Folate and colorectal cancer prevention

British Journal of Cancer

Volumn 100, Issue 2, 2009, Pages 233-239

  Hubner, R A ^a,b   Houlston, R S ^b  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Colorectal cancer; Folate; Prevention

Indexed keywords

ACETYLSALICYLIC ACID; CALCIUM; CYCLOOXYGENASE 2 INHIBITOR; FOLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; CLINICAL TRIAL; COLON POLYP; COLORECTAL ADENOMA; COLORECTAL CANCER; DIETARY INTAKE; DNA METHYLATION; DNA POLYMORPHISM; DNA SYNTHESIS; DRUG EFFICACY; DRUG SAFETY; FOLATE METABOLISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; VITAMIN INTAKE;

COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; FOLIC ACID; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN B COMPLEX;

EID: 58749098213     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604823     Document Type: Review

References (39)

1. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94: 3290-3295
2. Boyapati SM, Bostick RM, McGlynn KA, Fina MF, Roufail WM, Geisinger KR, Hebert JR, Coker A, Wargovich M (2004) Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States). Cancer Causes Control 15: 493-501
3. Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ (1996) A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 56: 4862-4864
4. Choi SW, Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132: 2413S-2418S
5. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297: 2351-2359
6. Cravo ML, Mason JB, Dayal Y, Hutchinson M, Smith D, Selhub J, Rosenberg IH (1992) Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 52: 5002-5006
7. de Vogel S, Bongaerts BW, Wouters KA, Kester AD, Schouten LJ, de Goeij AF, deBruine AP, Goldbohm RA, van den Brandt PA, van Engeland M, Weijenberg MP (2008) Association of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. Carcinogenesis 29: 1765-1773
8. Eden A, Gaudet F, Waghmare A, Jaenisch R (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300: 455
9. Giovannucci E (2002) Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 132: 2350S-2355S
10. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC (1998) Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 129: 517-524
11. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC (1993) Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85: 875-884
12. Hubner RA, Houlston RS (2007) MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations. Int J Cancer 120: 1027-1035
13. Hubner RA, Lubbe S, Chandler I, Houlston RS (2007) MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer. Hum Mol Genet 16: 1072-1077
14. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM, Swendseid ME (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in post-menopausal women. J Nutr 128: 1204-1212
15. Jacobs EJ, Connell CJ, Chao A, McCullough ML, Rodriguez C, Thun MJ, Calle EE (2003) Multivitamin use and colorectal cancer incidence in a US cohort: does timing matter? Am J Epidemiol 158: 621-628
16. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43-66
17. Kato I, Dnistrian AM, Schwartz M, Toniolo P, Koenig K, Shore RE, Akhmedkhanov A, Zeleniuch-Jacquotte A, Riboli E (1999) Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. Br J Cancer 79: 1917-1922
18. Kim YI (2004) Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 80: 1123-1128
19. Kim YI, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallal GE, Mason JB (1996) Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut 39: 732-740
20. Le Marchand L, Wilkens LR, Kolonel LN, Henderson BE (2005) The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 14: 1198-1203
21. Logan RF, Grainge MJ, Shepherd VC, Armitage NC, Muir KR (2008) Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 134: 29-38
22. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57: 1098-1102
23. Martinez ME, Thompson P, Jacobs ET, Giovannucci E, Jiang R, Klimecki W, Alberts DS (2006) Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway. Gastroenterology 131: 1706-1716
24. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH (2007) A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 16: 1325-1329
25. McKinnon PJ, Caldecott KW (2007) DNA strand break repair and human genetic disease. Annu Rev Genomics Hum Genet 8: 37-55
26. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338: 131-137
27. Otani T, Iwasaki M, Sasazuki S, Inoue S (2008) Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based Prospective Study Group. Cancer Causes Control 19: 67-74
28. Pogribny IP, Miller BJ, James SJ (1997) Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett 115: 31-38
29. Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ (2005) Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer 113: 825-828
30. Shane B (1995) Folate chemistry and metabolism. In Folate in health and disease Baile LB (ed), pp 1-22. Marcel Dekker: New York
31. Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159: 423-443
32. Sharp L, Little J, Brockton NT, Cotton SC, Masson LF, Haites NE, Cassidy J (2008) Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins, and colorectal cancer: a case-control study in a population with relatively low folate intake. Br J Nutr 99: 379-389
33. Song J, Medline A, Mason JB, Gallinger S, Kim YI (2000a) Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res 60: 5434-5440
34. Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI (2000b) Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Cancer Res 60: 3191-3199
35. Sweeney MR, McPartlin J, Scott J (2007) Folic acid fortification and public health: report on threshold doses above, which unmetabolised folic acid appear in serum. BMC Public Health 7: 41-47
36. Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML (2005) Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 14: 2509-2516
37. Ulrich CM, Potter JD (2007) Folate and cancer-timing is everything. JAMA 297: 2408-2409
38. Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A, Palmqvist R (2006) Low folate levels may protect against colorectal cancer. Gut 55: 1461-1466
39. World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Institute for Cancer Research: Washington, DC