Coronary vasoconstrictor effect of ghrelin is not mediated by growth hormone secretagogue receptor 1a type in dogs

Peptides

Volumn 32, Issue 2, 2011, Pages 362-367

  Sax, Balazs ^a   Nadasy, Gyorgy L ^a   Turi, Katalin ^a   Hirschberg, Kristof ^a,b   Furjesz, Dora ^a   Nagy, Andrea ^a   Merkely, Bela ^a   Szabo, Gabor ^b   Monos, Emil ^a   Kekesi, Violetta ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Canine; Coronary arterioles; Ghrelin; Growth hormone secretagogue receptor; Vasoconstriction

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; GHRELIN; GHRELIN RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1B; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DOG; DRUG EFFECT; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICROANGIOGRAPHY; NONHUMAN; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; WESTERN BLOTTING;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLCHOLINE; ANIMALS; ARTERIOLES; CORONARY VESSELS; DOGS; GHRELIN; HEART VENTRICLES; MYOCARDIUM; OLIGOPEPTIDES; PERICARDIUM; RECEPTORS, GHRELIN; VASOCONSTRICTION; VASODILATION;

CANIS FAMILIARIS;

EID: 78751647008     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.11.020     Document Type: Article

References (38)

1. G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, and A. Fubini Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT J Cell Biol 159 2002 1029 1037
2. I. Bedendi, G. Alloatti, A. Marcantoni, D. Malan, F. Catapano, and C. Ghe Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin Eur J Pharmacol 476 2003 87 95
3. V. Bodart, M. Febbraio, A. Demers, N. McNicoll, P. Pohankova, and A. Perreault CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart Circ Res 90 2002 844 849
4. L. Chang, Y. Ren, X. Liu, W.G. Li, J. Yang, and B. Geng Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart J Cardiovasc Pharm 43 2004 165 170
5. K.B. Chow, P.K. Leung, C.H. Cheng, W.T. Cheung, and H. Wise The constitutive activity of ghrelin receptors is decreased by co-expression with vasoactive prostanoid receptors when over-expressed in human embryonic kidney 293 cells Int J Biochem Cell Biol 40 2008 2627 2637
6. 3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors Eur J Pharmacol 537 2006 160 165
7. C. De Vriese, and C. Delporte Autocrine proliferative effect of ghrelin on leukemic HL-60 and THP-1 cells J Endocrinol 192 2007 199 205
8. D.Z. Dimitrova Contractile effect of ghrelin on isolated human mesenteric arteries CR Acad Bulg Sci 59 2006 853 858
9. D.Z. Dimitrova, D.N. Mihov, R. Wang, K.L. Hristov, L.I. Rizov, and T.B. Bolton Contractile effect of ghrelin on isolated guinea-pig renal arteries Vasc Pharmacol 47 2007 31 40
10. S. Frascarelli, S. Ghelardoni, S. Ronca-Testoni, and R. Zucchi Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart Basic Res Cardiol 98 2003 401 405
11. S. Gnanapavan, B. Kola, S.A. Bustin, D.G. Morris, P. McGee, and P. Fairclough The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans J Clin Endocrinol Metab 87 2002 2988
12. E. Grossini, C. Molinari, D.A.S.G. Mary, E. Ghigo, G. Bona, and G. Vacca Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs Endocrinology 148 2007 806 812
13. N. Hedayati, S. Annambhotla, J. Jiang, X. Wang, H. Chai, and P.H. Lin Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells J Vasc Surg 49 2009 199 207
14. C.X. Huang, M.J. Yuan, H. Huang, G. Wu, Y. Liu, and S.B. Yu Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect Peptides 30 2009 2286 2291
15. M. Iantorno, H. Chen, J.A. Kim, M. Tesauro, D. Lauro, and C. Cardillo Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells Am J Physiol Endocrinol Metab 292 2007 E756 E764
16. M.J. Iglesias, R. Pineiro, M. Blanco, R. Gallego, C. Dieguez, and O. Gualillo Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481 488
17. T. Kitazawa, H. Kaiya, and T. Taneike Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro Peptides 28 2007 617 624
18. M.J. Kleinz, J.J. Maguire, J.N. Skepper, and A.P. Davenport Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man Cardiovasc Res 69 2006 227 235
19. A.F. Leite-Moreira, A. Rocha-Sousa, and T. Henriques-Coelho Cardiac, skeletal, and smooth muscle regulation by ghrelin Vitam Horm 77 2008 207 238
20. Y. Lin, K. Matsumura, M. Fukuhara, S. Kagiyama, K. Fujii, and M. Iida Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats Hypertension 43 2004 977 982
21. K. Matsumura, T. Tsuchihashi, K. Fujii, I. Abe, and M. Iida Central ghrelin modulates sympathetic activity in conscious rabbits Hypertension 40 2002 694 699
22. M.I. Mladenov, K.L. Hristov, D.Z. Dimitriova, R. Schubert, L.T. Lubomirov, and I.K. Gjorgoski Ghrelin signalling in guinea-pig femoral artery smooth muscle cells Acta Physiol 194 2008 195 206
23. B. Moazed, D. Quest, and V. Gopalakrishnan Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels Eur J Pharmacol 604 2009 79 86
24. G. Muccioli, A. Baragli, R. Granata, M. Papotti, and E. Ghigo Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors Neuroendocrinology 86 2007 147 164
25. G. Muccioli, N. Pons, C. Ghe, F. Catapano, R. Granata, and E. Ghigo Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor Eur J Pharmacol 498 2004 27 35
26. G.L. Nadasy, M. Szekeres, L. Dezsi, S. Varbiro, B. Szekacs, and E. Monos Preparation of intramural small coronary artery and arteriole segments and resistance artery networks from the rat heart for microarteriography and for in situ perfusion video mapping Microvasc Res 61 2001 282 286
27. N. Nagaya, M. Kojima, M. Uematsu, M. Yamagishi, H. Hosoda, and H. Oya Hemodynamic and hormonal effects of human ghrelin in healthy volunteers Am J Physiol Regul Integr Comp Physiol 280 2001 1483 1487
28. N. Nagaya, K. Miyatake, M. Uematsu, H. Oya, W. Shimizu, and H. Hosoda Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure J Clin Endocrinol Metab 86 2001 5854 5859
29. N. Nagaya, J. Moriya, Y. Yasumura, M. Uematsu, F. Ono, and W. Shimizu Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674 3679
30. N. Nagaya, M. Uematsu, M. Kojima, Y. Ikeda, F. Yoshihara, and W. Shimizu Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
31. H. Okumura, N. Nagaya, M. Enomoto, E. Nakagawa, H. Oya, and K. Kangawa Vasodilatory effect of ghrelin, an endogenous peptide from the stomach J Cardiovasc Pharm 39 2002 779 783
32. C.J. Pemberton, H. Tokola, Z. Bagi, A. Koller, J. Pontinen, and A. Ola Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion Am J Physiol Heart Circ Physiol 287 2004 1522 1529
33. H. Schellekens, T.G. Dinan, and J.F. Cryan Lean mean fat reducing "ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity Neuropharmacology 58 2010 2 16
34. U.A. Shinde, K.M. Desai, C. Yu, and V. Gopalakrishnan Nitric oxide synthase inhibition exaggerates the hypotensive response to ghrelin: role of calcium-activated potassium channels J Hypertens 23 2005 779 784
35. J.B. Soares, A. Rocha-Sousa, P. Castro-Chaves, T. Henriques-Coelho, and A.F. Leite-Moreira Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels Peptides 27 2006 1616 1623
36. T. Soeki, I. Kishimoto, D.O. Schwenke, T. Tokudome, T. Horio, and M. Yoshida Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction Am J Physiol Heart Circ Physiol 294 2008 426 432
37. M.A. Vlasova, K. Jarvinen, and K.H. Herzig Cardiovascular effects of ghrelin antagonist in conscious rats Regul Pept 156 2009 72 76
38. K.E. Wiley, and A.P. Davenport Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1 Br J Pharmacol 136 2002 1146 1152