메뉴 건너뛰기




Volumn 71, Issue 9, 2003, Pages 5178-5187

Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in mice

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; GAMMA INTERFERON; IMMUNOGLOBULIN G2; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; INTERLEUKIN 4; MALARIA VACCINE; OLIGODEOXYNUCLEOTIDE; PARASITE ANTIBODY; PARASITE ANTIGEN; RECOMBINANT INTERLEUKIN 12;

EID: 0042825383     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.9.5178-5187.2003     Document Type: Article
Times cited : (64)

References (49)
  • 2
    • 0030938456 scopus 로고    scopus 로고
    • Prolonged Th1-like response generated by a Plasmodium yoelii-specific T cell clone allows complete clearance of infection in reconstituted mice
    • Amante, F. H., and M. F. Good. 1997. Prolonged Th1-like response generated by a Plasmodium yoelii-specific T cell clone allows complete clearance of infection in reconstituted mice. Parasite Immunol. 19:111-126.
    • (1997) Parasite Immunol. , vol.19 , pp. 111-126
    • Amante, F.H.1    Good, M.F.2
  • 3
    • 0037105590 scopus 로고    scopus 로고
    • Innate immune response to malaria: Rapid induction of IFN-γ from human NK cells by live Plasmodium falciparum-infected erythrocytes
    • Artavanis-Tsakonas, K., and E. M. Riley. 2002. Innate immune response to malaria: rapid induction of IFN-γ from human NK cells by live Plasmodium falciparum-infected erythrocytes. J. Immunol. 169:2956-2963.
    • (2002) J. Immunol. , vol.169 , pp. 2956-2963
    • Artavanis-Tsakonas, K.1    Riley, E.M.2
  • 4
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • Braziolot-Millan, C. L., R. Weeratna, A. M. Krieg, C. A. Siegrist, and H. L. Davis. 1998. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. USA 95:1555-1558.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1555-1558
    • Braziolot-Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 5
    • 0031964257 scopus 로고    scopus 로고
    • CpG is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • Davis, H. L., R. Weeratna, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870-876.
    • (1998) J. Immunol. , vol.160 , pp. 870-876
    • Davis, H.L.1    Weeratna, R.2    Waldschmidt, T.J.3    Tygrett, L.4    Schorr, J.5    Krieg, A.M.6
  • 6
    • 0026005902 scopus 로고
    • Protective value of elevated levels of γ interferon in serum against exoerythrocytic stages of P. falciparum
    • Deloran, P., C. Chougnet, J.-P. Lepers, S. Tallet, and P. Coulanges. 1991. Protective value of elevated levels of γ interferon in serum against exoerythrocytic stages of P. falciparum. J. Clin. Microbiol. 29:1757-1760.
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 1757-1760
    • Deloran, P.1    Chougnet, C.2    Lepers, J.-P.3    Tallet, S.4    Coulanges, P.5
  • 7
    • 0032944291 scopus 로고    scopus 로고
    • Immunostimulatory CpG motifs trigger a T helper-1 immune response to human immunodeficiency virus type-1 (HIV) gp160 envelope proteins
    • Demi, L., R. Schirmheck, J. Reimann, H. Wolf, and R. Wagner. 1999. Immunostimulatory CpG motifs trigger a T helper-1 immune response to human immunodeficiency virus type-1 (HIV) gp160 envelope proteins. Clin. Chem. Lab. Med. 37:199-204.
    • (1999) Clin. Chem. Lab. Med. , vol.37 , pp. 199-204
    • Demi, L.1    Schirmheck, R.2    Reimann, J.3    Wolf, H.4    Wagner, R.5
  • 8
    • 0030976099 scopus 로고    scopus 로고
    • Early gamma interferon responses in lethal and nonlethal murine blood-stage malaria
    • DeSouza, J. B., K. H. Williamson, T. Otani, and J. H. Playfair. 1997. Early gamma interferon responses in lethal and nonlethal murine blood-stage malaria. Infect. Immun. 65:1593-1598.
    • (1997) Infect. Immun. , vol.65 , pp. 1593-1598
    • DeSouza, J.B.1    Williamson, K.H.2    Otani, T.3    Playfair, J.H.4
  • 9
    • 0036535062 scopus 로고    scopus 로고
    • Absolute levels and ratios of pro-inflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to P. falciparum malaria
    • Dodoo, D. F. Omer, J. Todd, B. Akanmori, K. Koram, and E. Riley. 2002. Absolute levels and ratios of pro-inflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to P. falciparum malaria. J. Infect. Dis. 185:971-979.
    • (2002) J. Infect. Dis. , vol.185 , pp. 971-979
    • Dodoo, D.1    Omer, F.2    Todd, J.3    Akanmori, B.4    Koram, K.5    Riley, E.6
  • 10
    • 0030879397 scopus 로고    scopus 로고
    • Clinical trials of malaria vaccines: Progress and prospects
    • Facer, C. A., and M. Tanner. 1997. Clinical trials of malaria vaccines: progress and prospects. Adv. Parasitol. 39:1-68.
    • (1997) Adv. Parasitol. , vol.39 , pp. 1-68
    • Facer, C.A.1    Tanner, M.2
  • 11
    • 0030868259 scopus 로고    scopus 로고
    • The course of Plasmodium chabaudi chabaudi infections in interferon-gamma receptor deficient mice
    • Favre, N., B. Ryffel, G. Bordmann, and W. Rudin. 1997. The course of Plasmodium chabaudi chabaudi infections in interferon-gamma receptor deficient mice. Parasite Immunol. 19:375-383.
    • (1997) Parasite Immunol. , vol.19 , pp. 375-383
    • Favre, N.1    Ryffel, B.2    Bordmann, G.3    Rudin, W.4
  • 13
    • 0035525357 scopus 로고    scopus 로고
    • Towards a blood-stage vaccine for malaria: Are we following all the leads?
    • Good, M. F. 2001. Towards a blood-stage vaccine for malaria: are we following all the leads? Nat. Rev. Immunol. 1:117-125.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 117-125
    • Good, M.F.1
  • 14
    • 0033178522 scopus 로고    scopus 로고
    • Immune effector mechanisms in malaria
    • Good, M. F., and D. L. Doolan. 1999. Immune effector mechanisms in malaria. Curr. Opin. Immunol. 11:412-419.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 412-419
    • Good, M.F.1    Doolan, D.L.2
  • 15
    • 0035117252 scopus 로고    scopus 로고
    • Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    • Gramzinski, R. A., D. L. Doolan, M. Sedegah, H. L. Davis, S. M. Krieg, and S. L. Hoffman. 2001. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect. Immun. 69:1643-1649.
    • (2001) Infect. Immun. , vol.69 , pp. 1643-1649
    • Gramzinski, R.A.1    Doolan, D.L.2    Sedegah, M.3    Davis, H.L.4    Krieg, S.M.5    Hoffman, S.L.6
  • 16
    • 0030588550 scopus 로고    scopus 로고
    • IFN-γ independent production of IL-12 during murine endotoxemia
    • Heinzel, F. P., R. M. Rerko, F. Ahmed, and A. M. Hujer. 1996. IFN-γ independent production of IL-12 during murine endotoxemia. J. Immunol. 157:4521-4528.
    • (1996) J. Immunol. , vol.157 , pp. 4521-4528
    • Heinzel, F.P.1    Rerko, R.M.2    Ahmed, F.3    Hujer, A.M.4
  • 19
    • 0031225598 scopus 로고    scopus 로고
    • Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120
    • Jankovic, D., P. Caspar, M. Zweig, M. Garcia-Moll, S. D. Showalter, F. R. Vogel, and A. Sher. 1997. Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120. J. Immunol. 159:2409-2417.
    • (1997) J. Immunol. , vol.159 , pp. 2409-2417
    • Jankovic, D.1    Caspar, P.2    Zweig, M.3    Garcia-Moll, M.4    Showalter, S.D.5    Vogel, F.R.6    Sher, A.7
  • 20
    • 0032909393 scopus 로고    scopus 로고
    • Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-γ-dependent effector mechanisms
    • Jankovic, D., T. A. Wynn, M. C. Kullberg, S. Hieny, P. Caspar, S. James, A. W. Cheever, and A. Sher. 1999. Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-γ-dependent effector mechanisms. J. Immunol. 162:345-351.
    • (1999) J. Immunol. , vol.162 , pp. 345-351
    • Jankovic, D.1    Wynn, T.A.2    Kullberg, M.C.3    Hieny, S.4    Caspar, P.5    James, S.6    Cheever, A.W.7    Sher, A.8
  • 21
    • 0032864099 scopus 로고    scopus 로고
    • Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis
    • Kenney, R. T., D. L. Sacks, J. P. Sypek, L. Vilela, A. A. Gam, and K. Evans-Davis. 1999. Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J. Immunol. 163:4481-4488.
    • (1999) J. Immunol. , vol.163 , pp. 4481-4488
    • Kenney, R.T.1    Sacks, D.L.2    Sypek, J.P.3    Vilela, L.4    Gam, A.A.5    Evans-Davis, K.6
  • 22
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon on the immunoglobulin mu chain gene
    • Kitamura, D., J. Roes, R. Kühn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon on the immunoglobulin mu chain gene. Nature 350:423-426.
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 23
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ
    • Klinman, D., A.-K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ. Proc. Natl. Acad. Sci. USA 93:2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.1    Yi, A.-K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 24
    • 0036095711 scopus 로고    scopus 로고
    • Mouse models of blood-stage malaria infections: Immune responses and cytokines involved in protection and pathology
    • P. Perlmann and M. Troye-Blomberg (ed.). Karger, Basel, Switzerland
    • Langhorne, J., S. J. Quin, and L. A. Sanni. 2002. Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology, p. 204-228. In P. Perlmann and M. Troye-Blomberg (ed.), Malaria immunology. Karger, Basel, Switzerland.
    • (2002) Malaria Immunology , pp. 204-228
    • Langhorne, J.1    Quin, S.J.2    Sanni, L.A.3
  • 27
    • 0031572504 scopus 로고    scopus 로고
    • A synthetic peptide administered with IL-12 elicits immunity to Listeria monocytogenes
    • Miller, M. A., M. J. Skeen, and H. K. Ziegler. 1997. A synthetic peptide administered with IL-12 elicits immunity to Listeria monocytogenes. J. Immunol. 159:3675-3679.
    • (1997) J. Immunol. , vol.159 , pp. 3675-3679
    • Miller, M.A.1    Skeen, M.J.2    Ziegler, H.K.3
  • 28
    • 0031573144 scopus 로고    scopus 로고
    • Natural killer cell cytokine production, not cytotoxicity, contributes to resistance against blood-stage Plasmodium chabaudi AS infection
    • Mohan, K., P. Moulin, and M. M. Stevenson. 1997. Natural killer cell cytokine production, not cytotoxicity, contributes to resistance against blood-stage Plasmodium chabaudi AS infection. J. Immunol. 159:4990-5004.
    • (1997) J. Immunol. , vol.159 , pp. 4990-5004
    • Mohan, K.1    Moulin, P.2    Stevenson, M.M.3
  • 29
    • 0002959878 scopus 로고    scopus 로고
    • Acquired immunity to asexual blood stages
    • I. W. Sherman (ed.). American Society Microbiology, Washington, D.C.
    • Mohan, K., and M. M. Stevenson. 1998. Acquired immunity to asexual blood stages, p. 467-493. In I. W. Sherman (ed.), Malaria: parasite biology, pathogenesis, and protection. American Society Microbiology, Washington, D.C.
    • (1998) Malaria: Parasite Biology, Pathogenesis, and Protection , pp. 467-493
    • Mohan, K.1    Stevenson, M.M.2
  • 30
    • 0036151242 scopus 로고    scopus 로고
    • Improved immunogenecity and efficacy of the recombinant 19-kilodalton merozoite surface protein 1 by addition of oligodeoxynucleotide and aluminum hydroxide gel in a murine malaria vaccine model
    • Near, K. A., A. W. Stowers, D. Jankovic, and D. C. Kaslow. 2002. Improved immunogenecity and efficacy of the recombinant 19-kilodalton merozoite surface protein 1 by addition of oligodeoxynucleotide and aluminum hydroxide gel in a murine malaria vaccine model. Infect. Immun. 70:692-701.
    • (2002) Infect. Immun. , vol.70 , pp. 692-701
    • Near, K.A.1    Stowers, A.W.2    Jankovic, D.3    Kaslow, D.C.4
  • 31
    • 0028361047 scopus 로고
    • Role of cytokines in determining T-lymphocyte function
    • O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458-466.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 458-466
    • O'Garra, A.1    Murphy, K.2
  • 32
    • 0034044126 scopus 로고    scopus 로고
    • The immunology of malaria infection
    • Plebanski, M., and A. Hill. 2000. The immunology of malaria infection. Curr. Opin. Immunol. 12:437-441.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 437-441
    • Plebanski, M.1    Hill, A.2
  • 33
    • 0025964164 scopus 로고
    • + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS
    • + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infect. Immun. 59:51-58.
    • (1991) Infect. Immun. , vol.59 , pp. 51-58
    • Podoba, J.E.1    Stevenson, M.M.2
  • 34
    • 0033082520 scopus 로고    scopus 로고
    • In vivo IL-12 production and IL-12 receptors β1 and β2 mRNA expression in the spleen are differentially up-regulated in resistant B6 and susceptible A/J mice during early blood-stage Plasmodium chabaudi AS malaria
    • Sam, H., and M. M. Stevenson. 1999. In vivo IL-12 production and IL-12 receptors β1 and β2 mRNA expression in the spleen are differentially up-regulated in resistant B6 and susceptible A/J mice during early blood-stage Plasmodium chabaudi AS malaria. J. Immunol. 162:1582-1589.
    • (1999) J. Immunol. , vol.162 , pp. 1582-1589
    • Sam, H.1    Stevenson, M.M.2
  • 35
    • 0032768534 scopus 로고    scopus 로고
    • Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
    • Stacey, K. J., and J. M. Blackwell. 1999. Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infect. Immun. 67:3719-3726.
    • (1999) Infect. Immun. , vol.67 , pp. 3719-3726
    • Stacey, K.J.1    Blackwell, J.M.2
  • 36
    • 0019996586 scopus 로고
    • Murine malaria: Genetic control of resistance to Plasmodium chabaudi
    • Stevenson, M. M., J. J. Lyanga, and E. Skamene. 1982. Murine malaria: genetic control of resistance to Plasmodium chabaudi. Infect. Immun. 38:80-88.
    • (1982) Infect. Immun. , vol.38 , pp. 80-88
    • Stevenson, M.M.1    Lyanga, J.J.2    Skamene, E.3
  • 37
    • 0029045806 scopus 로고
    • IL-12 induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via an NO-dependent mechanism
    • Stevenson, M. M., M. F. Tam, S. F. Wolf, and A. Sher. 1995. IL-12 induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via an NO-dependent mechanism. J. Immunol. 155:2545-2556.
    • (1995) J. Immunol. , vol.155 , pp. 2545-2556
    • Stevenson, M.M.1    Tam, M.F.2    Wolf, S.F.3    Sher, A.4
  • 38
    • 0027411304 scopus 로고
    • Differential induction of helper T cell subsets during blood-stage Plasmodium chabaudi AS infection in resistant and susceptible mice
    • Stevenson, M. M., and M. F. Tam. 1993. Differential induction of helper T cell subsets during blood-stage Plasmodium chabaudi AS infection in resistant and susceptible mice. Clin. Exp. Immunol. 92:77-83.
    • (1993) Clin. Exp. Immunol. , vol.92 , pp. 77-83
    • Stevenson, M.M.1    Tam, M.F.2
  • 39
    • 0036467349 scopus 로고    scopus 로고
    • IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice
    • Su, Z., and M. M. Stevenson. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J. Immunol. 168:1348-1355.
    • (2002) J. Immunol. , vol.168 , pp. 1348-1355
    • Su, Z.1    Stevenson, M.M.2
  • 40
    • 0033914763 scopus 로고    scopus 로고
    • Central role of endogenous gamma interferon in protective immunity against blood-stage Plasmodium chabaudi AS infection
    • Su, Z., and M. M. Stevenson. 2000. Central role of endogenous gamma interferon in protective immunity against blood-stage Plasmodium chabaudi AS infection. Infect. Immun. 68:4399-4406.
    • (2000) Infect. Immun. , vol.68 , pp. 4399-4406
    • Su, Z.1    Stevenson, M.M.2
  • 41
    • 0028234676 scopus 로고
    • B cells are required for the switch from TH1- to TH2-regulated immune response to Plasmodium chabaudi chabaudi infection
    • Taylor-Robinson, A. W., and R. S. Philips. 1994. B cells are required for the switch from TH1- to TH2-regulated immune response to Plasmodium chabaudi chabaudi infection. Infect. Immun. 62:2490-2498.
    • (1994) Infect. Immun. , vol.62 , pp. 2490-2498
    • Taylor-Robinson, A.W.1    Philips, R.S.2
  • 43
    • 0027378346 scopus 로고
    • + T cell subsets to Plasmodium chabaudi chabaudi in B cell-deficient mice
    • + T cell subsets to Plasmodium chabaudi chabaudi in B cell-deficient mice. Int. Immunol. 5:1343-1348.
    • (1993) Int. Immunol , vol.5 , pp. 1343-1348
    • Von der Weid, T.1    Langhorne, J.2
  • 44
    • 0030001823 scopus 로고    scopus 로고
    • Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection
    • von der Weid, T., N. Honarvar, and J. Langhorne. 1996. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. J. Immunol. 156:2510-2516.
    • (1996) J. Immunol. , vol.156 , pp. 2510-2516
    • Von der Weid, T.1    Honarvar, N.2    Langhorne, J.3
  • 45
    • 0033997899 scopus 로고    scopus 로고
    • CpG DNA induces stronger immune responses with less toxicity than other adjuvants
    • Weeratna, R. D., M. J. McCluskie, Y. Xu, and H. S. Davis. 2000. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 18:1755-1762.
    • (2000) Vaccine , vol.18 , pp. 1755-1762
    • Weeratna, R.D.1    McCluskie, M.J.2    Xu, Y.3    Davis, H.S.4
  • 46
    • 0029142790 scopus 로고
    • An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection
    • Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594-596.
    • (1995) Nature , vol.376 , pp. 594-596
    • Wynn, T.A.1    Cheever, A.W.2    Jankovic, D.3    Poindexter, R.W.4    Caspar, P.5    Lewis, F.A.6    Sher, A.7
  • 47
    • 0029042649 scopus 로고
    • IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia
    • Wynn, T. A., D. Jankovic, S. Hieny, A. W. Cheever, and A. Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J. Immunol. 154:4701-4709.
    • (1995) J. Immunol. , vol.154 , pp. 4701-4709
    • Wynn, T.A.1    Jankovic, D.2    Hieny, S.3    Cheever, A.W.4    Sher, A.5
  • 48
    • 0030293445 scopus 로고    scopus 로고
    • IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite
    • Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068-4078.
    • (1996) J. Immunol. , vol.157 , pp. 4068-4078
    • Wynn, T.A.1    Reynolds, A.2    James, S.3    Cheever, A.W.4    Caspar, P.5    Hieny, S.6    Jankovic, D.7    Strand, M.8    Sher, A.9
  • 49
    • 0028070014 scopus 로고
    • Differential requirements for an intact spleen in induction and expression of B-cell-dependent immunity to Plasmodium chabaudi AS
    • Yap, G. S., and M. M. Stevenson. 1994. Differential requirements for an intact spleen in induction and expression of B-cell-dependent immunity to Plasmodium chabaudi AS. Infect. Immun. 62:4219-4225.
    • (1994) Infect. Immun. , vol.62 , pp. 4219-4225
    • Yap, G.S.1    Stevenson, M.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.