Glucocorticoid-Induced TNFR family Related gene (GITR) enhances dendritic cell activity

Immunology Letters

Volumn 135, Issue 1-2, 2011, Pages 24-33

  Ronchetti, Simona ^a   Nocentini, Giuseppe ^a   Petrillo, Maria Grazia ^a   Bianchini, Rodolfo ^a   Sportoletti, Paolo ^a   Bastianelli, Alessandra ^a   Ayroldi, Emira M ^a   Riccardi, Carlo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

CD4 T cells; Dendritic cells; Immune responses; Knock out mice

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BONE MARROW CELLS; CYTOKINES; DENDRITIC CELLS; GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY;

EID: 78751705229     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.09.008     Document Type: Article

References (54)

1. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005, 23:23-68.
2. Nocentini G., Ronchetti S., Cuzzocrea S., Riccardi C. GITR/GITRL: more than an effector T cell co-stimulatory system. Eur J Immunol 2007, 37:1165-1169.
3. Nocentini G., Giunchi L., Ronchetti S., Krausz L.T., Bartoli A., Moraca R., et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997, 94:6216-6221.
4. Esparza E.M., Arch R.H. Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation. J Immunol 2005, 174:7869-7874.
5. Tone M., Tone Y., Adams E., Yates S.F., Frewin M.R., Cobbold S.P., et al. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci USA 2003, 100:15059-15064.
6. Ronchetti S., Zollo O., Bruscoli S., Agostini M., Bianchini R., Nocentini G., et al. GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur J Immunol 2004, 34:613-622.
7. Ronchetti S., Nocentini G., Bianchini R., Krausz L.T., Migliorati G., Riccardi C. Glucocorticoid-induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells. J Immunol 2007, 179:5916-5926.
8. van Olffen R.W., Koning N., van Gisbergen K.P., Wensveen F.M., Hoek R.M., Boon L., et al. GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol 2009, 182:7490-7500.
9. Cohen A.D., Diab A., Perales M.A., Wolchok J.D., Rizzuto G., Merghoub T., et al. Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res 2006, 66:4904-4912.
10. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135-142.
11. Krausz L.T., Bianchini R., Ronchetti S., Fettucciari K., Nocentini G., Riccardi C. GITR-GITRL system, a novel player in shock and inflammation. ScientificWorldJournal 2007, 7:533-566.
12. Banchereau J, Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
13. Adler H.S., Steinbrink K. Tolerogenic dendritic cells in health and disease: friend and foe!. Eur J Dermatol 2007, 17:476-491.
14. Nocentini G., Riccardi C. GITR: a modulator of immune response and inflammation. Adv Exp Med Biol 2009, 647:156-173.
15. You S., Poulton L., Cobbold S., Liu C.P., Rosenzweig M., Ringler D., et al. Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target. PLoS One 2009, 4:e7848.
16. Sonawane S.B., Kim J.I., Lee M.K., Lee S.H., Duff P.E., Moore D.J., et al. GITR blockade facilitates Treg mediated allograft survival. Transplantation 2009, 88:1169-1177.
17. Motta A.C., Vissers J.L., Gras R., Van Esch B.C., Van Oosterhout A.J., Nawijn M.C. GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma. Respir Res 2009, 10:93.
18. Cuzzocrea S., Ronchetti S., Genovese T., Mazzon E., Agostini M., Di Paola R., et al. Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation. FASEB J 2007, 21:117-129.
19. Cuzzocrea S., Ayroldi E., Di Paola R., Agostini M., Mazzon E., Bruscoli S., et al. Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis. FASEB J 2005, 19:1253-1265.
20. Santucci L., Agostini M., Bruscoli S., Mencarelli A., Ronchetti S., Ayroldi E., et al. GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice. Gut 2007, 56:52-60.
21. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992, 176:1693-1702.
22. Boczkowski D., Nair S.K., Nam J.H., Lyerly H.K., Gilboa E. Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Res 2000, 60:1028-1034.
23. Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991, 139:271-279.
24. Gharagozloo M., Velardi E., Bruscoli S., Agostini M., Di Sante M., Donato V., et al. Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production. Pharmacol Res 2010, 61:405-409.
25. Bianchini R., Nocentini G., Krausz L.T., Fettucciari K., Coaccioli S., Ronchetti S., et al. Modulation of pro- and antiapoptotic molecules in double-positive (CD4+ CD8+) thymocytes following dexamethasone treatment. J Pharmacol Exp Ther 2006, 319:887-897.
26. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999, 223:77-92.
27. Steinbrink K., Graulich E., Kubsch S., Knop J., Enk A.H. CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 2002, 99:2468-2476.
28. Cools N., Van Tendeloo V.F., Smits E.L., Lenjou M., Nijs G., Van Bockstaele D.R., et al. Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cells. J Cell Mol Med 2008, 12:690-700.
29. Belkaid Y., Oldenhove G. Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity 2008, 29:362-371.
30. Bouma G., Burns S., Thrasher A.J. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood 2007, 110:4278-4284.
31. Choi B.K., Kim Y.H., Kwon P.M., Lee S.C., Kang S.W., Kim M.S., et al. 4-1BB functions as a survival factor in dendritic cells. J Immunol 2009, 182:4107-4115.
32. Brinster C., Shevach E.M. Bone marrow-derived dendritic cells reverse the anergic state of CD4+ CD25+ T cells without reversing their suppressive function. J Immunol 2005, 175:7332-7340.
33. Yamazaki S., Iyoda T., Tarbell K., Olson K., Velinzon K., Inaba K., et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003, 198:235-247.
34. Bleier J.I., Pillarisetty V.G., Shah A.B., DeMatteo R.P. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J Immunol 2004, 172:7408-7416.
35. Veldhoen M., Moncrieffe H., Hocking R.J., Atkins C.J., Stockinger B. Modulation of dendritic cell function by naive and regulatory CD4+ T cells. J Immunol 2006, 176:6202-6210.
36. Wakkach A., Fournier N., Brun V., Breittmayer J.P., Cottrez F., Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003, 18:605-617.
37. Henry E., Desmet C.J., Garze V., Fievez L., Bedoret D., Heirman C., et al. Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma. J Immunol 2008, 181:7230-7242.
38. Wang L. Adaptive Treg generation by DCs and their functional analysis. Methods Mol Biol 2010, 595:403-412.
39. Steinbrink K., Wolfl M., Jonuleit H., Knop J., Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997, 159:4772-4780.
40. Levings M.K., Gregori S., Tresoldi E., Cazzaniga S., Bonini C., Roncarolo M.G. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+ CD4+ Tr cells. Blood 2005, 105:1162-1169.
41. You S., Leforban B., Garcia C., Bach J.F., Bluestone J.A., Chatenoud L. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci USA 2007, 104:6335-6340.
42. Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003, 3:253-257.
43. Zheng S.G., Wang J.H., Gray J.D., Soucier H., Horwitz D.A. Natural and induced CD4+ CD25+ cells educate CD4+ CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 2004, 172:5213-5221.
44. Ito T., Yang M., Wang Y.H., Lande R., Gregorio J., Perng O.A., et al. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 2007, 204:105-115.
45. Bae E.M., Kim W.J., Suk K., Kang Y.M., Park J.E., Kim W.Y., et al. Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages. Mol Immunol 2008, 45:523-533.
46. Grohmann U., Volpi C., Fallarino F., Bozza S., Bianchi R., Vacca C., et al. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med 2007, 13:579-586.
47. Vecchiarelli A., Pericolini E., Gabrielli E., Agostini M., Bistoni F., Nocentini G., et al. The GITRL-GITR system alters TLR-4 expression on DC during fungal infection. Cell Immunol 2009, 257:13-22.
48. Kim J.D., Choi B.K., Bae J.S., Lee U.H., Han I.S., Lee H.W., et al. Cloning and characterization of GITR ligand. Genes Immun 2003, 4:564-569.
49. Igarashi H., Cao Y., Iwai H., Piao J., Kamimura Y., Hashiguchi M., et al. GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells. Biochem Biophys Res Commun 2008, 369:1134-1138.
50. Yu K.Y., Kim H.S., Song S.Y., Min S.S., Jeong J.J., Youn B.S. Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. Biochem Biophys Res Commun 2003, 310:433-438.
51. Kaminura Y., Iwai H., Piao J., Hashiguchi M., Azuma M. The Glucocorticoid-Induced TNF Receptor-related Protein (GITR)-GITR Ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity. J Immunol 2009, 182:2708-2716.
52. Kanamaru F., Youngnak P., Hashiguchi M., Nishioka T., Takahashi T., Sakaguchi S., et al. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 2004, 172:7306-7314.
53. Kim J., Choi W.S., Kang H., Kim H.J., Suh J.H., Sakaguchi S., et al. Conversion of alloantigen-specific CD8+ T cell anergy to CD8+ T cell priming through in vivo ligation of glucocorticoid-induced TNF receptor. J Immunol 2006, 176:5223-5231.
54. Kim H.J., Kim H.Y., Kim B.K., Kim S., Chung D.H. Engagement of glucocorticoid-induced TNF receptor costimulates NKT cell activation in vitro and in vivo. J Immunol 2006, 176:3507-3515.