi:10.1016/j.bcp.2004.04.003
    • Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D & Van de Casteele M 2004 Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochemical Pharmacology 68 409-416. (doi:10.1016/j.bcp.2004.04. 003)
    • (2004) Biochemical Pharmacology , vol.68 , pp. 409-416
    • Kefas, B.A.1    Cai, Y.2    Kerckhofs, K.3    Ling, Z.4    Martens, G.5    Heimberg, H.6    Pipeleers, D.7    Van De Casteele, M.8
  • 21
    • 9444234587 scopus 로고    scopus 로고
    • Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
    • doi:10.2337/diabetes.53.suppl-3.S225
    • Kwon G, Marshall CA, Pappan KL, Remedi MS & McDaniel ML 2004 Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 53 (Supplement 3) S225-S232. (doi:10.2337/diabetes.53.suppl-3.S225)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Kwon, G.1    Marshall, C.A.2    Pappan, K.L.3    Remedi, M.S.4    McDaniel, M.L.5
  • 22
    • 33645638812 scopus 로고    scopus 로고
    • Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: Effects on cell cycle progression in rodent islets
    • doi:10.1074/jbc.M508821200
    • Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS & McDaniel ML 2006 Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets. Journal of Biological Chemistry 281 3261-3267. (doi:10.1074/jbc.M508821200)
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 3261-3267
    • Kwon, G.1    Marshall, C.A.2    Liu, H.3    Pappan, K.L.4    Remedi, M.S.5    McDaniel, M.L.6
  • 24
    • 53549129190 scopus 로고    scopus 로고
    • The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes
    • doi:10.1111/j.1463-1326.2008.00952.x
    • Leibowitz G, Cerasi E & Ketzinel-Gilad M 2008 The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes. Diabetes, Obesity and Metabolism 10 (Supplement 4) 157-169. (doi:10.1111/j.1463-1326.2008.00952.x)
    • (2008) Diabetes, Obesity and Metabolism , vol.10 , Issue.SUPPL. 4 , pp. 157-169
    • Leibowitz, G.1    Cerasi, E.2    Ketzinel-Gilad, M.3
  • 25
    • 0028318109 scopus 로고
    • Preservation of glucose-responsive islet beta-cells during serum-free culture
    • DOI 10.1210/en.134.6.2614
    • Ling Z & Pipeleers DG 1994 Preservation of glucose-responsive islet beta-cells during serum-free culture. Endocrinology 134 2614-2621. (doi:10.1210/en.134.6.2614) (Pubitemid 24170878)
    • (1994) Endocrinology , vol.134 , Issue.6 , pp. 2614-2621
    • Ling, Z.1    Pipeleers, D.G.2
  • 27
    • 0031766627 scopus 로고    scopus 로고
    • Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells
    • Ling Z, Chen MC, Smismans A, Pavlovic D, Schuit F, Eizirik DL & Pipeleers DG 1998 Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells. Endocrinology 139 1540-1545. (doi:10.1210/en.139. 4.1540) (Pubitemid 28513807)
    • (1998) Endocrinology , vol.139 , Issue.4 , pp. 1540-1545
    • Ling, Z.1    Chen, M.-C.2    Smismans, A.3    Pavlovic, D.4    Schuit, F.5    Eizirik, D.L.6    Pipeleers, D.G.7
  • 28
    • 33644787081 scopus 로고    scopus 로고
    • Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity
    • doi:10.2337/diabetes.55.01.06.db05-0820
    • Ling Z, Wang Q, Stange G, In't Veld P & Pipeleers D 2006 Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity. Diabetes 55 78-85. (doi:10.2337/diabetes.55.01.06.db05-0820)
    • (2006) Diabetes , vol.55 , pp. 78-85
    • Ling, Z.1    Wang, Q.2    Stange, G.3    In't Veld, P.4    Pipeleers, D.5
  • 29
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • doi:10.2337/diabetes.51.10.2877
    • McDaniel ML, Marshall CA, Pappan KL & Kwon G 2002 Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 51 2877-2885. (doi:10.2337/diabetes.51.10.2877)
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 30
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • DOI 10.1042/0264-6021:3480607
    • Owen MR, Doran E & Halestrap AP 2000 Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal 348 607-614. (doi:10.1042/0264-6021: 3480607) (Pubitemid 30410251)
    • (2000) Biochemical Journal , vol.348 , Issue.3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 31
    • 0035447688 scopus 로고    scopus 로고
    • Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1
    • doi:10.1042/0264-6021:3580497
    • Patel J, Wang X & Proud CG 2001 Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1. Biochemical Journal 358 497-503. (doi:10.1042/0264-6021:3580497)
    • (2001) Biochemical Journal , vol.358 , pp. 497-503
    • Patel, J.1    Wang, X.2    Proud, C.G.3
  • 32
    • 0015730986 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity
    • doi:10.1210/endo-93-5-1001
    • Pipeleers DG, Marichal M & Malaisse WJ 1973 The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity. Endocrinology 93 1001-1011. (doi:10.1210/endo-93-5-1001)
    • (1973) Endocrinology , vol.93 , pp. 1001-1011
    • Pipeleers, D.G.1    Marichal, M.2    Malaisse, W.J.3
  • 34
    • 0036894342 scopus 로고    scopus 로고
    • Sulfonylurea stimulation of insulin secretion
    • doi:10.2337/diabetes.51.2007.S368
    • Proks P, Reimann F, Green N, Gribble F & Ashcroft F 2002 Sulfonylurea stimulation of insulin secretion. Diabetes 51 (Supplement 3) S368-S376. (doi:10.2337/diabetes.51.2007.S368)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Proks, P.1    Reimann, F.2    Green, N.3    Gribble, F.4    Ashcroft, F.5
  • 35
    • 0035912780 scopus 로고    scopus 로고
    • The target of rapamycin (TOR) proteins
    • doi:10.1073/pnas.121145898
    • Raught B, Gingras AC & Sonenberg N 2001 The target of rapamycin (TOR) proteins. PNAS 98 7037-7044. (doi:10.1073/pnas.121145898)
    • (2001) PNAS , vol.98 , pp. 7037-7044
    • Raught, B.1    Gingras, A.C.2    Sonenberg, N.3
  • 36
    • 57749114540 scopus 로고    scopus 로고
    • The AMP-regulated kinase family: Enigmatic targets for diabetes therapy
    • doi:10.1016/j.mce.2008.05.020
    • Rutter GA & Leclerc I 2009 The AMP-regulated kinase family: enigmatic targets for diabetes therapy. Molecular and Cellular Endocrinology 297 41-49. (doi:10.1016/j.mce.2008.05.020)
    • (2009) Molecular and Cellular Endocrinology , vol.297 , pp. 41-49
    • Rutter, G.A.1    Leclerc, I.2
  • 37
    • 0141905919 scopus 로고    scopus 로고
    • Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
    • DOI 10.1042/BJ20030048
    • Rutter GA, Da Silva Xavier G & Leclerc I 2003 Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochemical Journal 375 1-16. (doi:10.1042/BJ20030048) (Pubitemid 37255376)
    • (2003) Biochemical Journal , vol.375 , Issue.1 , pp. 1-16
    • Rutter, G.A.1    Da, S.X.G.2    Leclerc, I.3
  • 38
    • 0015455964 scopus 로고
    • The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats
    • doi:10.1007/BF01212167
    • Schatz H, Katsilambros N, Nierle C & Pfeiffer EE 1972 The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats. Diabetologia 8 402-407. (doi:10.1007/BF01212167)
    • (1972) Diabetologia , vol.8 , pp. 402-407
    • Schatz, H.1    Katsilambros, N.2    Nierle, C.3    Pfeiffer, E.E.4
  • 39
    • 0039829851 scopus 로고
    • Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • doi:10.1073/pnas.85.11.3865
    • Schuit FC, In't Veld PA & Pipeleers DG 1988 Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. PNAS 85 3865-3869. (doi:10.1073/pnas.85.11.3865)
    • (1988) PNAS , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 40
  • 41
    • 0021840516 scopus 로고
    • The sulphonylurea receptor may be an ATP-sensitive potassium channel
    • doi:10.1016/S0140-6736(85)90403-9
    • Sturgess NC, Ashford ML, Cook DL & Hales CN 1985 The sulphonylurea receptor may be an ATP-sensitive potassium channel. Lancet 2 474-475. (doi:10.1016/S0140-6736(85)90403-9)
    • (1985) Lancet , vol.2 , pp. 474-475
    • Sturgess, N.C.1    Ashford, M.L.2    Cook, D.L.3    Hales, C.N.4
  • 42
    • 44749087943 scopus 로고    scopus 로고
    • Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways
    • doi:10.1007/s00125-008-1026-8
    • Wang Q, Heimberg H, Pipeleers D & Ling Z 2008 Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways. Diabetologia 51 1202-1212. (doi:10.1007/s00125-008- 1026-8)
    • (2008) Diabetologia , vol.51 , pp. 1202-1212
    • Wang, Q.1    Heimberg, H.2    Pipeleers, D.3    Ling, Z.4
  • 43
    • 0032789150 scopus 로고    scopus 로고
    • Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes
    • Wiernsperger NF 1999 Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes. Diabetes and Metabolism 25 110-127.
    • (1999) Diabetes and Metabolism , vol.25 , pp. 110-127
    • Wiernsperger, N.F.1
  • 44
    • 0026011343 scopus 로고
    • Reconsideration of inhibitory effect of metformin on intestinal glucose absorption
    • Wilcock C & Bailey CJ 1991 Reconsideration of inhibitory effect of metformin on intestinal glucose absorption. Journal of Pharmacy and Pharmacology 43 120-121.
    • (1991) Journal of Pharmacy and Pharmacology , vol.43 , pp. 120-121
    • Wilcock, C.1    Bailey, C.J.2


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