메뉴 건너뛰기




Volumn 30, Issue 12, 2009, Pages 2286-2291

Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect

Author keywords

Ghrelin; Matrix metalloproteinase; Myocardial infarction; Pro inflammatory cytokines

Indexed keywords

GELATINASE A; GELATINASE B; GHRELIN; INTERLEUKIN 1BETA; MESSENGER RNA; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 70449656984     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.09.004     Document Type: Article
Times cited : (96)

References (36)
  • 1
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • Baldanzi G., Filigheddu N., Cutrupi S., Catapano F., Bonissoni S., Fubini A., et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. Journal of Cell Biology 159 (2002) 1029-1037
    • (2002) Journal of Cell Biology , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3    Catapano, F.4    Bonissoni, S.5    Fubini, A.6
  • 2
    • 31344466167 scopus 로고    scopus 로고
    • Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation
    • Deschamps A.M., and Spinale F.G. Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation. Cardiovascular Research 69 (2006) 666-676
    • (2006) Cardiovascular Research , vol.69 , pp. 666-676
    • Deschamps, A.M.1    Spinale, F.G.2
  • 3
    • 0036063690 scopus 로고    scopus 로고
    • Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats
    • Deten A., Volz H.C., Briest W., and Zimmer H.G. Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Cardiovascular Research 55 (2002) 329-340
    • (2002) Cardiovascular Research , vol.55 , pp. 329-340
    • Deten, A.1    Volz, H.C.2    Briest, W.3    Zimmer, H.G.4
  • 4
    • 1642576138 scopus 로고    scopus 로고
    • Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes
    • Diwan A., Dibbs Z., Nemoto S., DeFreitas G., Carabello B.A., Sivasubramanian N., et al. Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. Circulation 109 (2004) 262-268
    • (2004) Circulation , vol.109 , pp. 262-268
    • Diwan, A.1    Dibbs, Z.2    Nemoto, S.3    DeFreitas, G.4    Carabello, B.A.5    Sivasubramanian, N.6
  • 6
    • 0033932709 scopus 로고    scopus 로고
    • Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    • Ducharme A., Frantz S., Aikawa M., Rabkin E., Lindsey M., Rohde L.E., et al. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. Journal of Clinical Investigation 106 (2000) 55-62
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 55-62
    • Ducharme, A.1    Frantz, S.2    Aikawa, M.3    Rabkin, E.4    Lindsey, M.5    Rohde, L.E.6
  • 7
    • 14944362972 scopus 로고    scopus 로고
    • Healing after myocardial infraction
    • Ertl G., and Frantz S. Healing after myocardial infraction. Cardiovascular Research 66 (2005) 22-32
    • (2005) Cardiovascular Research , vol.66 , pp. 22-32
    • Ertl, G.1    Frantz, S.2
  • 11
    • 20344368295 scopus 로고    scopus 로고
    • Inflammation, as measured by the erythrocyte sedimentation rate, is an independent predictor for the development of heart failure
    • Ingelsson E., Arnlov J., Sundstrom J., and Lind L. Inflammation, as measured by the erythrocyte sedimentation rate, is an independent predictor for the development of heart failure. Journal of the American College of Cardiology 45 (2005) 1802-1806
    • (2005) Journal of the American College of Cardiology , vol.45 , pp. 1802-1806
    • Ingelsson, E.1    Arnlov, J.2    Sundstrom, J.3    Lind, L.4
  • 13
    • 19444361810 scopus 로고    scopus 로고
    • Blockade of NF-kappa B improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy
    • Kawamura N., Kubota T., Kawano S., Monden Y., Feldman A.M., Tsutsui H., et al. Blockade of NF-kappa B improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy. Cardiovascular Research 66 (2005) 520-529
    • (2005) Cardiovascular Research , vol.66 , pp. 520-529
    • Kawamura, N.1    Kubota, T.2    Kawano, S.3    Monden, Y.4    Feldman, A.M.5    Tsutsui, H.6
  • 15
    • 33947316374 scopus 로고    scopus 로고
    • Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study
    • Kelly D., Cockerill G., Ng L.L., Thompson M., Khan S., Samani N.J., et al. Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study. European Heart Journal 28 (2007) 711-718
    • (2007) European Heart Journal , vol.28 , pp. 711-718
    • Kelly, D.1    Cockerill, G.2    Ng, L.L.3    Thompson, M.4    Khan, S.5    Samani, N.J.6
  • 16
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 17
    • 2442419837 scopus 로고    scopus 로고
    • Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells
    • Li W.G., Gavrila D., Liu X.B., Wang L.X., Gunnlaugsson S., Stoll L.L., et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells. Circulation 109 (2004) 2221-2226
    • (2004) Circulation , vol.109 , pp. 2221-2226
    • Li, W.G.1    Gavrila, D.2    Liu, X.B.3    Wang, L.X.4    Gunnlaugsson, S.5    Stoll, L.L.6
  • 18
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method
    • Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 25 (2001) 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 19
    • 33847042684 scopus 로고    scopus 로고
    • Interleukin-1 beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKC alpha/beta(1) and MAPKs
    • Mountain D.J.H., Singh M., Menon B., and Singh K. Interleukin-1 beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKC alpha/beta(1) and MAPKs. American Journal of Physiology-Cell Physiology 292 (2007) C867-C875
    • (2007) American Journal of Physiology-Cell Physiology , vol.292
    • Mountain, D.J.H.1    Singh, M.2    Menon, B.3    Singh, K.4
  • 21
    • 33645725048 scopus 로고    scopus 로고
    • Therapeutic potential of ghrelin in the treatment of heart failure
    • Nagaya N., and Kangawa K. Therapeutic potential of ghrelin in the treatment of heart failure. Drugs 66 (2006) 439-448
    • (2006) Drugs , vol.66 , pp. 439-448
    • Nagaya, N.1    Kangawa, K.2
  • 22
    • 20844460120 scopus 로고    scopus 로고
    • Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    • Nagaya N., Moriya J., Yasumura Y., Uematsu M., Ono F., Shimizu W., et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 110 (2004) 3674-3679
    • (2004) Circulation , vol.110 , pp. 3674-3679
    • Nagaya, N.1    Moriya, J.2    Yasumura, Y.3    Uematsu, M.4    Ono, F.5    Shimizu, W.6
  • 23
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104 (2001) 1430-1435
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Ikeda, Y.4    Yoshihara, F.5    Shimizu, W.6
  • 24
    • 3042702881 scopus 로고    scopus 로고
    • Inflammatory cytokines and postmyocardial infarction remodeling
    • Nian M., Lee P., Khaper N., and Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circulation Research 94 (2004) 1543-1553
    • (2004) Circulation Research , vol.94 , pp. 1543-1553
    • Nian, M.1    Lee, P.2    Khaper, N.3    Liu, P.4
  • 25
    • 36649006686 scopus 로고    scopus 로고
    • Plasma MMP-2, MMP-9 and N-BNP in long-term survivors following complicated myocardial infarction: Relation to cardiac magnetic resonance imaging measures of left ventricular structure and function
    • Orn S., Manhenke C., Squire I.B., Ng L., Anand I., and Dickstein K. Plasma MMP-2, MMP-9 and N-BNP in long-term survivors following complicated myocardial infarction: Relation to cardiac magnetic resonance imaging measures of left ventricular structure and function. Journal of Cardiac Failure 13 (2007) 843-849
    • (2007) Journal of Cardiac Failure , vol.13 , pp. 843-849
    • Orn, S.1    Manhenke, C.2    Squire, I.B.3    Ng, L.4    Anand, I.5    Dickstein, K.6
  • 27
    • 2442457887 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats its inhibition as a primary effect of angiotensin-converting enzyme inhibitor
    • Sakata Y., Yamamoto K., Mano T., Nishikawa N., Yoshida J., Hori M., et al. Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats its inhibition as a primary effect of angiotensin-converting enzyme inhibitor. Circulation 109 (2004) 2143-2149
    • (2004) Circulation , vol.109 , pp. 2143-2149
    • Sakata, Y.1    Yamamoto, K.2    Mano, T.3    Nishikawa, N.4    Yoshida, J.5    Hori, M.6
  • 28
    • 1042303637 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium
    • Siwik D.A., and Colucci W.S. Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium. Heart Failure Reviews 9 (2004) 43-51
    • (2004) Heart Failure Reviews , vol.9 , pp. 43-51
    • Siwik, D.A.1    Colucci, W.S.2
  • 30
    • 8744267399 scopus 로고    scopus 로고
    • Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction
    • Sun M., Dawood F., Wen W.H., Chen M.Y., Dixon I., Kirshenbaum L.A., et al. Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction. Circulation 110 (2004) 3221-3228
    • (2004) Circulation , vol.110 , pp. 3221-3228
    • Sun, M.1    Dawood, F.2    Wen, W.H.3    Chen, M.Y.4    Dixon, I.5    Kirshenbaum, L.A.6
  • 31
    • 0346022982 scopus 로고    scopus 로고
    • Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice
    • Tao Z.Y., Cavasin M.A., Yang F., Liu Y.H., and Yang X.P. Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice. Life Sciences 74 (2004) 1561-1572
    • (2004) Life Sciences , vol.74 , pp. 1561-1572
    • Tao, Z.Y.1    Cavasin, M.A.2    Yang, F.3    Liu, Y.H.4    Yang, X.P.5
  • 32
    • 63649110166 scopus 로고    scopus 로고
    • Targeted deletion of nuclear factor kappa B p50 enhances cardiac remodeling and dysfunction following myocardial infarction
    • Timmers L., van Keulen J.K., Hoefer I.E., Meijs M.F.L., van Middelaar B., den Ouden K., et al. Targeted deletion of nuclear factor kappa B p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circulation Research 104 (2009) 699-706
    • (2009) Circulation Research , vol.104 , pp. 699-706
    • Timmers, L.1    van Keulen, J.K.2    Hoefer, I.E.3    Meijs, M.F.L.4    van Middelaar, B.5    den Ouden, K.6
  • 33
    • 0038796894 scopus 로고    scopus 로고
    • Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling
    • Wilson E.M., Moainie S.L., Baskin J.M., Lowry A.S., Deschamps A.M., Mukherjee R., et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation 107 (2003) 2857-2863
    • (2003) Circulation , vol.107 , pp. 2857-2863
    • Wilson, E.M.1    Moainie, S.L.2    Baskin, J.M.3    Lowry, A.S.4    Deschamps, A.M.5    Mukherjee, R.6
  • 34
    • 4544281016 scopus 로고    scopus 로고
    • Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1 beta
    • Xie Z.L., Singh M., and Singh K. Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1 beta. Journal of Biological Chemistry 279 (2004) 39513-39519
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 39513-39519
    • Xie, Z.L.1    Singh, M.2    Singh, K.3
  • 35
    • 25444519434 scopus 로고    scopus 로고
    • GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure
    • Xu X.B., Pang J.J., Cao J.M., Ni C., Xu R.K., Peng X.Z., et al. GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure. American Journal of Physiology-Heart and Circulatory Physiology 289 (2005) H1643-H1651
    • (2005) American Journal of Physiology-Heart and Circulatory Physiology , vol.289
    • Xu, X.B.1    Pang, J.J.2    Cao, J.M.3    Ni, C.4    Xu, R.K.5    Peng, X.Z.6
  • 36
    • 0032941861 scopus 로고    scopus 로고
    • Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography
    • Yoshiyama M., Takeuchi K., Omura T., Kim S., Yamagishi H., Toda I., et al. Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography. Hypertension 33 (1999) 961-968
    • (1999) Hypertension , vol.33 , pp. 961-968
    • Yoshiyama, M.1    Takeuchi, K.2    Omura, T.3    Kim, S.4    Yamagishi, H.5    Toda, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.