Total synthesis of natural and non-natural δ 5,6δ 12,13-jatrophane diterpenes and their evaluation as MDR modulators

Journal of Organic Chemistry

Volumn 76, Issue 2, 2011, Pages 512-522

  Schnabel, Christoph ^a   Sterz, Katja ^b   Müller, Henrik ^b   Rehbein, Julia ^a,c   Wiese, Michael ^b   Hiersemann, Martin ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CHEMOTHERAPY; CARBONYL-ENE REACTIONS; DFT CALCULATION; DITERPENES; DOUBLE BONDS; JATROPHA; MULTIDRUG RESISTANCE; PENTADECANE; RING CLOSING METATHESIS; SUZUKI-MIYAURA CROSS-COUPLING; TOTAL SYNTHESIS;

CHEMOTHERAPY; OLEFINS;

SYNTHESIS (CHEMICAL);

15 O ACETYL 3 O BENZOYLCHARACIOL OXIDE; ALPHA HYDROXY KETONE 23; BENZENEBORONIC ACID; BENZILIC ACID; BREAST CANCER RESISTANCE PROTEIN; DIOL 19; DITERPENE; JATROPHANE DITERPENE DERIVATIVE; KETONE 22; MULTIDRUG RESISTANCE PROTEIN 1; TRIENE 21; UNCLASSIFIED DRUG; VINYL IODIDE 15;

ARTICLE; CROSS COUPLING REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; EUPHORBIA;

ANTINEOPLASTIC AGENTS; BIOLOGICAL AGENTS; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; CYCLOPENTANES; DITERPENES; DRUG RESISTANCE, MULTIPLE; EUPHORBIA; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLANT EXTRACTS; STEREOISOMERISM;

EID: 78651520488     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo1019738     Document Type: Article

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