Mitochondria as source of free radicals

Frontiers of Gastrointestinal Research

Volumn 29, Issue , 2010, Pages 12-22

  Majima, Hideyuki J ^a   Indo, Hiroko P ^a   Suenaga, Shigeaki ^a   Kaneko, Tsuyoshi ^b   Matsui, Hirofumi ^b   Yen, Hsiu Chuan ^c   Ozawa, Toshihiko ^d  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

APOPTOSIS; ARTICLE; CELL AGING; DNA DAMAGE; GENETIC TRANSFECTION; HUMAN; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 78751540427     PISSN: 03020665     EISSN: None     Source Type: Book Series    
DOI: 10.1159/00031993311     Document Type: Article

References (62)

1. Halliwell B, Gutterridge JMC: Free radicals, other reactive species and disease; in Halliwell B, Gutterridge JMC (eds): Free Radicals in Biology and Medicine. Oxford, Oxford University Press, 1999, pp 617-784.
2. Halliwell B, Gutterridge JMC: Ageing, nutrition, disease and therapy: a role for antioxidants? in Halliwell B, Gutterridge JMC (eds): Free Radicals in Biology and Medicine. Oxford, Oxford University Press, 1999, pp 784-859.
3. McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ: In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci 2003;23:2212-2217.
4. Ikebe S, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T: Increase of deleted mitochondrial DNA in the striatum in Parkinsons disease and senescence. Biochem Biophys Res Commun 1990;170:1044-1048.
5. Beal MF: Mitochondria, oxidative damage, and inflammation in Parkinsons disease. Ann NY Acad Sci 2003;991:120-131.
6. Hoglinger GU, Carrard G, Michel PP, Medja F, Lombes A, Ruberg M, Friguet B, Hirsch EC: Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinsons disease. J Neurochem 2003;86:1297-1307.
7. Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA: Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. J Neurochem 2002;80:616-625.
8. Halliwell B, Gutterridge JMC: Why is superoxide cytotoxic?; in Halliwell B, Gutterridge JMC (eds): Free Radicals in Biology and Medicine. Oxford, Oxford University Press, 1999, pp 129-134.
9. McCord JM, Fridovich I: Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-6055.
10. Weisiger RA, Fridovich I: Mitochondrial superoxide dismutase. J Biol Chem 1973;248:4793-4796.
11. Sawyer DT, Valentine JS: How super is superoxide? Acc Chem Res 1981;14:393-340.
12. Palmer RM, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-526. (Pubitemid 17085822)
13. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990;87:1620-1624.
14. http://nobelprize.org/nobel-prizes/medicine/laureates/1998/.
15. Halestrap A: Biochemistry: a pore way to die. Nature 2005;434:578-579.
16. Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
17. Wei YH: Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med 1998;217:53-63.
18. Linnane AW, Marzuki S, Ozawa T, Tanaka M: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;333:642-645.
19. Wallace DC: Mitochondrial DNA in aging and disease. Sci Am 1997;277:40-47.
20. Boveris A, Cadenas E: Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration. FEBS Lett 1975;1: 311-314.
21. Takeshige K, Minakami S: NADH- and NADPHdependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J 1979;180:129-135.
22. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, Kroemer G: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995;182:367-377.
23. Liu X, Kim CN, Yang J, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996; 86:147-157.
24. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129-1132.
25. Majima H, Oberley TD, Furukawa K, Mattson MP, Yen H-C, Szweda LI, St Clair DK: Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkalineinduced cell death. J Biol Chem 1998;273: 8217-8224.
26. Majima HJ, Indo HP, Tomita K, Suenaga S, Motoori S, Kato H, Yen H-C, Ozawa T: Intracellular oxidative stress caused by ionizing radiation; in Singh KK (ed): Oxidative Stress, Disease and Cancer. London, Imperial College Press, 2006, pp 61-83.
27. Arai M, Imai H, Koumura T, Yoshida M, Emoto K, Umeda M, Chiba N, Nakagawa Y: Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem 1999;274:4924-4933.
28. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G: Molecular characterization of mitochondrial apoptosis- inducing factor. Nature 1999;397:441-446.
29. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM, Kroemer G: Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 1999; 189:381-394.
30. Suzuki A, Tsutomi Y, Yamamoto N, Shibutani T, Akahane K: Mitochondrial regulation of cell death: mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell death. Mol Cell Biol 1999;19:3842-3847.
31. Gray MW, Burger G, Lang BF: Mitochondrial evolution. Science 1999;283:1476-1481.
32. Salway JG: Oxidation of glucose yields 31 ATP molecules assuming the modern P/O ratios of 2.5 for NADH and 1.5 for FADH2, in Salway JG (ed): Metabolism at a Glance. Malden, Blackwell Publishing, 2004, pp 21.
33. Beyer RE: An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem Cell Biol 1992;70:390-403.
34. Boveris A, Chance B: The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973;134:707-716.
35. Indo HP, Davidson M, Yen H-C, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007;7:106-118.
36. Sato N, Wilson DF, Chance B: Two b cytochromes of pigeon heart mitochondria. FEBS Lett 1971;15: 209-212.
37. Dutton PL, Erecinska M, Sato N, Mukai Y, Pring M, Wilson DF: Reactions of b-cytochromes with ATP and antimycin A in pigeon heart mitochondria. Biochim Biophys Acta 1972;267:15-24.
38. Cross AR, Jones OT: Enzymic mechanisms of superoxide production. Biochim Biophys Acta 1991;1057: 281-298.
39. Zhang JG, Nicholls-Grzemski FA, Tirmenstein MA, Fariss MW: Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents. Chem Biol Interact 2001;138: 267-284.
40. Yamagishi S, Edelstein D, Du X, Kaneda Y, Guzman M, Brownlee M: Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001;276:25096-25100.
41. Muller FL, Liu Y, Van Remmen H: Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 2004;279:49064-49073.
42. Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T: Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 2003;278:3170-3175.
43. Barja G: Free radicals and aging. Trends Neurosci 2004;27:595-600.
44. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC: Mitochondrial DNA deletions in human brain; regional variability and increase with advanced age. Nat Genet 1992;2:324-329.
45. Hayakawa M, Hattori K, Sugiyama S, Ozawa T: Ageassociated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem Biophys Res Commun 1992;189:979-985.
46. Chomyn A, Attardi G: MtDNA mutations in aging and apoptosis. Biochem Biophys Res Commun 2003;304:519-529.
47. Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, Tuttle JB: Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimers disease. J Neurosci 1997;17: 4612-4622.
48. Chance B, Sies H, Boveris A: Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59: 527-605.
49. Kushnareva Y, Murphy AN, Andreyev A: Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation- reduction state. Biochem J 2002;368:545-553.
50. Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ: Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 2003;278:36027-36031.
51. Jezek P, Hlavata L: Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int J Biochem Cell Biol 2005;37:2478-2503.
52. Guidot DM, McCord JM, Wright RM, Repine JE: Absence of electron transport (Rho0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo. J Biol Chem 1993;268: 26699-26703.
53. Adam-Vizi V: Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal 2005;7:1140-1149.
54. Sancho S, Moraes CT, Tanji K, Miranda AF: Structural and functional mitochondrial abnormalities associated with high levels of partially deleted mitochondrial DNAs in somatic cell hybrids. Somat Cell Mol Genet 1992;18:431-442.
55. Miranda S, Foncea R, Guerrero J, Leighton F: Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun 1999; 258:44-49.
56. Marchetti P, Susin SA, Decaudin D, Gamen S, Castedo M, Hirsch T, Zamzami N, Naval J, Senik A, Kroemer G: Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Cancer Res 1996;56:2033-2038.
57. Bandy B, Davison AJ: Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic Biol Med 1990;8:523-539.
58. Peng T-I, Yu P-R, Chen J-Y, Wang H-L, Wu H-Y, Wei Y-H, Jou M-J: Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress. Biochim Biophys Acta 2006; 1762:241-255.
59. Mattson MP: Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000;1:120-129.
60. Mattson MP, Duan W, Pedersen WA, Culmsee C: Neurodegenerative disorders and ischemic brain diseases. Apoptosis 2001;6:69-81.
61. Motoori S, Majima HJ, Ebara M, Kato H, Hirai F, Kakinuma S, Yamaguchi C, Ozawa T, Nagano T, Tsujii H, Saisho H: Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line, HLE. Cancer Res 2001;61:5382-5388.
62. Hirai F, Motoori S, Kakinuma S, Tomita K, Indo HP, Kato H, Yamaguchi T, Yen H-C, St Clair DK, Nagano T, Ozawa T, Saisho H, Majima HJ: Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4. Antioxid Redox Signal 2004;6:523-535.