Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents

Chemico-Biological Interactions

Volumn 138, Issue 3, 2001, Pages 267-284

  Zhang, J G ^a   Nicholls Grzemski, F A ^a   Tirmenstein, M A ^a   Fariss, M W ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Tocopheryl succinate; Alkylating agents; Ethyl methanesulfonate; Hepatocyte suspensions; Mitochondrial electron transport chain; Reactive oxygen species; Vitamin E

Indexed keywords

ALKYLATING AGENT; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL SUCCINATE; ANTIMYCIN A1; LIPID HYDROPEROXIDE; MESYLIC ACID ETHYL ESTER; REACTIVE OXYGEN METABOLITE; ROTENONE; THENOYLTRIFLUOROACETONE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; LIPID PEROXIDATION; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICITY;

ANIMALS; ANTIMYCIN A; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; DRUG ANTAGONISM; ELECTRON TRANSPORT; ENZYME INHIBITORS; ETHYL METHANESULFONATE; HEPATOCYTES; LIPID PEROXIDATION; MALE; MITOCHONDRIA; NECROSIS; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; ROTENONE; THENOYLTRIFLUOROACETONE; TOCOPHEROLS; VITAMIN E;

EID: 0035930395     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00278-2     Document Type: Article

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