-
1
-
-
67650874081
-
Cancer statistics
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. Cancer J Clin 2009;59:225-49.
-
(2009)
Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
4
-
-
44749093232
-
Intravesical treatments of bladder cancer: Review
-
Shen Z, Shen T, Wientjes MG, O'Donnell MA, Au JL. Intravesical treatments of bladder cancer: review. Pharm Res 2008;25:1500-10.
-
(2008)
Pharm Res
, vol.25
, pp. 1500-1510
-
-
Shen, Z.1
Shen, T.2
Wientjes, M.G.3
O'Donnell, M.A.4
Au, J.L.5
-
5
-
-
68349113541
-
Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression
-
Wu KJ, Zeng J, Zhu GD, Zhang LL, Zhang D, Li L, et al. Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Acta Pharmacol Sin 2009; 30:1162-8.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 1162-1168
-
-
Wu, K.J.1
Zeng, J.2
Zhu, G.D.3
Zhang, L.L.4
Zhang, D.5
Li, L.6
-
6
-
-
35848966581
-
p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells
-
Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R. p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther 2007;6:2696-707.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2696-2707
-
-
Roy, S.1
Kaur, M.2
Agarwal, C.3
Tecklenburg, M.4
Sclafani, R.A.5
Agarwal, R.6
-
7
-
-
36348976518
-
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model
-
Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2007;67:11083-91.
-
(2007)
Cancer Res
, vol.67
, pp. 11083-11091
-
-
Raina, K.1
Blouin, M.J.2
Singh, R.P.3
Majeed, N.4
Deep, G.5
Varghese, L.6
-
8
-
-
59449085306
-
Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
-
Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 2008;14:7773-80.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7773-7780
-
-
Singh, R.P.1
Raina, K.2
Sharma, G.3
Agarwal, R.4
-
9
-
-
59449097284
-
Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling
-
Singh RP, Raina K, Deep G, Chan D, Agarwal R. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clin Cancer Res 2009;15:613-21.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 613-621
-
-
Singh, R.P.1
Raina, K.2
Deep, G.3
Chan, D.4
Agarwal, R.5
-
10
-
-
3242786628
-
Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
-
Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep 2004;11:493-9.
-
(2004)
Oncol Rep
, vol.11
, pp. 493-499
-
-
Tyagi, A.K.1
Agarwal, C.2
Chan, D.C.3
Agarwal, R.4
-
11
-
-
33846326821
-
Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells
-
Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS. Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochem Biophys Res Commun 2007;354:165-71.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 165-171
-
-
Lee, S.O.1
Jeong, Y.J.2
Im, H.G.3
Kim, C.H.4
Chang, Y.C.5
Lee, I.S.6
-
12
-
-
34248192416
-
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
-
DOI 10.1158/0008-5472.CAN-06-3955
-
Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res 2007;67:3483-91. (Pubitemid 46724890)
-
(2007)
Cancer Research
, vol.67
, Issue.7
, pp. 3483-3491
-
-
Gu, M.1
Singh, R.P.2
Dhanalakshmi, S.3
Agarwal, C.4
Agarwal, R.5
-
13
-
-
40949106128
-
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
-
Singh RP, Gu M, Agarwal R. Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res 2008;68:2043-50.
-
(2008)
Cancer Res
, vol.68
, pp. 2043-2050
-
-
Singh, R.P.1
Gu, M.2
Agarwal, R.3
-
14
-
-
33745239300
-
Effect of silibinin on the growth and progression of primary lung tumors in mice
-
Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, et al. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 2006;98:846-55.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 846-855
-
-
Singh, R.P.1
Deep, G.2
Chittezhath, M.3
Kaur, M.4
Dwyer-Nield, L.D.5
Malkinson, A.M.6
-
15
-
-
34447130474
-
Therapeutic value of orally administered silibinin in renal cell carcinoma: Manipulation of insulin-like growth factor binding protein-3 levels
-
Cheung CW, Taylor PJ, Kirkpatrick CM, Vesey DA, Gobe GC, Winterford C, et al. Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels. Bju Int 2007; 100:438-44.
-
(2007)
Bju Int
, vol.100
, pp. 438-444
-
-
Cheung, C.W.1
Taylor, P.J.2
Kirkpatrick, C.M.3
Vesey, D.A.4
Gobe, G.C.5
Winterford, C.6
-
16
-
-
53949096956
-
Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
-
Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 2008;272:61-9.
-
(2008)
Cancer Lett
, vol.272
, pp. 61-69
-
-
Li, L.1
Gao, Y.2
Zhang, L.3
Zeng, J.4
He, D.5
Sun, Y.6
-
17
-
-
0344495296
-
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells
-
Tyagi AK, Agarwal C, Singh RP, Shroyer KR, Glode LM, Agarwal R. Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem Biophys Res Commun 2003;312:1178-84.
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 1178-1184
-
-
Tyagi, A.K.1
Agarwal, C.2
Singh, R.P.3
Shroyer, K.R.4
Glode, L.M.5
Agarwal, R.6
-
18
-
-
4544287556
-
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
-
Tyagi A, Agarwal C, Harrison G, Glode LM, Agarwal R. Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 2004;25: 1711-20.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1711-1720
-
-
Tyagi, A.1
Agarwal, C.2
Harrison, G.3
Glode, L.M.4
Agarwal, R.5
-
19
-
-
33750468718
-
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/ p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2
-
Tyagi A, Singh RP, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/ p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis 2006;27:2269-80.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2269-2280
-
-
Tyagi, A.1
Singh, R.P.2
Agarwal, C.3
Agarwal, R.4
-
20
-
-
37549009050
-
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin
-
Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 2008;14:300-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 300-308
-
-
Singh, R.P.1
Tyagi, A.2
Sharma, G.3
Mohan, S.4
Agarwal, R.5
-
21
-
-
74549146799
-
Targeting silibinin in the antiproliferative pathway
-
Li L, Zeng J, Gao Y, He D. Targeting silibinin in the antiproliferative pathway. Expert Opin Invest Drugs 2010;19:243-255.
-
(2010)
Expert Opin Invest Drugs
, vol.19
, pp. 243-255
-
-
Li, L.1
Zeng, J.2
Gao, Y.3
He, D.4
-
22
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
DOI 10.1016/S0092-8674(00)80085-9
-
Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147-57. (Pubitemid 26256586)
-
(1996)
Cell
, vol.86
, Issue.1
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
24
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:41-6.
-
(1999)
Nature
, vol.397
, pp. 41-46
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
-
25
-
-
4344598699
-
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
-
Gallego MA, Joseph B, Hemstrom TH, Tamiji S, Mortier L, Kroemer G, et al. Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas. Oncogene 2004;23:6282-91.
-
(2004)
Oncogene
, vol.23
, pp. 6282-6291
-
-
Gallego, M.A.1
Joseph, B.2
Hemstrom, T.H.3
Tamiji, S.4
Mortier, L.5
Kroemer, G.6
-
26
-
-
41149087346
-
Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway
-
Gallego MA, Ballot C, Kluza J, Hajji N, Martoriati A, Castera L, et al. Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway. Oncogene 2008;27:1981-92.
-
(2008)
Oncogene
, vol.27
, pp. 1981-1992
-
-
Gallego, M.A.1
Ballot, C.2
Kluza, J.3
Hajji, N.4
Martoriati, A.5
Castera, L.6
-
27
-
-
23844434673
-
AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells
-
Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, et al. AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells. EMBO J 2005;24:2815-26.
-
(2005)
EMBO J
, vol.24
, pp. 2815-2826
-
-
Urbano, A.1
Lakshmanan, U.2
Choo, P.H.3
Kwan, J.C.4
Ng, P.Y.5
Guo, K.6
-
28
-
-
37549017366
-
Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice
-
Tyagi A, Raina K, Singh RP, Gu M, Agarwal C, Harrison G, et al. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 2007;6:3248-55.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3248-3255
-
-
Tyagi, A.1
Raina, K.2
Singh, R.P.3
Gu, M.4
Agarwal, C.5
Harrison, G.6
-
29
-
-
33847185959
-
High glucose induces caspase-independent cell death in retinal neural cells
-
Santiago AR, Cristovao AJ, Santos PF, Carvalho CM, Ambrosio AF. High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis 2007;25:464-72.
-
(2007)
Neurobiol Dis
, vol.25
, pp. 464-472
-
-
Santiago, A.R.1
Cristovao, A.J.2
Santos, P.F.3
Carvalho, C.M.4
Ambrosio, A.F.5
-
30
-
-
27144547642
-
Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines
-
Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, et al. Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. J Biol Chem 2005;280:34878-87.
-
(2005)
J Biol Chem
, vol.280
, pp. 34878-34887
-
-
Levrand, S.1
Pesse, B.2
Feihl, F.3
Waeber, B.4
Pacher, P.5
Rolli, J.6
-
31
-
-
0034698733
-
Two distinct pathways leading to nuclear apoptosis
-
Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med 2000;192:571-80.
-
(2000)
J Exp Med
, vol.192
, pp. 571-580
-
-
Susin, S.A.1
Daugas, E.2
Ravagnan, L.3
Samejima, K.4
Zamzami, N.5
Loeffler, M.6
-
32
-
-
0025154963
-
Characterization of an N-methyl-N-nitrosourea-induced autochthonous rat bladder cancer model
-
Steinberg GD, Brendler CB, Ichikawa T, Squire RA, Isaacs JT. Characterization of an N-methyl-N-nitrosourea-induced autochthonous rat bladder cancer model. Cancer Res 1990;50:6668-74. (Pubitemid 20348798)
-
(1990)
Cancer Research
, vol.50
, Issue.20
, pp. 6668-6674
-
-
Steinberg, G.D.1
Brendler, C.B.2
Ichikawa, T.3
Squire, R.A.4
Isaacs, J.T.5
-
33
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6:513-9.
-
(2000)
Nat Med
, vol.6
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
34
-
-
59449110529
-
Targeting the apoptosome for cancer therapy
-
Ledgerwood EC, Morison IM. Targeting the apoptosome for cancer therapy. Clin Cancer Res 2009;15:420-4.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 420-424
-
-
Ledgerwood, E.C.1
Morison, I.M.2
-
35
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94:481-90.
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
36
-
-
0037267333
-
Validating survivin as a cancer therapeutic target
-
Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003;3:46-54.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 46-54
-
-
Altieri, D.C.1
-
37
-
-
37549036729
-
Survivin, cancer networks and pathway-directed drug discovery
-
Altieri DC. Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 2008;8:61-70.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 61-70
-
-
Altieri, D.C.1
-
38
-
-
39349098773
-
Survivin: A promising biomarker for detection and prognosis of bladder cancer
-
Margulis V, Lotan Y, Shariat SF. Survivin: a promising biomarker for detection and prognosis of bladder cancer. World J Urol 2008;26:59-65.
-
(2008)
World J Urol
, vol.26
, pp. 59-65
-
-
Margulis, V.1
Lotan, Y.2
Shariat, S.F.3
-
39
-
-
0034617449
-
Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
-
Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin SA, Zamzami N, et al. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 2000;476: 118-23.
-
(2000)
FEBS Lett
, vol.476
, pp. 118-123
-
-
Daugas, E.1
Nochy, D.2
Ravagnan, L.3
Loeffler, M.4
Susin, S.A.5
Zamzami, N.6
-
40
-
-
18244386261
-
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis.Omi interactswith caspase-inhibitor XIAPand induces enhanced caspase activity
-
van Loo G, van GurpM, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, et al. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis.Omi interactswith caspase-inhibitor XIAPand induces enhanced caspase activity. Cell Death Differ 2002;9:20-6.
-
(2002)
Cell Death Differ
, vol.9
, pp. 20-26
-
-
Van Loo, G.1
Van Gurp, M.2
Depuydt, B.3
Srinivasula, S.M.4
Rodriguez, I.5
Alnemri, E.S.6
-
41
-
-
0037275960
-
Viral modulation of cell death by inhibition of caspases
-
Cassens U, Lewinski G, Samraj AK, von Bernuth H, Baust H, Khazaie K, et al. Viral modulation of cell death by inhibition of caspases. Arch Immunol Ther Exp 2003;51:19-27.
-
(2003)
Arch Immunol Ther Exp
, vol.51
, pp. 19-27
-
-
Cassens, U.1
Lewinski, G.2
Samraj, A.K.3
Von Bernuth, H.4
Baust, H.5
Khazaie, K.6
-
42
-
-
33746827856
-
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
-
Munoz-Pinedo C, Guio-Carrion A, Goldstein JC, Fitzgerald P, New-meyer DD, Green DR. Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci U S A 2006;103: 11573-8.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11573-11578
-
-
Munoz-Pinedo, C.1
Guio-Carrion, A.2
Goldstein, J.C.3
Fitzgerald, P.4
New-meyer, D.D.5
Green, D.R.6
-
43
-
-
0042626442
-
Intravesical therapy of superficial bladder cancer
-
Malmstrom PU. Intravesical therapy of superficial bladder cancer. Crit Rev Oncol Hematol 2003;47:109-26.
-
(2003)
Crit Rev Oncol Hematol
, vol.47
, pp. 109-126
-
-
Malmstrom, P.U.1
|