2-D structure of the a region of Xist RNA and its implication for PRC2 association

PLoS Biology

Volumn 8, Issue 1, 2010, Pages

  Maenner, Sylvain ^a   Blaud, Magali ^a   Fouillen, Laetitia ^b   Savoye, Anne ^a   Marchand, Virginie ^a,d   Dubois, Agnès ^c   Sanglier Cianférani, Sarah ^b   Van Dorsselaer, Alain ^b   Clerc, Philippe ^c   Avner, Philip ^c   Visvikis, Athanase ^a   Branlant, Christiane ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b INSTITUT DE RECHERCHES SUBATOMIQUES   (France)

^c INSTITUT PASTEUR   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE; POLYCOMB GROUP PROTEIN; POLYCOMB GROUP PROTEIN 2; RNA; UNCLASSIFIED DRUG; REPRESSOR PROTEIN; UNTRANSLATED RNA; X (INACTIVE) SPECIFIC TRANSCRIPT (XIST); X (INACTIVE)-SPECIFIC TRANSCRIPT (XIST);

ANIMAL CELL; ARTICLE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; IMMUNOPRECIPITATION; MASS SPECTROMETER; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RNA STRUCTURE; TERMINAL SEQUENCE; WESTERN BLOTTING; X CHROMOSOME; ANIMAL; CONFORMATION; FEMALE; GENETICS; HELA CELL; HUMAN; INTERSPERSED REPEAT; PHYLOGENY; X CHROMOSOME INACTIVATION;

EUTHERIA;

ANIMALS; CHROMOSOMES, HUMAN, X; FEMALE; HELA CELLS; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; MICE; NUCLEIC ACID CONFORMATION; PHYLOGENY; REPRESSOR PROTEINS; RNA, UNTRANSLATED; X CHROMOSOME; X CHROMOSOME INACTIVATION;

EID: 75749124997     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000276     Document Type: Article

References (34)

1. Lyon MF (1961) Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190: 372-373.
2. Brockdorff N, Ashworth A, Kay GF, McCabe VM, Norris DP, et al. (1992) The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71: 515-526.
3. Borsani G, Tonlorenzi R, Simmler MC, Dandolo L, Arnaud D, et al. (1991) Characterization of a murine gene expressed from the inactive X chromosome. Nature 351: 325-329.
4. Cohen HR, Panning B (2007) XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1. Chromosoma 116: 373-383.
5. Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, et al. (1992) The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71: 527-542.
6. Duret L, Chureau C, Samain S, Weissenbach J, Avner P (2006) The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science 312: 1653-1655.
7. Shevchenko AI, Zakharova IS, Elisaphenko EA, Kolesnikov NN, Whitehead S, et al. (2007) Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials. Chromosome Res 15: 127-136.
8. Brockdorff N (2002) X-chromosome inactivation: closing in on proteins that bind Xist RNA. Trends Genet 18: 352-358.
9. Hoki Y, Kimura N, Kanbayashi M, Amakawa Y, Ohhata T, et al. (2009) A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development 136: 139-146.
10. Chaumeil J, Le Baccon P, Wutz A, Heard E (2006) A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev 20: 2223-2237.
11. Wutz A, Rasmussen TP, Jaenisch R (2002) Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet 30: 167-174.
12. Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, et al. (2003) Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell 4: 481-495.
13. Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, et al. (2004) Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol 167: 1025-1035.
14. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, et al. (2003) Role of histone H3 lysine 27 methylation in X inactivation. Science 300: 131-135.
15. Mak W, Baxter J, Silva J, Newall AE, Otte AP, et al. (2002) Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Curr Biol 12: 1016-1020.
16. Kohlmaier A, Savarese F, Lachner M, Martens J, Jenuwein T, et al. (2004) A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol 2: E171. doi:10.1371/journal.pbio.0020171.
17. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, et al. (2002) Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298: 1039-1043.
18. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16: 2893-2905.
19. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, et al. (2007) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129: 1311-1323.
20. Cao R, Zhang Y (2004) The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 14: 155-164.
21. Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT (2008) Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322: 750-756.
22. Duszczyk MM, Zanier K, Sattler M (2008) A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat. Nucleic Acids Res 36: 7068-7077.
23. Kalantry S, Mills KC, Yee D, Otte AP, Panning B, et al. (2006) The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol 8: 195-202.
24. Gavory G, Symmons MF, Krishnan Ghosh Y, Klenerman D, Balasubramanian S (2006) Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling. Biochemistry 45: 13304-13311.
25. Perez I, McAfee JG, Patton JG (1997) Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein. Biochemistry 36: 11881-11890.
26. Auweter SD, Allain FH (2008) Structure-function relationships of the polypyrimidine tract binding protein. Cell Mol Life Sci 65: 516-527.
27. Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, et al. (2006) Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol 26: 5528-5543.
28. Pandey RR, Mondal T, Mohammad F, Enroth S, Redrup L, et al. (2008) Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell 32: 232-246.
29. Mougin A, Gregoire A, Banroques J, Segault V, Fournier R, et al. (1996) Secondary structure of the yeast Saccharomyces cerevisiae pre-U3A snoRNA and its implication for splicing efficiency. Rna 2: 1079-1093.
30. Jaeger JA, Turner DH, Zuker M (1989) Improved predictions of secondary structures for RNA. Proc Natl Acad Sci U S A 86: 7706-7710.
31. Zhou Z, Sim J, Griffith J, Reed R (2002) Purification and electron microscopic visualization of functional human spliceosomes. Proc Natl Acad Sci U S A 99: 12203-12207.
32. Dignam JD, Martin PL, Shastry BS, Roeder RG (1983) Eukaryotic gene transcription with purified components. Methods Enzymol 101: 582-598.
33. Jacquenet S, Mereau A, Bilodeau PS, Damier L, Stoltzfus CM, et al. (2001) A second exon splicing silencer within human immunodeficiency virus type 1 tat exon 2 represses splicing of Tat mRNA and binds protein hnRNP H. J Biol Chem 276: 40464-40475.
34. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual. New York: Cold Spring Harbor Laboratory Press.