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Volumn 40, Issue 11, 2008, Pages 2627-2637

The constitutive activity of ghrelin receptors is decreased by co-expression with vasoactive prostanoid receptors when over-expressed in human embryonic kidney 293 cells

Author keywords

Ghrelin receptors; Hetero oligomerization; Prostacyclin receptors; Prostaglandin E2 receptors; Thromboxane A2 receptors

Indexed keywords

GROWTH HORMONE SECRETAGOGUE RECEPTOR; PHOSPHOLIPASE C; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR SUBTYPE EP3 I; PROSTANOID RECEPTOR; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG;

EID: 48349110896     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.05.008     Document Type: Article
Times cited : (18)

References (56)
  • 2
    • 0036174608 scopus 로고    scopus 로고
    • Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function
    • Angers S., Salahpour A., and Bouvier M. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annual Reviews of Pharmacology and Toxicology 42 (2002) 409-435
    • (2002) Annual Reviews of Pharmacology and Toxicology , vol.42 , pp. 409-435
    • Angers, S.1    Salahpour, A.2    Bouvier, M.3
  • 4
    • 29144446196 scopus 로고    scopus 로고
    • Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library
    • Bikkavilli R.K., Tsang S.Y., Tang W.M., Sun J.X., Ngai S.M., Lee S.S.T., et al. Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library. Biochemical Pharmacology 71 (2006) 319-337
    • (2006) Biochemical Pharmacology , vol.71 , pp. 319-337
    • Bikkavilli, R.K.1    Tsang, S.Y.2    Tang, W.M.3    Sun, J.X.4    Ngai, S.M.5    Lee, S.S.T.6
  • 5
    • 4143144369 scopus 로고    scopus 로고
    • Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns
    • Bilson H.A., Mitchell D.L., and Ashby B. Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns. FEBS Letters 572 (2004) 271-275
    • (2004) FEBS Letters , vol.572 , pp. 271-275
    • Bilson, H.A.1    Mitchell, D.L.2    Ashby, B.3
  • 6
    • 29744441392 scopus 로고    scopus 로고
    • Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system
    • Cao J.M., Ong H., and Chen C. Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system. Trends in Endocrinology and Metabolism 17 (2006) 13-18
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , pp. 13-18
    • Cao, J.M.1    Ong, H.2    Chen, C.3
  • 7
    • 0035213705 scopus 로고    scopus 로고
    • Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
    • Chow K.B.S., Wong Y.H., and Wise H. Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics. British Journal of Pharmacology 134 (2001) 1375-1384
    • (2001) British Journal of Pharmacology , vol.134 , pp. 1375-1384
    • Chow, K.B.S.1    Wong, Y.H.2    Wise, H.3
  • 8
    • 33847716287 scopus 로고    scopus 로고
    • Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity
    • Chu K.M., Chow K.B.S., Leung P.K., Lau P.N., Chan C.B., Cheng C.H.K., et al. Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity. International Journal of Biochemistry and Cell Biology 39 (2007) 752-764
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , pp. 752-764
    • Chu, K.M.1    Chow, K.B.S.2    Leung, P.K.3    Lau, P.N.4    Chan, C.B.5    Cheng, C.H.K.6
  • 11
    • 0037105663 scopus 로고    scopus 로고
    • Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma
    • Ding W.Q., Cheng Z.J., McElhiney J., Kuntz S.M., and Miller L.J. Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma. Cancer Research 62 (2002) 5223-5229
    • (2002) Cancer Research , vol.62 , pp. 5223-5229
    • Ding, W.Q.1    Cheng, Z.J.2    McElhiney, J.3    Kuntz, S.M.4    Miller, L.J.5
  • 13
    • 0034233796 scopus 로고    scopus 로고
    • The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization
    • Elmhurst J.L., Xie Z., O'Dowd B.F., and George S.R. The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization. Molecular Brain Research 80 (2000) 63-74
    • (2000) Molecular Brain Research , vol.80 , pp. 63-74
    • Elmhurst, J.L.1    Xie, Z.2    O'Dowd, B.F.3    George, S.R.4
  • 14
    • 18744376919 scopus 로고    scopus 로고
    • Real-time monitoring of receptor and G-protein interactions in living cells
    • Galés C., Rebois R.V., Hogue M., Trieu P., Breit A., Hébert T.E., et al. Real-time monitoring of receptor and G-protein interactions in living cells. Nature Methods 2 (2005) 177-184
    • (2005) Nature Methods , vol.2 , pp. 177-184
    • Galés, C.1    Rebois, R.V.2    Hogue, M.3    Trieu, P.4    Breit, A.5    Hébert, T.E.6
  • 15
    • 33744505211 scopus 로고    scopus 로고
    • Overexpression of COX-2, prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-κB
    • Gómez-Hernández A., Martín-Ventura J.L., Sánchez-Galán E., Vidal C., Ortego M., Blanco-Colio L.M., et al. Overexpression of COX-2, prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-κB. Atherosclerosis 187 (2006) 139-149
    • (2006) Atherosclerosis , vol.187 , pp. 139-149
    • Gómez-Hernández, A.1    Martín-Ventura, J.L.2    Sánchez-Galán, E.3    Vidal, C.4    Ortego, M.5    Blanco-Colio, L.M.6
  • 16
    • 0031446639 scopus 로고    scopus 로고
    • Inhibition of gonandotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor
    • Grosse R., Schöneberg T., Schultz G., and Gudermann T. Inhibition of gonandotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Molecular Endocrinology 11 (1997) 1305-1318
    • (1997) Molecular Endocrinology , vol.11 , pp. 1305-1318
    • Grosse, R.1    Schöneberg, T.2    Schultz, G.3    Gudermann, T.4
  • 18
    • 33646857233 scopus 로고    scopus 로고
    • Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques
    • Hébert T.E., Galés C., and Rebois R.V. Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques. Cell Biochemistry and Biophysics 45 (2006) 85-109
    • (2006) Cell Biochemistry and Biophysics , vol.45 , pp. 85-109
    • Hébert, T.E.1    Galés, C.2    Rebois, R.V.3
  • 22
    • 36849039489 scopus 로고    scopus 로고
    • Importance of constitutive activity and arrestin independent mechanisms for intracellular trafficking of the ghrelin receptor
    • Holliday N.D., Holst B., Rodionova E.A., Schwartz T.W., and Cox H.M. Importance of constitutive activity and arrestin independent mechanisms for intracellular trafficking of the ghrelin receptor. Molecular Endocrinology 21 (2007) 3100-3112
    • (2007) Molecular Endocrinology , vol.21 , pp. 3100-3112
    • Holliday, N.D.1    Holst, B.2    Rodionova, E.A.3    Schwartz, T.W.4    Cox, H.M.5
  • 23
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
    • Holst B., Cygankiewicz A., Jensen T.H., Ankersen M., and Schwartz T.W. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Molecular Endocrinology 17 (2003) 2201-2210
    • (2003) Molecular Endocrinology , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 25
    • 1342264249 scopus 로고    scopus 로고
    • Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
    • Holst B., and Schwartz T.W. Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends in Pharmacological Sciences 25 (2004) 113-117
    • (2004) Trends in Pharmacological Sciences , vol.25 , pp. 113-117
    • Holst, B.1    Schwartz, T.W.2
  • 26
    • 0033798153 scopus 로고    scopus 로고
    • The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors
    • Karpa K.D., Lin R., Kabbani N., and Levenson R. The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Molecular Pharmacology 58 (2000) 677-683
    • (2000) Molecular Pharmacology , vol.58 , pp. 677-683
    • Karpa, K.D.1    Lin, R.2    Kabbani, N.3    Levenson, R.4
  • 28
    • 85047683217 scopus 로고    scopus 로고
    • 2 signalling in humans: a 'tail' of two receptors
    • 2 signalling in humans: a 'tail' of two receptors. Biochemical Society Transactions 29 (2001) 641-654
    • (2001) Biochemical Society Transactions , vol.29 , pp. 641-654
    • Kinsella, B.T.1
  • 29
    • 29144466031 scopus 로고    scopus 로고
    • Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
    • Kleinz M.J., Maguire J.J., Skepper J.N., and Davenport A.P. Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovascular Research 69 (2006) 227-235
    • (2006) Cardiovascular Research , vol.69 , pp. 227-235
    • Kleinz, M.J.1    Maguire, J.J.2    Skepper, J.N.3    Davenport, A.P.4
  • 30
    • 33947301456 scopus 로고    scopus 로고
    • The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor
    • Leung P.K., Chow K.B.S., Lau P.N., Chu K.M., Chan C.B., Cheng C.H.K., et al. The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cellular Signalling 19 (2007) 1011-1022
    • (2007) Cellular Signalling , vol.19 , pp. 1011-1022
    • Leung, P.K.1    Chow, K.B.S.2    Lau, P.N.3    Chu, K.M.4    Chan, C.B.5    Cheng, C.H.K.6
  • 31
    • 21344459008 scopus 로고    scopus 로고
    • The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology
    • Maggio R., Novi F., Scarselli M., and Corsini G.U. The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology. FEBS Journal 272 (2005) 2939-2946
    • (2005) FEBS Journal , vol.272 , pp. 2939-2946
    • Maggio, R.1    Novi, F.2    Scarselli, M.3    Corsini, G.U.4
  • 32
    • 23944450417 scopus 로고    scopus 로고
    • Regulation of vascular reactivity by established and emerging GPCRs
    • Maguire J.J., and Davenport A.P. Regulation of vascular reactivity by established and emerging GPCRs. Trends in Pharmacological Sciences 26 (2005) 448-454
    • (2005) Trends in Pharmacological Sciences , vol.26 , pp. 448-454
    • Maguire, J.J.1    Davenport, A.P.2
  • 36
    • 3042663287 scopus 로고    scopus 로고
    • G protein-coupled receptor dimerization: function and ligand pharmacology
    • Milligan G. G protein-coupled receptor dimerization: function and ligand pharmacology. Molecular Pharmacology 66 (2004) 1-7
    • (2004) Molecular Pharmacology , vol.66 , pp. 1-7
    • Milligan, G.1
  • 37
  • 39
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: structure, properties, and functions
    • Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structure, properties, and functions. Physiological Reviews 79 (1999) 1193-1226
    • (1999) Physiological Reviews , vol.79 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 43
    • 0031720169 scopus 로고    scopus 로고
    • Distribution of prostaglandin IP and EP receptor subtypes and isoforms in platelets and human umbilical artery smooth muscle cells
    • Paul B.Z.S., Ashby B., and Sheth S.B. Distribution of prostaglandin IP and EP receptor subtypes and isoforms in platelets and human umbilical artery smooth muscle cells. British Journal of Haematology 102 (1998) 1204-1211
    • (1998) British Journal of Haematology , vol.102 , pp. 1204-1211
    • Paul, B.Z.S.1    Ashby, B.2    Sheth, S.B.3
  • 44
    • 0037101774 scopus 로고    scopus 로고
    • Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
    • Ramsay D., Kellett E., McVey M., Rees S., and Milligan G. Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochemical Journal 365 (2002) 429-440
    • (2002) Biochemical Journal , vol.365 , pp. 429-440
    • Ramsay, D.1    Kellett, E.2    McVey, M.3    Rees, S.4    Milligan, G.5
  • 45
    • 33746871075 scopus 로고    scopus 로고
    • Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells
    • Rebois R.V., Robitaille M., Galés C., Dupré D.J., Baragli A., Trieu P., et al. Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. Journal of Cell Science 119 (2006) 2807-2818
    • (2006) Journal of Cell Science , vol.119 , pp. 2807-2818
    • Rebois, R.V.1    Robitaille, M.2    Galés, C.3    Dupré, D.J.4    Baragli, A.5    Trieu, P.6
  • 46
  • 49
    • 39149099430 scopus 로고    scopus 로고
    • Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways
    • Waseem T., Duxbury M., Ito H., Ashley S.W., and Robinson M.K. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143 (2008) 334-342
    • (2008) Surgery , vol.143 , pp. 334-342
    • Waseem, T.1    Duxbury, M.2    Ito, H.3    Ashley, S.W.4    Robinson, M.K.5
  • 50
    • 0036687932 scopus 로고    scopus 로고
    • Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1
    • Wiley K.E., and Davenport A.P. Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1. British Journal of Pharmacology 136 (2002) 1146-1152
    • (2002) British Journal of Pharmacology , vol.136 , pp. 1146-1152
    • Wiley, K.E.1    Davenport, A.P.2
  • 52
    • 23344447877 scopus 로고    scopus 로고
    • The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities
    • Wilson S., Wilkinson G., and Milligan G. The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities. Journal of Biological Chemistry 280 (2005) 28663-28674
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 28663-28674
    • Wilson, S.1    Wilkinson, G.2    Milligan, G.3
  • 53
    • 33846435175 scopus 로고    scopus 로고
    • Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells. Role of receptor heterodimerization
    • Wilson S.J., Dowling J.K., Zhao L., Carnish E., and Smyth E.M. Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells. Role of receptor heterodimerization. Arteriosclerosis Thrombosis and Vascular Biology 27 (2007) 290-296
    • (2007) Arteriosclerosis Thrombosis and Vascular Biology , vol.27 , pp. 290-296
    • Wilson, S.J.1    Dowling, J.K.2    Zhao, L.3    Carnish, E.4    Smyth, E.M.5
  • 54
    • 11144222569 scopus 로고    scopus 로고
    • Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation
    • Wilson S.J., Roche A.M., Kostetskaia E., and Smyth E.M. Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. Journal of Biological Chemistry 279 (2004) 53036-53047
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 53036-53047
    • Wilson, S.J.1    Roche, A.M.2    Kostetskaia, E.3    Smyth, E.M.4
  • 55
    • 4143111272 scopus 로고    scopus 로고
    • Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    • Wu R., Zhou M., Cui X., Simms H.H., and Wang P. Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. American Journal of Physiology 287 (2004) H1296-H1302
    • (2004) American Journal of Physiology , vol.287
    • Wu, R.1    Zhou, M.2    Cui, X.3    Simms, H.H.4    Wang, P.5
  • 56
    • 0032506160 scopus 로고    scopus 로고
    • Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function
    • Zhu X., and Wess J. Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37 (1998) 15773-15784
    • (1998) Biochemistry , vol.37 , pp. 15773-15784
    • Zhu, X.1    Wess, J.2


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